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http://dx.doi.org/10.1016/j.tjog.2024.05.019 | DOI Listing |
Int J Gynaecol Obstet
August 2025
Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/ Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Background: The p16/Ki-67 dual-staining is increasingly applied to increase diagnostic accuracy in detecting high-grade cervical lesions, including cervical intraepithelial neoplasia Grade 2 (CIN2+) and CIN3+.
Objectives: To compare the diagnostic performance of p16/Ki-67 dual-staining with the human papillomavirus (HPV) tests in the triage of women with atypical squamous cells of undetermined significance (ASC-US) and low-grade squamous intraepithelial lesions (LSIL) cytology results.
Search Strategy: Publications before April 27, 2024, were identified through PubMed, Embase, Web of Science, and Cochrane Library.
Afr J Reprod Health
July 2025
Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University,Nanjing 210008, Jiangsu China.
This study aimed to evaluate the triage accuracy of a six-gene methylation detection test in high-risk human papillomavirus-positive women in China. A total of 369 cervical exfoliated cell samples were collected from high-risk human papillomavirus-positive women undergoing cervical cancer screening at Nanjing Drum Tower Hospital from October 2018 to August 2019. The methylation status of six gene was assessed using real-time methylation-specific polymerase chain reaction.
View Article and Find Full Text PDFBiomedicines
July 2025
Department of General and Clinical Pathology, Faculty of Medicine, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
Cervical cancer remains a significant global health issue, with high incidence and mortality rates, particularly in Eastern Europe. Despite the availability of vaccines against human papillomavirus (HPV), regular screening remains crucial for prevention. Testing for HPV, alone or combined with cytology, has become an alternative to traditional methods.
View Article and Find Full Text PDFTransl Cancer Res
May 2025
Department of Obstetrics and Gynecology, The Seventh Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
Background: Cervical cancer remains a significant global health concern, necessitating effective screening strategies. Traditional methods, such as liquid-based cytology (LBC) and high-risk human papillomavirus (HR-HPV) testing, have limitations in sensitivity and specificity. This study aimed to evaluate the diagnostic performance of p16, Ki-67, and minichromosome maintenance protein 2 (MCM2) as biomarkers in cervical cancer screening, both as standalone methods and in combination, to improve early detection and risk stratification.
View Article and Find Full Text PDFActa Cytol
May 2025
Department of Applied Tumor Biology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Background: Cervical cancer is still a significant global health issue, especially in low- and middle-income countries. Human papillomavirus (HPV) infection is known to be the primary etiological factor in the development of cervical cancer. The identification of high-risk HPV (HR-HPV) infections in cervical cancer screening is becoming crucial for early detection and management of cervical pre-neoplasia.
View Article and Find Full Text PDF