Fucoidan enhances stability of gelatin/anthocyanin-based oleogels via hydrogen-bonded crosslinking.

Polyphenols and edible polysaccharides have emerged as promising crosslinking agents to enhance structural stabilities of protein emulsions and their templated oleogels. To enhance stabilities of gelatin (G) emulsion-based oleogels, three edible polysaccharides and two typical polyphenols were employed to oleogel preparation. Fucoidan (FUC) and flaxseed gum (FG) formed more compact network than sodium alginate, improving three-phase contact of gelatin.

Longan Polysaccharide as Adjuvant for Cyclophosphamide-Induced Side Effects in Murine Model.

Identifying effective adjuvants to prevent and alleviate the adverse effects of chemotherapy remains a critical challenge in cancer therapy. This study investigated the protective effects of longan polysaccharide (LP) against cyclophosphamide-induced immunosuppression and oxidative stress in mice. Our findings revealed that LP administration significantly improved systemic immune function, as evidenced by marked increases in serum immunoglobulin levels (IgG2a: 1.

Bioinspired oxidase nanozymes for chlorpyrifos sensing and tetracyclines eliminating.

Oxidases play a crucial role in living systems and in vitro biotransformation. Nonetheless, the intrinsic fragility of natural oxidases confined their extensive utilization. Nanozymes with intrinsic oxidase-mimicking activity are emerging as potential alternatives to natural oxidases.

Engineering oxygen nonbonding states in high entropy hydroxides for scalable water oxidation.

The lattice oxygen oxidation mechanism typically requires the removal of electrons from the metal-oxygen band, which may cause structural instability due to a decrease in the metal-oxygen bond order. To address this challenge, we introduce low-valence, non-catalytically active Na to construct oxygen non-bonding bands on high-entropy hydroxides, allowing electrons to be removed from the oxygen non-bonding band rather than the metal-oxygen bonds, thereby improving the stability of the catalyst. Na doped high-entropy layered double hydroxide (Na-HE LDH) with a low overpotential of 176 mV@10 mA cm⁻² under alkaline conditions.

Utilizing Peanut Oleosome to Stabilize Emulsifier-Free Casein-Maltodextrin-Peanut Oil Emulsion: A Comparative Study.

In recent years, growing concerns over the potential health risks of food emulsifiers have driven the search for natural alternatives. Oleosomes, naturally pre-emulsified lipids, hold great promise for developing emulsifier-free emulsion products. However, research on their functionality in complex food emulsion systems under real processing conditions remains limited.

Enhanced calcium and thermal stability of whey protein hydrolysate stabilized emulsions by ultrasound-assisted glycosylation: Influence of the degree of glycosylation.

Glycosylation can enhance the thermal stability and ionic tolerance of protein hydrolysate emulsions. Ultrasound-assisted wet-heat glycosylation (UA) and precise control over the degree of glycosylation (DG) are crucial for optimizing the modification effects. This study investigated the mechanisms underlying the influence of UA on the macroscopic stability of whey protein hydrolysate (WPH)-xylose (XL) conjugate emulsions.

Intelligent Prediction Platform for Sepsis Risk Based on Real-Time Dynamic Temporal Features: Design Study.

Background: The development of sepsis in the intensive care unit (ICU) is rapid, the golden rescue time is short, and the effective way to reduce mortality is rapid diagnosis and early warning. Therefore, real-time prediction models play a key role in the clinical diagnosis and management of sepsis. However, the existing sepsis prediction models based on artificial intelligence still have limitations, such as poor real-time performance and insufficient interpretation.

Black rice stepwise fermentation enhances yogurt gel quality: Solidification rate, texture, LAB distribution and viability persistence.

Water holding capacity (WHC) and texture stability primarily affect yogurt quality. In this study, black rice stepwise fermented yogurt (FBY) was produced, and the enhancement of texture quality was investigated. Compared with the control, FBY shortened the solidification time by 25.

Fabrication of Nanomaterial-Immobilized Lipase Enables Robust Enzymatic Interesterification: Lipid Characteristics and Underlying Catalytic Mechanism.

The precise regulation of enzyme conformation through the immobilization of enzymes on carriers using sewing techniques represents a key focus in the site-specific chemically modification engineering. Lipase-mediated enzymatic interesterification (EIE) is of considerable significance in lipid chemistry, having demonstrated substantial potential in the modification of lipids. In this study, we developed an innovative nanomaterial FeO-SiO-APTES for site-specific immobilization of Thermomyces lanuginosus lipase (TLL), achieving an immobilization yield of 51.

Ultrastable high internal phase Pickering emulsions stabilized by deamidated pea protein: Formation mechanisms and applications in 3D printing.

Food-grade high internal phase emulsions (HIPEs) show promise for 3D printing applications, yet stabilizing them with natural ingredients remains challenging. This study investigated enzymatically deamidated pea protein isolate (DPPI) as a novel HIPE stabilizer. Compared to native protein, DPPI-stabilized HIPEs exhibited smaller droplet sizes, higher viscosity, and enhanced viscoelasticity.

Global Disease Burden, Trends, and Inequalities of Brain and Central Nervous System Cancers, 1990-2021: A Population-Based Study with Projections to 2036.

Background: Brain and central nervous system (CNS) cancers pose a significant global health challenge, with marked regional variations. Updated evidence is essential to optimize resource allocation and inform targeted interventions.

Methods: Data from the Global Burden of Disease 2021 were systematically analyzed, including incidence, mortality, and disability-adjusted life years (DALYs), along with their corresponding age-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR), and age-standardized DALY rate (ASDR).

Novel insights into bound Phenolics: Conversion and release of phenolic compounds in lychee pulp by heat pump drying and lactic acid bacterial fermentation.

The bioactivities of lychee pulp (LP) phenolics have been extensively documented. However, the impact of processing techniques on the phenolics remains unclear. The objective of this study was to investigate the conversion and metabolism of phenolics in LP that was first heat pump-dried and then fermented by lactic acid bacteria.

The development of pyridazinone-based andrographolide derivatives as anti-cancer agents with the ability of inhibiting the TFAP4/Wnt/β-catenin signaling pathway.

Emerging evidence indicated that natural andrographolide and its derived compounds could exert anti-cancer effects on a broad range of cancer cells by several mechanisms of actions. However, the potent andrographolide derivatives with novel structures are needed and the comprehensive understanding of the underlying mechanisms of actions are still lacking. In this work, we reported the pyridazinone-based anti-cancer andrographolide derivative A61, which is superior to the widely-used anti-cancer drug 5-FU (around 5-fold more potent), it showed high potency to inhibit the growth and migration of a panel of cancer cells, in which the gastric cancer cells exhibited the highest drug sensitivity.

Cyclic trace enzymatic hydrolysis pretreatment enhances brown rice: Cooking and taste.

Brown rice is nutritious but with low acceptance due to its cooking inconvenience and poor taste. This study investigated the effect of cyclic trace enzymatic hydrolysis (CEH) on brown rice refining and compared it with other two treatments: cyclic trace water infiltration (CWI) and disposable enzymatic hydrolysis (DEH). As results, CEH increased the moisture content of brown rice with a relatively low crack rate.

Effects of molecular weight on simulated digestion and fecal fermentation of polysaccharides from longan pulp in vitro.

The gastrointestinal digestion and fermentation in vitro of longan polysaccharide (LP) and its degraded products (DLP-1, DLP-4, and DLP-8) with different molecular weights (Mw) were investigated. Results indicated that four polysaccharides were only slightly degraded in the gastrointestinal digestion and mainly utilized by gut microbiota in the colon. Among them, DLP-8 with the lowest Mw was easily utilized by intestinal bacteria accompanied by the highest production of acetic and butyric acids.

Multi-Omics Analysis Links Mitochondrial-Related Genes to Idiopathic Pulmonary Fibrosis and In Vivo Transcriptome Validation.

Mitochondrial dysfunction is closely associated with idiopathic pulmonary fibrosis (IPF). However, the causal association between mitochondria-related genes and IPF remains to be determined. We obtained gene expression, protein abundance, and methylation quantitative trait locus data for mitochondria-related genes from previous studies.

Modulation of Gut Mycobiome and Serum Metabolome by a MUFA-Rich Diet in Sprague Dawley Rats Fed a High-Fructose, High-Fat Diet.

The intake of oleic acid-rich fats, a hallmark of the Mediterranean diet, has well-documented beneficial effects on human metabolic health. One of the key mechanisms underlying these effects is the regulation of gut microbiota structure and function. However, most existing studies focus on gut bacteria, while gut fungi, as a vital component of the gut microbiota, remain largely unexplored.

Accumulation of Water-Soluble Polysaccharides during Lychee Pulp Fermentation with Involves Endoglucanase Expression.

In the current work, lychee pulp was subjected to ATCC 14917 fermentation, leading to a substantial increase (2.32-2.67-fold) in water-soluble polysaccharides (WSP).

Morphological and phylogenetic analyses reveal two new species of the (Hypocreales, Nectriaceae) species complex in China.

The species complex (FFSC) encompasses a diverse array of more than 80 phylogenetic species with both phytopathological and clinical importance. A stable taxonomy is crucial for species in the FFSC due to their economical relevance. Fungal strains used in this study were obtained from and , collected from Beijing and Shaanxi Province.

The development of α, β-unsaturated lactam-based andrographolide derivatives as anti-gastric cancer agents with the ability of inhibiting the ERK/c-Fos/Jun pathway.

Gastric cancer remains one of the global health threats for human beings. However, the therapeutic efficacy of the widely-used chemotherapy is usually limited due to the lack of specificity and the related toxicity. Only limited therapeutic agents were demonstrated to show selective and potent inhibitory activity to gastric cancer cells.

Assessing the Causal Effect of Circulating Protein-To-Protein Ratio on the Risk of Morbidity of Hepatocellular Carcinoma.

Objective: Several observational studies have identified an association between plasma proteins and hepatocellular carcinoma (HCC). This study aimed to explore the potential causal relationship between the circulating protein-to-protein ratio and the morbidity risk of HCC.

Methods: Genetic association data for circulating plasma proteins and 2821 protein-to-protein ratios were sourced from the UKB PPP and Suhre's study.

Entropy Manipulation of SrTiO Perovskite for Enhanced Thermoelectric and Mechanical Properties.

Reducing the thermal conductivity while maintaining excellent electrical transport properties is crucial for enhancing the thermoelectric performance of SrTiO-based perovskites. Here, we successfully achieved this goal through precisely manipulating the configurational entropy. A series of CaNdSr BaTiO ( = 0, 0.

NLRP3 inflammasome mediates pyroptosis of alveolar macrophages to induce radiation lung injury.

Alveolar macrophages play a crucial role in maintaining lung homeostasis. However, the mechanisms underlying alveolar macrophage pyroptosis and inflammasome activation in radiation-induced lung injury remain unclear. In this study, we employed multicolor flow cytometry and single-cell RNA sequencing to reveal the immune cell and cell death landscape in the tissue microenvironment of radiation-induced lung injury.