Ultrasonically enhanced photocatalytic degradation of methylene blue by Nano-CoFeO-immobilized Saccharomyces cerevisiae yeast composite as a photo-Fenton catalyst: A central composite design study.

In this study, a novel nano-CoFeO-immobilized Saccharomyces cerevisiae yeast nanobiocomposite (CFO-yeast) was synthesized by a physical immobilization method for ultrasonically enhanced photo-Fenton degradation of methylene blue (MB) from aqueous medium. CFO-yeast was comprehensively characterized by UV-Visible spectroscopy, FTIR, SEM, BET, pH and XRD before and after immobilization that revealed pure nano-CoFeO (CFO) possessed cubic spinel crystal system having 19.0 nm average crystallite size whereas after immobilization the size reduced to 14.

Effects of intensive blood pressure control on cardiovascular outcomes in patients with diabetes: A systematic review and meta-analysis.

Background: Hypertension frequently coexists with diabetes, affecting over two-thirds of diabetic patients and significantly increasing cardiovascular (CV) risk. While blood pressure (BP) reduction offers substantial benefits in this population, the optimal systolic blood pressure (SBP) target remains controversial. This meta-analysis evaluates the effects of intensive SBP lowering (<130 mmHg) versus standard therapy (<150 mmHg) on key CV outcomes in hypertensive patients with diabetes.

Recurrent Brown Tumors as a Presenting Complaint of Primary Hyperparathyroidism: A Case Report.

Brown tumor is a rare complication of hyperparathyroidism caused by bony remodeling. These tumors usually affect long bones, pelvis, and ribs, although every bone of the body can be involved. We report a case of a 36-year-old female who presented with complaints of swellings on the right mandible and left maxillary region.

Ameliorative effect of palonosetron against binge alcohol-induced neurodamage via targeting miR-155/AKT/mTOR/AMPK-mediated autophagic pathway.

Binge drinking (BD) is heavy episodic alcohol drinking that is progressively practiced. Vast evidence verified that BD elicits neuronal and cognitive impairments. Debilitated autophagic machinery is a key culprit in BD-induced neurotoxicity.

Clinical Utility and Cost-Effectiveness of Pretreatment NUDT15 Pharmacogenetic Testing to Prevent Thiopurine-Induced Myelosuppression: A Genotype-First Reverse Phenotyping Cohort Study Within the UK NIHR Inflammatory Bowel Disease Bioresource.

Background: The clinical utility and cost-effectiveness of pre-thiopurine NUDT15 pharmacogenetic testing in European and admixed populations are unknown.

Aims: To report the prevalence, penetrance, expressivity, and pathogenicity of NUDT15 variant allele carriage and the diagnostic accuracy and cost-effectiveness of an inexpensive loop-mediated isothermal amplification (LAMP) test.

Methods: Retrospective case-matched cohort study of rates of severe myelosuppression in patients with and without loss-of-function NUDT15 variant allele(s) treated with a thiopurine.

Disparities in epilepsy-associated mortality trends in the United States of America over two decades.

Introduction: Epilepsy affects millions of people in the US annually, leading to disability and death. This study aims to comprehensively delve into the epidemiological framework of epilepsy-related mortality by stratification of data through gender, ethnicity, and geographical regions over two decades, as these have not been done previously to this extent, with a view to addressing the target population precisely.

Methods: This retrospective study analyzed epilepsy-related mortality data in the United States from the CDC (Centers for Disease Control and Prevention) database of all age groups using ICD-10 codes of G40.

Rising burden of coronary artery disease-related mortality among USA adults with atrial fibrillation from 1999 to 2020.

Background: Coronary artery disease (CAD) and atrial fibrillation (AF) are significant cardiovascular conditions with substantial health and economic burdens. Despite advancements in treatment, long-term mortality trends among individuals with both conditions remain underexplored. This study investigates age-adjusted mortality rates (AAMRs) from 1999 to 2020 and examines trends to address these gaps and highlight demographic and geographic disparities.

Increased risk of cardiovascular disease in women with endometriosis: A systematic review and meta-analysis.

Background: The association between endometriosis and cardiovascular disease remains poorly understood. This study conducted a meta-analysis to evaluate the risk of adverse cardiovascular outcomes in women with endometriosis compared to those without the condition.

Methods: A comprehensive search of online databases was performed up to November 2024 to identify studies comparing adverse cardiovascular outcomes in women with and without endometriosis.

Development and in vitro evaluation of mefenamic acid orodispersible tablets prepared by direct compression.

Mefenamic acid functions as a nonsteroidal anti-inflammatory drug (NSAID) of the fenamate class, which treats pain and inflammation by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes to decrease prostaglandin production. Mefenamic acid has strong therapeutic properties that help to treat arthritis and dysmenorrhea. The rapid dissolution of orodispersible tablets (ODTs) makes them an effective treatment option for patients with dysphagia.

Effect of angiotensin receptor neprilysin inhibitors in patients with STEMI: a systematic review and meta-analysis.

Background: ST-segment elevation myocardial infarction (STEMI) is responsible for high morbidity and mortality rates globally. Although the use of angiotensin-converting enzyme inhibitors (ACEIs) remains the cornerstone treatment for patients with STEMI, the use of angiotensin-receptor neprilysin inhibitors (ARNIs) may offer better outcomes than ACEIs. This meta-analysis compares the efficacy and safety of ARNIs versus ACEIs in patients with STEMI.

Can oral minoxidil be the game changer in androgenetic alopecia? A comprehensive review and meta-analysis comparing topical and oral minoxidil for treating androgenetic alopecia.

Androgenetic alopecia (AGA) is a hair disorder seen in both sexes. Its aetiology is multifactorial. Treating AGA has always been a challenge for dermatologists.

Trends in Type 2 Diabetes Mellitus and Parkinson's Disease Related Mortality in the United States from 1999 to 2020.

Background: Emerging evidence indicates that individuals with Type 2 Diabetes Mellitus (T2DM) are at an elevated risk of Parkinson's Disease (PD). While mortality trends for each condition have been studied individually, the combined burden of T2DM- and PD-related mortality remains poorly understood. This study aims to evaluate national trends and disparities in T2DM and PD related mortality among older adults in the United States (U.

Continuation versus Discontinuation of Renin-Angiotensin System Inhibitors Before Noncardiac Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Objectives: The optimal management of renin-angiotensin system inhibitors (RASIs) before noncardiac surgery remains unclear. Continuing RASIs may increase intraoperative hypotension, while discontinuation risks postoperative hypertension and heart failure. Current guidelines suggest withholding RASI 24 hours prior to surgery, but evidence is limited.

Enhanced structural and optoelectronics performance of perovskite solar cells MnSe incorporation in a MAPbI absorber layer.

This study presents a novel approach for enhancing the efficiency of perovskite solar cells (PSCs) by incorporating MnSe into a MAPbI absorber layer. UV-visible (UV-vis) spectroscopy revealed a redshift in the absorption edge, reducing the bandgap from 1.71 eV to 1.

Current Surveillance Strategy Is Less Effective for Detecting Early-Stage Hepatocellular Carcinoma in Patients with Non-Viral and Non-Cirrhotic Liver Disease.

Introduction: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths. Current international guidelines recommend 6-monthly ultrasound surveillance in all patients with cirrhosis and those with hepatitis B virus-related risk factors to detect early-stage HCC. However, it is unknown whether the benefits of surveillance are comparable across patient groups and underlying disease-related factors.

Obesity paradox in coronary artery disease: national inpatient sample analysis.

Background: Although existing literature highlights obesity as a significant predictor for coronary artery disease (CAD), the impact of BMI on hospital outcomes among CAD patients remains unclear.

Methods: We extracted data from the National Inpatient Sample database for adult patients with CAD from 2018 to 2020. The study cohort was stratified into six BMI categories: underweight, normal weight, overweight, class I obesity, class II obesity, and class III obesity.

Cognitive biases, Robo advisor and investment decision psychology: An investor's perspective from New York stock exchange.

Investment decision making is a systematic process that becomes complex due to cognitive biases and risk perceptions. For rational investment decision making, the investors in the New York Stock Exchange (NYSE) tend to seek automated investment solutions through Robo Advisors and the volume of such trades is mounting. However, there is dearth of studies that depict the role of cognitive biases, Robo Advisor and risk perception in investment decision psychology.

A silent surge: Increasing stroke deaths among older adults with atrial fibrillation in the United States (1999-2020).

Background: Atrial fibrillation (AF) significantly increases stroke risk, particularly among older adults, leading to severe outcomes and elevated mortality. This study investigates trends and disparities in AF-related stroke mortality among U.S.

Trends in obesity-related ischemic heart disease mortality among adults in the United States from 1999 to 2020.

Background: Obesity is a critical risk factor for ischemic heart disease (IHD), affecting 42% of the U.S. population.

Trends and disparities in schizophrenia related mortality in the United States: An analysis of CDC WONDER database, 1999-2020.

Background: Schizophrenia is a mental health condition that typically begins between ages 18 and 25, significantly impairs daily functioning, ranks among the leading causes of disability worldwide, and is associated with a shortened lifespan. Mortality in schizophrenia is often linked to cardiovascular disease, driven by poor lifestyle choices, limited access to physical healthcare, frequent comorbidities, and non-compliance with antipsychotic medications. This article analyzes mortality trends among U.

eHealth interventions and patients with metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis.

Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health concern, with increasing mortality rates driven by the obesity pandemic. Weight loss has been shown to improve MASLD outcomes, yet the effectiveness of eHealth interventions in MASLD management remains uncertain. We aimed to evaluate the effectiveness of eHealth interventions compared with standard care in improving health outcomes among patients with MASLD.

Herding behavior, disposition effect, and investment decisions: A multi-mediation analysis of risk perception and dividend policy.

The traditional perspective of finance believes that volatility in the stock market is due to market efficiency. However, the perspective of modern behavioral finance is more concerned with the emotional and psychological factors associated with an investor. This research aims to identify the multi-mediating mechanism of risk perception and dividend policy in the Pakistan Stock Exchange (PSX).

Evaluating the Efficacy of Artificial Intelligence-Driven Chatbots in Addressing Queries on Vernal Conjunctivitis.

Background Vernal keratoconjunctivitis (VKC) is a recurrent allergic eye disease that requires accurate patient education to ensure proper management. AI-driven chatbots, such as Google Gemini Advanced (Mountain View, California, US), are increasingly being explored as potential tools for providing medical information. This study evaluates the accuracy, reliability, and clinical applicability of Google Gemini Advanced in addressing VKC-related queries.