The functioning of otolith organs in individuals with type-II diabetes mellitus.

Aim: Diabetes mellitus (DM), a systemic disease, is a major public health concern. It is possible that micro and macrovascular changes in the inner ear due to DM could affect both auditory and vestibular functioning. However, there is a lack of conclusive evidence for vestibular impairment in individuals with DM.

Common Variable Immunodeficiency Disorder: A Decade of Insights from a Cohort of 150 Patients in India and the Use of Machine Learning Algorithms to Predict Severity.

Common Variable Immunodeficiency (CVID) is a heterogeneous disorder characterized by impaired antibody production and recurrent infections. In this study we investigated the clinical and immunological features of CVID in Indian patients and develops a machine learning model for predicting disease severity. We retrospectively analyzed 150 patients diagnosed with CVID over a decade at a tertiary care center in India.

Bacterial Contamination of Spacer Devices Used by Asthmatic Children: A Cross-Sectional Study.

Objective: To assess the prevalence of bacterial contamination of spacer devices used by asthmatic children.

Methods: A cross-sectional study at a tertiary centre in India included asthmatic children aged 5 to 17 years who were using metered-dose inhaler (MDI) with a spacer for at least three months. A sterile cotton swab pre-moistened in sterile brain heart infusion (BHI) broth, rotated around the inner surface of the spacers, was smeared on blood agar and MacConkey agar plates.

Microbiological Profile of Airway in Indian Children With Cystic Fibrosis: A Multicenter Prospective Cohort Study.

Background: There is a paucity of information on the microbiological profile in Indian children with CF. This study aimed to evaluate the microbial profile of airways in Indian children with CF and to generate antibiotic sensitivity patterns.

Methods: Children ≤ 18 years old with newly diagnosed CF (Clinical and two positive sweat chloride tests) were included.

Assessment of Semicircular Canal Functioning Using a Video Head Impulse Test in Individuals with Occupational Noise Exposure.

Exposure to noise or loud sound damages the cochlea and can result in hearing loss, which has been well-documented. Research over the years has shown that individuals exposed to noise for a short or extended period may develop vestibular problems. The otolith organs are found to be more susceptible to noise exposure or acoustic trauma than the semicircular canals (SCC).

Symptoms of Depression and Inhaler Adherence Among Adolescents With Asthma: Is There an Association?

Background: The prevalence of depression among adolescents with asthma is reported to be 27%-34% across different geographical regions. Asthma control depends on inhaler adherence. Studies on the association of depression and inhaler adherence among adolescents with asthma are few, especially in the Indian subcontinent.

Diagnostic accuracy of ancillary tests in diagnosis of cystic fibrosis and development of cystic fibrosis clinical diagnostic score: A multicentre prospective cohort study.

Background: Diagnostic tests for cystic fibrosis (CF) are not readily available in resource-limited settings, which leads to delay in diagnosis and treatment of children with CF.

Methods: In a multicentric prospective study, children with recurrent/persistent pneumonia, failure to thrive, or steatorrhea with suspicion of CF were enrolled. Sweat chloride concentration was measured to confirm the diagnosis of CF.

Assessing bronchiolitis severity: a comparative analysis of two commonly used clinical scoring systems.

Unlabelled: The purpose of this study to compare the effectiveness of the Bronchiolitis Severity Score (BSS) and the Respiratory Distress Assessment Instrument (RDAI) in determining bronchiolitis severity and predicting outcomes. Additionally, it aimed to establish optimum cutoff points for both scores. In this prospective observational study, clinical details of enrolled infants, along with assessments using both scoring tools, were recorded.

Congenital cytomegalovirus pneumonia presents as pleural effusion in infancy.

Cytomegalovirus (CMV) infection is one of the most common congenital infections. We present a case of an infant who presented with respiratory distress since birth with a normal antenatal history. The infant had bilateral pleural effusion.