Single-Cell Transcriptome Profiling Reveals Dynamic Cell Populations and Immune Infiltration in Moyamoya Disease.

Background: The cellular composition and molecular mechanisms of the pathological arteries in Moyamoya disease (MMD) remain poorly understood. To improve our understanding of pathogenesis in MMD, we aimed to comprehensively map the cellular composition and molecular alterations within the pathological arteries of patients with MMD.

Methods: Superficial temporal artery samples were collected from patients with MMD (n=2) and healthy controls (n=3), yielding a total of 26 371 cells that were used for single-cell RNA sequencing.

Angiogenesis-related genes and immune microenvironment in moyamoya disease: a transcriptomic and functional analysis.

Background: Moyamoya disease (MMD) is a chronic, progressive occlusive cerebrovascular disease. It causes recurrent cerebrovascular stroke due to vascular closure and proliferation. An unclear pathophysiological mechanism is the most significant obstacle in the diagnosis and treatment of MMD.

High-Performance SbTe Thick Films via Diffusion-Induced Structural Tuning for Flexible Thermoelectric Energy Harvesting.

SbTe is a widely studied p-type thermoelectric material with great potential for flexible energy harvesting applications. To enable stable power supply for wearable electronics, enhancing the output power of thermoelectric thin-film devices is imperative, where high-performance thick films are advantageous for boosting power generation efficiency. In this work, we successfully fabricated 10 μm SbTe thick films with high performance by combining thermal evaporation and a thermal diffusion process.

Cognitive characteristics and ischemic prognosis of quantitative white matter hyperintensities in adult moyamoya disease.

Background: White matter hyperintensities (WMHs) are associated with long-term stroke and cognitive decline in the elderly population but differ from the young and middle-aged populations, especially for those with moyamoya disease (MMD). The aim of this study was to modify the Fazekas grade and quantitatively analyze the effects of WMHs on multiple cognitive domains and 2-year clinical ischemic events in adult MMD patients.

Methods: Adult MMD patients and healthy controls were recruited for a comprehensive cognitive assessment.

Biomni: A General-Purpose Biomedical AI Agent.

Biomedical research underpins progress in our understanding of human health and disease, drug discovery, and clinical care. However, with the growth of complex lab experiments, large datasets, many analytical tools, and expansive literature, biomedical research is increasingly constrained by repetitive and fragmented workflows that slow discovery and limit innovation, underscoring the need for a fundamentally new way to scale scientific expertise. Here, we introduce Biomni, a general-purpose biomedical AI agent designed to autonomously execute a wide spectrum of research tasks across diverse biomedical subfields.

Integrative Machine Learning Approach to Explore Glycosylation Signatures and Immune Landscape in Moyamoya Disease.

Moyamoya disease (MMD) is a rare, chronic cerebrovascular disorder of uncertain etiology. Although abnormal glucose metabolism has been implicated, the contribution of glycosylation-related genes in MMD remains elusive. In this study, we analyzed 2 transcriptome data sets (GSE189993 and GSE131293) from the Gene Expression Omnibus (GEO) database to identify 723 differentially expressed genes (DEGs) between MMD patients and controls.

Hierarchically Porous Wearable Composites for High-Performance Stretchable Supercapacitors.

With the rapid development of wearable electronic devices, the demand for flexible, durable, and high-performance energy storage systems has increased significantly. Nevertheless, maintaining stable electrochemical performance during stretching while ensuring high stretchability and mechanical stability remains a challenge. Herein, this study proposes a novel type of stretchable supercapacitors made from carbon nanotube (CNT) and styrene-butadiene-styrene (SBS) composite scaffolds prepared on pre-stretched carbon fabrics using the breath figure method.

Serum amyloid A2-induced phenotypic switching of vascular smooth muscle cells in moyamoya disease.

Objective: This study was conducted to explore the role of serum amyloid A2 (SAA2) protein in the phenotype changes of vascular smooth muscle cells (VSMCs) in moyamoya disease (MMD).

Methods: Between January 2020 and August 2022, individuals with diagnosed MMD were identified through a combination of their neuroradiological assessments and medical history. Control participants consisted of healthy adult volunteers who did not have MMD or any preexisting diseases.

Improvement in multiple cognitive domains via combined revascularization by 6 months' follow-up: a new potential surgical indication in moyamoya disease.

Objective: Moyamoya disease (MMD) is a cerebrovascular condition characterized by progressive stenosis of the main branches of the cerebral artery. Patients with MMD are prone to cognitive decline due to chronic hypoperfusion. Whether revascularization surgery can reverse cognitive dysfunction by improving cerebral blood flow perfusion and what types and levels of cognitive dysfunction can benefit most from the surgery remain unclear.

Dynamic cellular composition and immune landscape revealed by single-cell transcriptome profiling in a brain arteriovenous malformation.

Background: Cerebral arteriovenous malformation is a congenital blood vessel abnormality with its immune mechanism remains unclear. Our study characterized the change of cellular composition and gene expression landscape in brain arteriovenous malformation (bAVM).

Methods: We conducted single-cell RNA sequencing analysis on one bAVM sample and three healthy control (HC) samples.

Characterization of moyamoya disease molecular subtypes through disulfidptosis‑related genes and immune landscape analysis.

Moyamoya disease (MMD), a chronic cerebrovascular disorder, is characterized by progressive stenosis of major intracranial arteries. However, the mechanisms underlying the pathological narrowing have remained largely elusive. Disulfidptosis is a new mode of cell death caused by the vulnerability of the actin cytoskeleton to disulfide stress, and proteomic profiling of MMD has revealed that abnormal proliferation of endothelial cells may be induced by upregulation of focal adhesion-related proteins.

Advances in moyamoya disease: pathogenesis, diagnosis, and therapeutic interventions.

Moyamoya disease (MMD) is a type of cerebrovascular disease characterized by occlusion of the distal end of the internal carotid artery and the formation of collateral blood vessels. Over the past 20 years, the landscape of research on MMD has significantly transformed. In this review, we provide insights into the pathogenesis, diagnosis, and therapeutic interventions in MMD.

Cognitive dysfunction in Moyamoya disease: latest developments and future directions.

Cognitive dysfunction is common in Moyamoya disease (MMD). However, current knowledge of cognitive impairment in MMD is inadequate. In this review, we explored the characteristics of altered cognitive function associated with MMD and offered recommendations aimed at guiding potential research endeavors into the cognitive dysfunction in MMD.

Trade-offs among human, animal, and environmental health hinder the uniform progress of global One Health.

The One Health (OH) approach, integrating aspects of human, animal, and environmental health, still lacks robustly quantified insights into its complex relationships. To fill this knowledge gap, we devised a comprehensive assessment scheme for OH to assess its progress, synergies, trade-offs, and priority targets. From 2000 to 2020, we find evidence for global progress toward OH, albeit uneven, with its average score rising from 61.

Duplex recombinase aided amplification-lateral flow dipstick assay for rapid distinction of and .

Objectives: This study aims to develop a novel diagnostic approach using the recombinase aided amplification-lateral flow dipstick(RAA-LFD) assay for the distinction of (MTB) and (MAC), enabling rapid and convenient as well as accurate identification of them in clinical samples.

Methods: Our study established a duplex RAA-LFD assay capable of discriminating between MTB and MAC. Based on the principles of RAA primer and probe design, specific primers and probes were developed targeting the MTB and the MAC separately.

Achieving High Thermoelectric Performance in Bi(Te, Se) Thin Film with (00)-Oriented by Incorporating Tellurization and Selenization Processes.

Flexible thermoelectric (TE) generators have received great attention as a sustainable and reliable option to convert heat from the human body and other ambient sources into electricity. This study provides a synthesis route that involves thermally induced diffusion to introduce Te and Se into Bi, fabricating an n-type Bi-Te-Se flexible thin film on a flexible substrate. This specific synthesis alters the crystal orientation (00) of the thin film, improving in-plane electrical transportation and optimizing carrier concentration.

Deviceization of high-performance and flexible AgSe films for electronic skin and servo rotation angle control.

AgSe shows significant potential for near-room-temperature thermoelectric applications, but its performance and device design are still evolving. In this work, we design a novel flexible AgSe thin-film-based thermoelectric device with optimized electrode materials and structure, achieving a high output power density of over 65 W m and a normalized power density up to 3.68 μW cm K at a temperature difference of 42 K.

Uncovering leveraging and hindering factors in socio-ecological interactions: Agricultural production in the Yellow River Basin as an example.

Agricultural production and sustainable human livelihoods in large river basins are threatened by climate change, human activities, and resource constraints. However, due to the complexity of socio-ecological interactions and agricultural sustainability, current studies are still limited by a priori knowledge and systematic analyses, as well as by the lack of quantification and identification of key factors and valuable pathway structures for agricultural production activities. Here, we combined observation-based causal inference and network analysis to quantify and assess the complex interactions in agricultural production in the Yellow River Basin (YRB) based on data from 12 factors relevant to agriculture over 40 years.

Cross-scale coupling of ecosystem service flows and socio-ecological interactions in the Yellow River Basin.

As research on the full spectrum of ecosystem service (ES) generation and utilization within coupled human and natural systems (CHANS) has expanded, many studies have shown that the spatiotemporal dynamics of ESs are managed and influenced by human activities. However, there is insufficient research on how ESs are affected by bidirectional coupling between societal and ecological factors during spatial flow, particularly in terms of cross-scale impacts. These bidirectional influences between humans and nature are closely related to the utilization and transfer of ESs and affect the perception of spatiotemporal patterns of ESs and the formulation of management strategies.

Identification of oxidative phosphorylation-related genes in moyamoya disease by combining bulk RNA-sequencing analysis and machine learning.

Moyamoya disease (MMD) is a chronic cerebrovascular disease that can lead to ischemia and hemorrhagic stroke. The relationship between oxidative phosphorylation (OXPHOS) and MMD pathogenesis remains unknown. The gene expression data of 60 participants were acquired from three Gene Expression Omnibus (GEO) datasets, including 36 and 24 in the MMD and control groups.

Anion/Cation Co-Doping to Improve the Thermoelectric Performance of Sn-Enriched n-Type SnSe Polycrystals with Suppressed Lattice Thermal Conductivity.

Enhancing the thermoelectric performance of n-type polycrystalline SnSe is essential, addressing challenges posed by elevated thermal conductivity and compromised power factor inherent in its intrinsic p-type characteristics. This investigation utilized solid-state reactions and spark plasma sintering techniques for the synthesis of n-type SnSe. A significant improvement in the figure of merit (ZT) is achieved through strategic reduction in Se concentration and optimization of crystal orientation.

High-throughput sequencing-based analysis of the composition and diversity of the endophyte community in roots of Stellera chamaejasme.

Stellera chamaejasme (S. chamaejasme) is an important medicinal plant with heat-clearing, detoxifying, swelling and anti-inflammatory effects. At the same time, it is also one of the iconic plants of natural grassland degradation in northwest China, playing a key role in the invasion process.