Acupuncture for cancer-related insomnia: An evidence mapping.

Background: Acupuncture shows promise in treating cancer-related insomnia (CRI); however, the evidence level for its effectiveness remains low. This study systematically examined research quality and used evidence mapping (EM) to map and present evidence information to identify gaps and inform future research.

Methods: Two reviewers searched eight databases from inception to May 2024, screened eligible randomized controlled trials (RCTs), and extracted key characteristics from included studies.

Endplate morphology affects the risk of complications by changing the grafted bony occupancy rate in OLIF patients.

Background: Large contact areas between the grafted bone and the bony endplate (BEP) can optimize the load transmission pattern and decrease the risk of non-union and cage subsidence. The relationship between endplate morphology parameters and complications may stem from the difference in contact sufficiency between the grafted bone and BEP. This study was conducted to verify that changes in endplate morphology affect the risk of complications in patients with oblique lumbar interbody fusion (OLIF) by changing the grafted bony occupancy rate (GBOR).

Efficacy of acupuncture on upper limb dysfunction after stroke: a randomized controlled trial protocol with surface electromyography evaluation.

Background: Upper extremity functional reconstruction remains a major clinical challenge in post-stroke neurorehabilitation. Acupuncture has unique advantages as a complementary alternative therapy. Thus, in this study, we aim to compare sham acupuncture to reveal the efficacy and safety of acupuncture in the treatment of upper limb dysfunction post-stroke with surface electromyography (sEMG), a validated objective assessment tool, and a subjective index.

Multimodal model for the diagnosis of biliary atresia based on sonographic images and clinical parameters.

It is still challenging to diagnose biliary atresia (BA) in current clinical practice. The study aimed to develop a multimodal model incorporated with uncertainty estimation by integrating sonographic images and clinical information to help diagnose BA. Multiple models were trained on 384 infants and validated externally on 156 infants.

Relationships Between Cumulative Resting Heart Rate and the Incidence of Cardiovascular Events and All-Cause Mortality - Post Hoc Analysis of STEP Trial Data.

Background: The long-term effects of cumulative resting heart rate (cumRHR) on the incidence of cardiovascular events and all-cause mortality in older (age ≥60 years) hypertensive populations remain unclear. Therefore, the aim of this study was to investigate the association between cumRHR and cardiovascular events and all-cause mortality.

Methods And Results: This post hoc analysis used data from the Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients (STEP) trial of 7,517 patients in whom resting heart rate (RHR) was measured at 0, 3, 6, 9, and 12 months.

How effective is acupuncture in treating hot flashes in breast cancer patients? A systematic review and meta-analysis.

Background: Although acupuncture is recommended for managing breast cancer-related hot flashes, the level of evidence is limited. With the updating of randomized controlled trials, it is necessary to reassess its efficacy.

Objective: To assess the effectiveness of acupuncture in the treatment of hot flashes in patients with breast cancer.

Exploiting instance-label dynamics through reciprocal anchored contrastive learning for few-shot relation extraction.

In the domain of Few-shot Relation Extraction (FSRE), the primary objective is to distill relational facts from limited labeled datasets. This task has recently witnessed significant advancements through the integration of Pre-trained Language Models (PLMs) within a supervised contrastive learning schema, which effectively leverages the dynamics between instance and label information. Despite these advancements, the comprehensive utilization of extensive instance-label pairs, aimed at facilitating the extraction of semantically rich representations within this paradigm, has yet to be fully harnessed.

Sustained Endocytosis Inhibition via Locally-Injected Drug-Eluting Hydrogel Improves ADCC-Mediated Antibody Therapy in Colorectal Cancer.

The epidermal growth factor receptor (EGFR) is a validated therapeutic target for RAS/RAF wild-type colorectal cancer (CRC). However, monoclonal antibody-based anti-EGFR therapies such as cetuximab have limited effectiveness. Herein, it is identified that EGFR internalization is associated with poor treatment response and prognosis in patients with CRC, based on a retrospective analysis of patients treated with cetuximab.

Convolutional Dynamically Convergent Differential Neural Network for Brain Signal Classification.

The brain signal classification is the basis for the implementation of brain-computer interfaces (BCIs). However, most existing brain signal classification methods are based on signal processing technology, which require a significant amount of manual intervention, such as channel selection and dimensionality reduction, and often struggle to achieve satisfactory classification accuracy. To achieve high classification accuracy and as little manual intervention as possible, a convolutional dynamically convergent differential neural network (ConvDCDNN) is proposed for solving the electroencephalography (EEG) signal classification problem.

Potential molecular and cellular mechanisms of the effects of cuproptosis-related genes in the cardiomyocytes of patients with diabetic heart failure: a bioinformatics analysis.

Background: Diabetes mellitus is an independent risk factor for heart failure, and diabetes-induced heart failure severely affects patients' health and quality of life. Cuproptosis is a newly defined type of programmed cell death that is thought to be involved in the pathogenesis and progression of cardiovascular disease, but the molecular mechanisms involved are not well understood. Therefore, we aimed to identify biomarkers associated with cuproptosis in diabetes mellitus-associated heart failure and the potential pathological mechanisms in cardiomyocytes.

Endoplasmic reticulum stress-related gene expression causes the progression of dilated cardiomyopathy by inducing apoptosis.

Previous studies have shown that endoplasmic reticulum stress (ERS) -induced apoptosis is involved in the pathogenesis of dilated cardiomyopathy (DCM). However, the molecular mechanism involved has not been fully characterized. In total, eight genes were obtained at the intersection of 1,068 differentially expressed genes (DEGs) from differential expression analysis between DCM and healthy control (HC) samples, 320 module genes from weighted gene co-expression network analysis (WGCNA), and 2,009 endoplasmic reticulum stress (ERGs).

Acupressure: a possible therapeutic strategy for anxiety related to COVID-19: a meta-analysis of randomized controlled trials.

Background: From the end of 2019 to December 2023, the world grappled with the COVID-19 pandemic. The scope and ultimate repercussions of the pandemic on global health and well-being remained uncertain, ushering in a wave of fear, anxiety, and worry. This resulted in many individuals succumbing to fear and despair.

Simultaneous antioxidant and neuroprotective effects of two-dimensional (2D) MXene-loaded isoquercetin for ischemic stroke treatment.

Oxidative stress and reactive oxygen species drive ischemic stroke and its related complications. New antioxidant medications are therefore crucial for treating ischemic stroke. We developed TiC@BSA-ISO nanocomposites loaded with the hydrophobic drug isoquercetin (ISO) encapsulated in BSA on TiC nano-enzymes as a novel therapeutic nanomedicine for the treatment of ischemic stroke targeting reactive oxygen species (ROS).

Inducing the Abscopal Effect in Liver Cancer Treatment: The Impact of Microwave Ablation Power Levels and PD-1 Antibody Therapy.

Microwave ablation (MWA) is an effective treatment for liver cancer (LC), but its impact on distant tumors remains to be fully elucidated. This study investigated the abscopal effects triggered by MWA treatment of LC, at different power levels and with or without combined immune checkpoint inhibition (ICI). We established a mouse model with bilateral subcutaneous LC and applied MWA of varied power levels to ablate the right-sided tumor, with or without immunotherapy.

Liquid nitric oxide donor for adjuvant therapy of acute ischemic stroke via nasal administration.

Objectives: The aim of this study was to synthesize and characterize a novel NO donor, PEI-PO-NONOate, using propylene oxide and to investigate its biosafety and therapeutic efficacy via nasal administration in vitro and vivo.

Experimental Procedures: The PEI-PO-NONOate was synthesized based on polyethylenimine (PEI) with different molecular weights and characterized using Fourier transform infrared (FTIR), nuclear magnetic resonance (NMR), and ultraviolet (UV) spectroscopy. Cytotoxicity assays were performed on mouse fibroblast cells L929 and human nasal mucosa epithelial cells (HNEpC), and a rat middle cerebral artery occlusion (MCAO) model was established to evaluate the therapeutic efficacy of PEI-PO-NONOate via nasal administration.

The correlation between tic disorders and allergic conditions in children: A systematic review and meta-analysis of observational studies.

Aim: To evaluate the correlation between tic disorders and allergies and to inform strategies for the treatment and prevention of tic disorders.

Methods: We conducted online searches of the MEDLINE, Embase, Cochrane, CNKI, CBM, WanFang, and VIP Information databases. Case-control studies and cohort studies related to tic disorders and allergic conditions were searched.

IgG1 Is the Optimal Subtype for Treating Atherosclerosis by Inducing M2 Macrophage Differentiation, and Is Independent of the FcγRIIA Gene Polymorphism.

In recent years, it has been established that atherosclerosis is an autoimmune disease. However, little is currently known about the role of FcγRIIA in atherosclerosis. Herein, we sought to investigate the relationship between FcγRIIA genotypes and the effectiveness of different IgG subclasses in treating atherosclerosis.

Knockdown of IL4I1 Improved High Glucose-evoked Insulin Resistance in HepG2 Cells by Alleviating Inflammation and Lipotoxicity Through AHR Activation.

Insulin resistance (IR) is one of the leading causes of Type 2 diabetes mellitus (T2DM). Inflammation, as a result of the disordered immune response, plays important roles in IR and T2DM. Interleukin-4-induced gene 1 (IL4I1) has been shown to regulate immune response and be involved in inflammation progress.