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Cellular angiofibroma (CA) is a relatively recently described, rare, benign soft tissue tumor that predominantly occurs in the vulvoperineal region. It was first described in 1997 as a mesenchymal-origin tumor composed of connective (fibrous) tissue and blood vessels. We report a case of vaginal CA in a 40-year-old woman who presented with pressure symptoms, incidentally diagnosed with a vaginal mass and clinically suspected as vaginal myoma. This case was diagnosed based on histomorphology and immunohistochemistry and underwent surgical treatment. This tumor was a diagnostic dilemma for other benign and aggressive spindle cell tumors in the same area, such as endometrial stromal nodule, spindle cell lipoma, solitary fibrous tumors, and mixed tumors of the vagina.
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http://dx.doi.org/10.4103/jmh.jmh_186_23 | DOI Listing |
Ann Maxillofac Surg
March 2025
Department of Oral and Maxillofacial Surgery, Mahatma Gandhi Postgraduate Institute of Dental Sciences, Puducherry, India.
Rationale: Central giant cell granuloma (CGCG) is a non-neoplastic proliferative lesion that clinically and radiologically mimics various lesions without any unique pathognomic features.
Patient Concerns: A 14-year-old male patient reported with a chief complaint of swelling in the right upper back tooth region for four months.
Diagnosis: Incisional biopsy of the lesion shows numerous dilated and thin-walled blood vessels and focal areas of chronic inflammatory cell infiltrate beneath the epithelium suggestive of angiofibroma.
Int J Gynecol Pathol
July 2025
Department of Pathology, UPMC/University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Cellular angiofibroma is a benign mesenchymal neoplasm which usually occurs in the vulvovaginal or inguinoscrotal areas. Although benign, cellular angiofibroma may rarely undergo sarcomatous transformation. We report a case of vulvar cellular angiofibroma with sarcomatous transformation in a 62-yr-old woman and a literature review of previously reported cases.
View Article and Find Full Text PDFCellular Angiofibroma (CAF) is a rare and benign neoplasm with a good prognosis. Diagnosis of CAF can be challenging due to its nonspecific clinical and radiological features, which can often lead to a misdiagnosis, as in our case of a 77-year-old male. Histopathology and immunohistochemistry play a crucial role in identifying CAF and differentiating it from malignant tumors.
View Article and Find Full Text PDFJ Comp Pathol
May 2025
Institute of Veterinary Pathology, Faculty of Veterinary Medicine, Leipzig University, An den Tierkliniken 33, 04103, Leipzig, Germany. Electronic address:
A 34-year-old Haflinger gelding presented with a unilateral, expansile, intranasal mass that regrew after partial excision. After euthanasia, a large pedunculated mass that originated from the left caudal maxillary sinus and obliterated the left nasal cavity was seen by radiological and macroscopic examination. Histopathology revealed a poorly cellular, expansile, well-vascularized neoplasm composed of a loosely arranged meshwork of spindle cells and collagen fibres.
View Article and Find Full Text PDFEar Nose Throat J
April 2025
Department of Otorhinolaryngology, Al Mouwasat University Hospital, Damascus University, Damascus, Syria.
Angiofibroma is a rare, benign vascular tumor traditionally associated with the nasopharynx of adolescent males. In contrast, extranasopharyngeal angiofibromas (ENAs) exhibit a wider demographic distribution and may arise in diverse anatomical sites. We report a case involving a 45 year-old woman presenting with a 4 month history of a mass located on the lateral border of the anterior tongue.
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