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Contextual cueing is a phenomenon in which repeatedly encountered arrays of items can enhance the visual search for a target item. This is widely attributed to attentional guidance driven by contextual memory acquired during visual search. Some studies suggest that children may have an immature ability to use contextual cues compared to adults, while others argue that contextual learning capacity is similar across ages. To test the development of context-guided attention, this study compared contextual cueing effects among three age groups: adults (aged 18-33 years, N = 32), teenagers (aged 15-17 years, N = 41), and younger children (aged 8-9 years, N = 43). Moreover, this study introduced a measure of response time variability that tracks fluctuations in response time throughout the experiment, in addition to the conventional analysis of response times. The results showed that all age groups demonstrated significantly faster responses in repeated than non-repeated search contexts. Notably, adults and teenagers exhibited smaller response time variability in repeated contexts than in non-repeated ones, while younger children did not. This implies that children are less efficient at consolidating contextual information into a stable memory representation, which may lead to less stable attentional guidance during visual search.
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http://dx.doi.org/10.3758/s13414-024-02926-2 | DOI Listing |
Chem Commun (Camb)
September 2025
Inorganic Chemistry I Institute, Ruhr-Universität Bochum, Universitätsstrasse 150, 44801 Bochum, Germany.
Herein, we report a solid-state polycyclotrimerization of 1,4-diethynylbenzene using mechanochemical activation in a ball mill, yielding a highly porous and hydrophobic hyperbranched polymer (HBP) with a specific surface area of up to 570 m g. The reaction, catalyzed by Fe(hmds) and conducted under solvent-free conditions, was optimized by varying milling time and frequency. This method enables the efficient synthesis of insoluble, porous organic polymers with high yields (up to 95%) and offers an environmentally friendly alternative to traditional solution-based polymerizations.
View Article and Find Full Text PDFJ Mass Spectrom
October 2025
Department of Chemistry and Technology of Drugs, "Sapienza" University of Rome, Rome, Italy.
Ionic liquids (ILs) are a class of organic salts with melting points below 100°C. Owing to their unique chemical and physical properties, they are used as solvents and catalysts in various chemical transformations, progressively replacing common volatile organic solvents (VOCs) in green synthetic applications. However, their intrinsic ionic nature can restrict the use of mass spectrometric techniques to monitor the time progress of a reaction occurring in an IL medium, thus preventing one from following the formation of the reaction products or intercepting the reaction intermediates.
View Article and Find Full Text PDFFront Immunol
September 2025
Clinical Nutrition and Dietetics Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
In the last decades, immunotherapy has revolutionized cancer treatment. Despite its success, a significant number of patients fail to respond, and the underlying causes of ineffectiveness remain poorly understood. Factors such as nutritional status and body composition are emerging as key predictors of immunotherapy outcomes.
View Article and Find Full Text PDFFront Immunol
September 2025
Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Background: Cryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory disease caused by a gain-of-function mutation in the gene, which regulates inflammasome-mediated interleukin-1β (IL-1β) production. This leads to recurrent episodes of fever, rash, and arthritis, typically beginning in childhood.
Objective: To demonstrate the role of a missense mutation, c.
Front Immunol
September 2025
Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
NSG-SGM3 humanized mouse models are well-suited for studying human immune physiology but are technically challenging and expensive. We previously characterized a simplified NSG-SGM3 mouse, engrafted with human donor CD34 hematopoietic stem cells without receiving prior bone marrow ablation or human secondary lymphoid tissue implantation, that still retains human mast cell- and basophil-dependent passive anaphylaxis responses. Its capacities for human antibody production and human B cell maturation, however, remain unknown.
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