Genetic Control of tRNA-Derived Fragments Contributes to Cancer Risk.

Transfer RNA-derived fragments (tRFs) are a class of small non-coding RNAs that have exhibited several functions in cancer. Recent studies have shown that mutations in tRNA genes can lead to global changes in tRF expression levels and may affect tRF function, highlighting the need to further elucidate the regulation and functions of tRFs in cancer. Here, we conducted a pan-cancer analysis of tRF quantitative trait loci (tRFQTLs), encompassing 16,703 genetic variants associated with tRF expression across 31 cancer types.

LINC-PINT: A Distinctive Long Non-Coding RNA Functioning as a Potential Suppressor in Tumorigenesis.

Introduction: Long noncoding RNAs are essential regulators in numerous biological processes and have been linked to various diseases, including cancer. Despite their initial classification as transcriptional byproducts, lncRNAs have been shown to modulate chromatin structure, transcription, RNA processing, protein translation, and intranuclear transport. LINC-PINT, a lncRNA induced by P53, is particularly noteworthy for its role in tumor suppression across multiple cancers.

The Roles of Cytoplasmic Polyadenylation Element Binding Protein 1 in Tumorigenesis.

Background: CPEB1 is an alternative polyadenylation binding protein that promotes or suppresses the expression of related mRNAs and proteins by binding to a highly conserved Cytoplasmic Polyadenylation Element (CPE) in the mRNAs 3'UTR. It is found to express abnormally in multiple tumors and affect tumorigenesis through many pathways. This review summarizes the functions and mechanisms of CPEB1 in a variety of cancers and suggests new directions for future related treatments.

[Centerpiece plating in the cervical single open-door laminoplasty].

Objective: To evaluate the value of the Centerpiece plate in the cervical single open-door laminoplasty and compared its advantages with conventional suture fixation methods.

Methods: From December 2009 to August 2011,32 patients with cervical spondylotic myelopathy were treated with operation. Of them, 15 cases underwent cervical single open-door laminoplasty and Centerpiece plate fixation (group A),there were 8 males and 7 females,aged from 51 to 65 years old with an average of 60.