Photosensitizer-conjugated lignin nanoparticles for photodynamic antimicrobial inactivation.

Towards the goal of developing broad-spectrum, self-disinfecting, and cost-effective renewable antimicrobial materials for the prevention of pathogen transmission relevant to healthcare-associated infections (HAIs), a facile cyanuric chloride coupling strategy was employed to covalently attach a commercially available phenothiazine-based photosensitizer, thionine (Th), onto lignin nanoparticles (LNPs). The resultant photodynamic Th-LNPs conjugate was characterized by a variety of techniques, including elemental analysis, diffuse reflectance UV-visible and energy-dispersive X-ray spectroscopies, scanning electron microscopy, and thermal gravimetric analysis. Antibacterial photodynamic inactivation studies demonstrated high levels of inactivation (99.

RTA 408 attenuates TBHP-Induced apoptosis in nucleus pulposus cells via Nrf2/ARE and NF-κB signaling pathways: in vitro and in vivo evidence for mitigating rats' intervertebral disc degeneration.

Background: Intervertebral disc degeneration (IDD) is a leading cause of spinal disorders, driven by oxidative stress-induced nucleus pulposus cell (NPC) apoptosis and extracellular matrix (ECM) degradation. Nuclear factor erythroid 2-related factor 2 (Nrf2) activators hold therapeutic promise due to their antioxidative properties. This study investigates the efficacy of RTA 408, a synthetic Nrf2-activating terpenoid, in mitigating oxidative damage and IDD progression.

Azoxystrobin/ chitosan -graft- salicylic acid nanomicelles for dual-targeted rice protection: Antifungal and salt stress mitigation.

This paper studied the effect of a new type of nano-pesticide on the control of rice blast (Magnaporthe oryzae) disease. In this study, AZOX/CS-graft-SA (azoxystrobin/chitosan-salicylic acid) nanoformulations were prepared, and the inhibitory effects of different concentrations on rice blast fungus and effects on rice growth and development were determined. The results showed all three drugs could effectively inhibit fungal growth, and the higher the concentration, the more significant the effect.

From Exploration to Integration: 15 Years of Multisensory Research at Peking University.

We introduce how 'the rule of thumb' of multisensory integration, which was proposed in the seminal book The Merging of the Senses by Stein and Meredith in 1993, inspired the empirical research work conducted at Multisensory lab, Peking University (China) for the last 15 years. We also outline the potential research trends in the multisensory research field.

Managing the terror of publication bias: A systematic review of the mortality salience hypothesis.

We assessed the evidential value of the large literature ( = 643-825 studies) investigating the mortality salience (MS) hypothesis from terror management theory, employing a multitool assessment approach. First, we reviewed and evaluated recent efforts to replicate past experiments testing the MS hypothesis, summarizing the conflicting evidence and arguments to the evidential value of the MS literature. Next, we performed a random effects meta-analysis on the MS literature using multiple bias-correction meta-analytic techniques, including selection models, precision-effect test and precision-effect estimate with standard errors, weighted average of adequately powered studies and weighted least square, as well as the more recently developed -curve and -curve.

Preparation of DNF@UiO-67 and the insecticidal activity study and safety evaluation.

Background: Dinotefuran (DNF) is a neonicotinoid insecticide with strong systemic, poisoning and gastric toxicity, which is no cross-resistance with the existing pesticides, but its toxicity to environmental organisms such as bees and earthworms is high. The development of environmentally responsive pesticide controlled-release agents using nanomaterials to process the agents by physical or chemical methods can improve the utilization of the pesticide and better utilize the active molecules of the pesticide.

Results: To enhance the performance of dinotefuran, UiO-67 was prepared, characterized, and then combined with dinotefuran to form dinotefuran-UiO-67 (DNF@UiO-67) nanocomposites.

SNHG10: A Novel Long Non-coding RNA with Multifaceted Roles in Human Cancers.

Long non-coding RNAs (lncRNAs) are a type of RNA with a length of more than 200 nucleotides. They do not encode proteins but are crucial in regulating gene expression and affecting the malignant biological behavior of cancer. Small nucleolar RNA host gene 10 (SNHG10) is a novel lncRNA that plays a regulatory role in many malignant tumors.

Revisiting the Role of Long Non-coding RNA PSMA3-AS1 in Human Cancers: Current Evidence and Future Directions.

Long non-coding RNAs (lncRNAs) refer to RNA molecules that exceed 200 nucleotides in length. While lncRNAs do not possess the capacity to encode proteins, they play crucial roles in gene expression, chromatin remodeling, and protein relocation. PSMA3 antisense RNA 1 (PSMA3-AS1) is a newly discovered lncRNA located on human chromosome 14q23.

Total saponins from Panax japonicus reduced lipid deposition and inflammation in hepatocyte via PHD2 and hepatic macrophage-derived exosomal miR-463-5p.

Ethnopharmacological Relevance: Panax japonicus (T. Nees) C.A.

InP-Based Quantum Dots as Photosensitizers in Photodynamic Antimicrobial Materials.

Ligand-functionalized InP-based quantum dots (QDs) have been developed as an innovative class of nontoxic photosensitizer suitable for antimicrobial applications, aimed at reducing or preventing pathogen transmission from one host to another via high contact surfaces. A hot injection method followed by functionalization via ligand exchange with 9-anthracene carboxylic acid (ACA) yielded the desired core/shell InP/ZnSe/ZnS QDs. Transmission electron microscopy (TEM) revealed these QDs to be uniform in size (∼3.

The Dual Role of ADAMTS9-AS1 in Various Human Cancers: Molecular Pathogenesis and Clinical Implications.

Long non-coding RNA (lncRNA) is a type of non-coding RNA distinguished by a length exceeding 200 nucleotides. Recent studies indicated that lncRNAs participate in various biological processes, such as chromatin remodeling, transcriptional and post-transcriptional regulation, and the modulation of cell proliferation, death, and differentiation, hence influencing gene expression and cellular function. ADAMTS9-AS1, an antisense long non-coding RNA situated on human chromosome 3p14.

Triple-Combination Therapy with a Multifunctional Yolk-Shell Nanozyme Au@CeO Loaded with Dimethyl Fumarate for Periodontitis.

Periodontitis, a chronic inflammatory disease, is the leading cause of tooth loss in adults and is one of the most prevalent and complex oral conditions. Oxidative stress induced by the excessive generation of reactive oxygen species (ROS) leads to periodontitis, which is closely associated with pathological processes, including mitochondrial dysfunction of periodontal cells and local immune dysregulation. However, current treatment modalities that target single pathological processes have limited long-term therapeutic effects.

Single-strain probiotics enhance growth, anti-pathogen immunity, and resistance to Nocardia seriolae in grey mullet (Mugil cephalus) via gut microbiota modulation.

Grey mullet (Mugil cephalus) aquaculture is economically vital due to the high value of its roe. However, it faces significant risks from disease outbreaks, particularly from Nocardia seriolae. Current reliance on antibiotics has drawbacks, highlighting the potential of probiotics as a promising alternative.

LncRNA HAGLROS: A Vital Oncogenic Propellant in Various Human Cancers.

HAGLR Opposite Strand lncRNA (HAGLROS) is a long non-coding RNA (lncRNA) located on the long arm of human chromosome 2 at locus 2q31.1. Emerging evidence highlights HAGLROS as a pivotal player in human cancers, characterized by its significant upregulation across multiple malignancies where it functions as an oncogenic driver.

B4GALT1-dependent galectin-8 binding with TGF-β receptor suppresses colorectal cancer progression and metastasis.

Transforming growth factor (TGF)-β signaling is critical for epithelial-mesenchymal transition (EMT) and colorectal cancer (CRC) metastasis. Disruption of Smad-depednent TGF-β signaling has been shown in CRC cells. However, TGF-β receptor remains expressed on CRC cells.

Hybrid Eu(II)-bromide scintillators with efficient 5d-4f bandgap transition for X-ray imaging.

Luminescent metal halides are attracting growing attention as scintillators for X-ray imaging in safety inspection, medical diagnosis, etc. Here we present brand-new hybrid Eu(II)-bromide scintillators, 1D type [EtN]EuBr·MeOH and 0D type [MeN]EuBr·MeOH, with spin-allowed 5d-4f bandgap transition emission toward simplified carrier transport during scintillation process. The 1D/0D structures with edge/face -sharing [EuBr] octahedra further contribute to lowing bandgaps and enhancing quantum confinement effect, enabling efficient scintillation performance (light yield ~73100 ± 800 Ph MeV, detect limit ~18.

Invariant contexts reduce response time variability in visual search in an age-specific way: A comparison of children, teenagers, and adults.

Contextual cueing is a phenomenon in which repeatedly encountered arrays of items can enhance the visual search for a target item. This is widely attributed to attentional guidance driven by contextual memory acquired during visual search. Some studies suggest that children may have an immature ability to use contextual cues compared to adults, while others argue that contextual learning capacity is similar across ages.

Common intentional binding effects across diverse sensory modalities in touch-free voluntary actions.

The intentional binding effect refers to the phenomenon where the perceived temporal interval between a voluntary action and its sensory consequence is subjectively compressed. Prior research revealed the importance of tactile feedback from the keyboard on this effect. Here we examined the necessity of such tactile feedback by utilizing a touch-free key-press device without haptic feedback, and explored how initial/outcome sensory modalities (visual/auditory/tactile) and their consistency influence the intentional binding effect.

Contingent magnetic variation and beta-band oscillations in sensorimotor temporal decision-making.

The ability to accurately encode the temporal information of sensory events and hence to make prompt action is fundamental to humans' prompt behavioral decision-making. Here we examined the ability of ensemble coding (averaging multiple inter-intervals in a sound sequence) and subsequent immediate reproduction of target duration at half, equal, or double that of the perceived mean interval in a sensorimotor loop. With magnetoencephalography (MEG), we found that the contingent magnetic variation (CMV) in the central scalp varied as a function of the averaging tasks, with a faster rate for buildup amplitudes and shorter peak latencies in the "half" condition as compared to the "double" condition.

Improving the efficiency and environmental safety of emamectin benzoate through a pH-responsive metal-organic framework microencapsulation strategy.

Herein, we developed a technique for loading nanopesticides onto Metal-Organic Frameworks (MOFs) to control Spodoptera litura. The average short-axis length of the synthesized carrier emamectin benzoate@PCN-222 @hyaluronic acid (EB@PCN-222 @HA) was ∼40 nm, with an average long-axis length of ∼80 nm. This enabled the manipulation of its size, contact angle, and surface tension on the surface of leaves.

The Roles of Cytoplasmic Polyadenylation Element Binding Protein 1 in Tumorigenesis.

Background: CPEB1 is an alternative polyadenylation binding protein that promotes or suppresses the expression of related mRNAs and proteins by binding to a highly conserved Cytoplasmic Polyadenylation Element (CPE) in the mRNAs 3'UTR. It is found to express abnormally in multiple tumors and affect tumorigenesis through many pathways. This review summarizes the functions and mechanisms of CPEB1 in a variety of cancers and suggests new directions for future related treatments.

Effects of adding Bacillus subtilis natto NTU-18 in paste feed on growth, intestinal morphology, gastrointestinal microbiota diversity, immunity, and disease resistance of Anguilla japonica glass eels.

Japanese eel, Anguilla japonica, holds significant importance in Taiwanese aquaculture. With the intensification of eel farming, the impact of Edwardsiella tarda has become increasingly severe. Consequently, the abusive use of antibiotics has risen.

Atmospheric CO in the megacity Hangzhou, China: Urban-suburban differences, sources and impact factors.

Limited observation sites and insufficient monitoring of atmospheric CO in urban areas restrict our comprehension of urban-suburban disparities. This research endeavored to shed light on the urban-suburban differences of atmospheric CO in levels, diurnal and seasonal variations as well as the potential sources and impact factors in the megacity of Hangzhou, China, where the economically most developed region in China is. The observations derived from the existing Hangzhou Atmospheric Composition Monitoring Center Station (HZ) and Lin'an Regional Atmospheric Background Station (LAN) and the newly established high-altitude Daming Mountain Atmospheric Observation Station (DMS), were utilized.

Synesthetic Correspondence: An Overview.

Intramodal and cross-modal perceptual grouping based on the spatial proximity and temporal closeness between multiple sensory stimuli, as an operational principle has built a coherent and meaningful representation of the multisensory event/object. To implement and investigate the cross-modal perceptual grouping, researchers have employed excellent paradigms of spatial/temporal ventriloquism and cross-modal dynamic capture and have revealed the conditional constraints as well as the functional facilitations among various correspondence of sensory properties, with featured behavioral evidence, computational framework as well as brain oscillation patterns. Typically, synesthetic correspondence as a special type of cross-modal correspondence can shape the efficiency and effect-size of cross-modal interaction.