A real-world pharmacovigilance study of Certolizumab pegol based on FAERS database.

Certolizumab pegol (CZP), a PEGylated anti-tumor necrosis factor alpha (TNF-α) biologic, is approved for treating autoimmune disorders, including psoriatic arthritis (PsA). Despite its good therapeutic effects, its real-world safety remains limited. This study aims to evaluate the real-world safety of CZP using the FDA Adverse Event Reporting System (FAERS).

Comprehensive post-marketing safety analysis of tildrakizumab: insights from the FDA adverse event reporting system.

Background: Tildrakizumab is a biologic agent approved for the treatment of moderate to severe psoriasis. Although its safety has been established in clinical trials, its real-world safety profile remains to be further investigated.

Research Design And Methods: This study analyzed adverse events (AEs) from the FDA Adverse Event Reporting System (FAERS) database between the first quarter of 2018 and the first quarter of 2024.

Adverse events associated with vismodegib: insights from a real-world pharmacovigilance study using the FAERS database.

Background: Vismodegib, an inhibitor of the Hedgehog signaling pathway, has been widely used in the treatment of advanced basal cell carcinoma. Given its critical role in managing advanced basal cell carcinoma and the relatively high rate of treatment discontinuation, it is crucial to comprehensively understand its safety profile in real-world settings.

Methods: This study analyzed all adverse event reports that identified vismodegib as the primary suspected drug since 2012 in the FDA Adverse Event Reporting System database.

Bibliometric and visual analysis in the field of macrophages in Traditional Chinese Medicine from 2003 to 2023.

Objective: Macrophages are increasingly recognized as crucial therapeutic targets in the treatment of diverse pathological conditions. While considerable research has focused on macrophage-related mechanisms within Traditional Chinese Medicine (TCM), there remains a notable absence of comprehensive quantitative analyses in this field. This study aims to examine the evolutionary trajectory of macrophage-related research in TCM from 2003 to 2023, providing insights to guide future investigative directions.

Real-world safety of deucravacitinib: insights from the Food and Drug Administration Adverse Event Reporting System.

Background: Deucravacitinib, a selective inhibitor of TYK2 kinase, has been recently approved for the treatment of moderate to severe plaque psoriasis. Although the safety of deucravacitinib has been observed in clinical trials, its safety in the real world remains to be fully understood.

Aim: The purpose of this study was to analyze post-marketing adverse events (AEs) associated with deucravacitinib using data from the Food and Drug Administration Adverse Event Reporting System (FAERS) to better understand its safety in real-world conditions.

Safety assessment of apremilast: real-world adverse event analysis from the FAERS database.

Apremilast, a unique oral immunomodulatory phosphodiesterase 4 inhibitor, has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of psoriasis and psoriatic arthritis (PsA).

A real-world Pharmacovigilance study of brodalumab based on the FDA adverse event reporting system.

Brodalumab, a humanized monoclonal antibody that targets the interleukin-17 receptor A, is primarily used to manage moderate-to-severe plaque psoriasis. Although it has demonstrated favorable efficacy and safety in clinical trials, the strict inclusion and exclusion criteria may not fully reflect its safety profile in real-world settings. As its use becomes more widespread in clinical practice, understanding its safety in real-world applications is crucial.

Oral Microbiota Variations in Psoriasis Patients Without Comorbidity.

Background: Psoriasis is a chronic inflammatory skin disease, and its etiology is still unclear. There is increasing evidence suggesting that microorganisms may trigger psoriasis. However, the relationship between psoriasis and oral microbiota remains poorly understood.

Assessing the real-world safety of tralokinumab for atopic dermatitis: insights from a comprehensive analysis of FAERS data.

Background: Tralokinumab, a humanized monoclonal antibody targeting interleukin-13, has been primarily used for the treatment of moderate-to-severe atopic dermatitis. Given its extensive use in clinical practice, understanding its safety profile in the real-world setting is crucial.

Methods: This study utilized disproportionality analysis to evaluate the safety of tralokinumab in clinical practice by analyzing all adverse event reports since 2021 in the FDA Adverse Event Reporting System database that identified tralokinumab as the primary suspected drug.

A Multi-Information Spreading Model for One-Time Retweet Information in Complex Networks.

In the realm of online social networks, the spreading of information is influenced by a complex interplay of factors. To explore the dynamics of one-time retweet information spreading, we propose a Susceptible-Infected-Completed (SIC) multi-information spreading model. This model captures how multiple pieces of information interact in online social networks by introducing inhibiting and enhancement factors.

Symptomatic and asymptomatic pronated feet show differences in the forefoot abduction motion during jogging, but not in the arch deformation.

Pronated feet have been associated with higher risks of running-related overuse injuries than neutral feet. However, it remains unclear why some pronated feet develop running-related injuries, while others do not. This study aimed to examine the differences in foot kinematics during jogging among individuals with symptomatic pronated feet (SP), asymptomatic pronated feet (AP) and asymptomatic neutral feet (AN).

Comprehensive Analysis to Identify as a Prognostic Biomarker in Cervical Cancer.

, secreted phosphoprotein 1, is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family. Previous studies have proven overexpressed in a variety of cancers and can be identified as a prognostic factor, while no study has explored the function and carcinogenic mechanism of in cervical cancer. We aimed to demonstrate the relationship between expression and pan-cancer using The Cancer Genome Atlas (TCGA) database.

is a Prognostic Biomarker and Correlated With Immune Cell Infiltration in Cervical Cancer.

Inhibin A (), a member of the - superfamily, has been shown to be differentially expressed in various cancer types and is associated with prognosis. However, its role in cervical cancer remains unclear. We aimed to demonstrate the relationship between expression and pan-cancer using The Cancer Genome Atlas (TCGA) database.

Exploring an Efficient Remote Biomedical Signal Monitoring Framework for Personal Health in the COVID-19 Pandemic.

Nowadays people are mostly focused on their work while ignoring their health which in turn is creating a drastic effect on their health in the long run. Remote health monitoring through telemedicine can help people discover potential health threats in time. In the COVID-19 pandemic, remote health monitoring can help obtain and analyze biomedical signals including human body temperature without direct body contact.

Body mass index and all-cause mortality in patients with cardiogenic shock: A systematic review and meta-analysis.

Background: The association between body mass index (BMI) and all-cause mortality of patients with Cardiogenic Shock (CS) is still controversial. The objective of this analysis is to summarize the available evidence of this association and perform meta-analysis using adjusted estimates.

Methods: PubMed, Embase and Cochrane databases were systematically searched for eligible studies up to July 2020.

A novel manganese complex selectively induces malignant glioma cell death by targeting mitochondria.

Despite advances in treatment, malignant glioma commonly exhibits recurrence, subsequently leading to a poor prognosis. As manganese (Mn) compounds can be transported by the transferrin‑transferrin receptor system, the present study synthesized and examined the potential use of Adpa‑Mn as a novel antitumor agent. Adpa‑Mn time and dose‑dependently inhibited U251 and C6 cell proliferation; however, it had little effect on normal astrocytes.

A novel manganese complex LMnAc selectively kills cancer cells by induction of ROS-triggered and mitochondrial-mediated cell death.

We previously identified a novel synthesized metal compound, LMnAc ([L2Mn2(Ac)(H2O)2](Ac) (L=bis(2-pyridylmethyl) amino-2-propionic acid)). This compound exhibited significant inhibition on cancer cell proliferation and was more selective against cancer cells than was the popular chemotherapeutic reagent cisplatin. In this study, we further investigated the underlying molecular mechanisms of LMnAc-induced cancer cell death.

[Onset timing of acute ST segment elevation myocardial infarction in middle-aged and old patients].

Objective: To compare the differences on onset timing of acute ST segment elevation myocardial infarction (STEMI) in young and aged patients.

Methods: The exact onset time of symptoms was obtained from 1024 consecutive patients with STEMI admitted to our hospital between January 2000 and May 2010. Patients were classified as the middle-aged group [< 65 years old, mean (52.

Anticancer activity, attenuation on the absorption of calcium in mitochondria, and catalase activity for manganese complexes of N-substituted di(picolyl)amine.

In order to find multifunction anticancer complexes, three Mn(II) complexes of N-substituted di(2-pyridylmethyl)amine were characterized and used as agents to interfere with the functions of mitochondria and the metabolite of O(2) in cancer cells. It was found that carboxylate-bridged dimanganese(II) systems are good models of catalase and exhibit good inhibition of the proliferation of U251 and HeLa cells. The inhibiting activity of these manganese(II) complexes on the tumor cells in vitro was related to their disproportionating H(2)O(2) activity.

Targeting cancer cells through iron(III) complexes of di(picolyl)amine modified silica core-shell nanospheres.

In this report, we aim at optimizing the approach of delivering and imaging cancer cell targeting using anti-proliferative nanoparticle complex. Rhodamine B isothiocyanate doped silica-coated (RBITC-SiO₂) were prepared by microemulsion method. Fe(III) complex of di(picolyl)amine was conjugated on to the surface RBITC-SiO₂ to produce final nanosphere (RBITC-SiO₂ @dpa-Fe) with an average hydrodynamic diameter of 74 nm.

Interaction with DNA and different effect on the nucleus of cancer cells for copper(II) complexes of N-benzyl di(pyridylmethyl)amine.

Three new copper(II) complexes of N-benzyl di(pyridylmethyl)amine (phdpa) were synthesized and characterized by spectroscopic methods. The interaction between CT-DNA and the complexes was studied by UV and fluorescence titration methods. It was found that the complex [(phdpa)Cu(H(2)O)Ac)](Ac), with the non-planar aromatic heterocyclic ring ligand (phdpa), showed good anticancer properties and could cause the fragmentation of the nucleus, although its interaction with CT-DNA was weaker than that of 1,10-phenanthroline (phen)-based copper(II) complexes.

In vivo percutaneous absorption, skin barrier perturbation, and irritation from JP-8 jet fuel components.

JP-8 jet fuel has been reported to cause systemic and dermal toxicities in animal models and humans. There is a great potential for human exposure to JP-8. In this study, we determined percutaneous absorption and dermal toxicity of three components of JP-8 (i.

In vitro permeability and binding of hydrocarbons in pig ear and human abdominal skin.

Human skin has continual exposure to chemicals due to various occupational activities. Chemicals that get on skin have the potential to be absorbed. Hence, the potential human health hazards of a chemical must include an estimate for percutaneous absorption.