Brief guide to assays for measuring health parameters using Caenorhabditis elegans.

Mol Cells

Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, South Korea. Electronic address:

Published: August 2025


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Article Abstract

Assessing health parameters is essential for understanding the decline of physiological functions during aging. The nematode Caenorhabditis elegans serves as a powerful model in aging research. This paper introduces representative methods for evaluating health parameters using C. elegans and provides quantitative indicators of functional declines during aging. This manuscript will be useful for researchers unfamiliar with healthspan studies using C. elegans and may help perform physiological experiments for healthy aging.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206147PMC
http://dx.doi.org/10.1016/j.mocell.2025.100233DOI Listing

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