A Trailblazing Quenching Strategy for Simultaneous LiF Formation at Surface and Intergranular Interfaces for Enhanced Stability of High-Ni NCM Cathodes.

Water-washing effectively removes surface residual lithium from high-Ni LiNiCoMnO (NCM) cathodes; however, it inevitably degrades the electrochemical performance. To address this issue, integrated strategies targeting the conversion of surface residual lithium into artificial coating layers on high-Ni NCM cathodes have been proposed; however, these require further processing, thus hindering their industrial application. This study proposes a trailblazing strategy for directly converting residual lithium into a LiF layer simultaneously formed on both the surface of secondary particles and the interfaces between the primary particles of high-Ni NCM, without requiring further processing.

Short-term effects of oral dissolving film on halitosis and oral pathogenic bacteria: a pilot non-randomized controlled trial.

Introduction: Halitosis is a major issue that negatively affects individuals' social interactions and quality of life. This study aimed to evaluate the effects of oral dissolving film (ODF) on halitosis and oral pathogenic bacteria.

Objective: To compare and evaluate the effects of ODF and tongue cleaner on reducing halitosis-related compound concentrations and oral pathogenic bacteria.

Comprehensive analysis of patients with rheumatoid arthritis associated interstitial lung disease.

Background/aims: To investigate the demographics, disease characteristics, and treatment modalities of patients with rheumatoid arthritis (RA) associated interstitial lung disease (ILD), focusing on ILD exacerbation and mortality.

Methods: This retrospective study included individuals aged ≥ 18 years diagnosed with RA-ILD at Ajou University Hospital from January 1999 to March 2022. Diagnosis was based on chest computed tomography (CT) scans; progression was monitored based on available follow-up pulmonary function tests (PFTs) and chest CTs.

Clinicopathological Factors Influencing PD-L1 Expression and The Effect of Immune Checkpoint Inhibitors on Survival Outcomes in Patients with Gastric Cancer Depending on Sex in a Tertiary Hospital in South Korea.

Purpose: Programmed cell death ligand-1 (PD-L1) negatively regulates T-cell activation, and exhibits sex-based differences in expression and immune responses. This study investigated sex-related differences in clinicopathological factors influencing PD-L1 expression and the effect of immune checkpoint inhibitors (ICIs) on survival in gastric cancer (GC) patients in South Korea.

Materials And Methods: We analyzed a prospective cohort of 468 GC patients who underwent PD-L1 immunohistochemistry.

Morphological and Phylogenetic Characterization of Endophytic Fungi Isolated from Brown Algae (Phaeophyceae) in Korea.

Seaweed-associated endophytic fungi have recently attracted considerable attention due to their ecological significance and potential application as biological resources. Accordingly, research efforts to isolate and characterize fungal endophytes from marine macroalgae have accelerated. This study aimed to isolate and identify endophytic fungi from two brown algae, and , collected from intertidal zones in Tongyeong and Pohang, Korea.

Pediatric Emergency Transfers Following Virtual Urgent Care Visits.

Objectives: Telemedicine use has surged since the COVID-19 pandemic, offering patients access to remote health care and the potential to reduce nonemergent emergency department (ED) visits. This study aims to describe postpandemic virtual urgent care (VUC) utilization, including VUC-to-ED referral rates and outcomes in children.

Methods: We performed a retrospective cohort study of patients under 21 years presenting to the ED within 72 hours following a VUC visit from March 1, 2021, through February 28, 2023, using the electronic medical record.

Estradiol rescues male hydroxyl radical-mediated Charcot-Marie-Tooth 2Z by Morc2a stabilization through autophagy inhibition in a murine model.

Charcot-Marie-Tooth disease type 2Z (CMT2Z) is an inherited axonal neuropathy caused by haploinsufficiency of microrchidia CW-type zinc finger protein 2 (MORC2), which leads to elevated hydroxyl radical levels, reduced ATPase activity, and apoptosis-mediated neuromuscular degeneration. CMT2Z presents with severe clinical manifestations, yet no widely applicable and affordable treatment has been developed. While gene therapy presents a theoretical solution, its feasibility remains constrained by prohibitive costs and delivery challenges.

Surgical treatment of first branchial cleft anomalies using retrograde facial nerve dissection technique.

Purpose: First branchial cleft anomalies (FBCAs) are infrequent congenital malformations. In FBCAs removal surgery, due to the previous infection history and the anatomical proximity of the FBCAs tract to the facial nerve, postoperative recurrence and facial paralysis are not uncommon. This study aimed to assess the clinical feasibility and outcomes of FBCAs resection using the retrograde facial nerve dissection technique.

Ethanol Extract Attenuates Muscle Loss and Body Fat Reduction in Sarcopenic Obesity by Regulating AMPK in High-Fat Diet-Induced Obese Mice.

Sarcopenic obesity, characterized by the concurrent presence of sarcopenia and obesity, presents a complex challenge due to the synergistic detrimental effects of muscle loss and excess body fat. This study investigated the potential of (SV) supplementation for mitigating the impact of sarcopenic obesity on diet-induced obese mice. Mice in the study were divided into groups and fed a normal diet, a high-fat diet (HFD), or an HFD supplemented with 0.

The index endoscopic characteristics associated with gastric neoplasms in serial screening of upper gastrointestinal endoscopy.

Background: Although biennial upper gastrointestinal endoscopy is recommended for gastric cancer screening in Korea, data regarding the endoscopic characteristics associated with the diagnosis of gastric neoplasms in serial endoscopic screening are limited. We aimed to evaluate the index endoscopic characteristics associated with the diagnosis of gastric neoplasms and adequate gastric cancer screening interval.

Methods: We retrospectively reviewed cases of the patients diagnosed with gastric neoplasms, who showed no evidence of gastric neoplasms on index endoscopy between October 2005 and December 2022.

Pharmacological Treatment of Gastritis: A Narrative Review with a Systematic Literature Search.

Gastritis, characterized by gastric mucosal inflammation, is a common gastrointestinal disorder with diverse etiologies, such as infection, nonsteroidal anti-inflammatory drugs use, and autoimmune conditions. Pharmacological treatment aims primarily to heal the mucosa and resolve symptoms, and such treatments include mucoprotective agents, histamine-2 receptor antagonists (H2RAs), proton pump inhibitors (PPIs), and potassium-competitive acid blockers (P-CABs). Mucoprotective agents enhance gastric mucosal protection through multiple mechanisms, such as by promoting mucosal regeneration, reducing inflammation, and mitigating oxidative stress.

Comparative Effectiveness of Anbalcabtagene Autoleucel versus Tisagenlecleucel in Patients with Relapsed/Refractory Diffuse Large B-cell Lymphoma.

Purpose: Anbalcabtagene autoleucel (anbal-cel) is a second-generation CD19-targeted chimeric antigen receptor-T cell therapy reducing T-cell exhaustion through PD-1 and TIGIT downregulation. We compared efficacy of anbal-cel with tisagenlecleucel (tisa-cel) in relapsed/refractory diffuse large B-cell lymphoma using external control arm study design.

Materials And Methods: We performed a matching-adjusted indirect comparison (MAIC) using individual patient data from CRC01-01 (NCT#04836507) and aggregate data from JULIET trial (NCT#02445248).

Impact of post-warming culture duration and blastocyst morphology on reproductive outcomes in vitrified-warmed cycles: A retrospective cohort study.

Aim: The use of vitrified-warmed blastocyst transfer (VBT) cycles has increased significantly. This study aimed to investigate the effects of the post-warming culture duration and blastocyst morphology on clinical outcomes in VBT cycles.

Methods: We conducted a retrospective cohort study of 1551 VBT cycles.

Prevalence and thrombotic risk of SGLT-2 inhibitor-associated erythrocytosis: a retrospective cohort study.

Background: Sodium-glucose cotransporter 2 (SGLT-2) inhibitors, widely used for type 2 diabetes and cardiorenal conditions, may induce erythrocytosis, potentially increasing cardiovascular risk. This study investigates its prevalence, risk factors, and thrombotic implications.

Methods: In a single-center retrospective study, we analyzed 6787 patients prescribed SGLT-2 inhibitors (2014-2024).

Structural and functional insights of AmpG in muropeptide transport and multiple β-lactam antibiotics resistance.

Anhydromuropeptide permease (AmpG) is a transporter protein located in the inner membrane of certain gram -negative bacteria, involved in peptidoglycan (PG) recycling and β-lactamase induction. Decreased AmpG function reduces resistance of antibiotic-resistant bacteria to β-lactam antibiotics. Therefore, AmpG-targeting inhibitors are promising 'antibiotic adjuvants'.

Highly ordered clustering of TNFα and BAFF ligand-receptor-intracellular adaptor complexes on a lipid membrane.

The TNF family plays a critical role in immune regulation. Here, we present high-resolution structures of clusters formed by two TNF receptor family proteins, TNFR1 and BAFFR. Using a lipid monolayer method to mimic their membrane-bound state, we observe that the TNFα-TNFR1 complex forms highly ordered clusters of trimers on the lipid membrane.

Hybrid epoxy-acrylate resins for wavelength-selective multimaterial 3D printing.

Structures in nature combine hard and soft materials in precise three-dimensional (3D) arrangements, imbuing bulk properties and functionalities that remain elusive to mimic synthetically. However, the potential for biomimetic analogues to seamlessly interface hard materials with soft interfaces has driven the demand for innovative chemistries and manufacturing approaches. Here, we report a liquid resin for rapid, high-resolution digital light processing (DLP) 3D printing of multimaterial objects with an unprecedented combination of strength, elasticity and resistance to ageing.

Comparative analysis of osteoporotic versus pathologic fracture in metastatic colorectal cancer patients.

Unlabelled: In metastatic colorectal cancer (mCRC) patients, the incidence rate of osteoporotic fracture (OF) was comparable to that of pathologic fracture (4.5% vs 4.2% over 2 years), and even higher in those aged ≥ 70.

Multicolor Digital Light Processing 3D Printing Enables Dissolvable Supports for Freestanding and Non-Assembly Structures.

The limited diversity in photocurable resin chemistries has precluded access to certain geometries using digital light processing (DLP) 3D printing, a rapid, precise, economical, and low-waste manufacturing technology. Specifically, freestanding structures with floating overhangs (e.g.

Single-port hairline approach thyroidectomy (SPHAT) in male patients: a retrospective analysis of cosmetic and surgical outcomes.

Background: While the concern for visible scars might traditionally be associated more with female patients, male patients are increasingly valuing cosmetic outcomes in surgical procedures. A single port robot thyroidectomy using only a hairline approach is feasible in female patients. The purpose of this study is to investigate the safety, utility, and cosmetic outcomes of single port hairline approach thyroidectomy (SPHAT), emphasizing its ability to minimize visible scarring in male patients.

Uncovering Putative Causal Non-Coding RNAs in Acute and Chronic Myeloid Leukemia: A Genome-Wide Mendelian Randomization Study.

Purpose: Although non-coding RNAs (ncRNAs) have often been implicated in various cancers, their causal roles in acute (AML) and chronic myeloid leukemia (CML) remain unclear. Here, we conducted a genome-wide two-sample Mendelian randomization (MR) study to investigate the causal effects of a comprehensive set of ncRNAs on AML and CML.

Materials And Methods: We used summary statistics of blood expression quantitative trait loci (eQTL) from the eQTLGen consortium (31,684 European participants) as exposure data.

A real-world comparison of subcutaneous to intravenous administration of infliximab in patients with inflammatory bowel disease.

Background/aims: We compared intravenous and subcutaneous infliximab (IFX) as treatment for inflammatory bowel disease (IBD).

Methods: This retrospective, multicenter, observational study enrolled patients treated with either intravenous or subcutaneous IFX. Sequential parameters were compared at baseline, 6 months, and 12 months following the initiation of treatment with either type of IFX.

Early growth response 1 as a key regulator of PD-L1 expression and immune evasion in extranodal NK/T-cell lymphoma.

This study investigates the role of Early Growth Response 1 (EGR1) in extranodal natural killer/T-cell lymphoma (ENKTL) and its correlation with PD-L1 expression. Analysis of 62 ENKTL patient samples revealed that high EGR1 expression was linked to PD-L1 positivity, the immune evasion-A subtype, and early-stage disease. Although EGR1 expression was not an independent prognostic factor for overall survival, patients with higher EGR1 levels showed a trend toward better outcomes.

Successful Endoscopic Vacuum-Assisted Closure Therapy for Esophageal Perforation: A Case Report.

Esophageal perforation can lead to serious complications, and rapid diagnosis and treatment significantly affect the prognosis. Endoscopic vacuum-assisted closure (EndoVAC) therapy is widely accepted as a safe, well-tolerated, effective, versatile and practical procedure for the management of esophageal perforation in selected patients. We report the successful use of EndoVAC therapy for management of an esophageal perforation secondary to foreign body removal.