Network Analysis of Problematic Internet Use and Adolescent Psychological Issues: The Role of Socioeconomic Status.

This study examined the interplay between anxiety, depression, rumination, and problematic internet use (PIU) among 24,470 Chinese adolescents (mean age = 14.37 years; 51.60 percent male), with particular attention to socioeconomic status (SES) variations.

Macrophage DGK-mediated phosphatidic acid remodeling aggravates acute liver failure.

Acute liver failure (ALF) is a life-threatening condition associated with macrophage-mediated inflammatory responses. Effective therapies and drugs are still lacking to date. Here, we reveal that a derivative of xanthohumol, CAM12203, alleviates lipopolysaccharide (LPS) + d-galactosamine (D-GalN)-induced ALF through limiting macrophage-mediated inflammation, with the most significant impact on interleukin-1 (IL-1) transcription.

The downregulation of hormone-sensitive lipase and dysregulation of cholesterol receptors/transporter affect testicular lipid homeostasis and function in HFD-induced oligoasthenospermia mice.

Background: Obesity-induced oligoasthenospermia is associated with testicular lipid metabolism. However, the mechanisms underlying the lipid homeostasis imbalance of obesity-induced oligoasthenospermia are unclear.

Methods: Male C57BL/6 mice fed a high-fat diet were established for the in vivo model.

Zhuling Yanzong formula ameliorates obesity-induced oligoasthenozoospermia via regulating HSL/StAR and HSL/TIMP-1.

Ethnopharmacological Relevance: Zhuling Yanzong Formula (ZLYZF) is composed of Jiawei Buzhong Yiqi Decoction (Fuqingzhu Nvke) and Wuzi Yanzong Pill (Shesheng Zhongmiao Fang). Jiawei Buzhong Yiqi Decoction has been utilized in medical practice for thousands of years in China for treating obesity-related infertility. Wuzi Yanzong Pill is a famous prescription for male infertility.

Discovery of Novel Tridentate Alkenyl Diacid Derivatives as Potent ATP Citrate Lyase Inhibitors for the Treatment of Hepatocellular Carcinoma.

Metabolic reprogramming is a hallmark of hepatocellular carcinoma (HCC), with enhanced lipogenesis playing a critical role in tumor progression. ATP citrate lyase (ACLY), linking carbohydrate metabolism to lipid biosynthesis, has emerged as a promising therapeutic target in HCC. Herein, we report the development of a series of novel tridentate alkenyl diacid derivatives as potent ACLY inhibitors.

The impact of social support on the improvement of positive coping styles among disadvantaged breadwinner mothers.

This study examines how social support boosts positive coping styles in disadvantaged breadwinner mothers in a Chinese province. We analyzed data from 380 program beneficiaries using hypothesis testing and stepwise regression. Results indicate that mothers' perceptions and evaluations of social support enhance their coping abilities and foster social trust, leading to improved coping styles.

Amplifying Anti-Tumor Immune Responses via Mitochondria-Targeting Near-Infrared Photodynamic Therapy.

Pro-inflammatory photodynamic therapy (PDT) holds immense potential to ignite robust and long-lasting systemic anti-tumor immune responses. However, the limited penetration depth of conventional ultra violet (UV)-visible irradiation and the tumor hypoxia microenvironment significantly constrain the efficacy of immune-regulatory PDT. Here, a mitochondria-targeting enhanced nanoplatform (NZ) is reported, activated by near-infrared (NIR) light-driven PDT, to address these challenges and amplify systemic anti-tumor immunity.

Elucidating the Mechanisms of DEHP-Induced Insulin Resistance: A Comprehensive Network Toxicology and In Vitro Approach.

Di (2-ethylhexyl) phthalate (DEHP) is an environmental endocrine disruptor that can induce insulin resistance (IR), a risk factor for type 2 diabetes. This study explored the molecular mechanism of DEHP-induced IR by network toxicology and cellular experiments. We identified eight core targets (CASP3, CTNNB1, TNF, ITGB1, PRKCA, ACE2, EGFR, NCOR2), and AGE-RAGE signaling pathway, insulin resistance, lipid and atherosclerosis, cell adhesion, PI3K-Akt and other key signaling pathways related to IR.

Overlap of Takayasu Arteritis and Kawasaki Disease in Infants.

Echocardiography showed the myocardial ischemia presentation of an 8-month-old boy.

Frontier advances in molecular dynamics simulations for the design and optimization of oil-displacement polymers.

This comprehensive review paper delves into the application and recent advancements of molecular dynamics (MD) simulation techniques in the design and optimization of polymers for oil displacement. Initially, the paper outlines the pivotal role of polymers in oil displacement, particularly highlighting the challenges associated with their stability and rheological property optimization under high-temperature and high-salinity conditions. Subsequently, it meticulously introduces the theoretical foundation of MD simulations, the selection of simulation parameters, and the emerging trends in the integration of machine learning with MD simulations.

Dehydrogenated and Aromatized ent-Cleistanthane Diterpenoids From the Roots of Glochidion philippicum.

The first comprehensive phytochemical investigation of Glochidion philippicum roots resulted in the isolation and characterization of seven new ent-cleistanthane-type diterpenoids, glochiphenols A-G (1-7), along with two known analogs (8 and 9). Compounds 1-6 all feature a rare alkynyl group, with 1-3 representing highly aromatized 20-nor-ent-cleistanthane diterpenoids. Their structures were elucidated by comprehensive spectroscopic analysis, and absolute configurations were established via electronic circular dichroism (ECD) calculations.

Evaluation and application of andrographolide against largemouth bass ranavirus.

It is well-established that Largemouth bass ranavirus (LMBRaV) induces viral ulcerative syndrome, a highly transmissible and lethal viral disease afflicting largemouth bass aquaculture. Given the urgent need for available prevention and control methods, this study evaluated the antiviral activities of fifteen naturally occurring compounds derived from herbal medicines against LMBRaV using an in vitro cell model. Andrographolide (Andro) was one of the substances that was evaluated and showed highly effective anti-LMBRaV activity of a 99.

Association of Increased SOAT2 Expression with Abnormal Cholesterol Esterification and Testosterone Deficiency in Late-Onset Hypogonadism Rats.

Background: Late-Onset Hypogonadism (LOH) is a prevalent age-related condition in men, characterized by a decline in testosterone (T) and associated symptoms.

Objective: This study explored the mechanism of T deficiency in LOH.

Methods: Male SD rats were raised until 20 months of age in order to establish the LOH models.

Enantiomeric meroterpenoids from Rhododendron capitatum and their anti-inflammatory activity.

Ten enantiomeric pairs of meroterpenoids were isolated from Rhododendron capitatum Maxim. Among them, (+/-)-capitanoids A-F, (+)-ranhuadujuanine B, (-)-rubiginosin G, and (-)-anthopogochromene B are undescribed compounds. Their structures were fully established by spectroscopic techniques, X-ray crystallographic analyses, modified Mosher's method, and ECD calculation.

A natural small molecule isoginkgetin alleviates hypercholesterolemia and atherosclerosis by targeting ACLY.

Atherosclerotic cardiovascular disease (ASCVD) represents the predominant cause of mortality and morbidity globally. Given the established role of hypercholesterolemia as a significant risk factor for ASCVD, the discovery of new lipid-lowering medications is of paramount importance. ATP citrate lyase (ACLY) is a crucial enzyme in cellular metabolism, providing acetyl-CoA as the building block for the biosynthesis of fatty acids and cholesterol.

Longitudinal Trajectory of Left Ventricular Systolic Function in Children During Anthracycline-Based Chemotherapy Assessed by Noninvasive Myocardial Work.

Background: Noninvasive myocardial work (MW), which incorporates myocardial deformation and blood pressure, can be used to quantitatively evaluate left ventricular (LV) systolic function in children undergoing chemotherapy. However, the trajectories of MW indices (MWIs) in children during anthracycline-based chemotherapy remain unclear.

Objective: To investigate the longitudinal trajectories of MWIs during anthracycline-based chemotherapy and compare the relative changes between MWIs and conventional echocardiographic parameters.

Systemic inflammation mediates the association between dietary inflammation index and incident anxiety and depression in UK Biobank.

Background: Evidence on whether systemic inflammation mediates the association between diet and depression and anxiety is lacking.

Methods: We analyzed 55,799 participants from the UK Biobank, assessing dietary inflammatory index (DII) based on 3 days' 24-hour dietary recall. Systemic inflammation was represented by systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI).

Meroterpenoids with bicyclic polyprenylated acylphloroglucinol scaffold and anti-inflammatory activity from Hypericum lancasteri.

Twelve undescribed meroterpenoids possessing bicyclic polyprenylated acylphloroglucinol (BPAP) scaffold, (±)-lancasternoids A-D and lancasternoids E-H, together with fourteen known analogues, were isolated from Hypericum lancasteri (Hypericaceae) and structurally characterized. (±)-Lancasternoids A-D are the first examples of bicyclo[3.2.

Enhancing Empathy for Visual Impairments: A Multi-Modal Approach in VR Serious Games.

Visual impairments significantly impact individuals' ability to perceive their surroundings, affecting everyday tasks and spatial navigation. This study explores SEEK VR,s a multi-modal virtual reality game designed to foster empathy and raise awareness about the challenges faced by visually impaired individuals. By integrating visual feedback, 3D spatial audio, and haptic feedback, the game provides an immersive experience that helps participants understand the physical and emotional struggles of visual impairment.

A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics of BGT-002, a Novel ATP-Citrate Lyase Inhibitor, in Healthy Chinese Subjects.

Objective: This Phase I study evaluated the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of BGT-002, a novel ATP-citrate lyase (ACLY) inhibitor, in healthy Chinese adults.

Methods: This study included three parts: Part I (single-ascending-dose study), Part II (multiple-ascending-dose study), and Part III (food effect study). A total of 104 healthy subjects were enrolled in the study and were given BGT-002 tablet or placebo per protocol requirements.

Dasatinib and Quercetin Mitigate Age-Related Alveolar Bone Inflammaging and Neutrophil Infiltration.

Objective: Age-related alveolar bone resorption poses a major dental health challenge, yet its mechanisms and treatments are poorly understood. This study investigates the impact of dasatinib and quercetin (D + Q) treatment on senescent cells (SnCs), senescence-associated secretory phenotype (SASP), and neutrophil infiltration in aged alveolar bone, aiming to develop new strategies for combating age-related bone resorption.

Methods: C57BL/6 mice (2 and 18 months) were used to examine alveolar bone resorption, inflammaging, and neutrophil infiltration.

Management of CAR-T cell therapy in patients with multiple myeloma: a systematic review and expert consensus in Australia.

Background: Regulatory bodies have recently approved chimeric antigen receptor (CAR)-T cell therapies for patients with multiple myeloma (MM), but the treatment process involves complex decision making. To support the introduction of these therapies, we aimed to establish consensus expert opinion on best practices of all aspects of the management of patients with MM undergoing CAR-T cell therapy in Australia.

Methods: We conducted a modified RAND/UCLA two-round Delphi panel informed by a systematic literature review (SLR).