Glymphatic Function as a Prognostic Biomarker in Prolonged Disorders of Consciousness.

Objective: The glymphatic system is a major waste clearance system in the central nervous system. We aim to investigate the glymphatic function and its prognostic values in patients with prolonged disorders of consciousness (pDoC).

Methods: We conducted a prospective and explorative cohort study including 40 patients with pDoC and 20 healthy controls.

Effect of cerebellar stimulation on awareness recovery in disorders of consciousness (CARE-DoC): A randomized, sham-controlled, crossover clinical trial.

Disorders of consciousness (DoC) are major clinical challenges. We aimed to evaluate the effects of cerebellar intermittent theta-burst stimulation (CRB-iTBS) in the treatment of DoC. We conducted a randomized, sham-controlled, double-blind, cross-over clinical trial.

Recurrent hypoglycaemia leads to impairment in glucagon-mediated hepatic glycogenolysis in type 1 diabetic mice.

Aims: To explore the alterations in pancreatic α cells and hepatic glycogen metabolism in mice with type 1 diabetes mellitus (T1DM) following recurrent hypoglycaemia, aiming to elucidate the underlying mechanisms that contribute to impaired counterregulatory responses to hypoglycaemia.

Materials/methods: The alterations in pancreatic α cells and hepatic glycogenolysis were assessed in T1DM mice experiencing recurrent hypoglycaemia induced by insulin. Furthermore, glucagon intervention experiments were conducted on T1DM mice subjected to recurrent hypoglycaemia and on their primary hepatocytes to clarify further the mechanisms responsible for the observed changes in hepatic glycogenolysis.

Concept, Influencing Factors, and Interventions of Nursing Health Leadership: A Scoping Review.

With increasing burnout and turnover rates among nurses, health leadership can effectively improve the health and well-being of both leaders and staff. However, in the nursing field, the definition and mechanisms of health leadership remain unclear and require further research. The main objective of this study was to define the concept of health leadership in nursing, construct a nursing model program, and promote the formation of normative nursing health leadership theories and strategies.

Unveiling the role of GATA4 in endothelial cell senescence and atherosclerosis development.

Background And Aims: Cellular senescence is intimately linked to atherosclerosis development and progression. However, the mechanism is not well known. GATA4 is a classical regulator in human fibroblast senescence.

Cyclic neutropenia: a case report and literature review.

To enhance the understanding of cyclic neutropenia (CyN) and improve the diagnosis and treatment of related diseases. Clinical data were analyzed from a 19-month-old child with recurrent infections and oral ulcers who was admitted to Inner Mongolia Maternal and Child Health Hospital on August 27, 2021 and a literature review was conducted. The patient developed an infection every 14-47 days, with fever, oral ulcers, bacterial infections, and decreased blood neutrophil counts at disease onset.

MS4A6A regulates ox-LDL-induced endothelial dysfunction and monocyte adhesion in atherosclerosis via the IKK/NF-kappaB pathway.

Atherosclerosis (AS) is characterized by chronic inflammation, which is a significant pathogenic factor of cardiovascular diseases (CVDs). Alleviating endothelial dysfunction and monocyte adhesion are effective ways to halt the development of AS. Membrane Spanning 4-Domains A6A (MS4A6A) is associated with inflammation and primarily regulates immunity and cell signaling.

The U-shaped relationship between serum osmolality and in-hospital mortality in patients with traumatic brain injury: a retrospective study based on the MIMIC-IV database.

Background: Disturbances in serum osmolality are associated with poor prognosis in many diseases and are more likely to occur in patients with traumatic brain injury (TBI). However, studies correlating serum osmolality and patient prognosis are lacking. Therefore, this study investigated the correlation between serum osmolality and in-hospital all-cause mortality in patients with TBI based on a large sample of TBI patients from the Medical Information Mart for Intensive Care-IV (MIMIV-IV) database.

Perioperative tislelizumab plus chemotherapy for locally advanced gastroesophageal junction adenocarcinoma (NEOSUMMIT-03): a prospective, nonrandomized, open-label, phase 2 trial.

This prospective, nonrandomized, open-label phase 2 trial (Chinese Clinical Trial Registry, ChiCTR2200061906) aimed to evaluate the effectiveness of adding the PD-1 antibody tislelizumab to perioperative chemotherapy in patients with locally advanced gastroesophageal junction adenocarcinoma (GEJA). This study enrolled patients with GEJA clinically staged as cT3-4aNanyM0 or cT1-2N+M0 from October 2022 to June 2023. Eligible patients were administered three preoperative and five postoperative 3-week cycles of treatment with PD-1 antibody tislelizumab plus SOX (S-1 and oxaliplatin) regimen.

Cationic Modification in Hybrid Iodates: A Pathway to Superior Performance.

The utilization of nonlinear optical (NLO) crystals plays a crucial role in the contemporary laser industry, and the advancement of novel NLO-active units is essential for the exploration of NLO materials. Two novel organic-inorganic hybrid iodates, designated as (CNH)MoO(IO)·3HO () and (CNIH)MoO(IO)·4HO () were synthesized via mild hydrothermal methods, exhibiting band gaps of 3.75 and 3.

OAS1 induces endothelial dysfunction and promotes monocyte adhesion through the NFκB pathway in atherosclerosis.

Cardiovascular disease is characterized by chronic inflammation and atherosclerosis (AS) is the pathological basis. Mitigating endothelial dysfunction and mononuclear cell adhesion is a crucial approach in impeding the initial advancement of AS. As an inflammation-immune regulation-related protein, 2'-5'-oligoadenylate synthetase 1 (OAS1) plays a critical role in inflammation, but its impact on endothelial dysfunction and mononuclear cell adhesion is not well understood.

Cerebellar transcranial magnetic stimulation to treat drug-resistant epilepsy: A randomized, controlled, crossover clinical trial.

Objective: Epilepsy is one of the most prevalent brain diseases. Approximately one third of patients consistently experience drug-resistant epilepsy (DRE), a condition where seizures persist despite the use of antiseizure medications. Exploration of new therapies for DRE is urgently needed.

A nomogram prediction model for the risk of intra-abdominal infection after endoscopic full-thick resection of gastric submucosal tumors.

Background: This study aimed to investigate the risk factors for complication of intra-abdominal infection (IAI) after endoscopic full-thickness resection of gastric submucosal tumors (GSMT) and to establish a nomogram prediction model for the occurrence of IAI.

Methods: Clinical data of patients with GSMT who underwent endoscopic full-thick resection (EFR) from January 2018 to July 2023 were retrospectively analyzed. The patients were divided into IAI and non-IAI groups according to whether IAI occurred during postoperative hospitalization.

Establishment and validation of a predictive model for tracheotomy in critically ill patients and analysis of the impact of different tracheotomy timing on patient prognosis.

Background: In critically ill patients receiving invasive mechanical ventilation (IMV), it is unable to determine early which patients require tracheotomy and whether early tracheotomy is beneficial.

Methods: Clinical data of patients who were first admitted to the ICU and underwent invasive ventilation for more than 24 h in the Medical Information Marketplace in Intensive Care (MIMIC)-IV database were retrospectively collected. Patients were categorized into successful extubation and tracheotomy groups according to whether they were subsequently successfully extubated or underwent tracheotomy.

Mice harboring the T316N variant in the GABAR γ subunit exhibit sleep-related hypermotor epilepsy phenotypes and hypersynchronization in the thalamocortical pathway.

Objective: Sleep-related hypermotor epilepsy (SHE) is a focal epilepsy syndrome characterized by seizures that predominantly occur during sleep. The pathogenesis of these seizures remains unclear. We previously detected rare variants in GABRG2, which encodes the γ subunit of γ-aminobutyric acid type A receptor (GABAR), in patients with SHE and demonstrated that these variants impaired GABAR function in vitro.

XELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial.

Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial (ClinicalTrials.gov: NCT03950154) assessed the efficacy and adverse events (AEs) of the combination of PD-1 blockade-activated DC-CIK (PD1-T) cells with XELOX plus bevacizumab as a first-line therapy in patients with mCRC.

WeChat mini program in laboratory biosafety education among medical students at Guangzhou Medical University: a mixed method study of feasibility and usability.

Background: Laboratory biosafety should be a priority in all healthcare institutions. In traditional laboratory safety teaching students typically receive knowledge passively from their teachers without active involvement. The combination of experiential learning and mobile learning may provide students with greater engagement, retention, and application of knowledge.

A 12 Week Fetus with Anophthalmia, Limb Anomalies and Infratemporal Teratoma.

Background: Microphthalmia is a rare autosomal recessive condition commonly known as Waardenburg anophthalmia syndrome (WAS) or oculo-acromal formation syndrome (MIM#206920).

Case Description: Here, we report the case of a woman whose fetal ultrasonography at 12 weeks of pregnancy revealed multiple fetal abnormalities. These included the absence of the left upper limb, an unclear display of the right orbit, a visible maxillary space, and a round, echoless appearance measuring 4 mm in diameter in the middle of the forehead.

On the genus Tegestria Roewer, 1936, new senior synonym of Gintingius Roewer, 1938 with the description of a new species (Opiliones: Epedanidae: Sarasinicinae).

Tegestria altmannae sp. nov. is described and illustrated based on male and female specimens collected in Malaysia.

Health Monitoring via Heart, Breath, and Korotkoff Sounds by Wearable Piezoelectret Patches.

Real-time monitoring of vital sounds from cardiovascular and respiratory systems via wearable devices together with modern data analysis schemes have the potential to reveal a variety of health conditions. Here, a flexible piezoelectret sensing system is developed to examine audio physiological signals in an unobtrusive manner, including heart, Korotkoff, and breath sounds. A customized electromagnetic shielding structure is designed for precision and high-fidelity measurements and several unique physiological sound patterns related to clinical applications are collected and analyzed.

Effect of bacillus subtilis strain Z15 secondary metabolites on immune function in mice.

Background: Previous studies have shown that secondary metabolites of Bacillus subtilis strain Z15 (BS-Z15) are effective in treating fungal infections in mice. To evaluate whether it also modulates immune function in mice to exert antifungal effects, we investigated the effect of BS-Z15 secondary metabolites on both the innate and adaptive immune functions of mice, and explored its molecular mechanism through blood transcriptome analysis.

Results: The study showed that BS-Z15 secondary metabolites increased the number of monocytes and platelets in the blood, improved natural killer (NK) cell activity and phagocytosis of monocytes-macrophages, increased the conversion rate of lymphocytes in the spleen, the number of T lymphocytes and the antibody production capacity of mice, and increased the levels of Interferon gamma (IFN-γ), Interleukin-6 (IL-6), Immunoglobulin G (IgG) and Immunoglobulin M (IgM) in plasma.

Research progress of rhizosphere microorganisms in L. medicinal plants.

The soil's rhizosphere is a highly active place where the exchange of substances and information occurs among plants, soils, and microorganisms. The microorganisms involved are crucial to the activities of plant growth and development, metabolism, and reproduction. L.

Corneal histomorphology and electron microscopic observation of R124L mutated corneal dystrophy in a relapsed pedigree.

Aim: To investigate the histological characteristics and ultrastructure of recurrent Chinese R124L mutated corneal dystrophy after keratoplasty.

Methods: The subjects were enrolled from a Chinese family of corneal dystrophy with R124L heterozygous gene mutation and with a history of consanguineous marriage. Normal corneal samples were used as controls.