Therapeutic Potential of Carnosic Acid in Alopecia: A Mechanistic Perspective.

Alopecia, characterised by partial or complete hair loss, significantly affects the psychological and social well-being of individuals. Current FDA-approved treatments, such as topical minoxidil and oral finasteride, often present limitations, including skin irritation and suboptimal efficacy, compromising patient adherence. In recent years, natural compounds have garnered attention as potential alternatives, with carnosic acid emerging as a promising candidate due to its multifaceted biological activities.

Exploring the Therapeutic Potential of Lipid Nanocarriers in Psoriasis Management: Advances and Applications.

Psoriasis is a chronic inflammatory skin disorder characterized by hyperproliferation of keratinocytes and immune dysregulation, leading to erythematous, scaly plaques. Conventional treatments, including corticosteroids, immunosuppressants, and biologics, often present challenges such as systemic side effects, poor skin penetration, and reduced patient compliance. Lipid nanocarriers (LNCs) have emerged as promising drug delivery systems for psoriasis management, offering enhanced drug stability, targeted delivery, improved skin penetration, and controlled drug release.

A Systematic Review of Drone Customization and Application in Public Health Innovation.

A drone, also known as an unmanned aerial vehicle (UAV), is an aircraft operated without a human pilot on board embedded with diverse capabilities. Recent advancements in drone technology have expanded their applicability beyond military and recreational use, enabling critical functions across civilian sectors. In particular, the integration of UAVs into healthcare systems presents new opportunities to overcome logistical barriers, especially in hard-to-reach or underserved regions.

Advancing pulmonary therapy: the role of dry powder inhalation technology in lung disease management.

Chronic respiratory diseases represent a growing global health challenge, marked by rising prevalence and mortality rates. Inflammatory lung conditions including asthma, chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome, and idiopathic pulmonary fibrosis are major contributors to this burden. These disorders are typically associated with persistent inflammation in the airways or lung tissue, resulting in obstructive or restrictive patterns of respiratory dysfunction.

Chitosan-coated nanostructured lipid carriers of amantadine for nose-to-brain delivery: formulation optimization, in vitro-ex vivo characterization, and in vivo anti-parkinsonism assessment.

Amantadine hydrochloride (AMH) is a repurposed moiety of anti-viral category having significant response against Parkinsonism. Nasal route is linked with the direct delivery of drugs to brain through olfactory and trigeminal nerves. The mucociliary clearance is the major obstacle for effective delivery of drugs.

Unveiling the nexus: A bibliometric analysis of nano plastic's health impact.

Plastics are integral to daily life due to their flexibility, durability, low viscosity, and poor conductivity. However, UV exposure, weathering, and biodegradation fragment plastics into microplastics and nano plastics, forming a heterogeneous mix categorized as large microplastics (5 mm to 1 mm), small microplastics (1 mm to 1 μm), and nano plastics (<1 μm). Concerns over the health impacts of micro and nano plastic (MNP) pollution have spurred extensive research, revealing increased disease susceptibility.

Carvacrol in asthma management: a comprehensive review of its therapeutic potential and mechanisms of action.

Asthma, a chronic inflammatory disorder of the airways, remains a significant global health concern. Current treatments focus on symptom management and inflammation control, but the search for more effective and safer therapies continues. Carvacrol, a naturally occurring monoterpenoid phenol found in essential oils of various plants, has emerged as a promising bioactive compound with potent anti-inflammatory, antioxidant, and bronchodilatory properties.

In situ Forming Nanoemulgel for Diabetic Retinopathy: Development, characterization, and in vitro efficacy assessment.

Diabetic retinopathy, the most common microvascular complication of diabetes mellitus, is the leading cause of vision impairment worldwide. Flavonoids with antioxidant properties have been shown to slow its progression. Myricetin, a flavonoid polyphenolic compound, possesses antioxidant properties, but its clinical use in ocular delivery is limited by poor aqueous solubility, stability, and bioavailability.

Exploring Menatetrenone: Origin, Chemistry, Therapies and Delivery.

Menatetrenone (MK-4), a potent form of vitamin K2, has gained significant attention for its diverse therapeutic potential, particularly in bone health, cardiovascular protection, and metabolic disorders. This manuscript explores the origins and chemical structure of menatetrenone, highlighting its synthesis from dietary sources and its enzymatic conversion in the body. The review examines the extensive therapeutic applications of MK-4, focusing on its role in treating osteoporosis, diabetes, and cardiovascular diseases, along with emerging evidence of its anticancer and neuroprotective effects.

Innovating alopecia treatment: nanostructured lipid carriers as advanced delivery platforms.

Alopecia, a common dermatological condition, poses significant psychological and social challenges. Despite the availability of various treatments, their efficacy is often limited by poor bioavailability and delivery challenges. Nanostructured lipid carriers have emerged as promising advanced drug delivery systems for alopecia treatment due to their ability to encapsulate both hydrophilic and lipophilic compounds, enhancing their stability, solubility, and controlled release.

Exploring the HPLC Profiling and Antioxidant Potency in Methanolic Extracts of Curcuma longa L. Rhizomes.

In this exploration of Linn., commonly known as turmeric, renowned for its therapeutic history, our study focuses on the bioactive compound curcumin. We established and validated an HPLC method for precise curcumin quantification, complemented by an examination of total phenolic and flavonoid content, as well as antioxidant capabilities in a methanolic extract from rhizomes obtained through a methanol-based Soxhlet extraction.

Enhancing clinical drug trial monitoring with blockchain technology.

Background: Clinical drug trials are intricate, involving numerous stakeholders, substantial data, and stringent regulations. Traditional systems for recording, storing, and sharing trial data often face data integrity, transparency, security, and interoperability challenges. The utilization of blockchain technology has emerged as a transformative influence in various industries, and its potential within healthcare, particularly in clinical drug trials, is increasingly gaining recognition.

Leveraging nanostructured lipid carriers to enhance targeted delivery and efficacy in breast cancer therapy: a comprehensive review.

Cancer, characterized by uncontrolled cell growth and proliferation, continues to be a major global health concern. Breast cancer, the most commonly diagnosed cancer among women, remains a leading cause of cancer-related deaths worldwide. Conventional treatment modalities such as surgery, radiation, and chemotherapy have made significant strides in improving patient outcomes.

Assessing the Compatibility of Menatetrenone with Excipients: A Spectroscopic Approach and Implication in Drug Formulation Development.

An experiment was conducted to evaluate the compatibility of menatetrenone with selected pharmaceutical excipients. Fourier Transform Infrared Spectroscopy (FTIR) was used to assess drug-excipient compatibility. The present research systematically investigates the FTIR spectrum of each chemical compound separately and their physical blends, analyzing for possible shifts, alterations or novel peak that may indicate chemical interactions.

Scaffold-Mediated Drug Delivery for Enhanced Wound Healing: A Review.

Wound healing is a complex physiological process involving coordinated cellular and molecular events aimed at restoring tissue integrity. Acute wounds typically progress through the sequential phases of hemostasis, inflammation, proliferation, and remodeling, while chronic wounds, such as venous leg ulcers and diabetic foot ulcers, often exhibit prolonged inflammation and impaired healing. Traditional wound dressings, while widely used, have limitations such poor moisture retention and biocompatibility.

Development and efficacy assessment of polyherbal phytosomal gel for accelerated wound healing.

L. and L. are renowned for their antioxidant, anti-inflammatory, and wound-healing properties, primarily attributed to their polyphenolic compounds.

Potassium: A Frontier in Osteoporosis.

Osteoporosis is a significant public health concern, particularly in aging populations, leading to fractures, decreased mobility, and reduced quality of life. While calcium and vitamin D have long been recognized as essential for bone health, emerging research suggests that potassium may play a crucial role in maintaining bone density and preventing osteoporosis. This manuscript explores the relationship between potassium and osteoporosis, delving into the mechanisms, epidemiological evidence, and potential therapeutic implications of potassium in bone health.

Dermaceutical Utilization of Nigella sativa Seeds: Applications and Opportunities.

Skin diseases have recently become a major concern among people of all ages due to their highly visible symptoms and persistent and difficult treatment, which significantly impact their quality of life. seeds, also known as "black seeds" or "kalonji," are one of the most commonly used herbal medicines due to their wide range of biological and pharmacological activities. It contains a wide range of bioactive constituents found in both fixed and essential oils.

Nanocarrier Mediated Intranasal Drug Delivery Systems for the Management of Parkinsonism: A Review.

The transport of drugs to the brain becomes a key concern when treating disorders of the central nervous system. Parkinsonism is one of the major concerns across the world populations, which causes difficulty in coordination and balance. However, the blood-brain barrier is a significant barrier to achieving optimal brain concentration through oral, transdermal, and intravenous routes of administration.

A cross-sectional study on COVID-19 vaccine hesitancy in peri-urban areas in Kanpur, Uttar Pradesh, India.

Vaccination is a potential public health solution for the prevention of infection. It reduces the severity of symptoms in the case of COVID-19. Despite the availability of vaccines, some people are hesitant to be vaccinated.