Halogen anion (Cl-, Br-) and alkali metal cation (Cs+, K+, Rb+) synergistic binding behaviors using a belt shaped dual-functional hydrocarbon receptor.

The belt shaped functionalized hydrocarbon receptors have attracted great interest because of their special "frustum-like" configuration, in which the openings at the upper and lower ends (dual-functional sites) are more beneficial when used as ion recognition sites. In this paper, the binding behaviors of the belt shaped dual-functional hydrocarbon receptors for halogen anions (Cl- and Br-) and alkali metal cations (K+, Rb+, and Cs+) were investigated in depth using density functional theory calculations. It is found that anion/cation binding can be enhanced and synergistically regulated by counterion and the corresponding conformational changes of the receptor, which well reflects the electrical complementary matching and mutual reinforcement effects.

Vellus Hair-Inspired Triboelectric Antenna for Approach and Pressure Sensing.

Mimicking the human sensory function of hair tissue for robotic tactile and noncontact perception is significant but remains challenging. In this work, we designed a triboelectric artificial antenna (TAA) with controllable mechanical properties inspired by the structure of human hair to achieve proximity perception and detection of weak pressure. External forces or charged objects can disturb the original spatial electric field generated by space charges in the polymer fibers, leading to changes in the potentials on the electrodes of the triboelectric device.

A Permeable Triboelectric Fiber Mat with 35 V cm Voltage Output for Wearable Wireless Sensing Electronics.

Textile-based triboelectric nanogenerators have emerged as a promising solution for self-powered wearable electronics, owing to their exceptional comfort derived from the inherent flexibility of textiles, coupled with their remarkable capability to efficiently harvest low-frequency energy from human motions. However, one primary challenge lies in how to enhance output and management efficiency without compromising comfort to meet the high-power consumption demands of electronics. Herein, a permeable triboelectric nanogenerator (pTENG) is reported with a voltage output exceeding 35 V cm while maintaining breathability.

De Novo Transcriptome Sequencing Analysis Revealed the Expression Patterns of Genes in Different Organs and the Molecular Basis of Polysaccharide Synthesis in .

Background: (Thunb.) Rchb.f.

Lipin1-dependent transcriptional inactivation of SREBPs contributes to selinexor sensitivity in multiple myeloma.

Selective nuclear export inhibitor selinexor (SEL) represents a promising therapeutic strategy for relapsed/refractory multiple myeloma (RRMM). But its mechanisms of action as well as factors that influence therapeutic responses have not been fully characterized yet. In this study we employed catTFRE proteomics technique to profile changes in nuclear abundance of activated transcription factors (TFs)/co-factors (TCs) in myeloma cells following SEL treatment.

A two-dimensional amorphous VOPO/graphene heterostructure for high-voltage aqueous Zn-ion batteries.

A novel two-dimensional (2D) amorphous VOPO/graphene (A-VOP/G) heterostructure, which features rapid ion diffusion pathways, numerous active sites, high conductivity, and superior stability, serves as a high-voltage cathode for zinc-ion batteries (ZIBs). The A-VOP/G cathode achieves a high-voltage platform (1.50 V) and is stable over 2000 cycles at 5 A g.

Targeting deubiquitinase USP7-mediated stabilization of XPO1 contributes to the anti-myeloma effects of selinexor.

Background: Targeting exportin1 (XPO1) with Selinexor (SEL) is a promising therapeutic strategy for patients with multiple myeloma (MM). However, intrinsic and acquired drug resistance constitute great challenges. SEL has been reported to promote the degradation of XPO1 protein in tumor cells.

Porous Conductive Textiles for Wearable Electronics.

Over the years, researchers have made significant strides in the development of novel flexible/stretchable and conductive materials, enabling the creation of cutting-edge electronic devices for wearable applications. Among these, porous conductive textiles (PCTs) have emerged as an ideal material platform for wearable electronics, owing to their light weight, flexibility, permeability, and wearing comfort. This Review aims to present a comprehensive overview of the progress and state of the art of utilizing PCTs for the design and fabrication of a wide variety of wearable electronic devices and their integrated wearable systems.

Erratum: CircRNA_100395 inhibits cell proliferation and metastasis in ovarian cancer via regulating miR-1228/p53/epithelial-mesenchymal transition (EMT) axis: Erratum.

[This corrects the article DOI: 10.7150/jca.35041.

Whether the green credit policy effectively promote green transition of enterprises in China? Empirical analysis and mechanism verification.

Promoting green and low-carbon development has become the consensus of the policymakers and the academic, with green transformation of enterprises being the top priority. This paper adopts the difference-in-difference model to investigate the effect of green credit policy on green transition in China, by utilizing the "Green Credit Guidelines" (2012 Guidelines) policy as a quasi-natural experiment. Using panel data from publicly listed companies in China, an empirical investigation is conducted, we explain the dependent variable from two dimensions: economic performance and environmental performance, leading to the following results.

How does blockchain technology affect the development of green finance? Theoretical analysis and empirical verification.

Facing the problem of a lack of endogenous incentive mechanisms for the development of green finance, we regard blockchain technology as an institutional technology and elevate it to the height of governance mechanisms. Using a dynamic stochastic general equilibrium (DSGE) model framework, we compare and analyze its effects with traditional supportive policies such as fiscal subsidies. The modeling simulation results show that the blockchain green finance platform model is conducive to better promoting the development of green finance.

C-reactive protein impairs immune response of CD8 T cells via FcγRIIb-p38MAPK-ROS axis in multiple myeloma.

Background: C-reactive protein (CRP) is a prototypical acute phase protein in humans with the function of regulating immune cells. Serum CRP levels are elevated in multiple myeloma (MM), associated with MM cell proliferation and bone destruction. However, its direct effects on T lymphocytes in MM have not been elucidated.

Unravelling the imbalanced Th17-like cell differentiation by single-cell RNA sequencing in multiple myeloma.

Multiple myeloma (MM) is a bone marrow resident hematological malignancy. T helper (Th) cells play an essential role in maladjustment of immune function and promotion of myeloma cell proliferation and survival, which has not been fully elucidated. Here, we compared transcriptome profiles of CD4 T cells in bone marrow samples of 3 healthy individuals and 10 MM patients before and after treatment using single-cell RNA sequencing.

EBV-encoded miRNAs BHRF1-1 and BART2-5p aggravate post- transplant lymphoproliferative disorder via LZTS2-PI3K-AKT axis.

Post-transplant lymphoproliferative disorder (PTLD) is one of the most serious complications after transplantation. Epstein-Barr virus (EBV) is a key pathogenic driver of PTLD. About 80% of PTLD patients are EBV positive.

Single-cell technologies in multiple myeloma: new insights into disease pathogenesis and translational implications.

Multiple myeloma (MM) is a hematological malignancy characterized by clonal proliferation of plasma cells. Although therapeutic advances have been made to improve clinical outcomes and to prolong patients' survival in the past two decades, MM remains largely incurable. Single-cell sequencing (SCS) is a powerful method to dissect the cellular and molecular landscape at single-cell resolution, instead of providing averaged results.

Single-cell RNA sequencing reveals XBP1-SLC38A2 axis as a metabolic regulator in cytotoxic T lymphocytes in multiple myeloma.

The mechanisms underlying the functional impairment and metabolic reprogramming of T lymphocytes in multiple myeloma (MM) have not been fully elucidated. In this study, single-cell RNA sequencing was used to compare gene expression profiles in T cells in bone marrow and peripheral blood of 10 newly diagnosed MM patients versus 3 healthy donors. Unbiased bioinformatics analysis revealed 9 cytotoxic T cell clusters.

Distinct mechanisms of dysfunctional antigen-presenting DCs and monocytes by single-cell sequencing in multiple myeloma.

Multiple myeloma (MM) is an incurable plasma cell malignancy with the hallmark of immunodeficiency, including dysfunction of T cells, NK cells, and APCs. Dysfunctional APCs have been reported to play a key role in promoting MM progression. However, the molecular mechanisms remain elusive.

Dynamic single-cell RNA-seq analysis reveals distinct tumor program associated with microenvironmental remodeling and drug sensitivity in multiple myeloma.

Background: Multiple myeloma (MM) is a hematological malignancy characterized by clonal proliferation of malignant plasma cells. Despite extensive research, molecular mechanisms in MM that drive drug sensitivity and clinic outcome remain elusive.

Results: Single-cell RNA sequencing was applied to study tumor heterogeneity and molecular dynamics in 10 MM individuals before and after 2 cycles of bortezomib-cyclophosphamide-dexamethasone (VCD) treatment, with 3 healthy volunteers as controls.

NLRP3 mediates trophoblastic inflammasome activation and protects against infection during pregnancy.

Background: Intrauterine () infections pose a major threat during pregnancy via affecting placental immune responses. However, the underlying mechanisms of placental defense against this pathogen remain ill-defined. Therefore, this study aims to investigate the function and the mechanism of inflammasomes on against infection during pregnancy.

Laminated Triboelectric Nanogenerator for Enhanced Self-Powered Pressure-Sensing Performance by Charge Regulation.

Triboelectric sensors provide an effective approach to solving the power supply problem for distributed sensing nodes. However, the poor stability and repeatability of the output signal limit its further development due to structural deficiencies and intrinsic working mechanisms. This work proposes a contact-separation mode laminated triboelectric nanogenerator (L-TENG) by introducing multifunctional layers to regulate triboelectric charges.

Rapid generation of genetically engineered T cells for the treatment of virus-related cancers.

Adoptive transfer of T cell receptor (TCR)-engineered T cells targeting viral epitopes represents a promising approach for treating virus-related cancers. However, the efficient identification of epitopes for T cells and the corresponding TCR remains challenging. Here, we report a workflow permitting the rapid generation of human papillomavirus (HPV)-specific TCR-T cells.

A Five-Gene Risk Score Model for Predicting the Prognosis of Multiple Myeloma Patients Based on Gene Expression Profiles.

Multiple myeloma is a heterogeneous plasma cell malignancy that remains incurable because of the tendency of relapse for most patients. Survival outcomes may vary widely due to patient and disease variables; therefore, it is necessary to establish a more accurate prognostic model to improve prognostic precision and guide clinical therapy. Here, we developed a risk score model based on myeloma gene expression profiles from three independent datasets: GSE6477, GSE13591, and GSE24080.

An Integrated Self-Powered Real-Time Pedometer System with Ultrafast Response and High Accuracy.

As accurate step counting is a critical indicator for exercise evaluation in daily life, pedometers give a quantitative prediction of steps and analyze the amount of exercise to regulate the exercise plan. However, the merchandized pedometers still suffer from limited battery life and low accuracy. In this work, an integrated self-powered real-time pedometer system has been demonstrated.

Generation of neoantigen-specific T cells for adoptive cell transfer for treating head and neck squamous cell carcinoma.

Adoptive cell therapy using TCR-engineered T cells (TCR-T cells) represents a promising strategy for treating relapsed and metastatic cancers. We previously established methods to identify neoantigen-specific TCRs based on patients' PBMCs. However, in clinical practice isolation of PBMCs from advanced-stage cancer patients proves to be difficult.

Isotactic-Alternating, Heterotactic-Alternating, and ABAA-Type Sequence-Controlled Copolyester Syntheses via Highly Stereoselective and Regioselective Ring-Opening Polymerization of Cyclic Diesters.

Synthesizing different types of sequence-controlled copolyesters can enrich the diversity of copolyesters and modify their properties more precisely, but it is still a challenge to synthesize a complicated sequence-controlled copolyester using different hydroxy acids in a living polymerization manner. In this work, a highly regioselective and stereoselective catalytic system was developed to synthesize biorenewable and biodegradable copolyesters of mandelic acid and lactic acid with isotactic-alternating, heterotactic-alternating, and ABAA-type precise and complicated sequences. Because of the regular incorporation of mandelic acid into polylactide, these sequence-controlled copolymers of mandelic acid and lactic acid show higher glass-transition temperatures than polylactide and a random copolymer.