OfWRKY33 binds to the promoter of key linalool synthase gene to stimulate linalool synthesis in flowers.

Volatile aroma compounds make significant contributions to human perception of flowers. is a famous aroma plant, and linalool is proved to be the dominant aroma active compound. Although some terpene synthases have been characterized, a comprehensive study of the hub metabolic gene and its transcriptional regulation remain to be revealed.

The efficacy and safety of submucosal tunnel endoscopic resection for the treatment of upper gastrointestinal submucosal tumors: a systematic review and meta-analysis.

Objective: The comprehensive systematic review was conducted to assess the efficacy and associated factors of submucosal tunnel endoscopic resection (STER) in the treatment of upper gastrointestinal submucosal tumor.

Methods: Databases including PubMed, Web of Science, CNKI, Wang Fang, VIP and Embase were electronically searched for studies on STER for the treatment of upper gastrointestinal submucosal tumors from inception to September 17, 2024. Two authors conducted the literature search independently.

BACTEROIDETES/FIRMICUTES RATIO AS AN EARLY BIOMARKER FOR NEC DEVELOPMENT IN PRETERM INFANTS.

Backgroud: Neonatal necrotizing enterocolitis (NEC) is a severe intestinal disease potentially linked to gut microbiota dysbiosis. This prospective observational study aimed to evaluate the role of dysbiosis in NEC development.

Method: We included preterm infants with a birth weight <1500 g or gestational age <32 weeks, admitted to Shanghai Children's Hospital from April 9, 2019, to March 30, 2023.

The effects of parenting styles on eating concerns in patients with eating disorders: the mediating role of self-compassion.

Background: Eating concerns are core symptoms of eating disorders (EDs). Attachment theory assists in understanding the underlying psychological mechanisms behind eating concerns and suggests that the relationship between eating concerns and parenting styles may be connected through patients' self-compassion. Consequently, the present study aims to investigate the relationship between parenting styles and eating concerns, along with the mediating role of self-compassion.

Nanomaterials for smart wearable fibers and textiles: A critical review.

Smart wearable devices with functionality and comfort are highly anticipated in practical applications for health monitoring, personal thermal management, and electromagnetic shielding. As an important branch of wearable devices, smart wearable fibers and textiles with high breathability and comfortability are eagerly desired for practical wearable applications, which have revolutionized the development of smart apparel. The introduction of nanomaterials (including carbon nanotubes, graphene, MXene, conductive polymers, and metal nanowires) with unique mechanical, electrical, and chemical properties can not only improve the functionality of wearables, but also maintain the flexibility of wearables.

XPtychoSR: a self-supervised super-resolution framework for X-ray ptychography.

Ptychography has been extensively used for nanoscale imaging of catalysts, cells, and chips. The interpolation-based magnification is no longer adequate. A clearer imaging quality is expected for observing fine structures in the reconstructed images.

Development and validation of a conventional MRI-based model to predict cerebral palsy in infants (aged 6-24 months) with periventricular white matter injury: a multicentre, retrospective cohort study.

Background: Periventricular white matter injury (PVWMI) is the most common form of brain injury and the leading cause of cerebral palsy (CP). Early prediction of CP within the first 2 years of life is crucial for timely and effective intervention. Early CP prediction tools for infants with PVWMI are lacking.

[Correlation between pathological features at the positive margin and biochemical recurrence after radical prostatectomy in patients with organ-confined prostate cancer].

Objective： To investigate the correlation between pathological features at the positive margins and biochemical recurrence after radical prostatectomy for prostate cancer. Methods： From June 2014 to December 2019, a total of 200 patients with organ-confined prostate cancer who underwent radical prostatectomy were included in this study by the method of case matching (1∶1). One hundred patients with positive surgical margin and 100 with negative surgical margin were enrolled in this study.

Maternal blood pressure during pregnancy and children's cardiometabolic function: A birth cohort study.

Background And Aim: The evidence regarding the effect of the trajectory of blood pressure (BP) during pregnancy on children's cardiometabolic risk (CMR) was absence. The purpose of this study was to explore the relationship between maternal BP in the first, second, and third trimester of pregnancy and the trajectory of maternal BP during pregnancy and children's cardiometabolic function.

Methods And Results: 2159 mother-child pairs with singleton live births from the Ma'anshan Birth Cohort were included in the study.

Controlled Synthesis of N-Doped Hierarchical Porous Carbon Spheres Through Polydopamine for CO Adsorption and High-Performance Supercapacitors.

Hierarchical porous N-doped carbon spheres featuring a combination of micropores, mesopores and macropores as well as tuneable properties were synthesised using dopamine as a carbon precursor and triblock copolymers (F127, P123 and F127/P123 composites) as templates via direct polymerisation-induced self-assembly. The structures and textures of these materials were characterised using X-ray diffraction, scanning electron microscopy, transmission electron microscopy, N adsorption-desorption isotherm analysis, Fourier-transform infrared spectroscopy, Raman spectroscopy and X-ray photoelectron spectroscopy. The sample synthesised at an F127:P123 molar ratio of 1:3 (NCS-FP3) exhibited the highest surface area (463 m/g) and pore volume (0.

Impact of Tirofiban and Cilostazol on Cardiac Recovery in Elderly Patients with Acute Coronary Syndrome.

BACKGROUND Acute coronary syndrome (ACS) is a prevalent cardiovascular disease with persistent risks of myocardial under-perfusion and adverse events after percutaneous coronary intervention (PCI). The combination of tirofiban and cilostazol has shown potential efficacy, but clinical validation remains limited. This study evaluated the effects of tirofiban combined with cilostazol on cardiac function recovery and prognosis in elderly ACS patients after PCI.

A Multicentre Clinical Trial Protocol of Shuganjieyu Capsules Combined With Fluoxetine in the Treatment of Depression.

Background  Depression is a global disease with high prevalence, recurrence, and disability rates. Currently, antidepressant chemical drug therapeutic regimens are the mainstay, but they have low recovery rates, and a significant portion of patients develop refractory depression. Consequently, traditional Chinese medicine (TCM) has emerged as a crucial alternative, with various studies investigating its potential in both standalone and adjunctive treatments for depression.

miR-210 Regulates Autophagy Through the AMPK/mTOR Signaling Pathway, Reduces Neuronal Cell Death and Inflammatory Responses, and Enhances Functional Recovery Following Cerebral Hemorrhage in Mice.

Recently, a growing body of research has shown that microRNAs (miRNAs) are crucial in the pathophysiological mechanisms of brain disorders, miR-210 is one of the significant miRNAs implicated in these disorders, and its function in intracerebral hemorrhage (ICH) is not yet fully understood. Research the impact of miR-210 on intracerebral hemorrhage and probe into its working mechanism. The ICH model was established by injecting collagenase into the basal ganglia of male C57/BL6 mice (n = 142).

P-Selectin, Vascular Endothelial Cadherin, and Vascular Cell Adhesion Molecule-1 as Novel Biomarkers for ABO Hemolytic Disease of the Fetus and Newborn.

This study aims to assess the potential of vascular endothelial injury markers, namely, P-selectin (PS), vascular endothelial cadherin (VE-Cad), and vascular cell adhesion molecule-1 (VCAM-1), as diagnostic and prognostic biomarkers for ABO hemolytic disease of the fetus and newborn (HDFN). A total of 218 pregnant women with ABO blood group incompatibility were recruited from the Third People's Hospital of Bengbu Affiliated to Bengbu Medical University. The serum levels of PS, VCAM-1, and VE-Cad were measured, and the participants were followed up until postpartum.

Effect of cyanobacterial bloom proliferation on antibiotic resistance genes in the sediments of a eutrophic lake.

Antibiotic resistance genes (ARGs) represent an emerging pollutant of increasing concern. In this study, we analyzed the composition and spatiotemporal variation of ARGs in the sediments of eutrophic Chaohu Lake, China, using a metagenomic method. A total of 22 ARGs and 199 ARGs subtypes were detected, with the most prevalent subtypes being multidrug (57.

Plasma-Derived Small Extracellular Vesicles miR- 182 - 5p Is a Potential Biomarker for Diagnosing Major Depressive Disorder.

Depression, particularly major depressive disorder (MDD), is a debilitating neuropsychiatric condition characterized by high disability rates, primarily driven by chronic stress and genetic predispositions. Emerging evidence highlights the critical role of microRNAs (miRNAs) in the pathogenesis of depression, with plasma-derived small extracellular vesicles (sEVs) emerging as promising biomarkers. In this study, we collected peripheral blood plasma samples from patients diagnosed with MDD, as assessed by the Hamilton Depression Rating scale, alongside healthy individuals serving as controls.

[ARID1B Gene Deletion Promotes the Proliferation, Migration and Invasion of NSCLC Cells].

Background: Abnormalities of the switch/sucrose nonfermentable (SWI/SNF) chromatin-remodeling complex are closely related to various cancers, and ARID1B (AT-rich interaction domain 1B) is one of the core subunits of the SWI/SNF complex. Mutations or copy number deletions of the ARID1B gene are associated with impaired DNA damage response and altered chromatin accessibility. However, whether ARID1B deficiency affects the proliferation, migration and invasion abilities of non-small cell lung cancer (NSCLC) cells and its molecular mechanisms remain poorly understood.

Canine rabies vaccination, surveillance and public awareness programme in Beijing, China, 2014-2024.

Objective: To evaluate the operation and outcomes of an integrated dog-mediated rabies elimination programme in the Beijing municipality, China.

Methods: Beginning in 2014, the Beijing Animal Disease Control Center launched a dog-mediated rabies elimination programme in collaboration with local government and nongovernmental organizations. The programme involved: (i) a compulsory canine rabies vaccination campaign; (ii) rabies surveillance of local dog populations; (iii) educational rabies awareness programmes in public areas and schools; and (iv) the establishment of an online service platform to strengthen communications on rabies with the public.

Macrophage ATF6 accelerates corticotomy-assisted orthodontic tooth movement through promoting Tnfα transcription.

Corticotomy is a clinical procedure to accelerate orthodontic tooth movement characterized by the regional acceleratory phenomenon (RAP). Despite its therapeutic effects, the surgical risk and unclear mechanism hamper the clinical application. Numerous evidences support macrophages as the key immune cells during bone remodeling.

Seasonal distribution patterns of P-cycling-related microbes and its association with internal phosphorus release in the eutrophic Lake Chaohu, China.

Understanding the coupling relationships among lake physicochemical properties, internal nutrient recycling, and related microbes is key for the control of freshwater eutrophication. In this study, seasonal variations in microorganisms at the sediment-water interface (SWI) of the eutrophic Lake Chaohu in China were analyzed, in order to reveal changes in phosphorus (P)-cycling-related microbes in the sediments and its association with internal P release during the cyanobacterial life cycle. The identified P-cycling-related microbes include phosphorus-solubilizing bacteria (PSB) (dominant of Bacillus, Thiobacillus and Acinetobacter), sulfate-reducing bacteria (SRB) (dominant of Sva0081_ sediment_ group, norank_ c__ Thermodesulfovibrionia and Desulfatiglans) and iron-reducing bacteria (FeRB) (dominant of Geothermobacter, Anaeromyxobacter, Thermoanaerobaculum and Clostridium_sensu_stricto_1).

Evaluation of the Health Status and Eldercare Needs of Urban Elderly People in Ili Kazak Autonomous Prefecture, Xinjiang Uygur Autonomous Region.

Objective: This study aimed to evaluate the health status and eldercare needs of elderly people in urban Ili Kazak Autonomous Prefecture of Xinjiang Uygur Autonomous Region.

Methods: Using an online questionnaire, 2057 elderly people aged >60 years in Ili Kazak Autonomous Prefecture, Xinjiang, were enrolled for analysis following data collection.

Results: The major source of financial support was retirement pension, with spouse's income accounting for a relatively low proportion.

The association between derived TyG index and the risk of heart failure in the elderly population: a prospective cohort study from 2017 to 2023.

Background: Diabetes and obesity are established risk factors for heart failure(HF). Although the TyG (triglyceride-glucose) index serves as a sensitive marker for identifying insulin resistance, there is a lack of comprehensive evidence regarding whether its integration with obesity indices can enhance the predictive capacity for HF. This prospective cohort study is designed to explore the correlation between TyG indices in conjunction with obesity indices (TyG-body mass index, or TyG-BMI; TyG-waist circumference, or TyG-WC; TyG-waist circumference-to-height ratio, or TyG-WHtR) and the risk of HF.

Posterior reversible encephalopathy syndrome in adult acute post-streptococcal glomerulonephritis.

Posterior reversible encephalopathy syndrome is characterized by abnormal white matter findings and neurological symptoms. However, it is clinically rare and can easily be misdiagnosed. Herein, we describe a case of posterior reversible encephalopathy syndrome in an adult patient with acute post-streptococcal glomerulonephritis, confirmed by renal pathology and magnetic resonance imaging, and provide diagnostic suggestions for clinicians.

Predictive value of mNUTRIC score for chronic critical illness in patients of sepsis complicated with ARDS.

ObjectiveTo explore the predictive value of the modified NUTrition Risk in the Critically ill (mNUTRIC) for patients with sepsis and acute respiratory distress syndrome (ARDS) developing into chronic critical illness (CCI).BackgroundSepsis is an important risk factor for Acute respiratory distress syndrome (ARDS), and sepsis induced ARDS accounts for 32% of patients. Patients with this subtype of ARDS have a worse prognosis than those with sepsis alone or ARDS, usually facing higher mortality rates and lower success rates of extubation, and have received more attention in clinical practice.

Disrupted functional connectivity of the emotion regulation network in major depressive disorder and its association with symptom improvement: A multisite resting-state functional MRI study.

Background: The emotion regulation network (ERN) in the brain provides a framework for understanding the neuropathology of affective disorders. Although previous neuroimaging studies have investigated the neurobiological correlates of the ERN in major depressive disorder (MDD), whether patients with MDD exhibit abnormal functional connectivity (FC) patterns in the ERN and whether the abnormal FC in the ERN can serve as a therapeutic response signature remain unclear.

Methods: A large functional magnetic resonance imaging dataset comprising 709 patients with MDD and 725 healthy controls (HCs) recruited across five sites was analyzed.