Natural variation in CHELATASE SUBUNIT I-A increases grain weight and enhances wheat yield.

Grain weight is a major determinant of wheat (Triticum aestivum L.) yield and is controlled by quantitative trait loci (QTLs) derived from natural variations. Here, we report the cloning of a major yield QTL in bread wheat that functions in the chlorophyll biosynthesis pathway.

A power-free microfluidic device for the detection of hepatitis B virus in resource-limited settings.

Background: Rapid on-site nucleic acid testing plays a critical role in the prevention, diagnosis, and treatment of infectious diseases. Although real-time fluorescence polymerase chain reaction (PCR) technique, as the gold standard method, is widely used for nucleic acid quantification, its reliance on complex instrumentation and trained personnel in centralized laboratories presents significant challenges in applications such as rapid home-based self-testing or screening in remote areas. Therefore, there is an urgent need to develop miniaturized, low-cost, user-friendly, and high-performance point-of-care testing (POCT) devices for nucleic acid detection to meet the demands of infectious pathogen screening in resource-limited settings.

Intergenerational differences in turnover intention of nurses: a cross-sectional survey in Jiangsu province, China.

Purpose: This study aimed to learn the turnover intention of nurses in the workplace and analyze the influencing factors, commonalities, and differences from the perspective of intergenerational differences.

Methods: Between 4 September and 5 October 2023, a stratified cluster sampling was conducted among 2299 nurses at 16 tertiary hospitals in Jiangsu Province in China, using the questionnaire composited of General sociodemographic information, Work-Family Conflict Scale, Perceived Social Support Scale, Resilience Scale, and Turnover Intention Scale. SPSS v26.

Machine learning prediction prior to onset of mild cognitive impairment using T1-weighted magnetic resonance imaging radiomic of the hippocampus.

Background: Early identification of individuals who progress from normal cognition (NC) to mild cognitive impairment (MCI) may help prevent cognitive decline. We aimed to build predictive models using radiomic features of the bilateral hippocampus in combination with scores from neuropsychological assessments.

Methods: We utilized the Alzheimer's Disease Neuroimaging Initiative (ADNI) database to study 175 NC individuals, identifying 50 who progressed to MCI within seven years.

A rapid and ultrasensitive RPA-assisted CRISPR-Cas12a/Cas13a nucleic acid diagnostic platform with a smartphone-based portable device.

The spread of infectious diseases can be controlled by early identification of the source of infection and timely diagnosis to stop transmission. Real-time fluorescence quantitative polymerase chain reaction (PCR) is the current gold standard for pathogen diagnosis, with high detection sensitivity and accuracy. However, due to the need for specialized equipment, laboratories, and personnel, it is difficult to achieve rapid and immediate diagnosis during large-scale infectious disease outbreaks.

Exploring the impact of interpersonal sensitivity on anxiety symptoms: the mediating role of psychological capital and social support among nursing students.

Background: As the demand for healthcare in society continues to rise, nursing students are likely to face various challenges related to their profession in the future. Anxiety symptoms have increasingly become a significant factor affecting their mental health. Given that nursing students are crucial to building the future nursing workforce, it is essential to prioritize their mental well-being.

Aerobic exercise improves clearance of amyloid-β via the glymphatic system in a mouse model of Alzheimer's Disease.

Background: Aerobic exercise training can promote the recovery of learning and memory ability in Alzheimer's disease (AD), but the specific mechanism is still unclear. Previous studies have suggested that aquaporin-4 (AQP4)-mediated glymphatic system is an important way to clear β-amyloid (Aβ) in the brain, which is closely related to learning and memory impairment in AD. However, it remains unclear whether AQP4 regulates glymphatic clearance of Aβ which contributes to the beneficial effects of aerobic exercise in AD patients.

Effects of Income on Subjective Well-Being in the Elderly: Complete Mediation Roles of Self-Rated Health and Psychological Capital.

Although income and living conditions of residents have greatly improved in recent years, people's subjective well-being does not seem to increase daily. This study aimed to explore income, self-rated health, and psychological capital on subjective well-being, using data from the China General Social Survey conducted in 2017. A total of 1136 elderly as subsamples data were selected from 12 582 participants, involving general sociodemographic characteristics, income, self-rated health, psychological capital, and subjective well-being.

The Bifunctional Effects of Lactoferrin (LFcinB11) in Inhibiting Neural Cell Adhesive Molecule (NCAM) Polysialylation and the Release of Neutrophil Extracellular Traps (NETs).

The expression of polysialic acid (polySia) on the neuronal cell adhesion molecule (NCAM) is called NCAM-polysialylation, which is strongly related to the migration and invasion of tumor cells and aggressive clinical status. Thus, it is important to select a proper drug to block tumor cell migration during clinical treatment. In this study, we proposed that lactoferrin (LFcinB11) may be a better candidate for inhibiting NCAM polysialylation when compared with CMP and low-molecular-weight heparin (LMWH), which were determined based on our NMR studies.

Brain network hierarchy reorganization in subthreshold depression.

Background: Hierarchy is the organizing principle of human brain network. How network hierarchy changes in subthreshold depression (StD) is unclear. The aim of this study was to investigate the altered brain network hierarchy and its clinical significance in patients with StD.

Psychological Capital and Its Factors as Mediators Between Interpersonal Sensitivity and Depressive Symptoms Among Chinese Undergraduates.

Purpose: Current interpersonal sensitivity among college students is easily linked to mood disorders such as anxiety, depression and other mood disorders. This study aims to examine the mediating role of psychological capital and its dimensions in the relationship between interpersonal sensitivity and depressive symptoms among undergraduates.

Methods: The cross-sectional survey was conducted by using cluster stratified random sampling method across six Chinese universities between November and December 2022.

Atypical characteristic changes of surface morphology and structural covariance network in developmental dyslexia.

Background: Developmental dyslexia (DD) is a neurodevelopmental disorder that is characterized by difficulties with all aspects of information acquisition in the written word, including slow and inaccurate word recognition. The neural basis behind DD has not been fully elucidated.

Method: The study included 22 typically developing (TD) children, 16 children with isolated spelling disorder (SpD), and 20 children with DD.

Chromosome-level genomes of three key Allium crops and their trait evolution.

Allium crop breeding remains severely hindered due to the lack of high-quality reference genomes. Here we report high-quality chromosome-level genome assemblies for three key Allium crops (Welsh onion, garlic and onion), which are 11.17 Gb, 15.

Altered morphological characteristics and structural covariance connectivity associated with verbal working memory performance in ADHD children.

Objectives: Deficits in verbal working memory (VWM) observed in attention deficit hyperactivity disorder (ADHD) children can persist into adulthood. Although previous studies have identified brain regions that are activated during VWM tasks, the neural mechanisms underlying the relationship between VWM deficits remain unclear. The objective of this study was to investigate the structural covariance network connectivity and brain morphology changes that are associated with VWM performance in ADHD children.

Structural variation and introgression from wild populations in East Asian cattle genomes confer adaptation to local environment.

Background: Structural variations (SVs) in individual genomes are major determinants of complex traits, including adaptability to environmental variables. The Mongolian and Hainan cattle breeds in East Asia are of taurine and indicine origins that have evolved to adapt to cold and hot environments, respectively. However, few studies have investigated SVs in East Asian cattle genomes and their roles in environmental adaptation, and little is known about adaptively introgressed SVs in East Asian cattle.

Automatic brain extraction for rat magnetic resonance imaging data using U-Net.

Skull stripping is a key step in the pre-processing of rodent brain magnetic resonance images (MRI). This study aimed to develop a new skull stripping method via U-Net, a neural network model based on deep learning method, for rat brain MRI.In this study, 599 rats were enrolled and U-Net was applied to segment MRI images of rat brain.

A high-precision thermometry strategy by replacing the infrared with visible light for detection.

We have developed a high-precision thermometry strategy based on I-I (I) and S-I (I) transitions of Er, after replacing the measurement of the I-I (I) transition with the S-I transition, i.e., using visible light for detection instead of infrared.

Ratiometric optical thermometry based on upconversion luminescence with different multi-photon processes in CaWO:Tm/Yb phosphor.

Ratiometric optical thermometry based on upconversion (UC) luminescence with different multi-photon processes in CaWO:Tm,Yb phosphor was developed. A new fluorescence intensity ratio (FIR) thermometry, utilizing the ratio of the cube of F emission to the square of G emission of Tm and retaining the feature of anti-interference of excitation light source fluctuations, is proposed. Under the hypotheses of the UC terms being neglected in the rate equations and the ratio of the cube of H emission to the square of G emission of Tm being a constant in a relatively narrow temperature range, the new FIR thermometry is valid.

Effects of interpersonal sensitivity on depressive symptoms in postgraduate students during the COVID-19 pandemic: Psychological capital and sleep quality as mediators.

Background: This study aimed to examine depressive symptoms associated with interpersonal sensitivity, sleep quality, and psychological capital among postgraduate students during static campus management after the COVID-19 pandemic in China.

Methods: Research data were obtained during static campus management (10-19 April 2022) after the reappearance of COVID-19 in cities in eastern China. We collected data through an online questionnaire, and the anonymous self-reported questionnaire included the Patient Health Questionnaire, the interpersonal sensitivity subscale of Symptom Checklist-90, the Psychological Capital Questionnaire, and the Pittsburgh Sleep Quality Index.

Effects of psychological capital and social support availability on anxiety and depression among Chinese emergency physicians: Testing moderated mediation model.

Introduction: Anxiety often precedes depression, and the pathway from anxiety to depression may be affected by multiple exposures. Our research aims to explore the mediating effect of the social support availability (SSA) between anxiety and depression and how it is moderated by psychological capital.

Methods: A cross-sectional study was conducted among Chinese emergency physicians at the top-level general hospitals in eastern China.

The study of psychological traits among Chinese college students during the COVID-19 campus lockdown.

To investigate the prevalence of interpersonal sensitivity, anxiety, depression symptoms and associated risk factors among a large-scale sample of college students in China during the COVID-19 campus lockdown. The survey was conducted among undergraduate students at a university in eastern part of China in April 2022. The Chi-square test was used to compare the different variable groups and multivariable analysis was performed for the risk factors associated with interpersonal sensitivity, anxiety, and depression symptoms.

Interpersonal sensitivity on college freshmen's depression: A moderated moderation model of psychological capital and family support.

Background: The prevalence of depressive symptoms has become very high among college freshmen, with interpersonal sensitivity serving as an important predictor of depression. Combining internal and external positive resources can effectively prevent and alleviate depression. This study explores the moderating role of psychological capital (PsyCap) in the relationship between interpersonal sensitivity and depression, as well as the moderating effect of familial support on the conditional influence of PsyCap among Chinese college freshmen.