Pollen-inspired magnetic nanoparticles with dual-recognition sensing interfaces for intelligent-response modulation of circulating tumor cells capture and release.

A critical prerequisite for translating circulating tumor cells (CTCs) detection technologies into clinical practice is achieving high-efficiency capture and non-destructive release of low-abundance CTCs in blood. In recent years, innovative designs and surface modification of bioinspired topological micro/nanostructured materials have provided efficient solutions to capture and release CTCs. Motivated by pollen morphology and multimodal regulation, this study designed pollen-inspired spiky topological magnetic nanoparticles (IP-GSMNs) based on dual-recognition interface and intelligent-response modulation for high-efficiency capture and non-destructive release of CTCs from peripheral whole blood.

sp. nov., sp. nov., sp. nov., sp. nov., sp. nov., sp. nov., sp. nov. and sp. nov., isolated from ginseng rhizosphere.

Thirteen novel strains - J2L1-78, J2P1-59, J22R24, J22R133, J22P168, J22P271, J22R187, J22R193, J2L1-63, J2R1-6, J22G21, J22G47, and J31P216 - were isolated from the rhizosphere of 20-year-old ginseng in Jilin Province, P.R. China.

Revelation of prognosis and tumor microenvironment of colorectal cancer based on genes related to antibody-dependent cellular phagocytosis and single-cell landscape.

Background: Increasing evidence highlights the crucial role of antibody-dependent cellular phagocytosis (ADCP) in colorectal cancer (CRC). However, how to use ADCP-related genes to predict prognosis in CRC and guide treatment remains unelucidated.

Methods: Gene expression profiles and clinical data information on CRC were sourced from the Cancer Genome Atlas (TCGA) database.

Pseudarthrobacter raffinosi sp. nov. and Pseudarthrobacter cellobiosi sp. nov. Two Heavy-Metal-Tolerant and Psychrotolerant Bacteria Isolated from Glaciers.

In a study on bacterial diversity on glacier surfaces in China, five bacterial strains (HLT1-5, HLT3-5, MDT3-26, MDT3-9, and MDT3-28) were isolated from soil samples collected from the surfaces of Hailuogou glacier and Midui glacier. Phylogenetic analysis based on 16S rRNA gene sequences placed these strains close to Pseudarthrobacter humi RMG13, Pseudarthrobacter psychrotolerans YJ56, and Pseudarthrobacter sulfonivorans ALL, with sequence similarity ranging from 98.98 to 100%.

Hysteroscopic Myomectomy for Type 2 Submucosal Myoma Pretreated by HIFU and Mifepristone Treatment: A Case Report and Literature Review.

Hysteroscopic myomectomy is the first-line treatment for the removal of submucosal myoma in women facing fertility requirements. However, in the face of large diameter type 2 submucosal myoma, patients are at greater risk of complications such as uterine perforation and fluid overload during hysteroscopy. When the diameter of type 2 submucous myoma is greater than 4cm, the three-phase treatment of high intensity focused ultrasound (HIFU), drugs and hysteroscopy is effective and safe.

Identification of colorectal cancer molecular subtypes and prognostic features based on basement membrane-related genes.

Recent evidence suggests that the basement membrane (BM) plays an important role in the progression of colorectal cancer (CRC). Here, we investigate the prognostic value of CRC based on BM-associated genes. BM-related differentially expressed genes (DEGs) in CRC were obtained through analysis of The Cancer Genome Atlas public database and literature.

In vitro 3D drug sensitivity testing for patient-derived tumor-like cell clusters and whole-exome sequencing to personalize postoperative treatment: A study protocol for a multicenter randomized controlled trial.

Background: Colorectal cancer (CRC) ranks as the third most common cancer globally, with significant postoperative recurrence and metastasis rates. The heterogeneity of CRC presents challenges in the selection of adjuvant chemotherapy regimens, highlighting the need for personalized treatment strategies. The development of in vitro models for drug sensitivity testing, including a novel patient-derived tumor-like cell cluster (PTC) model, offers a potential solution for predicting drug efficacy and guiding treatment.

A MXene-Based Nanothermal Knife Inhibits Aggresome-Mediated Persister Formation for Preventing Dental Caries.

Early childhood caries (ECC) is one of the most common chronic diseases among children globally, affecting the health and quality of life of children. Despite various treatments, cariogenic bacteria persist, resulting in a pessimistic outlook for the prevention and treatment of ECC. A notable presence of persister cells is found within the cariogenic bacterial population, with their dormancy enabling them to evade antiseptics.

Ensemble fault detection based on magnetic flux leakage images with noise robustness for steel wire ropes.

Localization of local flaws is critical to the magnetic flux leakage inspection of steel wire ropes. Existing studies mainly focus on improving the denoising ability to improve LF localization accuracy, but encounter limitations caused by inconsistencies in the noise features. In contrast, the localization technique still lacks enough attention.

Flavobacterium algoriphilum sp. nov., Flavobacterium arabinosi sp. nov., Flavobacterium cryoconiti sp. nov., Flavobacterium galactosi sp. nov., Flavobacterium melibiosi sp. nov., and Flavobacterium algoris sp. nov., six novel cold-adapted bacteria isolated from glaciers.

Background: Six novel cold-adapted bacteria, LB3P122, LT1R49, ZT3R17, ZT3R25, XS2P12, and GB2R13, were isolated from glaciers on the Tibetan Plateau. This study aimed to characterize their taxonomic status and elucidate their molecular adaptations to cold environments using a polyphasic approach.

Results: All strains were Gram-stain-negative, rod-shaped, and psychrophilic, growing at 0 °C with an optimum at 14-20 °C and at pH values of 6.

Comparison of Essential Oil Components and Antioxidant Activity of from Different Parts.

is a traditional Chinese herb, but limited information is available concerning its composition and pharmacological effects of essential oils from different parts of . This study examined the composition and antioxidant activity of essential oils from different parts of in China. The results indicate that the highest essential oil extraction rate was obtained from the pericarps (0.

Leveraging adenosine triphosphate for cancer theranostics.

Manipulation of the biochemical composition of the tumor microenvironment (TME) is a thriving research area in cancer treatment. Adenosine triphosphate (ATP), a key biochemical component, serves as an energy source for cancer cell proliferation. Notably, ATP can also act as a potent signal transducer to prime anti-tumor immune responses.

The effectiveness of treatment with probiotics in preventing necrotizing enterocolitis and related mortality: results from an umbrella meta-analysis on meta-analyses of randomized controlled trials.

Introduction: Probiotic supplementation has been proposed as a preventive measure for necrotizing enterocolitis (NEC) in preterm infants. This umbrella meta-analysis assesses the effects of probiotics, including single-strain and multi-strain formulations, on NEC and related mortality.

Methods: A comprehensive search was conducted in PubMed, Scopus, ISI Web of Science, and Embase for studies up to August 2024.

Evaluation of immune effect to recombinant potential protective antigens of Mycoplasma ovipneumoniae in mice.

Mycoplasma ovipneumoniae is a primary causative agent of pneumonia in ruminants, causing chronic non-progressive pneumonia in domestic sheep and goats, but leading to higher morbidity and mortality in bighorn sheep and wild small ruminants. This disease has become a widespread epidemic, resulting in significant losses to the sheep industry. In this study, we evaluated the immunogenicity and initial protective effects of four antigenic proteins of M.

SALL4/ABCB6 Axis Suppresses Ferroptosis in Colon Cancer by Mediating Mitophagy.

According to reports, the inhibition of ferroptosis is an essential culprit of malignant progression in various tumors, including colon cancer (CC). However, the relevant study on the regulatory mechanism of CC ferroptosis is sparse. This project was designed to identify the key genes modulating CC ferroptosis as well as specific mechanisms.

Description of sp. nov., sp. nov. and sp. nov., three new members of the genus .

Three novel strains, designated LB3P45, LS2P90 and ZS1P70, were isolated from glaciers located on the Tibetan Plateau, PR China. These strains were Gram-stain-negative, aerobic, rod-shaped and yellow or orange coloured. Phylogenetic analysis based on the 16S rRNA gene and genomic sequences indicated that they belong to the genus .

Energy metabolism in health and diseases.

Energy metabolism is indispensable for sustaining physiological functions in living organisms and assumes a pivotal role across physiological and pathological conditions. This review provides an extensive overview of advancements in energy metabolism research, elucidating critical pathways such as glycolysis, oxidative phosphorylation, fatty acid metabolism, and amino acid metabolism, along with their intricate regulatory mechanisms. The homeostatic balance of these processes is crucial; however, in pathological states such as neurodegenerative diseases, autoimmune disorders, and cancer, extensive metabolic reprogramming occurs, resulting in impaired glucose metabolism and mitochondrial dysfunction, which accelerate disease progression.

Application of machine learning in depression risk prediction for connective tissue diseases.

This study retrospectively collected clinical data from 480 patients with connective tissue diseases (CTDs) at Nanjing First Hospital between August 2019 and December 2023 to develop and validate a multi-classification machine learning (ML) model for assessing depression risk. Addressing the limitations of traditional assessment tools, six ML models were constructed using univariate analysis and the LASSO algorithm, with the categorical boosting (Catboost) model emerging as the best performer, demonstrating strong predictive ability across different depression severity levels (none_F1 = 0.879, mild_F1 = 0.

Exploring the Genetic Association Between Connective Tissue Diseases and the Risk of Pulmonary Arterial Hypertension: A Mendelian Randomization Analysis.

This study aimed to explore the potential causal link between genetic predisposition to various connective tissue diseases (CTDs), namely systemic lupus erythematosus (SLE), Sjögren's syndrome (SS), polymyositis (PM), dermatomyositis (DM), systemic sclerosis (SSc), mixed connective tissue disease (MCTD), and rheumatoid arthritis (RA), and the incidence of pulmonary arterial hypertension (PAH) utilizing Mendelian randomization (MR). Employing a two-sample MR approach, genetic variants associated with CTDs served as instrumental variables to investigate the exposure-outcome relationship, with GWAS data sourced from the FinnGen Biobank. Comprehensive statistical analyses, including the inverse variance weighted (IVW) method, were conducted, alongside heterogeneity, pleiotropy, and sensitivity tests to ensure the robustness and validity of findings.

Identifying the genetic association between rheumatoid arthritis and the risk of pulmonary arterial hypertension.

Epidemiological and observational studies have indicated an association between rheumatoid arthritis (RA) and pulmonary arterial hypertension (PAH). However, consistent conclusions have not been reached due to various limitations. In order to determine whether RA and PAH are causally related, we conducted a Mendelian randomization (MR) study with two samples.

CKS2 induces autophagy-mediated glutathione metabolic reprogramming to facilitate ferroptosis resistance in colon cancer.

Background: Ferroptosis, a form of cell death characterized by lipid peroxidation, plays a crucial role in tumor suppression, offering novel avenues for cancer therapy. Previous studies have indicated that high levels of cyclin-dependent kinase subunit 2 (CKS2) promote the progression of various cancers. However, the potential interplay between CKS2 and ferroptosis in colon cancer (CC) remains unclear.

MiR-875-5p suppresses Gli1 to alter the hedgehog signaling pathway, which in turn has hepatocellular cancer-related tumor suppressing properties.

Background: One of the most prevalent cancers worldwide is HCC, which has put patient health at risk. Increasing evidence indicated that messenger RNAs (mRNAs) played significant roles in modulating tumorigenesis. It has been established that Gli1 acts as an oncogene in a number of malignancies.