ZC3H13 facilitates the progression of acute myeloid leukemia through m6A-FOXP1-mediated metabolic reprogramming.

Acute myeloid leukemia (AML) is a complex hematologic malignancy characterized by rapid progression and high relapse rates. Zinc finger CCCH domain-containing protein 13 (ZC3H13) has been implicated in the pathogenesis of various diseases, but its role in AML remains unclear. This study aimed to elucidate the function and underlying mechanisms of ZC3H13 in AML.

Extracellular vesicles from ovarian cancer cells induce senescent lipid-laden macrophages to facilitate omental metastasis.

Background: Ovarian cancer exhibits striking metastatic tropism for the omentum, where lipid-laden macrophages are key mediators that fuel disease progression. However, the mechanisms governing their formation and pro-metastatic functions remain poorly understood. As extracellular vesicles (EVs) have as critical regulators of tumor-stroma crosstalk in metastatic niches, we sought to define how ovarian cancer-derived EVs orchestrate macrophages and adipocytes, and their impact on omental metastasis, aiming to explore potential therapeutic interventions.

Ultralow-threshold upconversion infrared vision via a microsphere-mediated directional photofield.

Constructing micro-/nanostructure-modulated photofields in upconversion devices to absorb low-energy photons and emit high-energy light is revolutionary for bioimaging, lasers, and photovoltaics, with proven capability to boost upconversion luminescence (UCL) by orders of magnitude. However, photoenergy dissipation and inadequate absorption result in excitation thresholds exceeding 1 mW/cm, which exceeds retinal safety limits and hinders wearable upconversion optics. Here, we report the use of upconversion core-shell microsphere-induced infrared field convergence, NaYF:Yb,Er shell-based resonant cavities for multiple reflection-absorption-upconversion and photonic crystal amplifiers to improve UCL intensity three orders of magnitude, and achieve ultralow threshold (0.

Combined Role of Zinc and Anemia and their Association with 10-Year Atherosclerotic Cardiovascular Disease Risk in Patients with Early-Stage Chronic Kidney Disease.

This study aimed to investigate the combined impact of zinc (Zn) intake and anemia on the atherosclerotic cardiovascular disease (ASCVD) risk score of patients with chronic kidney disease (CKD). A total of 2,612 individuals diagnosed with CKD from the National Health and Nutrition Examination Survey 2007-2018 were included in this study. The 10-year ASCVD risk was the outcome variable, and patients with a risk score of ≥ 20% were categorized as having a high 10-year ASCVD risk, whereas those with a risk score of < 20% were considered to be low risk.

hnRNPA2B1 facilitates ovarian carcinoma metastasis by sorting cargoes into small extracellular vesicles driving myofibroblasts activation.

Background: Ovarian carcinoma (OvCa) metastasis is initiated and boosted by tumor-stroma interactions mediated by small extracellular vesicles (sEVs) containing microRNAs (miRNAs). However, the mechanisms of sorting relevant miRNAs into tumoral sEVs remain elusive.

Results: In this study, among the RNA-binding proteins, hnRNPA2B1 was identified as the most significant factor associated with survival in OvCa patients, and its expression was higher in omental metastases compared to paired ovarian lesions.

A nomogram for predicting T315I-free survival in chronic phase chronic myeloid leukemia patients: a multicenter retrospective study.

The T315I mutation poses a significant threat to patients with chronic phase chronic myeloid leukemia (CP-CML). This study aimed to establish a nomogram to predict the risk of T315I mutation in CP-CML patients. The training cohort included 1,466 patients from 24 hematology centers, and the validation cohort included 820 patients from an additional 20 centers.

Characteristics of debris flow development in Daxilada watershed and its hazard analysis on Lexi Expressway.

The occurrence of frequent debris flow catastrophes in the mountainous regions of southwest China has necessitated the inclusion of debris flow disaster analysis and prevention as an essential component in the planning and construction of mountainous roadways. Daxilada watershed is located in the south of Mabian Yi Zuzizhixian, Leshan City, Sichuan Province, and the proposed Leshan-Xichang Expressway (Lexi Expressway) will pass through the upper reaches of Daxilada watershed. It is essential to consider that the presence of debris flows within the Daxilada watershed could have detrimental effects on the construction and functionality of the proposed Luoshanxi Bridge.

Evaluation of highway debris flow hazard based on geomorphic evolution theory coupled with material response rate.

Assessments of highway feasibility frequently lack the detailed data and geological information necessary to conduct hazard evaluations of debris flows. This study discusses the processes of debris flow development when regional rainfall meets the critical level required for debris flow initiation. It utilizes geomorphic evolution theory and establishes a regional risk assessment matrix for debris flow by combining information about gullies and source sensitivity.

Parent Artery Chronical Occlusion after Endovascular Treatment of a Unruptured "True" Posterior Communicating Artery Aneurysm.

A case of a patient with a true large unruptured posterior communicating artery (PCoA) aneurysm in a distal segment of PCoA, who was treated by interventional therapy via an ipsilateral occlusion of the internal carotid artery (ICA), is reported. Although the treatment went very well and the patient recovered very well, angiography 6 months after the operation showed that left PCoA had occluded and the aneurysm disappeared. The temporary recanalization of occluded ophthalmic segment of ICA can be a pathway for interventional therapy.

Case report: Conservative treatment for fertility preservation in a woman with hemoperitoneum due to an invasive mole.

Background: Invasive moles are a subtype of gestational trophoblastic neoplasia (GTN) that usually develops after hydatidiform molar pregnancies. Uterine rupture in high-risk GTN is a rare and potentially catastrophic event. The treatment of invasive mole perforation with uterine rupture is particularly challenging in young women who desire fertility preservation.

Tumour-derived exosomal piR-25783 promotes omental metastasis of ovarian carcinoma by inducing the fibroblast to myofibroblast transition.

Ovarian carcinoma inherently possesses a distinct metastatic organotropism for the adipose-rich omentum, contributing to disease progression. Although the premetastatic microenvironment (PMM) has been known to often play a prometastatic role during the process, incomplete mechanistic insight into PMM formation has prevented its therapeutic targeting. Omental fibroblasts can be activated by tumour cells to differentiate into myofibroblasts, termed the fibroblast-to-myofibroblast transition (FMT), which, in turn, enhances cancer aggressiveness.

Analysis of the evolution trends and influential factors of bankfull discharge in the Lower Yellow River.

After the Xiaolangdi Reservoir (XLDR) was put into operation, new water and sediment conditions have improved the silting condition of the Lower Yellow River (LYR), but against this background, the flow capacity of the LYR has become more complex. In this research, the measured water and sediment data of seven hydrological stations in the LYR from 1950 to 2020 were systematically collated. The evolution trend and development period of the bankfull discharge in this area were studied based on the wavelet analysis method, and the main factors influencing the evolution of the bankfull discharge were explored.

Locally advanced cervical rhabdomyosarcoma in adults: A case report.

Background: Rhabdomyosarcoma is a soft tissue tumor of primitive mesenchymal cells origin, occurring predominantly in children and adolescents, but extremely rare in adults and the data regarding its treatment are sparse. Here, we would like to share our experience in the treatment of a locally advanced primary embryonal rhabdomyosarcoma of cervix in a 39-year-old female.

Case Summary: The patient was admitted with symptoms of intermenstrual bleeding and postcoital bleeding for six months.

A meta-analysis of survival after minimally invasive radical hysterectomy versus abdominal radical hysterectomy in cervical cancer: center-associated factors matter.

Purpose: To explore the possible factors that contributed to the poor performance of minimally invasive surgery (MIS) versus abdominal surgery regarding progression-free survival (PFS) and overall survival (OS) in cervical cancer.

Methods: MEDLINE, EMBASE, Cochrane Library and Web of Science were searched (January 2000 to April 2021). Study selection was performed by two researchers to include studies reported oncological safety.

Tumor cell-derived exosomes deliver TIE2 protein to macrophages to promote angiogenesis in cervical cancer.

Tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 2 (TIE2)-expressing macrophages (TEMs) are an angiogenesis-promoting subset of tumor-associated macrophages that have been demonstrated to be increased in solid tumors and associated with the progression of cervical cancer. However, the induction mechanism of TEMs remains unclear. Here, based on multicolor immunofluorescence of 58 cervical cancer tissues and the GEPIA database, we found that TEMs were increased in TIE2-high cervical cancer and related to shorter survival.

FABP4 is an independent risk factor for lymph node metastasis and poor prognosis in patients with cervical cancer.

Background: Pelvic lymph node metastasis (LNM) is a crucial independent prognostic factor in cervical cancer (CCa) and serves as an indicator for radiation therapy as the primary or an adjuvant treatment option. However, preoperative diagnosis of LNM remains challenging. Thus, we aimed to identify biomarkers of LNM in patients with presumed early-stage CCa.

Monitoring the Spatiotemporal Difference in Glacier Elevation on Bogda Mountain from 2000 to 2017.

The difference in glacier surface elevation is a sensitive indicator of climate change and is also important for disaster warning and water supply. In this paper, 25 glaciers on Bogda Mountain, in the eastern Tianshan Mountains, are selected as the study object as they are typical of glaciers in arid or semi-arid areas with importance for water supply. The Repeat Orbit Interferometry (ROI) method is used to survey the surface elevation of these glaciers using Sentinel-1A Radar data from 2017.

Deformation Time Series and Driving-Force Analysis of Glaciers in the Eastern Tienshan Mountains Using the SBAS InSAR Method.

Glacier melting is one of the important causes of glacier morphology change and can provide basic parameters for calculating glacier volume change and glacier mass balance, which, in turn, is important for evaluating water resources. However, it is difficult to obtain large-scale time series of glacier changes due to the cloudy and foggy conditions which are typical of mountain areas. Gravity-measuring satellites and laser altimetry satellites can monitor changes in glacier volume over a wide area, while synthetic-aperture radar satellites can monitoring glacier morphology with a high spatial and temporal resolution.

Laparoscopic procedure compared with open radical hysterectomy with pelvic lymphadenectomy in early cervical cancer: a retrospective study.

Objective: To compare clinical outcomes in laparoscopic and open radical hysterectomy with pelvic lymphadenectomy (LRH) in early cervical cancer without the selection bias.

Methods: One special retrospective study was conducted with more than 400 patients involved in laparoscopic procedure.

Results: Our results suggest that estimated blood loss and transfusion requirements were significantly lower in the LRH group.

CXCR3 is a prognostic marker and a potential target for patients with solid tumors: a meta-analysis.

Objective: To deeply verify the clinical significance of CXCR3 in prediction of cancer patients' prognosis.

Data Sources: We performed a meta-analysis including 12 studies searched from PubMed, Web of Science, Embase, and Cochrane databases. A total of 1,751 patients were used to analyze the association between CXCR3 and patients' prognosis, based on either overall survival or time to tumor progression.

Role of HER family members in predicting prognoses in epithelial ovarian cancer: a meta-analysis.

Aims And Background: Human epidermal receptor (HER) family receptors are commonly overexpressed in various human tumors, and their overexpression is thought to play a critical role in tumor progression. The aim of this meta-analysis was to evaluate the prognostic significance of HER family members in epithelial ovarian cancer (EOC).

Methods: Relevant studies published between January 1, 1980, and April 24, 2013, that evaluated the associations of HER family members with overall survival (OS), progression-free survival (PFS), response to platinum-based chemotherapy, lymph node metastasis, or ascites in EOC were identified via searches of PubMed and EMBASE.

The role of the PTEN/PI3K/Akt pathway on prognosis in epithelial ovarian cancer: a meta-analysis.

The PTEN/PI3K/Akt signaling pathway, a key player in mediating apoptosis, metabolism, cell proliferation, and cell growth, is frequently dysregulated in many cancers. However, the pathway's prognostic impact in epithelial ovarian cancer (EOC) is still inconsistent. We performed a meta-analysis based on individual study outcomes to more precisely evaluate its clinical significance in EOC patients.

Tumor-associated macrophages induce lymphangiogenesis in cervical cancer via interaction with tumor cells.

Our studies were conducted to investigate the clinical and functional significance of tumor-associated macrophages (TAMs) in cervical tumor lymphatic metastasis. We found that the increase in macrophages in tumor stroma is significantly associated with lymphatic metastasis (p = 0.017), through performing immunohistochemical staining in 111 cervical samples (55 invasive squamous carcinomas of uterine cervix, 27 cervical intraepithelial neoplasms III, and 29 normal cervix).