Enhancing singlet excitons delocalization via selective asymmetric fluorination of electron acceptors for efficient organic solar cells.

Exciton dissociation in organic solar cells (OSCs) is primarily achieved through interfacial charge-transfer (CT) states, leading to a trade-off between open-circuit voltage () and short-circuit current (). Spatially dispersed delocalized singlet excitons (DSEs) in nonfullerene acceptors (NFAs) provide an alternative channel to promote charge generation without interfacial CT state. Here, we manipulate intermolecular interactions, carrier dynamics, and photovoltaic properties through selective asymmetric fluorination.

Impact of Flipped Classroom Instruction on Brain-Mediated Motor Skill Performance in University Students: A Systematic Review and Meta-Analysis.

Objective: This systematic review and meta-analysis evaluates how the flipped classroom model-considered as a neurocognitive training environment-affects cognitive-motor integration and brain-mediated motor skill performance in university students, providing scientific evidence for optimizing higher-education physical education pedagogy (a course related to physical literacy and the cultivation of physical and mental health, rather than a training program for professional physical education teachers).

Methods: In order to compare the effects of flipped classroom and traditional teaching on the motor skill performance of university students, this study conducted a systematic review and meta-analysis according to PRISMA rules, whereby studies were screened according to specific inclusion criteria and data were extracted, assessed for quality, and then meta-analyzed to assess the effectiveness of the flipped classroom model in improving motor skill performance.

Results: A total of 12 original randomized controlled trials (RCTs) were included in the study.

20.6% Efficiency Organic Solar Cells Enabled by Incorporating a Lower Bandgap Guest Nonfullerene Acceptor Without Open-Circuit Voltage Loss.

Simultaneously mitigating both photovoltage and photocurrent losses is crucial for organic solar cells (OSCs) to approach the Shockley-Queisser limit of ideal efficiency. Incorporating a narrower bandgap nonfullerene acceptor (NFA) as a guest component into the host donor:NFA system broadens the absorption spectrum. However, this can also increase the nonradiative decay rate according to the energy-gap law.

The Critical Isomerization Effect of Core Bromination on Nonfullerene Acceptors in Achieving High-Performance Organic Solar Cells with Low Energy Loss.

Highly efficient nonfullerene acceptors (NFAs) for organic solar cells (OSCs) with low energy loss (E) and favorable morphology are critical for breaking the efficiency bottleneck and achieving commercial applications of OSCs. In this work, quinoxaline-based NFAs are designed and synthesized using a synergistic isomerization and bromination approach. The π-expanded quinoxaline-fused core exhibits different bromination sites for isomeric NFAs, namely AQx-21 and AQx-22.

Multiplexing Imaging of Closely Located Single-Nucleotide Mutations in Single Cells via Encoded PCR.

Mutation accumulation in RNAs results in closely located single-nucleotide mutations (SNMs), which is highly associated with the drug resistance of pathogens. Imaging of SNMs in single cells has significance for understanding the heterogeneity of RNAs that are related to drug resistance, but the direct "see" closely located SNMs remains challenging. Herein, we designed an encoded ligation-mediated polymerase chain reaction method (termed enPCR), which enabled the visualization of multiple closely located SNMs in bacterial RNAs.

Regioisomeric thieno[3,4-]thiazole-based A-Q-D-Q-A-type NIR acceptors for efficient non-fullerene organic solar cells.

This study explores the potential of regioisomeric quinoidal-resonance π-spacers in designing near-infrared (NIR) non-fullerene acceptors (NFAs) for high-performance organic solar cell devices. Adopting thienothiazole as the π-spacer, two new isomeric A-Q-D-Q-A NFAs, TzN-S and TzS-S, are designed and synthesized. Both NFAs demonstrate a broad spectral response extended to the NIR region.

High Open-Circuit Voltage Organic Solar Cells with 19.2% Efficiency Enabled by Synergistic Side-Chain Engineering.

Restricted by the energy-gap law, state-of-the-art organic solar cells (OSCs) exhibit relatively low open-circuit voltage (V) because of large nonradiative energy losses (ΔE). Moreover, the trade-off between V and external quantum efficiency (EQE) of OSCs is more distinctive; the power conversion efficiencies (PCEs) of OSCs are still <15% with Vs of >1.0 V.

Cas12a-Based Allele-Specific PCR for Imaging Single-Nucleotide Variations in Foodborne Pathogenic Bacteria.

profiling of single-nucleotide variations (SNVs) can elucidate drug-resistant genotypes with single-cell resolution. The capacity to directly "see" genetic information is crucial for investigating the relationship between mutated genes and phenotypes. Fluorescence hybridization serves as a canonical tool for genetic imaging; however, it cannot detect subtle sequence alteration including SNVs.

Nonfullerene Acceptor Featuring Unique Self-Regulation Effect for Organic Solar Cells with 19 % Efficiency.

The blend nanomorphology of electron-donor (D) and -acceptor (A) materials is of vital importance to achieving highly efficient organic solar cells. Exogenous additives especially aromatic additives are always needed to further optimize the nanomorphology of blend films, which is hardly compatible with industrial manufacture. Herein, we proposed a unique approach to meticulously modulate the aggregation behavior of NFAs in both crystal and thin film nanomorphology via self-regulation effect.

Aerobic exercise combined with chlorogenic acid exerts neuroprotective effects and reverses cognitive decline in Alzheimer's disease model mice (APP/PS1) via the SIRT1/ /PGC-1α/PPARγ signaling pathway.

Alzheimer's disease (AD) is a prevalent neurodegenerative disease account for 60-80% of the total number of people with dementia, but its treatment and prevention strategies are still in a long process of exploration. It has been reported that a healthy lifestyle may be an effective non-pharmacological intervention for the prevention and treatment of AD, including increased physical activity and the consumption of polyphenol-rich foods. This study, therefore, investigated the effects of 8 weeks of moderate-intensity aerobic exercise (EX), administration of chlorogenic acid administration (GCA), and a combination of both (EX+GCA) on β-amyloid (Aβ) deposition, inflammatory factors, oxidative stress markers, neuronal damage, and cognitive performance in the brains of AD model mice (APP/PS1) and which signaling pathways may be responsible for these effects.

Which exercise interventions are more helpful in treating primary obesity in young adults? A systematic review and Bayesian network meta-analysis.

Introduction: Network meta-analysis was used to evaluate the effectiveness of different exercise interventions in the treatment of obesity in young people and recommend the most suitable exercise method.

Material And Methods: We searched five electronic databases for articles on obesity treatment in the youth population from inception to April 2022. The two researchers independently retrieved and screened the articles, carried out a quality assessment and data extraction, and carried out a network meta-analysis in the Bayesian framework in Stata software.

Precious but convenient means of prevention and treatment: physiological molecular mechanisms of interaction between exercise and motor factors and Alzheimer's disease.

Disproportionate to the severity of Alzheimer's disease (AD) and the huge number of patients, the exact treatment and prevention of AD is still being explored. With increasing ageing, the search for means to prevent and treat AD has become a high priority. In the search for AD, it has been suggested that exercise may be one of the more effective and less costly means of preventing and treating AD, and therefore a large part of current research is aimed at exploring the effectiveness of exercise in the prevention and treatment of AD.

Organic Solar Cells with Over 19% Efficiency Enabled by a 2D-Conjugated Non-Fullerene Acceptor Featuring Favorable Electronic and Aggregation Structures.

The π-expansion of non-fullerene acceptors is a promising method for boosting the organic photovoltaic performance by allowing the fine-tuning of electronic structures and molecular packing. In this work, highly efficient organic solar cells (OSCs) are fabricated using a 2D π-expansion strategy to design new non-fullerene acceptors. Compared with the quinoxaline-fused cores of AQx-16, the π-expanded phenazine-fused cores of AQx-18 induce more ordered and compact packing between adjacent molecules, affording an optimized morphology with rational phase separation in the blend film.

Where Is the Way Forward for New Media Empowering Public Health? Development Strategy Options Based on SWOT-AHP Model.

(1) Background: In recent years, new media and the integration of sport and medicine have promoted the rapid integration and development of the two fields of health and, to a certain extent, the pursuit of public health knowledge and the promotion of health concepts. However, the overall development process is at an early stage and the aim of this paper is to make an empirical analysis of its development through a SWOT-AHP model and give corresponding recommendations. (2) Methods: The SWOT-AHP model was constructed to quantitatively and qualitatively analyse the four dimensions of strengths, weaknesses, opportunities and threats obtained through the Delphi method, with regard to development and to determine the strategic direction of its development.

A Multifactor Quantitative Assessment Model for Safe Mining after Roof Drainage in the Liangshuijing Coal Mine.

To prevent coal mine roof water damage, the water generally needs to be evacuated in advance. It can be mined with the water inrush risk assessed as safe. However, a single index is often employed in the water safety evaluation after the roof drainage, which causes a large gap between the evaluation results and the actual situation.

Flos Extract Promotes Sleep in Sleep-Deprived and Lipopolysaccharide-Challenged Mice.

Flos (LJF) is commonly used in Chinese herbal medicines and exhibits anti-viral, anti-oxidative, and anti-inflammatory properties. The reciprocal relationship between sleep, the immune system and the central nervous system is well-established in the animal models. In this study, we used the mouse model to analyze the beneficial effects of the LJF on the dysregulated sleep-wakefulness cycle in response to acute sleep deprivation and lipopolysaccharide (LPS)-induced inflammation and the potential underlying mechanisms.

Strong CPL of achiral liquid crystal fluorescent polymer the regulation of AIE-active chiral dopant.

Ternary polymer dispersed cholesteric liquid crystals (PD-CLCs) prepared by doping AIE-active binaphthyl-based molecules (R/S-AD, chiral dopant) and the achiral liquid crystal fluorescent polymer, poly(p-phenylene ethynylene) (LC-PPE, CPL emitter) into 5CB, can emit strong circularly polarized luminescence (CPL) with gem up to 0.97. This work develops a new strategy for designing strong CPL materials.

The amplified circularly polarized luminescence regulated from D-A type AIE-active chiral emitters via liquid crystals system.

Two pairs of D-A type AIE-active chiral dyes (R-/S-1 and R-/S-2) as chiral emitters doped into nematic liquid crystals (5CB, N-LCs) can form chiral nematic liquid crystals (N*-LCs) and regulate the amplified circularly polarized luminescence (CPL) signals. R-/S-2 with stronger D-A structure and more planar conformation could induce higher CPL response (glum = ±0.37) via the supramolecular self-assembly in N*-LCs system.

Corrigendum: Superior Adsorption and Regenerable Dye Adsorbent Based on Flower-Like Molybdenum Disulfide Nanostructure.

This corrects the article DOI: 10.1038/srep43599.

Superior Adsorption and Regenerable Dye Adsorbent Based on Flower-Like Molybdenum Disulfide Nanostructure.

Herein we report superior dye-adsorption performance for flower-like nanostructure composed of two dimensional (2D) MoS nanosheets by a facile hydrothermal method, more prominent adsorption of cationic dye compared with anodic dye indicates the dye adsorption performance strongly depends on surface charge of MoS nanosheets. The adsorption mechanism of dye is analyzed, the kinetic data of dye adsorption fit well with the pseudo-second-order model, meanwhile adsorption capability at different equilibrium concentrations follows Langmuir model, indicating the favorability and feasibility of dye adsorption. The regenerable property for MoS with full adsorption of dye molecules by using alkaline solution were demonstrated, showing the feasibility of reuse for the MoS, which is promising in its practical water treatment application.

Characterization of the function of cytoglobin as an oxygen-dependent regulator of nitric oxide concentration.

The endogenous vasodilator nitric oxide (NO) is metabolized in tissues in an O(2)-dependent manner. This regulates NO levels in the vascular wall; however, the underlying molecular basis of this O(2)-dependent NO consumption remains unclear. While cytoglobin (Cygb) was discovered a decade ago, its physiological function remains uncertain.