Clinical and Pathological Predictors for Occult Lymph Node Involvement in Patients With Clinical Node-Negative Bladder Cancer Undergoing Radical Cystectomy.

Background: Occult pathological lymph node involvement in patients with clinical node-negative (cN0) bladder cancer (BC) remains a diagnostic challenge. We evaluate predictors of lymph node positivity (pN+) in patients with cT1-4N0M0 BC undergoing radical cystectomy and pelvic lymph node dissection (RC-PLND).

Methods: We included patients with cT1-4N0M0 BC undergoing RC-PLND from February 2004 through October 2020.

Formulation and shelf life evaluation of nutrient rich Urochloa ramosa muffins enriched with Madhuca longifolia extract.

This study investigates the development and shelf life of nutrient-enriched muffins suspended with Mahua flower extract (MFE) and brown top millet (BTM) flour. BTM is a nutrient-dense grain, while mahua flowers are rich in bioactive compounds. Muffins were prepared with varying BTM (5-7%; w/w), MFE (4-6%; v/w) levels and baking temperature (170-180 °C) and their physicochemical properties, total phenolic content (TPC), antioxidant activity (AA), and sensory qualities were analyzed.

Impact of metal oxides on thermal response of zirconia coated diesel engines fueled by Momordica biodiesel machine learning insights.

Biodiesel presents a favourable economic outlook and environmental benefits, yet it faces limitations such as diminished calorific value and suboptimal combustion characteristics. Recent research focuses on enhancing biodiesel performance using nanoparticles and thermal barrier coatings. This study investigates non-edible biodiesel from Momordica seed oil, tested on a single-cylinder diesel engine.

Artificial Intelligence-Based Genome Editing in CRISPR/Cas9.

Artificial intelligence (AI) plays a critical role in predicting and improving genome editing methods, including CRISPR/Cas9. Recently, several AI models, such as DeepCRISPR, CRISTA, and Deep High Fidelity (DeepHF), have been utilized to design guide RNAs (gRNAs) for CRISPR-Cas systems. These models assess genomic context, desired mutation type, on-target and off-target scores, and potential off-target locations.

The representation of facial emotion expands from sensory to prefrontal cortex with development.

Facial expression recognition develops rapidly during infancy and improves from childhood to adulthood. As a critical component of social communication, this skill enables individuals to interpret others' emotions and intentions. However, the brain mechanisms driving the development of this skill remain largely unclear due to the difficulty of obtaining data with both high spatial and temporal resolution from young children.

Comparative Genomic Characterization of Small Cell Carcinoma of the Bladder Compared With Urothelial Carcinoma and Small Cell Lung Carcinoma.

Purpose: Small cell bladder cancer (SCBC) is a rare histologic variant of bladder cancer with an aggressive disease course and poor outcomes. Given its uncommon nature, there is a paucity of high-quality data characterizing genomic drivers of this disease, and most patients are treated with approaches mirroring small cell lung cancer (SCLC). Leveraging the Tempus Lens deidentified clinically annotated genomic data set, we sought to evaluate the mutational landscape of SCBC relative to urothelial carcinoma (UC) and SCLC.

ML techniques increasing the power factor of a compression ignition engine that is powered by Annona biodiesel using SATACOM.

The global production of biodiesel in 2023 amounted to 34 billion liters because compression ignition engines need environmentally friendly fuel alternatives. The research investigates Annona biodiesel in combination with machine learning (ML) and STATCOM (Static Synchronous Compensator) technology to enhance power quality along with noise and vibration control in CI engines. Engine performance testing of diesel and B20-20% Annona biodiesel occurs under controlled conditions at rpm from 1200 to 2400 at which point STATCOM implemented both power factor improvement and current harmonic reduction for enhanced power quality.

Eligibility Criteria in Advanced Urothelial Cancer Clinical Trials: An Assessment of Modernization and Inclusion.

Introduction: In a joint statement, Friends of Cancer Research and the American Society of Clinical Oncology affirmed the need for broadening clinical trial eligibility criteria to expand patient access to investigational treatments and enroll cohorts more representative of the general population. Our study aimed to characterize and analyze the prevalence of overly exclusionary eligibility criteria in contemporary clinical trials involving patients with locally advanced and metastatic urothelial cancer.

Methods: Utilizing MeSH query terms "(metastatic OR advanced OR stage IV OR unresectable) AND (bladder cancer OR upper tract urothelial carcinoma OR upper tract urothelial cancer)" in ClinicalTrials.

The Role of Chalcogen Bonding in Organic Dichalcogenides of Biological Interest.

Dichalcogenides are important intermediates in the catalytic cycle of the Glutathione peroxidase (GPx), the enzyme regulating the level of reactive oxygen species (ROS). Due to their redox sensitivity, dichalcogenides are also employed in anticancer systems. The biological activity of these compounds can be related to the electrophilic behaviour of the chalcogen atoms, namely their ability to form Chalcogen Bonds (ChBs) with nucleophilic species.

Transforming lemon Peel into a sustainable reservoir of bioactives: A green osmotic dehydration strategy.

Osmotic dehydration (OD) is a sustainable alternative, offering reduced energy consumption compared to traditional drying approaches. This study investigates the role of OD in stabilizing bioactive compounds in lemon peel, fostering sustainable citrus by-product applications. Employing Response Surface Methodology (RSM) framework, pivotal variables-temperature (30-60 °C), exposure time (60-180 min), and sucrose concentration (50-70°Brix)-were optimized to enhance water loss (WL) and solid gain (SG) while safeguarding bioactive retention.

Enhancing safety in surface mine blasting operations with IoT based ground vibration monitoring and prediction system integrated with machine learning.

Monitoring and predicting ground vibration levels during blasting operations is essential to safeguard mining sites and surrounding communities. This study introduces an IoT-based ground vibration monitoring device specifically designed for limestone mining operations, combined with machine learning algorithms to predict ground vibration intensity. The primary aim is to provide an efficient predictive tool for anticipating hazardous vibration levels, enabling proactive safety measures.

Performance assessment of solar PV panels under varying environmental conditions: a laboratory and field-based approach for sustainable energy in mining operations.

This study provides a novel and comprehensive assessment of solar photovoltaic (PV) panel performance under varying environmental conditions, integrating laboratory experiments with real-world field studies to address challenges specific to mining operations. The research uniquely explores the combined effects of shading, temperature, humidity, dust deposition, and tilt angle, delivering actionable insights for optimizing PV systems in harsh conditions. Laboratory experiments demonstrated that a parallel configuration significantly minimizes power losses under partial shading, while a rise in temperature from 35 to 75 °C resulted in a notable 21.

Valorization of raw papaya () and citrus peels for development of antimicrobial and biodegradable edible film.

Most of the food packaging materials used in the market are petroleum-based plastics; such materials are neither biodegradable nor environmentally friendly and require years to decompose. To overcome these problems, biodegradable and edible materials are encouraged to be used because such materials degrade quickly due to the actions of bacteria, fungi, and other environmental effects. The present study examined that starch can be effectively used as raw material to develop biodegradable, edible films.

Lutein and Zeaxanthin: Source, Extraction, Stability, Bioactivity, and Functional Food Applications.

Nature has been acknowledged as a fundamental source of diverse bioactive molecules. Among natural carotenoids, lutein, zeaxanthin, and their oxidative metabolites are specifically deposited in the macular region of living organisms. Lutein and zeaxanthin are carotenoids primarily found in green leafy vegetables, eggs, and various fruits.

Emergence of the stromal vascular fraction and secretome in regenerative medicine.

Recently, we read a mini-review published by Jeyaraman . The article explored the optimal methods for isolating mesenchymal stromal cells from adipose tissue-derived stromal vascular fraction (SVF). Key factors include tissue source, processing techniques, cell viability assessment, and the advantages/disadvantages of autologous allogeneic use.

Clinical Implications of the Molecular and Genomic Landscape of Upper Tract Urothelial Carcinoma.

Purpose Of Review: Upper tract urothelial carcinoma (UTUC) is an aggressive entity with treatment strategies mirroring bladder cancer. Genomic and molecular profiling allows for a better characterization of this disease and allows for patient-tailored approaches. We aim to describe the genomic and molecular implications of this disease.

Final Overall Survival Analysis of S1500: A Randomized, Phase II Study Comparing Sunitinib With Cabozantinib, Crizotinib, and Savolitinib in Advanced Papillary Renal Cell Carcinoma.

JCO Mesenchymal-epithelial transition (MET) signaling pathway plays a role in the pathogenesis of selected patients with papillary renal cell carcinoma (PRCC). In the phase II PAPMET trial (ClinicalTrials.gov identifier: NCT02761057), cabozantinib significantly prolonged progression-free survival and improved objective response rate compared with sunitinib in patients with advanced PRCC.

Adjuvant Everolimus in Non-Clear Cell Renal Cell Carcinoma: A Secondary Analysis of a Randomized Clinical Trial.

Importance: Clinical trial data on adjuvant therapy in patients with non-clear cell renal cell carcinoma (RCC) are scant.

Objective: To evaluate the effect of adjuvant everolimus after nephrectomy on recurrence-free survival (RFS) and overall survival (OS) in patients with localized papillary and chromophobe RCC.

Design, Setting, And Participants: This prespecified subgroup analysis of a phase 3 randomized clinical trial, EVEREST, included patients enrolled between April 1, 2011, and September 15, 2016.

Polyhydroxyalkanoates (PHAs) and its copolymer nanocarrier application in cancer treatment: An overview and challenges.

In the modern era, nanomedicine has developed novel drug-delivery strategies to improve chemotherapy. Nanotechnological-based treatment approaches for cancer through targeted tumour drug delivery and stimulus-responsive tumour microenvironment have gained tremendous success in oncology. The application of building block materials of these nanomedicines plays a vital role in cancer remediation.