Clustering of Adverse Perinatal Outcomes in Women with Multiple Sensitizing Events: A Data-Driven Approach Using Clinical and Immunohematologic Profiles.

Background: Red-cell alloimmunisation is a preventable driver of haemolytic disease of the fetus and newborn, yet most risk scores rely on single-parameter thresholds and overlook clinically important heterogeneity.

Objective: To uncover latent phenotypes among sensitised pregnancies by clustering routinely collected clinical and immunohaematologic variables.

Methods: We retrospectively analysed 2084 antenatal records (2020 - 2021).

Unveiling the hidden culturable endophytic fungal diversity in aerial vegetative parts of Wrightia tinctoria (Roxb.) R.Br. of southern Aravalli hills.

Endophytic fungi significantly influence plant health, growth, and ecological interactions, yet comprehensive insights into their diversity within medicinal plants remain limited. This study provides the first comprehensive analysis of alpha and beta diversity of fungal endophytic communities residing within Wrightia tinctoria (Roxb.) R.

Artificial light at night accelerates aging processes in pre-pubertal female rats.

Urbanization has introduced multiple factors that promote circadian clock dependent or independent disruption of physiology. Conditions such as late-night light (ALAN) exposure, shift working, cross-continental traveling may lead to circadian dysregulation leading to obesity, metabolic disorders and physiological alterations. As ALAN affects the circadian clock with concomitant effects on stress and free radical physiology, we hypothesised that night exposure to artificial light may affect the rate of aging.

Utility of Fallopian Tube Brush Cytology and Cell Blocks as a Screening Tool for Epithelial Ovarian Cancer in Patients Undergoing Gynaecological Surgeries for Benign and Malignant Indications: Attempt at a Classification System.

Introduction: Fallopian tube (FT) cytology is an evolving and as yet not well-established field. Through this study, we aimed to establish the utility of FT brush cytology by stratification into cytological diagnostic categories.

Methods: Cytological specimens were collected using an endobrush from the fimbrial end of the tubes at the time of gynaecological surgeries, and LBC preparation (liquid-based cytology slides prepared by SurePath technique) and cell blocks were prepared.

Revisiting ultrasonographic soft markers of aneuploidy: A thoughtful analysis in low-risk and screening naïve Indian antenatal women.

This study aimed to assess the prevalence of soft markers on second-trimester sonography in low-risk and screening naïve Indian antenatal women and determine their association with aneuploidy. Soft markers were evaluated through ultrasound, and likelihood ratios (LRs) and modified risk (MR) for aneuploidy were calculated. Pregnant women with a MR >1:250 underwent genetic counseling and invasive testing, whereas those with a lower risk received follow-up.

The Role of Glucagon-Like Peptide-1 Receptor Agonists in Alcohol Use Disorder.

Alcohol use disorder (AUD) is a critical health condition that increases the risk of a variety of social and physical health impairments. Glucagon-like peptide-1 (GLP-1) receptor agonists are potentially effective in reward system-related disorders. The use of GLP-1 receptor agonists has been shown to decrease overall consumption of alcohol in AUD in addition to managing obesity and weight loss.

Easing the Pain: Lignocaine Spray in Mid-Trimester Amniocentesis - A Randomized Double-Blind, Placebo-Controlled Trial.

Background: To evaluate the effect of lignocaine spray on maternal pain perception during mid-trimester amniocentesis compared to placebo.

Methodology: This was a double-blinded, prospective, randomized controlled trial conducted at a tertiary teaching hospital in Western Rajasthan. Singleton pregnancies between 15- and 24-weeks' gestation undergoing amniocentesis were included.

Trends and disparities in schizophrenia related mortality in the United States: An analysis of CDC WONDER database, 1999-2020.

Background: Schizophrenia is a mental health condition that typically begins between ages 18 and 25, significantly impairs daily functioning, ranks among the leading causes of disability worldwide, and is associated with a shortened lifespan. Mortality in schizophrenia is often linked to cardiovascular disease, driven by poor lifestyle choices, limited access to physical healthcare, frequent comorbidities, and non-compliance with antipsychotic medications. This article analyzes mortality trends among U.

Seasonal dynamics and enzyme profiles of diverse endophytic fungi in Sterculia urens Roxb.: insights into host-associated trends.

Sterculia urens Roxb., well known for its medicinal uses, remains largely unexplored in terms of its fungal endophytic communities. This study is the first comprehensive assessment of fungal endophyte diversity in S.

Incidence, Causes, and Perinatal Outcomes of "Near-Miss" Obstetric Emergencies during the COVID-19 Pandemic: Experience from a Tertiary Referral Center of Western Rajasthan, India.

Background: Pregnant women and neonates are often considered as being a vulnerable group during the coronavirus disease 2019 (COVID-19) pandemic. Several studies have compared the impact of COVID-19 on pregnant and nonpregnant women. This study aimed to examine the reasons for severe acute maternal morbidity (SAMM) and "near-miss cases" and their effects on perinatal outcomes before and during the COVID-19 pandemic.

Vaginal Cellular Angiofibroma: Report of a Rare Case with Literature Review.

Cellular angiofibroma (CA) is a relatively recently described, rare, benign soft tissue tumor that predominantly occurs in the vulvoperineal region. It was first described in 1997 as a mesenchymal-origin tumor composed of connective (fibrous) tissue and blood vessels. We report a case of vaginal CA in a 40-year-old woman who presented with pressure symptoms, incidentally diagnosed with a vaginal mass and clinically suspected as vaginal myoma.

Expression of Programmed Death Ligand 1 [PD-L1] and Mismatch Repair Status in Squamous Cell Carcinomas of Cervix.

Background And Objectives: To assess mismatch repair (MMR) status and programmed death-ligand 1 (PD-L1) expression in squamous cell carcinomas of the cervix and their association with clinicopathologic parameters.

Material And Methods: Expression of PD-L1 and MMR status (MSH2, MSH6, MLH1, and PMS2) was assessed on 50 cases of SCCs of the cervix by immunohistochemistry.

Results: 80% of tumor cells and 84% of tumor-infiltrating lymphocytes showed PD-L1 expression.

Temporal Gene Expression Profiles From Pollination to Seed Maturity in Sorghum Provide Core Candidates for Engineering Seed Traits.

Sorghum (Sorghum bicolor (L.) Moench) is a highly nutritional multipurpose millet crop. However, the genetic and molecular regulatory mechanisms governing sorghum grain development and the associated agronomic traits remain unexplored.

Tranexamic acid in preventing postpartum blood loss in vaginal delivery: a double-blinded randomized controlled trial.

Background: Postpartum hemorrhage (PPH) is an obstetrical emergency that occurs in 1% to 10% of all deliveries and contributes to nearly one-quarter of all maternal deaths worldwide. Tranexamic acid has been established as an adjunct in the treatment of PPH but its role in its prevention of PPH following vaginal delivery has not been widely studied.

Objective: This study aimed to assess the effect of prophylactic tranexamic acid (1 g) along with active management of the third stage of labor in reducing postpartum blood loss and the incidence of postpartum hemorrhage after vaginal delivery.

A novel interplay between PRC2 and miR-3189 regulates epithelial-mesenchymal transition (EMT) via modulating COL6A2 in glioblastoma.

Recent studies have shed light on disrupted collagen signaling in Gliomas, yet the regulatory landscape remains largely unexplored. This study enquired into the role of polycomb repressive complex-2 (PRC2)-mediated H3K27me3 modification, a key epigenetic factor in glioma. Using in-house data, we identified miRNAs downregulated in glioblastoma (GBM) with the potential to regulate Collagen VI family genes.