Laparoscopy combined with intraoperative choledochoscopy for the treatment of cheoledochal cysts.

Objective: To evaluate the efficacy of laparoscopy combined with intraoperative choledochoscopy in treating choledochal cysts and preventing postoperative complications.

Patients And Methods: This single-center retrospective study included 208 patients with Todani type I choledochal cysts treated laparoscopically from January 2016 to January 2023. Patients undergoing open surgery were excluded.

Molecular Fractionation Induced by Viscosity-Driven Segregative Phase Separation Behavior of Gum Arabic/Hydroxypropyl Methylcellulose.

Segregative phase separation technology demonstrates substantial potential for precise molecular fractionation in food and biomaterial applications. The investigation elucidates the causal relationship between viscosity variations and phase separation dynamics, which govern molecular fractionation in GA/HPMC composite systems. By conducting a comparative analysis of two GA subtypes (CGA and SGA) and three HPMC grades with controlled viscosity gradients, we utilized gel permeation chromatography-multi-angle laser light scattering (GPC-MALLS) coupled with rheological characterization to elucidate the critical relationship between continuous phase viscosity and fractionation efficiency.

Sinusoidal spiral-bent crystal for high-resolution X-ray spectrometer: theory and implementation.

X-ray diagnosis technology predicated on crystal diffraction is a vital modality for garnering key parameters within the scope of X-ray spectroscopy diagnosis. Conventional spectrometers, such as cylindrically bent crystal, spherically bent crystal, and other structures, suffer from a resolution-bandwidth trade-off, thus limiting the uses of the device. A spectrometer design method based on the sinusoidal spiral bent crystal dispersion module is proposed in this paper to correct this serious aberration in an extended energy range.

Near-borehole imaging with dipole acoustic logging based on full waveform inversion.

In acoustic logging, the dipole-mode wave is a type of guided wave that propagates along the borehole, and its dispersion characteristics are typically used to invert the shear-wave velocity of the formation around the borehole. However, traditional dispersion-based inversions rely on the layered model assumption, limiting their applicability to formations that are either uniformly distributed along the borehole axis or exhibit gradual variations. As a method that directly fits observed waveforms, full waveform inversion (FWI) can be applied to various formation models without being constrained by the assumption of two-dimensional homogeneity.

Associations between coexposure to bisphenols mixture and metabolic diseases: based on three statistical models.

Introduction: Bisphenol A (BPA) and its substitutes are common environmental endocrine disruptors. We investigated whether coexposure to BPA and its substitutes are associated with metabolic diseases (MDs), the related indicators, and their multimorbidity.

Methods: The study included 1409 participants from the National Health and Nutrition Examination Survey (NHANES).

Identification and validation of prognostic genes associated with T-cell exhaustion and macrophage polarization in breast cancer.

Background: The most frequent malignant tumor in women is breast cancer (BRCA). It has been discovered that T-cell exhaustion and macrophages play significant roles in BRCA. It was necessary to explore prognostic genes associated with T-cell exhaustion and macrophage polarization in BRCA.

Drug treatment of breast cancer brain metastases: progress and challenges.

Breast cancer is one of the most prevalent malignancies among women worldwide, with brain metastasis occurring in approximately 10-16% of cases, significantly contributing to poor prognosis and reduced quality of life. The treatment of breast cancer brain metastasis requires a multidisciplinary approach, prioritizing local therapies such as surgery and radiotherapy to address central nervous system lesions. However, local treatments often struggle to effectively control the progression of brain metastases and are associated with multiple complications, necessitating adjunctive systemic and supportive therapies.

Predictive Value of C-Reactive Protein/Albumin Ratio for Necrotizing Enterocolitis in Preterm Infants With Neonatal Sepsis.

Background: Necrotizing enterocolitis (NEC), a critical neonatal digestive disease, is recognized as a contributing factor to neonatal sepsis. However, the role of the C-reactive protein/albumin ratio (CAR) in diagnosing neonatal sepsis within the context of NEC remains under-researched.

Aim: Our objective was to evaluate the clinical utility of the C-reactive protein/albumin (CRP/ALB) ratio in predicting neonatal sepsis at the NEC diagnosis stage.

Health benefits and digestive properties of Ca-regulated sodium alginate from an endogenous method in buckwheat noodles.

The present study investigated the impact of Ca regulated sodium alginate gelation on buckwheat noodle digestion, as well as its physiological and biochemical effects on rat. An endogenous method was employed for noodle preparation, and the rate of starch hydrolysis was evaluated. Buckwheat noodles prepared using this approach exhibited significantly reduced rates of starch digestion compared to conventional methods.

Analysis of risk factors and establishment of predictive models for neonatal necrotizing enterocolitis: a retrospective study.

Background: Necrotizing enterocolitis (NEC) is a leading gastrointestinal condition in preterm infants, characterized by significant morbidity and mortality. Early recognition of risk factors is crucial for its prevention and prediction. This study focuses on identifying factors that contribute to the development of NEC in neonates.

Large deformation of food gels: Influencing factors, theories, models, and applications-A review.

Gels possess remarkable properties, and they hold particular importance in food science. After consumption, food gels undergo large deformation, which impacts the overall texture of the food. This process is influenced by various factors, including temperature, pressure, and presence of crosslinking agents.

The impact of molecular weight on the segregative phase separation-induced molecular fractionation of aqueous gum Arabic/xanthan mixtures.

Segregative phase separation of natural polymers has drawn significant research interest because of its diverse applications in the food industry. However, there is limited research on how molecular weight (Mw) influences segregative phase separation. This study aims to investigate the impact of Mw on segregative phase separation-induced molecular fractionation in mixed gum Arabic/Xanthan (GA/XG) solutions.

Does urban-rural integration contribute to environmental health? Exploring the interplay between urban-rural integration and air quality dynamics in Yangtze River middle reaches city cluster.

Background: Exploring the coordinated relationship between urban-rural integration and air quality has significant implications for promoting urban-rural development, preventing air pollution and ensuring residents' health. This study takes Yangtze River middle reaches city cluster as a case study, calculates the levels of urban-rural integration and air quality development, analyzes their coupled coordination relationship and driving factors, and explores the path of coordinated development.

Methods: This study constructs a coupling coordination degree model to analyze the relationship between the urban-rural integration development level and air quality development level.

Rare and common genetic variants underlying the risk of Hirschsprung's disease.

Hirschsprung's disease (HSCR) is a congenital enteric neuropathic disorder characterized by high heritability (>80%) and polygenic inheritance (>20 genes). The previous genome-wide association studies (GWAS) identified several common variants associated with HSCR and demonstrated increased predictive performance for HSCR risk in Europeans using a genetic risk score, there remains a notable gap in knowledge regarding Chinese populations. We conducted whole exome sequencing in a HSCR case cohort in Chinese.

The mediating role of maternal fasting plasma glucose level and lipid levels in the third trimester of pregnancy between pre-pregnancy BMI and offspring physical development at birth.

Unlabelled: While previous research has established correlations between pre-pregnancy body mass index (BMI), late-pregnancy blood glucose, and late-pregnancy blood lipid levels during pregnancy and offspring's physical development, the underlying mechanism of their interaction remains elusive. A birth cohort study was conducted on pregnant women, who are biologically female, delivering at a tertiary hospital in Wuhan City between May 2023 and April 2024, encompassing 1620 participants. We collected maternal socio-demographic data through questionnaires and obtained information on fasting blood glucose (FPG), lipid levels during the third trimester, and neonatal physical development from medical records.

Enhancement of Calcium Chelating Activity in Peptides from Sea Cucumber Ovum through Phosphorylation Modification.

Recently, phosphorylation has been applied to peptides to enhance their physiological activity, taking advantage of its modification benefits and the extensive study of functional peptides. In this study, water-soluble peptides (WSPs) of sea cucumber ovum were phosphorylated in order to improve the latter's calcium binding capacity and calcium absorption. Enzymatic hydrolysis methods were screened via ultraviolet-visible absorption spectroscopy (UV-Vis), the fluorescence spectrum, and calcium chelating ability.

Fabrication and functional application of zein-based core-shell structures: A review.

Core-shell structures exhibit a number of distinct absorptive properties that make them attractive tools for use in a range of industrial contexts including pharmaceuticals, biotechnology, cosmetics, and food/agriculture. Several recent studies have focused on the development and fabrication of zein-based core-shell structures for a range of functional material deliveries. However, no recent review article has evaluated the fabrication of such core-shell structures for food-based applications.

Scale-Aware Edge-Preserving Full Waveform Inversion with Diffusion Filter for Crosshole Sensor Arrays.

Full waveform inversion (FWI) is recognized as a leading data-fitting methodology, leveraging the detailed information contained in physical waveform data to construct accurate, high-resolution velocity models essential for crosshole surveys. Despite its effectiveness, FWI is often challenged by its sensitivity to data quality and inherent nonlinearity, which can lead to instability and the inadvertent incorporation of noise and extraneous data into inversion models. To address these challenges, we introduce the scale-aware edge-preserving FWI (SAEP-FWI) technique, which integrates a cutting-edge nonlinear anisotropic hybrid diffusion (NAHD) filter within the gradient computation process.

Liquid-liquid biopolymers aqueous solution segregative phase separation in food: From fundamentals to applications-A review.

As a result of the spontaneous movement of molecules, liquid-liquid biopolymer segregative phase separation takes place in an aqueous solution. The efficacy of this type of separation can be optimized under conditions where variables such as pH, temperature, and molecular concentrations have minimal impact on its dynamics. Recently, interest in the applications of biopolymers and their segregative phase separation-associated molecular stratification has increased, particularly in the food industry, where these methods permit the purification of specific particles and the embedding of microcapsules.

Clinical characteristics of postoperative necrotizing enterocolitis in patients with congenital jejunoileal atresia and its risk factors.

Objective: To review postoperative necrotizing enterocolitis (NEC) in patients with jejunoileal atresia (JIA) and to explore the potential risk factors related to the concurrence of NEC.

Methods: Patients diagnosed with JIA who received surgical treatment from January 2016 to June 2021 were enrolled. Demographics, viral infection of the fetus, transfusion within 48 hours before NEC, sepsis before JIA repair, pathological and anatomical classification of JIA, combined malformation, occurrence time of NEC after the operation, treatment, and prognosis of patients were analyzed.

A historical controlled study of domestic trastuzumab and pertuzumab in combination with docetaxel for the neoadjuvant treatment of early HER2-positive breast cancer.

Background: HER2-positive molecular breast cancer subtypes are characterized by high aggressiveness and malignancy, and their metastasis and mortality rates are among the highest of all types of breast cancer. The use of anti-HER2-targeted agents in neoadjuvant therapy has significantly improved the prognosis of patients with HER2-positive breast cancer. In this study, we investigated the efficacy and safety of a neoadjuvant Chinese THP regimen (docetaxel, trastuzumab biosimilar TQB211 plus the pertuzumab biosimilar TQB2440 or pertuzumab) for ER/PR-negative and HER2-positive breast cancer in China.