Anatomical-Based Diagnosis and Filler Injection Techniques: Nasolabial Folds.

Nasolabial folds significantly impact facial appearance and are a common aesthetic concern. This article reviews anatomic considerations and filler injection techniques for treating these folds, with a focus on the Korean population. The dermal filler used in this study is Maili hyaluronic acid filler (Sinclair Pharma), derived from a novel proprietary manufacturing technology known as OxiFree™ technology (Kylane Laboratoires , Switzerland).

Combination Therapy With Poly D-L Lactic Acid and Autologous Fat Transplantation for Infraorbital Rejuvenation.

Background: Multiple approaches exist for treating infraorbital hollowing, including hyaluronic acid fillers and autologous fat transfer. However, traditional single-modality treatments often present limitations such as the Tyndall effect or unpredictable fat retention rates.

Objective: To evaluate the efficacy and safety of a novel combination therapy using poly-D,L-lactic acid (PDLLA) with autologous fat transplantation for infraorbital rejuvenation.

Interaction between chronotype and ultra-processed food intake on triglyceride-glucose index in Korean adults.

Background/objectives: Chronotype and ultra-processed food (UPF) intake are individually associated with metabolic risk, but their combined effect remains unclear. This study examined the interaction between chronotype and UPF intake in relation to insulin resistance, assessed by the triglyceride-glucose (TyG) index.

Subjects/methods: Data were obtained from 542 adults in the Gangwon Obesity and Metabolic Syndrome (GOMS) Study.

Anatomical Guideline for Retrobulbar Hyaluronidase Injection.

Background: Vision loss following cosmetic filler injections is a rare but devastating complication resulting from inadvertent intravascular embolization, most often affecting the ophthalmic artery. Retrobulbar hyaluronidase injection has been proposed as an emergency intervention, yet anatomical guidelines for its administration remain poorly defined.

Objective: To propose an anatomically informed protocol for safe and effective retrobulbar hyaluronidase injection in cases of filler-induced central retinal artery occlusion.

Correction of Facial Asymmetry Using Dermal Fillers: Understanding the Role of Facial Rotation.

Facial asymmetry is a common challenge in esthetic medicine, requiring a comprehensive understanding of three-dimensional rotation patterns-X, Y, and Z axes-that significantly influence treatment outcomes. Traditional correction methods often overlook these rotational dynamics. This manuscript presents a case study of a 38-year-old Asian male patient with facial asymmetry, treated with hyaluronic acid (HA) fillers using a novel approach incorporating facial rotation concepts.

Toward intelligent 3D food printing: a review on the perspective of materials, fabrication, monitoring, and control.

Three-dimensional food printing (3DFP) involves the creation of edible products by structuring materials using 3D printing technology. 3DFP has garnered significant attention due to its vast potential in the food industry, offering advantages in food customization, precision, creativity, and reducing waste during food production. The key components of 3DFP include food ink materials, fabrication processes, and sensing and control technologies.

Mediodorsal thalamic nucleus mediates resistance to ethanol through Ca3.1 T-type Ca regulation of neural activity.

Thalamocortical activity is known to orchestrate sensory gating and consciousness switching. The precise thalamic regions involved, or the firing patterns related to the unconsciousness, remain unclear. Interestingly, the highly -expressed thalamic T-type calcium currents have been considered as a candidate for the ionic mechanism for the generation of thalamocortically driven change in conscious state.

Hypothetical Role of Multiwavelength Diode Laser (755, 808, and 1064 nm) in Addressing Bony Resorption in Facial Aging: A Clinical Commentary.

Background: Facial aging involves not only soft tissue laxity but also progressive bony resorption, particularly in the maxilla and mandible. Current non-invasive aesthetic modalities primarily target soft tissues, neglecting skeletal changes that contribute to volume loss and structural descent.

Objective: To propose the hypothetical role of multiwavelength diode laser (MWDL) in stimulating osteogenesis via controlled thermal delivery to the periosteum, offering a novel, non-invasive strategy for counteracting facial bone resorption.

The Impact of Primary Disease on Patient Satisfaction in Outpatient Care: A Nationwide Analysis.

Background: Patient satisfaction is a key indicator of health care quality, yet the impact of primary diseases on outpatient satisfaction remains underexplored. This study examined whether the primary disease independently influences patient satisfaction.

Methods: We retrospectively analyzed 8,259 outpatient experience records from clinics (n = 6,347), hospitals (n = 1,374), and tertiary hospitals (n = 538) using data from the 2023 Medical Service Experience Survey in Korea.

Shoulder Aesthetics: A Novel Synergy of Calcium Hydroxylapatite Fillers and Neuromodulators.

Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.

Identification of key factors influencing patient satisfaction for practical prioritization in healthcare settings: a nationwide survey analysis.

Background: Understanding the factors influencing patient satisfaction is essential for improving healthcare services. However, the diverse elements affecting patient satisfaction at medical institutions make it impractical and inefficient to enhance all factors simultaneously. The purpose of this study is to analyze the factors influencing patient satisfaction based on the Patient Experience Survey and to identify key predictors ranked by importance for efficient application in clinical and hospital settings.

Efficacy and safety of epaminurad, a potent hURAT1 inhibitor, in patients with gout: a randomized, placebo-controlled, dose-finding study.

Background: Gout is the most common inflammatory arthritis. Current urate-lowering therapies have limitations, such as adverse drug reactions or limited efficacy. Epaminurad is a novel selective human urate transporter 1 (hURAT1) inhibitor that has been shown to reduce serum urate (sUA) levels in healthy volunteers and patients with gout.

Difficult-to-treat rheumatoid arthritis among elderly patients from the KOBIO registry.

Background: 'Difficult-to-treat (D2T)' rheumatoid arthritis (RA) refers to patients who fail to achieve low disease activity or remission despite multiple biologic or targeted synthetic disease modifying anti-rheumatic drugs (b/tsDMARD) cycles. Elderly RA patients often have higher disease activity and more comorbidities. This study aimed to determine the prevalence of D2T-RA in elderly RA patients treated with b/tsDMARDs and examine their characteristics and treatment outcomes.

Exosome-Based Topical Therapy for Facial Atopic Dermatitis.

Background: Atopic dermatitis (AD) is a chronic inflammatory skin condition that significantly impairs quality of life. Current therapies, including corticosteroids and calcineurin inhibitors, often provide incomplete relief or have undesirable side effects. Exosome-based therapies derived from adipose-derived mesenchymal stem cells (ADMSCs) offer a novel, multifaceted approach to addressing inflammation, skin barrier dysfunction, and pruritus, presenting a promising alternative for AD management.

Advancements in Clinical Utilization of Recombinant Human Collagen: An Extensive Review.

Introduction: Recombinant human collagen, developed through advanced recombinant DNA technology, has emerged as a cutting-edge biomaterial with diverse applications in medicine. It addresses significant limitations of animal-derived collagens, such as immunogenicity and the risk of zoonotic diseases.

Objective: This review evaluates the clinical applications, benefits, and challenges associated with recombinant human collagen, focusing on its potential to transform medical and surgical practices.

Characterising infusion/injection-related reactions in patients with rheumatoid arthritis treated with biologic agents.

Objectives: Biologic disease-modifying anti-rheumatic drugs (bDMARDs) have transformed the management of rheumatoid arthritis (RA), but their efficacy can be limited by infusion/injection-related reactions (IRRs). This study investigated demographic and clinical factors associated with IRRs in patients with RA using data from the Korean College of Rheumatology Biologics & Targeted Therapy (KOBIO) Registry.

Methods: We analysed 1,832 patients with RA, categorising them into IRR and non-IRR groups.

Wide Bandgap Perovskites: A Comprehensive Review of Recent Developments and Innovations.

Recent advances in wide-bandgap (WBG) perovskite solar cells (PSCs) demonstrate a burgeoning potential to significantly enhance photovoltaic efficiencies beyond the Shockley-Queisser limit for single-junction cells. This review explores the multifaceted improvements in WBG PSCs, focusing on novel compositions, halide substitution strategies, and innovative device architectures. The substitution of iodine with bromine and organic ions such as FA and MA with Cs in the perovskite lattice is emphasized for its effectiveness in achieving higher open-circuit voltages and reduced thermalization losses.

Psychotropic Drug Use in Korean Patients With Osteoarthritis.

Background: There are few safe effective ways to relieve osteoarthritis (OA) pain; as a result, off-label psychotropic drug prescriptions have increased worldwide. This study examined the change in psychotropic drug prescriptions for patients with OA from 2011 to 2020 using the Korean National Health Insurance Service dataset.

Methods: The study population consisted of patients with hip or knee OA aged ≥ 65 years.

Differential association between cumulative dose of 5α-reductase inhibitors and mortality.

The association between various cumulative doses of 5-ARIs and mortality remains unclear. To examine the absolute and time-averaged cumulative doses of 5-ARIs and their association with all-cause and cause-specific mortality among patients with benign prostatic hyperplasia (BPH) or androgenic alopecia (AGA). A nested case-control study was conducted.

Analysis of Electron-Induced Chemical Transformations in Vapor-Phase-Synthesized Al-Based Inorganic-Organic Hybrid Thin Films for EUV Resist Platform.

The rapid advancement and stringent requirements of extreme ultraviolet (EUV) lithography technology necessitate the development of advanced photoresist systems for next-generation microelectronics. Recent studies have demonstrated that inorganic-based hybrid photoresists offer notable improvements in EUV sensitivity, etch resistance, and greater insusceptibility to pattern collapse compared to their purely organic counterparts. However, variations in the synthesis/coating approaches and chemistry of inorganic-organic photoresists can result in distinct exposure mechanisms.

The future of neurotechnology: From big data to translation.

Advances in neurotechnologies, including molecular tools, neural sensors, and large-scale recording, are transforming neuroscience and generating vast datasets. A recent meeting highlighted the resulting challenges in global collaboration, data management, and effective translation, emphasizing the need for innovative strategies to harness big data for diagnosing and treating brain disorders.

Effect of La and Si additives in Zr-doped HfO capacitors for pseudo-linear high-κ dielectric applications.

This study investigates the impact of dopants on HfZrO-based capacitors for high-performance, hysteresis-free dielectric applications. Control of the crystalline structure of HfZrO films is crucial for achieving superior dielectric properties. The tetragonal (t) phase of HfZrO exhibits anti-ferroelectric (AFE) characteristics and shows promise due to its high dielectric constant (κ).

Chromosome-level genome assembly and improved annotation of onion genome (Allium cepa L.).

Onion (Allium cepa L.) is an economically valuable crop, but its large, repeat-enriched genome makes genome assembly difficult and limits molecular breeding and biological studies. Herein, we present a chromosomal-level reference genome assembly of the double-haploid onion line DHW30006, constructed by combining PacBio, Illumina, and Hi-C sequencing approaches.