Burden of Sexually Transmitted Infections in Madhya Pradesh, India: A Systematic Review and Meta-analysis.

Background: Sexually transmitted infections (STIs) pose a global public health threat, with over 30 pathogens known to spread sexually. In 2020, the World Health Organization reported 374 million new cases, with varied prevalence in India, especially among at-risk groups.

Objectives: The objective of the study was to assess the prevalence of syphilis, chlamydia, and gonorrhea among the general population and blood donors in Madhya Pradesh.

Burden of Sexually Transmitted Infections in Rajasthan, India: A Systematic Review and Meta-analysis.

Background: There is a notable gap persisting in the existing body of evidence regarding the prevalence of sexually transmitted infections (STIs) in the general population in India.

Objectives: The primary aim of this review is to provide a comprehensive assessment and quantification of the burden of STIs within the state of Rajasthan.

Materials And Methods: The study findings conformed to the criteria outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.

Water, sanitation and infection control practices in rural health facilities of Jodhpur District, India: an intervention through supportive supervision.

Background: Inadequate water, sanitation, and hygiene (WASH) infrastructure in rural healthcare facilities in India, poses significant challenges to effective infection control, contributing to the prevalence of healthcare-associated infections (HAIs) and poor patient outcomes. Despite ongoing global efforts to enhance WASH standards, these facilities often lack the necessary resources and management systems to sustain improvements. Supportive supervision has emerged as a potential strategy to address these gaps.

Comparison of Quality of Life in Postoperative High-Grade Glioma Patients Treated Using EORTC and RTOG Target Delineation Techniques for Postoperative Radiotherapy.

Introduction: High-grade gliomas (HGGs) have dismal prognosis even with multimodality treatment entailing surgery, radiotherapy, and chemotherapy. Hence, assessment of improvement in quality of life (QOL) for evaluating treatment is critical. Target delineation for radiotherapy in HGG is often done according to the European Organization for Research and Treatment of Cancer (EORTC) and Radiotherapy and Oncology Group (RTOG) contouring guidelines, which differs on exclusion and inclusion of peritumoral edema believed to harbor malignant cells; the guidelines have not been prospectively compared for probable difference in QOL, considering the probable difference in treated volume.

Genetic and molecular landscape of comorbidities in people living with HIV.

People living with HIV (PLHIV) have an increased susceptibility to non-AIDS comorbidities. In this study, we systematically profiled 1,342 PLHIV across five omics layers and immune function. We found latent factors, resulting from integrating epigenomics, transcriptomics, proteomics, metabolomics and immune responses, linked to cardiovascular diseases, the presence of carotid plaque and chronic obstructive pulmonary disease in PLHIV.

Quality of life and widowhood: a cross-sectional study of social security scheme beneficiaries.

Introduction: After losing a spouse, a woman experiences diverse changes in her life, and varying cultural settings add to them. Research has shown the impact of widowhood on one's quality of life. This study evaluated the quality of life and its predictors of widows of Jodhpur enrolled in Ekal Nari Samman Pension Yojna, a state-sponsored pension scheme for widowed, divorced, or abandoned women from an economically weaker section of Rajasthan.

TLR-based therapeutic strategies for hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a leading cause of cancer-related deaths worldwide. Chronic inflammation and immune dysregulation, often driven by viral infections or metabolic disorders, play a significant role in its pathogenesis. Toll-like receptors (TLRs), key components of innate immunity, have emerged as important regulators in the progression of liver disease and tumorigenesis.

The histone-methyltransferase DOT1L cooperates with LSD1 to control cell division in blast-phase MPN.

Persistence of JAK2-mutated clones that may undergo clonal evolution and malignant transformation remains a challenge in myeloproliferative neoplasms (MPN), Novel therapeutic approaches to attenuate clonal evolution and progression to blast-phase are therefore urgently needed. LSD1 (KDM1A) inhibitors reduce symptoms and clonal burden in MPN, but whether these compounds may be effective in advanced disease stages remained so far elusive. Using a chromatin-focused CRISPR-Cas9 screen, we identified the histone methyltransferase DOT1L as a synthetic lethal target under pharmacologic LSD1 inhibition.

Sex-specific DNA methylation associations with circulating urate levels and BCG-induced urate changes.

Background: Urate concentration and the physiological regulation of urate homeostasis exhibit clear sex differences. DNA methylation has been shown to explain a substantial proportion of serum urate variance, mediate the genetic effect on urate concentration, and co-regulate with cardiometabolic traits. However, whether urate concentration is associated with DNA methylation in a sex-dependent manner is unknown.

Case Report on Radiation-Induced Osteosarcoma of the Nasopharynx: Unmasking the Aftermath.

Radiotherapy is commonly used in the curative treatment of head and neck cancers, serving both definitive and adjuvant roles. As oncologic outcomes improve, there is a rising occurrence of second malignancies among long-term survivors of these cancers. Radiation-induced osteosarcoma (RIOS) is an uncommon malignancy that emerges as a late consequence of radiotherapy.

Feasibility and outcomes of laparoscopic management in perforation peritonitis: A prospective cohort study with propensity score matching.

Background: Perforation peritonitis remains a significant cause of morbidity and mortality in emergency surgical patients. Conventionally, open laparotomy has been the preferred approach. However, with advancements in minimally invasive techniques, laparoscopic management has emerged as a potential alternative.

A flexible MXene-carbon nanotube-based triboelectric nanogenerator for self-powered pH sensors.

Two-dimensional materials with semiconducting nature exhibit triboelectric responses, which is an important factor for the development of nanogenerators, tribotronics, and various electronic devices. Here, the manuscript describes the synthesis of MXene from the TiAlC MAX phase using the etching method, followed by the development of a flexible self-powered triboelectric nanogenerator (FTENG) based on TiCT MXene-carbon nanotubes (CNTs), which produces an output voltage of 47.6 V, which is greater than that of the pure carbon nanotube-based TENG.

Design, synthesis, , anticancer evaluations of -acylhydrazone derivatives as STAT3 inhibitors.

Aim: -acylhydrazone derivatives were synthesized, evaluated in-vitro and further subjected to cell cycle analysis, cell apoptosis, western bloting, and in-silico analysis targeting STAT3.

Materials And Methods: A series of -acylhydrazones () were synthesized and evaluated against MIA PaCa-2 cancer cells. 5 h and 5 l were further evaluated against PANC-1, MCF-7 and hTERT-HPNE cells.

Analysis of clinicopathological factors associated with recurrence after post operative radiotherapy in oral cavity squamous cell carcinoma.

Introduction: Surgery is the primary course of treatment for most patients with oral cavity tumors; however, adjuvant radiation is advised to increase the likelihood of locoregional cancer control in the presence of adverse risk factors such as pathological tumor (T3/T4) stage, nodal metastases, perineural invasion, lymphovascular invasion, and positive margins. In the present study, the outcome was assessed after post-operative radiotherapy along with factors associated with recurrence in patients with oral cavity squamous cell carcinoma.

Material And Methods: This retrospective study included postoperative oral cavity squamous cell carcinoma (OCSCC) patients treated with adjuvant radiotherapy.

On-chip amorphous terahertz topological photonic interconnects.

Valley Hall photonic crystals (VPCs) offer the potential for creating topological waveguides capable of guiding light through sharp bends on a chip, enabling seamless integration with functional components in compact spaces, making them a promising technology for terahertz topological photonic integrated circuits. However, a key limitation for terahertz-scale integrated VPC-based devices has been the absence of arbitrary bend interconnects, as traditional VPC-designs restricted to principal lattice axes (i.e.

Response to Induction Chemotherapy as a Predictor of Clinical Outcome After Chemoradiation in Locally Advanced Head and Neck Squamous Cell Carcinoma Patients: A Retrospective Study.

Introduction: Concurrent chemo-radiotherapy is standard of care for locally advanced Head and Neck squamous cell carcinoma. Induction chemotherapy is given to reduce locoregional relapse, distant metastases and tumor shrinkage. Response to induction chemotherapy can predict response to radiotherapy, but impact of IC response to survival benefit after radical treatment is less studied.

Study the consequences of magnetic dipoles on atomic parameters of magnetic compounds at their K, L and M shell absorption edge.

The effect of magnetic dipole on atomic parameters jump factor (J, J and J), jump ratio (r, r, and r), effective atomic number (Z), linear attenuation coefficient (μ), Davisson-Kirchner ratio (D) and magnetic spin (S) of diamagnetic compounds (CH, CFO, CaF, CCl, HO, NaCl, CHCl, SiO, ZnSO, AgCl), paramagnetic compounds (NO, FeBr, FeSO, MnO, CuSO, FeCl, MnCl, CoCl, CuCl FeO) and ferromagnetic compounds (BaFeO, CrO, FeN, ZnFeO, FeO, MgFeO, SmCo, NiFeO, CoFeO, EuO) has been calculated at K, L, M shells absorption edges. In this study, a wide irregularity in atomic parameters (J, r, J, r, J, r, Z, μ, D and S) at the absorption edges of K-Shell, L-Shell and M-Shell in diamagnetic, paramagnetic and ferromagnetic compounds at different incident energies has been observed. For the measurement of these atomic parameters, WinXCOM and FFAST two well designed, reliable, and authentic offline and online data tables were used to calculate and compare the values of these atomic parameters.

Flexible High Temperature Stable Hydrogel Based Triboelectric Nanogenerator for Structural Health Monitoring and Deep Learning Augmented Human Motion Classification.

Triboelectric nanogenerators (TENGs) are an emerging technology that harvests abundant vibrational energy present in ambient environment. TENGs typically rely on polymer contact interfaces, which, while ideal for wearable and flexible applications, limit their applicability in industry settings, where high-temperature plant equipment generates plentiful and wasted vibrational energy. In this study, a biocompatible PDMS-hydrogel nanocomposite TENG is fabricated, containing nanoparticles of ZnAl-layered double hydroxide (LDH).

Revisiting ultrasonographic soft markers of aneuploidy: A thoughtful analysis in low-risk and screening naïve Indian antenatal women.

This study aimed to assess the prevalence of soft markers on second-trimester sonography in low-risk and screening naïve Indian antenatal women and determine their association with aneuploidy. Soft markers were evaluated through ultrasound, and likelihood ratios (LRs) and modified risk (MR) for aneuploidy were calculated. Pregnant women with a MR >1:250 underwent genetic counseling and invasive testing, whereas those with a lower risk received follow-up.

Electronic structures, bonding aspects and photophysical properties of N-heterocyclic carbene manganese complexes: DFT and TDDFT exploration.

Here we explored the influence of axial ligands on the structural, electronic, and photophysical properties of Mn(II)(TPP)(1,3-MeImd)(L) complexes, where L = -NH, -OCH, -SH, -Cl, and -NO, using density functional theory (DFT) and time-dependent DFT (TDDFT) methods. Frontier molecular orbital analysis was performed to assess the reactivity behavior of the complexes which exhibit strong nonlinear optical properties due to their high polarizability. The nature of bonding and charge distribution was further investigated through electrostatic potential mapping, quantum theory of atoms in molecules, electron localization function and localized orbital locator analyses.

CRISPR/Cas9-directed epigenetic editing in colorectal cancer.

Colorectal cancer (CRC) remains a leading cause of cancer-related illness and death worldwide, arising from a complex interplay of genetic predisposition, environmental influences, and epigenetic dysregulation. Among these factors, epigenetic modifications-reversible and heritable changes in gene expression-serve as crucial regulators of CRC progression. Understanding these modifications is essential for identifying potential biomarkers for early diagnosis and developing targeted therapeutic strategies.

Easing the Pain: Lignocaine Spray in Mid-Trimester Amniocentesis - A Randomized Double-Blind, Placebo-Controlled Trial.

Background: To evaluate the effect of lignocaine spray on maternal pain perception during mid-trimester amniocentesis compared to placebo.

Methodology: This was a double-blinded, prospective, randomized controlled trial conducted at a tertiary teaching hospital in Western Rajasthan. Singleton pregnancies between 15- and 24-weeks' gestation undergoing amniocentesis were included.

Human Brucellosis Presenting with Rheumatic Manifestations: An Underdiagnosed Condition in Eastern India.

Human brucellosis is a chronic systemic infection mostly presenting as afebrile illness with musculoskeletal complaints with organomegaly and diagnosis is based on serology. The diagnostic tests are sparsely available in India and even less prescribed. We report six cases of human of brucellosis presenting as fever with rheumatic manifestation along with their outcome.

Symptoms of Depression and Inhaler Adherence Among Adolescents With Asthma: Is There an Association?

Background: The prevalence of depression among adolescents with asthma is reported to be 27%-34% across different geographical regions. Asthma control depends on inhaler adherence. Studies on the association of depression and inhaler adherence among adolescents with asthma are few, especially in the Indian subcontinent.

Depth of Invasion as an Independent Indication for Postoperative Radiation Therapy in Oral Tongue Squamous Cell Carcinoma.

Purpose: Over the years, scientific literature has highlighted the importance of depth of invasion (DOI) in managing oral squamous cancers, particularly its association with nodal metastasis. However, determining the role of DOI in postoperative radiation therapy (PORT) remains a clinical challenge. This study aimed to evaluate PORT with a DOI cutoff of 5 mm.