98%
921
2 minutes
20
Unlabelled: The purpose of this study to compare the effectiveness of the Bronchiolitis Severity Score (BSS) and the Respiratory Distress Assessment Instrument (RDAI) in determining bronchiolitis severity and predicting outcomes. Additionally, it aimed to establish optimum cutoff points for both scores. In this prospective observational study, clinical details of enrolled infants, along with assessments using both scoring tools, were recorded. The performance of these scores in predicting "severe disease," defined by respiratory support requirements other than nasal prongs, PICU admission, respiratory acidosis, and/or altered consciousness, was evaluated. A total of 64 infants diagnosed with bronchiolitis were enrolled with a median age of 5 (3.8) months, and 16 (25%) infants had severe disease. BSS showed 25% sensitivity and 97.9% specificity at established cutoffs of > 8 for severe bronchiolitis. BSS performed better than RDAI in differentiating severe bronchiolitis [AUC, 0.733 vs 0.605; p = 0.035]. New cutoffs of > 5 points for BSS and > 8 points for RDAI increased BSS sensitivity to 68.8% and RDAI sensitivity to 56.3%.
Conclusion: BSS demonstrated superior discriminative ability compared to RDAI in identifying severe bronchiolitis. New cutoff points enhanced BSS's ability to classify severe cases while establishing a cutoff for RDAI. Additional studies are required to validate these revised cutoffs.
What Is Known: • Bronchiolitis severity score (BSS) and Respiratory Distress Assessment Instrument (RDAI) helps in determining bronchiolitis severity.
What Is New: • BSS has superior discriminatory ability as compared to RDAI in determining bronchiolitis severity. • This study also highlights that neither BSS nor RDAI is perfect, emphasizing the importance of clinical judgment over scoring systems.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1007/s00431-025-06000-3 | DOI Listing |
Br J Haematol
September 2025
Department of Internal Medicine, National Taiwan University Cancer Center, Taipei, Taiwan.
Pulmonary chronic graft-versus-host disease (cGVHD), particularly bronchiolitis obliterans syndrome (BOS), is a severe complication of allogeneic haematopoietic stem cell transplantation (allo-HSCT) with significant morbidity and mortality. This report, developed collaboratively by experts from the Taiwan Society of Blood and Marrow Transplantation (TBMT) and the Taiwan Society of Pulmonary and Critical Care Medicine (TSPCCM), provides consensus statements for the diagnosis, surveillance and management of pulmonary cGVHD. Early detection through pulmonary function tests (PFTs) is critical, with serial monitoring recommended after allo-HSCT.
View Article and Find Full Text PDFBMJ Paediatr Open
September 2025
Division of Medical Critical Care, Boston Children's Hospital, Boston, Massachusetts, USA.
Background: Limited evidence exists on the additive risk of bradycardia in children with respiratory syncytial virus (RSV) bronchiolitis receiving dexmedetomidine (DMED). We aim to study the association between RSV bronchiolitis and bradycardia during DMED administration.
Methods: This retrospective cohort study included 273 children under 2 years old admitted to the intensive care units at Boston Children's Hospital with severe bronchiolitis and sedated with DMED from 2009 to 2022.
JHLT Open
November 2025
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Respiratory viruses encompass a diverse group of viruses, including influenza, respiratory syncytial virus (RSV), parainfluenza (PIV), human metapneumovirus (hMPV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and adenovirus. Lung transplant recipients are particularly vulnerable to complications from respiratory viral infections (RVIs), leading to increased morbidity and mortality. This heightened risk is a result of both anatomical and functional modifications from transplant surgery, as well as immunosuppressive therapy.
View Article and Find Full Text PDFViruses
July 2025
Pediatric Unit, Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, 98124 Messina, Italy.
Respiratory syncytial virus (RSV) is a major cause of acute lower respiratory infections (ALRIs) in young children, especially bronchiolitis, with significant global health and economic impact. Increasing evidence links early-life RSV infection to long-term respiratory complications, notably recurrent wheezing and asthma. This narrative review examines these associations, emphasizing predictive factors and emerging biomarkers for risk stratification.
View Article and Find Full Text PDFMicroorganisms
August 2025
Department of Microbiology, Medical School of Athens, National and Kapodistrian University of Athens, 75 Mikras Asias Street, 11527 Athens, Greece.
Respiratory syncytial virus (RSV) remains a leading cause of acute lower respiratory tract infections globally, particularly affecting infants, older adults, and immunocompromised individuals. While recent advances in prophylaxis, such as long-acting monoclonal antibodies and maternal immunization, offer promise for prevention, therapeutic options for active infection remain limited. Severe RSV disease is often driven not solely by viral replication but by dysregulated host immune responses, including excessive cytokine production, T helper type 2 (Th2) and T helper type 17 (Th17) cell polarization, and impaired interferon signaling.
View Article and Find Full Text PDF