From Tradition to Innovation: Acupuncture Therapies Targeting Ferroptosis in Neurological Disorders.

Introduction: Age-related neurodegenerative diseases (NDDs) and stroke represent significant public health challenges due to their high morbidity, mortality, and associated cognitive decline. Current therapeutic strategies often fall short in addressing the complex underlying pathological mechanisms, underscoring the urgent need for innovative treatment approaches. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has emerged as a critical factor contributing to neuronal damage in NDDs and stroke.

Ambient ozone exposure and course of non-communicable diseases among elderly individuals with hypertension, diabetes or dyslipidemia: Prospective cohort study in GOLD-Health.

The association between ozone (O) exposure and the dynamic and accelerated progression of non-communicable diseases (NCDs) remains unclear in elderly individuals with hypertension (HTN), diabetes mellitus (DM), or dyslipidemia. This study included 250,246 participants with HTN, DM, or dyslipidemia from the Guangzhou Older Longitudinal Dynamic Health. Long-term O exposure was estimated using bilinear interpolation based on geocoded residential addresses.

Crossword puzzle training and neuroplasticity in mild cognitive impairment (COGIT-2): 78-week, multi-site, randomized controlled trial with cognitive, functional, imaging and biomarker outcomes.

Background: Cognitive training represents an important potential therapeutic strategy for mild cognitive impairment (MCI). In our recently completed trial, crossword puzzles were superior to computerized cognitive training on Alzheimer's disease assessment scale-cognitive subscale-11 (ADAS-Cog11) and function, correlating with decreased brain atrophy over 78 weeks.

Methods: COGIT-2 is a 78-week, multicenter, clinical trial comparing home-based, high-dose crosswords (4 puzzles per week) to low-dose crosswords (1 puzzle per week) and a health education control group in 240 MCI subjects.

Ursolic Acid Inhibits Triple-Negative Breast Cancer Progression by Modulating the FGFR1/AKT/ERK Pathway: Evidence from Network Pharmacology and Experimental Validation.

Introduction: Ursolic acid (UA) exhibits antitumor activity; however, its effects and mechanisms on triple-negative breast cancer (TNBC) cells are not well understood. The present study aimed to explore the anti- TNBC mechanisms of UA by network pharmacology and experimental validation.

Methods: TNBC cell lines MDA-MB-231 and BT-549 cells were treated with UA.

KDM4 Orchestrates Epigenomic Remodeling of Senescent Cells and Potentiates the Senescence-Associated Secretory Phenotype.

Cellular senescence restrains the expansion of neoplastic cells through several layers of regulation. We report that the histone H3-specific demethylase KDM4 is expressed as human stromal cells undergo senescence. In clinical oncology, upregulated KDM4 and diminished H3K9/H3K36 methylation correlate with poorer survival of patients with prostate cancer after chemotherapy.

Inflammation mediates the association between hyperuricemia and stroke mortality: a cohort study.

Background: Stroke is a leading cause of mortality and disability worldwide. The relationship between hyperuricemia and stroke prognosis remains controversial. This study aims to investigate the association between hyperuricemia and stroke prevalence, as well as the impact of hyperuricemia on mortality risk among stroke patients, utilizing data from the National Health and Nutrition Examination Survey (NHANES) 2001-2018.

Head‑to‑head comparison of contrast‑enhanced mammography and MRI in assessing the tumor response to neoadjuvant therapy in breast cancer: a prospective, multireader study.

Purpose: To compare contrast-enhanced mammography (CEM) and MRI in the evaluation of the tumor response to neoadjuvant therapy (NAT) in breast cancer.

Materials And Methods: Patients who underwent CEM and breast MRI before and after NAT were prospectively enrolled in this study. Three readers with different levels of experience independently assessed the images and classified the tumor response following NAT.

Pragmatic, multicentre, factorial, randomised controlled trial of sepsis electronic prompting for timely intervention and care (SEPTIC trial): a protocol.

Introduction: Sepsis is a major cause of death both globally and in the United States. Early identification and treatment of sepsis are crucial for improving patient outcomes. International guidelines recommend hospital sepsis screening programmes, which are commonly implemented in the electronic health record (EHR) as an interruptive sepsis screening alert based on systemic inflammatory response syndrome (SIRS) criteria.

The relationship between chronic air pollution exposure, neighborhood environmental vulnerability, and adverse COVID-19 morbidities among hospitalized New York City residents.

Introduction: Communities disproportionately burdened by adverse neighborhood-level social and structural factors may experience greater vulnerability to environmental exposures, contributing to health inequities, including adverse COVID-19. We assessed the effects of chronic air pollution on COVID-19 morbidities in NYC and examined whether these effects varied by neighborhood-level vulnerability.

Methods: We used NYC COVID-19 hospitalization records (3/1/2020-2/28/2021) and conducted analyses in the full sample and within hospital catchment.

Exposure to environmental toxicants and gout risk in adults: Unveiling the associations and potential targets.

Emerging environmental toxicants may jeopardise uric acid metabolism, but the associations between toxicants and gout risk remain unknown. This study aimed to comprehensively assess the associations of toxicants with gout and to investigate the mediated mechanisms. This cross-sectional study included 22,591 adults diagnosed with gout in the NHANES 2011-2018.

Leveraging two-phase data for improved prediction of survival outcomes with application to nasopharyngeal cancer.

Accurate survival predicting models are essential for improving targeted cancer therapies and clinical care among cancer patients. In this article, we investigate and develop a method to improve predictions of survival in cancer by leveraging two-phase data with expert knowledge and prognostic index. Our work is motivated by two-phase data in nasopharyngeal cancer (NPC), where traditional covariates are readily available for all subjects, but the primary viral factor, human papillomavirus (HPV), is substantially missing.

Kearns-Sayre syndrome presenting with fanconi syndrome: a case report.

Background: Kearns-Sayre syndrome (KSS) is a mitochondrial genetic disorder characterized by progressive external ophthalmoplegia, short stature, atrioventricular block, and proximal renal tubular dysfunction. While Fanconi syndrome is a recognized renal manifestation of KSS, it is rare as the initial presenting feature. This report describes the clinical and genetic features of a child with KSS who initially presented with Fanconi syndrome.

Neighborhood environmental vulnerability factors strongly drove COVID-19 fatality and excess all-cause mortality in New York City, while long-term air pollutant associations were weak and varied.

Purpose: We evaluated associations among long-term air pollution exposure, neighborhood-level social and structural drivers of environmental vulnerability, and COVID-19 death during the first pandemic year in New York City (NYC).

Methods: We triangulated findings across statistical approaches susceptible to different biases: a hospital-based COVID-19 fatality analysis using Cox proportional hazard models and two ZIP code-level, city-wide excess all-cause mortality analyses using periodic and linear regression models. We estimated chronic fine particulate matter (PM.

Status and influencing factors of dual health literacy in modern medicine and traditional Chinese medicine among Chinese residents.

Background: Dual Health Literacy (DHL), integrating modern and traditional Chinese medicine (TCM), is crucial for health management in China. However, many struggle with both systems, causing fragmented decisions and poor outcomes. Most studies address only one system, overlooking their interplay.

Potential effect of Irisin on sarcopenia: a systematic review.

Objective: Sarcopenia, a progressive musculoskeletal disorder associated with aging, is characterized by the deterioration of muscle mass, strength, and physical performance. This condition significantly increases the risk of debilitating consequences including functional impairment, diminished life quality, and increased mortality. With the progress of aging, it will affect a large number of people in the world and bring many problems.

Imaging flow cytometry: from high - resolution morphological imaging to innovation in high - throughput multidimensional biomedical analysis.

Imaging flow cytometry (IFC), as an extension of conventional flow cytometry, has emerged as a cutting-edge cellular analysis tool by integrating high-resolution imaging technology, and has shown significant potential and application value in biomedical research. In this paper, we comprehensively review the evolution of IFC from its early theoretical development to its current mature application, and explain its working principle, unique advantages, and the current status of its application in several biomedical fields. The paper focuses on how IFC integrates high-throughput and morphological imaging, highlighting its key role in cell biology, immunology, oncology, and environmental monitoring.

The latest advances on the formation, exposure level and control strategies of nitrosamines in meat, poultry and fish products.

Nitrosamines have been widely detected in various meat, poultry and fish products. This review provided an in-depth analysis on the nitrosation mechanisms of nitrosamines in meat, poultry and fish products, revealing the specificity of nitrosamines generation across different food types. The mechanisms by which nitrosamines form harmful adducts within human cells were also discussed.

Rutin-Associated Hepatoprotection: A Review of Mechanisms and Therapeutic Prospects.

Background: Liver disorders pose a considerable global health challenge, accompanied by rising mortality rates. Current therapeutic strategies, though effective, often face limitations due to adverse effects and therapeutic resistance, prompting the exploration of alternative treatments, particularly safer natural compounds. Rutin, a widely available bioflavonoid, has emerged as a promising candidate owing to its varied pharmacological properties.

The administration sequences of immune checkpoint inhibitors and chemotherapy cause discrete efficacy when treating non-small cell lung cancer: a retrospective study.

Background: Immune checkpoint inhibitors (ICIs) combined with chemotherapy have become a standard first-line treatment for advanced non-small cell lung cancer (NSCLC). However, the optimal sequence of administrating the two treatments remains controversial.

Methods: This study included advanced NSCLC patients who received ICIs combined with chemotherapy at Renmin Hospital of Wuhan University and Xiangyang Hospital, Hubei University of Chinese Medicine between 1st September 2020 and 30th September 2024.

Effects of exogenous substances on the characteristics of low-salt tilapia surimi gel.

This study investigated the enhancement of freshwater surimi product quality by applying various exogenous substances to low-salt tilapia surimi gels prepared using microwave and ultrasound techniques. Using single-factor experiments and response surface methodology, the optimal interaction ratios (THG) of glutamine transaminase (TGase), hydroxypropyl distarch phosphate (HDP), and gellan gum were 0.6 %, 9 %, and 0.

Metagenomic analysis reveals differences in antibiotic resistance and transmission risks across various poultry farming models.

As living standards in rural areas continue to improve, farmers are increasingly seeking to diversify their farming models beyond monoculture farming. However, the differences in bacterial resistance and the associated transmission risks between monoculture poultry farming and integrated poultry farming remain poorly understood. This study utilizes metagenomic methods to examine the distribution and transmission of antibiotic resistance across three types of farms in Zhejiang Province, as well as to investigate the horizontal transmission mechanisms of plasmid-mediated bla within these agricultural systems.

Trapping phenylacetaldehyde by litchi shell polyphenols and their characteristic catechins in chemical model and roast pork patty: Identification of catechins-adducts and toxicity assessment.

Inhibitory effects of litchi shell polyphenols (LC) and their characteristic catechins on 2-amino-1-methyl-6-phenylimidazole [4,5-b] pyridine (PhIP) formation were investigated in chemical model and roast pork patty. Eight catechins-adducts were identified by UPLC-Q-TOF-MS and their toxicity were evaluated by Discovery Studio. Results showed inhibition rates of LC on bound-PhIP could reach 10.

Implementing remote patient monitoring to improve hypertension control in a primary care network: Rationale and design of the monitor-BP Cluster Randomized Trial.

Background: Home blood pressure monitoring with clinical or technological support (Supported HBPM) is an evidence-based intervention recommended by national guidelines for improving hypertension (HTN) control. However, few healthcare systems have implemented Supported HBPM because it remains unclear how best to promote uptake among patients and clinicians, and the real-world effectiveness of Supported HBPM is unknown. The Monitor-BP Trial aims to determine the impact of implementing a flexible Supported HBPM program on practice-level HTN control and to evaluate the reach, adoption, maintenance, and cost-effectiveness of the program in a socioeconomically diverse primary care network.

An epidemiological model of monkeypox: model prediction and control application.

Background: Monkeypox (Mpox) is an  emerging infectious disease caused by the Mpox virus (MPX Virus). The outbreak of Mpox epidemic has caused global panic and is now a public health incident. Various approaches have been proposed in the recent literature to study and analyze the epidemiological dynamics of this infection and effective prevention and control measures.