Multidisciplinary approach to Klippel-Trenaunay syndrome: a case report.

Klippel-Trenaunay syndrome (KTS) is a rare inherited disorder presenting as a triad of capillary malformations (cutaneous hemangiomas), soft tissue hypertrophy, and varicosities. Two out of three signs are enough to make a diagnosis. It is associated with gastrointestinal, hematological, neuro-ophthalmic, dermatological, pulmonary, oro-dental, renal cardiac, and vascular complications.

Design, synthesis, and docking studies of novel cinnamaldehyde-chalcone derivatives with anti-cancer potential and acute oral toxicity profiling.

Cinnamaldehyde is a natural compound known for its antimicrobial and anticancer properties. Fourteen novel cinnamaldehyde-chalcone analogues (5a-5n) were synthesized and evaluated for anti-cancer, anti-bacterial, and anti-fungal activities. Among these, bromoethane chalcone 5n exhibited significant cytotoxicity against DU145 (IC50: 8.

Ambient air pollution during developmental windows of spermatogenesis and semen quality among an infertility treatment seeking population.

Prior studies have observed impacts of air pollution on semen quality, but timing of exposure during developmental windows of spermatogenesis and impacts of low-to-moderate air pollution is less well understood. We examined the relation between air pollution and semen quality in the Folic Acid and Zinc Supplementation Trial (2013-2018), which enrolled male partners of couples seeking infertility treatment in the Salt Lake City, Utah region (n = 2015). Semen quality parameters were assessed at baseline, 2-, 4-, and 6-months follow-up.

Endophytic Pseudomonas oryzihabitans CB24 Boosts Photosynthesis Through Monogalactosyldiacylglycerol Driven Lipid Reprogramming.

Pelargonium graveolens, valued for its essential oil, is significantly influenced by its endosymbiotic associations impacting its physiology and phytochemistry, though the exact mechanisms driving this modulation remain largely unexplored. This study unveils that inoculating Pseudomonas oryzihabitans CB24 into P. graveolens significantly alters plant's lipid dynamics, leading to increased accumulation of chloroplast glycerolipids like monogalactosyldiacylglycerol (MGDG) and sulfolipids, sulfoquinovosyldiacylglycerol (SQDG).

Caregiver burden in the families of the patients suffering from bipolar affective disorder: A cross-sectional study in central India.

Background: Caregivers of patients with bipolar affective disorder (BPAD) experience significant burdens.

Aim: Understanding the factors influencing caregiver burden is essential for developing effective, culturally relevant interventions.

Materials And Methods: This cross-sectional study assessed the caregiving burden among 120 primary caregivers of BPAD patients attending the Psychiatry Outpatient Department at a tertiary care hospital in Central India.

Bioremediation of hexavalent chromium Cr (VI) in fluoride contaminated environment by novel bacteria Bacillus albus SSAU-9.

Cr (VI) is highly toxic, persistent, and non-biodegradable in soil-water systems, while fluoride levels in many aquatic environments are rising to similarly hazardous concentrations. This study investigates the capacity of Bacillus albus strain SSAU-9, isolated from the River Ganges and identified by 16S rRNA gene sequencing- to remove Cr (VI) in both the absence and presence of fluoride. Several parameters (inoculum size, salinity, pH, external electron donor, and initial Cr (VI) and fluoride concentrations) were optimized to maximize removal efficiency.

Protective effects of novel probiotic strains against LPS-induced inflammation in RAW264.7 macrophages.

Plant-based fermented foods offer an underexplored reservoir of probiotic strains with therapeutic potential. In this study, we isolated and screened lactic acid bacteria (LAB) from spontaneously fermented vegetables through a comprehensive in-vitro approach involving stress tolerance assays, antioxidant capacity, adhesion evaluations, and immune modulation studies using RAW 264.7 macrophages.

Indian Himalayan Arabidopsis thaliana population reflects deep history and might be the source of species expansion in the eastern edge.

Deciphering the origin, demography and adaptation strategies of species are important goals of biologists. In this context, the model plant species Arabidopsis thaliana has been studied in details using regional and large scale global collections. However, these studies did not include Indian Himalayan populations.

Artificial light at night accelerates aging processes in pre-pubertal female rats.

Urbanization has introduced multiple factors that promote circadian clock dependent or independent disruption of physiology. Conditions such as late-night light (ALAN) exposure, shift working, cross-continental traveling may lead to circadian dysregulation leading to obesity, metabolic disorders and physiological alterations. As ALAN affects the circadian clock with concomitant effects on stress and free radical physiology, we hypothesised that night exposure to artificial light may affect the rate of aging.

Exploring Psychological Impact of Legal Procedure and Victim Blaming on Women Domestic Violence Victims.

Background: Domestic violence includes pattern of abusive or coercive behaviours that occur over time and typically escalate in severity. These patterns of behaviour are directed to assert power, dominance, control and/or coercion over women in line with patriarchal notions of marriage. Prior literature had profoundly addressed the multi-factor implications of encounters with domestic violence, but the gap persists in the areas of societal victim-blaming and re-victimisation that occur during legal procedures.

Fluoride: Toxicity, Mechanism and Role of Bioremediation in Detoxification.

Fluoride is a naturally occurring element found in the environment. However, excessive exposure to fluoride can lead to fluoride toxicity, posing serious risk to human health, plant growth, aquatic animals, and microorganisms. Prolonged exposure to high levels of fluoride can cause dental and skeletal fluorosis, causing brittle bones, joint pain, and damaged enamel.

A Systematic Review of Drone Customization and Application in Public Health Innovation.

A drone, also known as an unmanned aerial vehicle (UAV), is an aircraft operated without a human pilot on board embedded with diverse capabilities. Recent advancements in drone technology have expanded their applicability beyond military and recreational use, enabling critical functions across civilian sectors. In particular, the integration of UAVs into healthcare systems presents new opportunities to overcome logistical barriers, especially in hard-to-reach or underserved regions.

Assessing and mining grain amaranth diversity for sustainable cropping systems.

Global challenges and new demands require adaptation of cropping systems. Plant genetic diversity can contribute to adapt and improve crops and create more sustainable agricultural systems. In order to harness this diversity, a unified framework that combines genomic, ecological, and geographical approaches is needed for targeted conservation efforts and breeding strategies.

Going New Places: Successful Adaptation and Genomic Integrity of Grain Amaranth in India.

Global climate change will impact the geographic distribution of plant populations. The rapid changes will require range shifts and the adaptation of plants. The recent global spread of crops across different continents shows how plants successfully coped with drastically different environments.

Artificial Intelligence-Based Genome Editing in CRISPR/Cas9.

Artificial intelligence (AI) plays a critical role in predicting and improving genome editing methods, including CRISPR/Cas9. Recently, several AI models, such as DeepCRISPR, CRISTA, and Deep High Fidelity (DeepHF), have been utilized to design guide RNAs (gRNAs) for CRISPR-Cas systems. These models assess genomic context, desired mutation type, on-target and off-target scores, and potential off-target locations.

Bioremediation of Cr(VI) using novel thermophilic bacteria Brevibacillus borstelensis SSAU-3 T: optimization, mechanism and phytotoxicity study.

Rapid industrialization and advancement of chemical fertilizers in agriculture get infused with water causing heavy pollution of inorganic pollutants has become a serious problem. This research focuses on the utilization of a thermophilic bacteria Brevibacillus borstelensis, SSAU-3 T in the bioremediation of hexavalent chromium (Cr (VI)). The strain has capability in > 99% removal of 40 ppm Cr (VI).

Lithium-ion conducting self-assembled organic nanowires: optimizing mechanical performance and ionic conductivity through programmable supramolecular interactions.

The emergence of wearable devices has led to a greater need for battery materials that are safe, resilient, and exhibit high levels of ionic conductivity. Here, we present a supramolecular design as a useful tactic through fine tuning of the noncovalent interactions to overcome the standard trade-off in solid state Li-ion conductors between ionic conductivity and mechanical resilience. We report solution processable self-assembled organic nanowires (SONs) with varying supramolecular interactions through structural mutation to boost Li-ion conductivity and mechanical integrity.

Front-of-package food labeling and noncommunicable disease prevention: A comprehensive bibliometric analysis of three decades.

Noncommunicable diseases (NCDs) are a major obstacle to global sustainable development, as recognized in the Agenda 2030 framework. Each year, NCDs cause around 41 million deaths, making up 74% of global annual deaths. Alarmingly, 17 million of these deaths occur in people under 70 years old.

Multivariate Analysis of the Efficiency of Bio-Actives Extraction from Laboratory-Generated By-Products of Citrus reticulata Blanco.

A growing demand for sustainable methods to valorize agricultural by-products underscores the need for efficient, green extraction techniques. This study evaluated ultrasound-assisted extraction (UAE) of bioactive compounds from Citrus reticulata Blanco peel and pomace using multivariate analysis across six key metrics: total phenolic content (TPC), flavonoid content, and four antioxidant assays. UAE significantly outperformed conventional extraction (CE), achieving a 207% higher average composite performance score (2.

Circulating Megakaryocytes in a Peripheral Blood Smear at the Feathered Edge: An Incidental Finding in a Case of Systemic Inflammatory Response Syndrome.

Megakaryocytes are large cells with lobulated nuclei found within the bone marrow and comprising 0.01% of all nucleated cells. Circulating megakaryocytes in the peripheral blood smear (PBS) have been rarely described in the literature.

Expressed Emotions in Families of Patients With Bipolar Disorder.

Introduction Bipolar affective disorder (BPAD) is a chronic psychiatric illness characterized by recurrent episodes of mania, hypomania, and depression, significantly impacting both patients and their caregivers. Expressed emotion (EE), which includes criticism, hostility, and emotional over-involvement, plays a crucial role in caregiver burden and patient outcomes. High EE environments have been linked to increased relapse rates and hospitalization, while low EE settings promote better adherence and stability.

Molecular Determinants of A9 Dopaminergic Neurons.

In the human brain, the nigrostriatal pathway regulates motor functions, and its selective deterioration leads to the onset of Parkinson's disease (PD), a neurodegenerative disorder characterized by motor dysfunction and significant disability. The A9 neurons, a subgroup of ventral mesencephalic dopaminergic (DA) neurons, form the nigrostriatal pathway that emerges from the nigral region and innervates into the striatum. These DA neurons exhibit extensive and arborized axonal terminals projecting into the dorsal striatum.

A Mechanistic Insight in Cr (VI) Bioremediation by Bacillus spp. SSAU-2 Under Multi-Heavy Metal Contamination.

Climate change has significantly contributed to high level of contamination of multi-pollutants in the environment. For instance, it increases the intensity of rainfall, leading to soil erosion and leaching of heavy metals, pesticides and other pollutants into the water bodies. Additionally, climate change intensifies both natural processes and anthropogenic activities resulting in the widespread release and dispersal of heavy metals (HMs) and other pollutants, posing great risk to environment and human health.

PARP-2 acts on ILK signaling and pharmacological targeting of PARP-2 ameliorate endometriosis in a mouse model.

Endometriosis, an endocrine disorder in reproductive-aged women with an occurrence of ∼10 %, gives rise to inflammation, pelvic pain, menstrual irregularity, infertility, etc. One study demonstrated the elevated plasma level of PARP during endometriosis. Thus, we studied the role of PARP-2 during endometriosis using human endometriotic tissue and cells along with an endometriosis mouse model.

Human-centered design of a health recommender system for orthopaedic shoulder treatment.

Background: Rich data on diverse patients and their treatments and outcomes within Electronic Health Record (EHR) systems can be used to generate real world evidence. A health recommender system (HRS) framework can be applied to a decision support system application to generate data summaries for similar patients during the clinical encounter to assist physicians and patients in making evidence-based shared treatment decisions.

Objective: A human-centered design (HCD) process was used to develop a HRS for treatment decision support in orthopaedic medicine, the Informatics Consult for Individualized Treatment (I-C-IT).