Intravascular Imaging-Guided PCI vs Coronary Artery Bypass Grafting for Left Main or 3-Vessel Disease.

Background: Previous trials have shown that coronary artery bypass graft (CABG) has better clinical outcomes compared with percutaneous coronary intervention (PCI) for patients with left main coronary artery or 3-vessel disease. However, it is unclear whether intravascular imaging (IVI)-guided PCI would reduce the difference in clinical events compared to CABG.

Objectives: The present study sought to compare the clinical outcomes of patients with left main or 3-vessel disease who underwent IVI-guided PCI with those who underwent CABG.

Effectiveness of Ethanol Extract of Rosa rugosa Thunb. on Ear Edema.

This study investigated the anti-inflammatory and skin barrier-restoring effects of a 50% ethanol extract of Rosa rugosa Thunb. (RT50) using both in vitro and in vivo models, including HaCaT keratinocytes and a 1-Chloro-2,4-dinitrobenzene (DNCB)-induced ear edema mouse model. The aim was to evaluate the potential efficacy of RT50 in treating hypersensitivity-related skin conditions, such as atopic and contact dermatitis, and to explore natural therapeutic alternatives with fewer side effects for managing inflammatory skin diseases.

Controlling gene expression through five zinc finger domains of ZNF18.

Zinc finger (ZF) proteins are the most abundant transcription factors in vertebrates, and they regulate gene expression through interactions with cis-acting elements. ZF domains selectively recognize specific sequences to accelerate or repress target genes. Zinc finger protein 18 (ZNF18) contains five CXCXHXH-type ZFs at the C-terminus, which are expressed in the brain and other organs of the biological system.

T-CLASS: An Online Tool for the Identification and Classification of Aging and Senescence Using Transcriptome Data.

Transcriptome analysis has become increasingly utilized in aging research. However, the identification of the key molecular changes underlying aging processes and longevity-promoting regimens from transcriptome data remains challenging. Here, we present Transcriptomic CLassification via Adaptive learning of Signature States (T-CLASS), an online tool that identifies, from transcriptome data, gene sets of several hundred genes that provide an optimal representation of longevity and aging paradigms.

Topic Modeling Analysis of Children's Food Safety Management Using BigKinds News Big Data: Comparing the Implementation Times of the Comprehensive Plan for Children's Dietary Safety Management.

As digital technologies and food environments evolve, ensuring children's food safety has become a pressing public health priority. This study examines how the policy discourse on children's dietary safety in Korea has shifted over time by applying Latent Dirichlet Allocation (LDA) topic modeling to news articles from 2010 to 2024. Using a large-scale news database (BigKinds), the analysis identifies seven key themes that have emerged across five phases of the national Comprehensive Plans for Safety Management of Children's Dietary Life.

Pelota-mediated ribosome-associated quality control counteracts aging and age-associated pathologies across species.

Ribosome-associated quality control (RQC) is a pivotal biological process that governs the fidelity of messenger RNA (mRNA) homeostasis and protein synthesis. Defects in RQC are implicated in cellular dysfunction and proteotoxicity, but their impact on aging remains elusive. Here, we show that Pelota, the ribosome rescue factor, promotes longevity and protects against age-related pathological phenotypes in multiple metazoan species.

Roles of RNA modifications in aging and age-related diseases.

RNA modifications are key epigenetic alterations that play regulatory functions in RNA biology, including RNA stability and translation. Emerging evidence indicates that RNA modification is crucial for various physiological and pathological processes, including aging. This review describes functions of key RNA modifications, including N6-methyladenosine (m6A), 5-methylcytosine (m5C), N7-methylguanosine (m7G), 2'-O-methylation (Nm), N1-methyladenosine (m1A), adenosine-to-inosine (A-to-I) RNA editing, pseudouridylation (ψ), and N4-acetylcytidine (ac4C), highlighting their roles in aging and age-associated diseases.

Remnant Preservation Improves 10-Year Graft Survival and Rotational Stability in Anatomic Single-Bundle Hamstring Anterior Cruciate Ligament Reconstruction.

Purpose: To compare clinical outcomes and survival rates of isolated anterior cruciate ligament reconstruction (ACLR) with versus without remnant preservation using hamstring autografts at a minimum 10-year follow-up.

Methods: We retrospectively reviewed unilateral isolated ACLRs with hamstring autografts performed between 2005 and 2012. Inclusion criteria were primary anterior cruciate ligament rupture, single-bundle 4-strand hamstring autograft, and a minimum 10-year follow-up.

Diagnosis, treatment and prognosis of simple hepatic cyst: Clinical practice guideline.

Simple hepatic cysts are now diagnosed in over 8,000 individuals annually in South Korea, largely due to the widespread adoption of medical check-ups and advancements in imaging techniques. However, no appropriate clinical practice guideline has been established to address this condition. While international guidelines have recently been published, differences in clinical and epidemiological contexts have highlighted the need for a tailored guideline to assist domestic clinicians.

Brief guide to Caenorhabditis elegans imaging and quantification.

Caenorhabditis elegans is a powerful model organism for fluorescence imaging to study gene regulation and cellular biomarkers. This concise MiniResource introduces essential imaging techniques for live and fixed C. elegans, sample preparations, microscopy, and common applications.

Harnessing Antioxidant Properties of Plant-Derived Bioactive Compounds to Alleviate Atopic Dermatitis Symptoms: A Review.

Atopic dermatitis (AD) is a common chronic inflammatory skin disorder affecting both children and adults, characterized by intense itching, erythema, and xerosis. The pathogenesis of AD is multifactorial, involving genetic predisposition, immune dysregulation, skin barrier dysfunction, and environmental factors. A growing body of evidence suggests that oxidative stress plays a critical role in AD, contributing to chronic inflammation, immune cell activation, and skin barrier disruption.

Gender Differences in Ultra-Processed Food Consumption and Its Association with Obesity Among Korean Adults.

Background/objectives: This study aimed to examine the association between ultra-processed food (UPF) consumption and obesity in Korean adults.

Methods: Data from the 2019 to 2021 Korea National Health and Nutrition Examination Survey were analyzed. Dietary intake and UPF consumption were assessed using the NOVA food classification based on 24 h recall data from 9662 participants (aged 19-64 years).

Regulation of carcinogenesis through multiple zinc fingers in ZBTB20.

Zinc finger (ZF) proteins regulate transcription by interacting with -acting elements for gene expression in response to stimuli within physiological systems. Bioinformatic studies have proposed that zinc finger and BTB (Broad complex, Tramtrack, Bric-à-brac) domain-containing protein 20 (ZBTB20) acts as a key regulator of crucial genes associated with carcinogenesis. However, biochemical experiments using purified proteins remain unreported.

Mesenchymal stem cells enhance selective ER-phagy to promote α-synuclein clearance in Parkinson's disease.

Ample evidence suggests that α-synuclein (αSyn) accumulation in the endoplasmic reticulum (ER) leads to ER stress, resulting in neurodegeneration in Parkinson's disease (PD). Selective degradation of accumulated αSyn through ER-phagy can alleviate ER stress and rescue neurodegeneration. In the present study, we investigated whether mesenchymal stem cells (MSCs) exert neuroprotective effects against PD by modulating ER-phagy.

Brief guide to gene cloning.

Analysis and manipulation of DNA is fundamental to understand gene function and expression. Gene cloning is a routine and versatile technique for molecular biology, allowing isolation, amplification, and production of recombinant DNA molecules. Here, we provide an overall process, various types, and applications of gene cloning.

Brief guide to Caenorhabditis elegans survival assays.

Caenorhabditis elegans is a versatile model organism widely used in survival assays to investigate aging, stress resistance, and pathogen infection. Here, we report an overview of survival assays using C. elegans, focusing on assay types, commonly used reagents, and notable analysis platforms.

Brief guide to assays for measuring health parameters using Caenorhabditis elegans.

Assessing health parameters is essential for understanding the decline of physiological functions during aging. The nematode Caenorhabditis elegans serves as a powerful model in aging research. This paper introduces representative methods for evaluating health parameters using C.

Bioengineered Approaches for Esophageal Regeneration: Advancing Esophageal Cancer Therapy.

Esophageal cancer (EC) is the eighth leading cause of cancer-related deaths globally, largely due to its late-stage diagnosis and aggressive progression. Esophagectomy remains the primary treatment, typically requiring organ-based reconstruction techniques such as gastric pull-up or colonic interposition. However, these reconstruction methods often lead to severe complications, significantly reducing the quality of life of patients.

Functional Characterization and Heterogeneity Analysis of Ribosomal Proteins in Mouse Preimplantation Embryos.

Translational control is important during the mammalian preimplantation phase, when maternal RNAs and proteins are degraded and de novo synthesis of RNAs and proteins increases. Proteins are synthesized in ribosomes, which are assembled from ~82 ribosomal proteins (RPs). The function of ribosomes varies depending on the resident RPs, suggesting that ribosome heterogeneity can lead to functional specialization.

Integrated Hygiene Control Strategies in Food Manufacturing: Technologies, Regulations, and Socioeconomic Impacts.

In the food manufacturing sector, maintaining industry standards and ensuring consumer health rely fundamentally on the quality and safety of the products. To achieve these objectives, hygiene and environmental control procedures are essential for preserving product integrity and minimizing the risk of contamination. Hygiene practices encompass strict sanitation guidelines, such as regular and thorough hand washing, meticulous equipment sterilization, and stringent requirements for the personal cleanliness of food handlers.

Re-do laparoscopic common bile duct exploration for recurrent common bile duct stones: a single-center retrospective cohort study.

Purpose: Common bile duct (CBD) stone recurrence after laparoscopic CBD exploration (LCBDE) is relatively common. No studies have been conducted evaluating the safety and feasibility of re-do LCBDE in the treatment of recurrent CBD stones.

Methods: This single-center retrospective study reviewed 340 consecutive patients who underwent LCBDE for CBD stones between January 2004 and December 2020.

Microglia-driven inflammation induces progressive tauopathies and synucleinopathies.

Alzheimer's disease and Parkinson's disease are characterized by distinct types of abnormal protein aggregates within neurons. These aggregates are known as neurofibrillary tangles and Lewy bodies, which consist of tau and α-synuclein, respectively. As the diseases progress, these aggregates spread from one cell to another, causing protein pathology to affect broader regions of the brain.

Comparative Efficacy of High-Dose Rosuvastatin and Atorvastatin in Preventing Cystatin C-Oriented Contrast-Induced Nephropathy in Patients With Acute Myocardial Infarction: RACCOON-AMI Registry.

Background: Prevention of contrast-induced nephropathy (CIN) is crucial in acute myocardial infarction (AMI) patients undergoing coronary interventions. Previous studies suggest that high-dose statins may aid in CIN prevention, yet comparative studies among different statin types using cystatin C (cysC) as a biomarker for CIN are absent. This study evaluated the effectiveness of high-dose rosuvastatin versus atorvastatin in preventing cysC-based CIN (cysC-CIN) in AMI patients.