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Gastrodin alleviates mitochondrial energy metabolism dysfunction via activating β-catenin/c-Myc/MCT2 signaling in Alzheimer's disease models.
J Ethnopharmacol
September 2025
Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou Province, China. Electronic address:
Ethnopharmacological Relevance: Gastrodia elata, also known as Chijian, belongs to the Orchidaceae family of plants. The "Compendium of Materia Medica" records that Gastrodia elata treats "confused speech, excessive fear, and loss of willpower". Gastrodin (GAS) is the main bioactive component of Gastrodia elata.
View Article and Find Full Text PDFCannabidiol dampens propagation of hippocampal hyperactivity and differentially modulates feedforward and feedback inhibition.
bioRxiv
August 2025
Department of Neuroscience and Physiology.
Cannabidiol (CBD) decreases seizures in patients with severe pediatric-onset epilepsies including Dravet, Lennox-Gastaut, and Tuberous Sclerosis syndromes. However, the effects of CBD on neuronal activity and circuits remain obscure. In the mouse hippocampus, we found that CBD causes a GPR55-independent decrease in CA1 pyramidal neuron firing frequency and a GPR55-dependent reduction in CA3 to CA1 hippocampal activity propagation.
View Article and Find Full Text PDFDose-Dependent Dual Effect of the Endozepine ODN on Neuronal Spiking Activity.
Brain Sci
August 2025
Univ Rouen Normandie, Inserm, Normandie Univ, NORDIC UMR 1239, F-76000 Rouen, France.
Background/objectives: Endozepines known as the endogenous ligands of benzodiazepine-binding sites, include the diazepam binding inhibitor (DBI) and its processing products, the triakontatetraneuropeptide (TTN) and the octadecaneuropeptide (ODN). Despite indisputable evidence of the binding of ODN on GABAR-BZ-binding sites, their action on this receptor lacks compelling electrophysiological observations, with some studies reporting that ODN acts as a negative allosteric modulator (NAM) of GABAR while others suggest the opposite (positive allosteric modulation, PAM effect). All these studies were carried out in vitro with various neuronal cell types.
View Article and Find Full Text PDFChloride/Bicarbonate Exchange Adversely Modifies Cardiovascular Responses to Traumatic Brain Injury.
Am J Physiol Heart Circ Physiol
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Wayne State University, Detroit, MI.
Physical trauma, psychosocial stress, and oxidative stress increase the neuronal transcription of genes encoding the sodium-potassium chloride cotransporter (Nkcc1, Slc12a2) and the potassium chloride cotransporter (Kcc2, Slc12a5), which leads to neuronal depolarization and excitability. We hypothesized that increases in the Nkcc1:Kcc2 ratio of gene transcription in these injuries would be countered with downregulation of the gene encoding the cardiac and neuronal isoform of the chloride/bicarbonate exchanger (Ae3, Slc4a3). We found a reflex decrease in cardiac and neuronal Ae3 transcription that was associated with diminished TBI-induced increases in systolic blood pressure and decrements in heart rate and PTSD-induced anxiety.
View Article and Find Full Text PDFAssociation between antidiabetic drug targets and psychiatric disorders.
Schizophrenia (Heidelb)
August 2025
Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China.
Psychiatric disorders present a significant global health burden with limited effective medications. Observing the widespread comorbidities between diabetes and psychiatric disorders, we explored the potential of repurposing antidiabetic drug targets for psychiatric treatments. We identified 32 target genes of 60 antidiabetics and performed Mendelian randomization analyses using expression and protein quantitative trait loci data from brain tissues alongside summary data for seven psychiatric disorders.
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