Methylation-mediated LncRNA CRAT40 promotes colorectal cancer progression by recruiting YBX1 to initiate RelA transcription.

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide. Long noncoding RNAs (lncRNAs) have emerged as crucial regulators in the initiation and progression of various malignancies, including CRC. In this study, we found that lnc-CRAT40 was upregulated in CRC and associated with poor prognosis following CRC resection.

miRNA-204-5p acts as a tumor suppressor in gastric cancer by inhibiting cell migration, invasion, and glycolysis via the RAB22A/PI3K/AKT axis.

Gastric cancer (GC) is a highly prevalent and lethal malignancy worldwide. Accumulating evidence has shown that microRNAs (miRNAs) play essential roles in the development and progression of GC. In this study, we aimed to investigate the expression, functions, and molecular mechanisms of miRNA-204-5p in GC.

Norethindrone causes oxidative stress, intestinal injury, and disturbed gut microbiota composition in adult female western mosquitofish (Gambusia affinis).

Norethindrone (NET), a widely used synthetic progestin, has been consistently detected in diverse aquatic ecosystems, raising significant concerns about its potential ecological risks. In this study, adult female western mosquitofish (Gambusia affinis) were exposed to environmentally relevant concentrations of NET (5.0, 50.

Balanced Iodophilicity and Solvophilicity Unlocks Fast Iodine Conversion Chemistry.

The shuttling of polyiodides and sluggish redox kinetics greatly hinder the implementation of an aqueous Zn-I battery. Despite numerous catalysts have been implemented to improve the iodine cathode stability, an important aspect, the balance between polyiodide adsorption and interfacial mass transport kinetics at the cathode surface, has been overlooked. It is known that insufficient intermediate trapping ability will cause low iodine utilization and fast capacity decay.

Deciphering SN2-Type Nucleophilic Substitution via Halogen-Free Intermediates for High-Energy Zinc-Iodine Batteries.

High-valence halogen conversion reactions are promising for realizing high-energy-density aqueous batteries. It has been more challenging to realize a stable and reversible / conversion than the facile / conversion. While interhalogen chemistry has been employed to realize a reversible /I/ (i.

A Synchronous Strategy to Zn-Iodine Battery by Polycationic Long-Chain Molecules.

Aqueous Zn-iodine batteries (ZIBs) face the formidable challenges towards practical implementation, including metal corrosion and rampant dendrite growth on the Zn anode side, and shuttle effect of polyiodide species from the cathode side. These challenges lead to poor cycle stability and severe self-discharge. From the fabrication and cost point of view, it is technologically more viable to deploy electrolyte engineering than electrode protection strategies.

Deep multi-task learning framework for gastrointestinal lesion-aided diagnosis and severity estimation.

Accurate diagnosis and severity estimation of gastrointestinal tract (GT) lesions are crucial for patient care and effective treatment plan decisions. Traditional methods for diagnosing lesions face challenges in accurately estimating severity due to requiring interpretable biomarkers, inter-observer variability, and overlapping lesions. Moreover, existing deep-learning models treat lesion classification and severity estimation as separate tasks, complicating diagnosis.

Simultaneous Manipulation of Electric Double Layer and Zn (100) Deposition Enabled by Anions for Highly Stable Zn Anodes.

Controlling the growth orientation of zinc (Zn) is an effective method of stabilizing Zn anodes. Although Zn (100) exhibits faster Zn electroplating/stripping kinetics than Zn (002), its high chemical reactivity results in susceptibility to water-induced side reactions. Herein, a two-pronged electrolyte engineering strategy is proposed to enhance the reversibility of Zn anodes, that is, modulating vertically oriented Zn (100) plating while simultaneously constructing a water-poor electrical double layer (EDL).

Experimental Study on Surface Polishing of SLM-316L Stainless Steel via Laser Treatment and Mechanical Grinding.

The 316L stainless steel material boasts exceptional corrosion resistance and plasticity, among other benefits, and finds extensive application in automotive components, molds, aerospace parts, biomedical equipment, and more. This work focuses on the surface polishing of selective laser melting (SLM) 316L stainless steel using 1064 nm nanosecond laser processing and mechanical grinding. The influence of laser processing parameters on the surface roughness of SLM-316L stainless steel was investigated using an orthogonal experiment.

Multimodal electrolyte architecting for static aqueous zinc-halogen batteries.

Rechargeable static aqueous zinc-halogen batteries (AZHBs) thrive in energy-storage applications due to their suitable redox potential, abundant reserves and relatively high energy density. This non-flow battery relies on the collaboration of the reversible stripping/plating process of Zn metal and the halogen-participating zincation reactions. However, the corrosion of Zn metal and the shuttling of the halogen species result in serious capacity decay, posing challenges to their reversibility and lifespan.

Stabilizing Residual Monomers within Polymerized Electrolytes for High-Voltage Lithium Metal Batteries.

Poly(1,3-dioxolane) (PDOL)-based electrolyte has gained wide attention due to its high compatibility with the lithium metal anode, intimate contact with electrodes, and high ionic conductivity. However, its application in high-voltage batteries is limited because the residual DOL monomers are prone to oxidation at high voltage. Here, we report that LiDFOB-initiated polymerization stabilizes these residual monomers, thus overcoming the oxidation-related limitations of PDOL-based electrolytes.

Sexual dimorphism of lung immune-regulatory units imprint biased pulmonary fibrosis.

Pulmonary fibrosis (PF) is sexually dimorphic, with a relatively high prevalence and severity in males; however, the mechanism remains unclear. Our study revealed pronounced sexual dimorphism of immune cell genes in the lung, among which grancalcin (GCA) showed profound sex differences. GCA was produced by lung-infiltrating bone marrow macrophages triggered by heightened inflammation in the lung.

CMOS-Compatible Protonic Three-Terminal Memristor for Analog Synapse in Neuromorphic Computing.

All-solid-state inorganic hydrogen-based three-terminal memristors (H-3TMs) suffer from poor retention, susceptibility to humidity and temperature, and the reliance on wet chemistry during fabrication, hindering their manufacturability within existing foundry processes. To address these, this study presents a CMOS-compatible H-3TM based on reversible intercalation and extraction of protons between the SiN electrolyte and WO channel. The protons are introduced via a straightforward hydrogen plasma treatment, promoting a compatible fabrication process with back-end-of-line integration.

Effects of Dendrobium nobile on antioxidant capacity, hormone levels, testicular metabolism, and reproductive performance of aged roosters.

Oxidative stress is a major cause of semen quality decline in old roosters. Dendrobium nobile Lindl (DNL), a Chinese herbal medicine, exhibits excellent antioxidant activity. Therefore, the present study aimed to investigate the effects of dietary DNL supplementation on semen quality, antioxidant capacity, reproductive hormone levels, and testicular tissue structure in aged roosters.

Optimizing visible light absorption, exciton dissociation, and charge transfer through the interaction of donor-acceptor materials to enhance xanthate photodegradation.

Bulk heterojunctions, formed by blends of donor and acceptor materials, are attractive for developing efficient photocatalysts due to their tunable optical and electrical properties. However, their potential for enhancing organic wastewater treatment through adjustable light absorption bands and intensities remains largely unexploited. In this work, a novel kaolin (KA) based ternary heterojunction photocatalyst PBT1-C:IDT8CN-M:PDI-V/KA (PIV/KA) with strong absorption capability in the spectral range of 470-800 nm was synthesized through the clever combination of donor and acceptor materials and the construction of Förster resonance energy transfer (FRET) between IDT8CN-M (I) and PDI-V (V).

Additive Manufacturing and Influencing Factors of Lattice Structures: A Review.

Lattice structures have the characteristics of light weight, excellent heat dissipation and mechanical properties. Because of excellent properties, lattice structures have been widely used in aerospace, automobile manufacturing, biomedical and other fields. At present, additive manufacturing is the mainstream method for manufacturing lattice structures.

The effect of moral identity on facial emotion processing in adolescents with hearing loss: an event-related potentials study.

Objective: This study investigates how the moral characters of others influence the recognition of facial emotional expressions in adolescents with hearing loss (HL), and compares these effects with those in adolescents with typical hearing (TH).

Methods: A moral priming paradigm was employed to explore the neural mechanisms underlying facial emotion perception (happy, neutral, and angry) in different moral contexts (high moral, low moral). Event-related potentials (ERP) were utilized to assess brain responses.

Microwave-assisted modification of magnetic Mg/Al/Fe-LDH hydrotalcite for efficient arsenic removal from water.

In recent years, arsenic contamination in aquatic environments has become increasingly severe. Hydrotalcites are widely used for arsenic removal, but challenges remain regarding their removal efficiency and recyclability. To enhance the adsorption performance of Hydrotalcite-like(LDH) for arsenic and facilitate solid-liquid separation, in this study, magnetic FeO was combined with LDH and thermally modified using microwave treatment to obtain microwave-assisted modification of magnetic LDH(WFeO@MAF-LDH), which was used for arsenic removal.

Oxygen-Doped MoS with Expanded Interlayer Spacing for Rapid and Stable Polysulfide Conversion.

Lithium-sulfur batteries face challenges such as the polysulfide shuttle effect and sluggish redox kinetics, leading to poor sulfur utilization and limited cyclic stability. Herein, an oxygen-doped engineering approach is presented to achieve pillar-free interlayer extension of MoS (E-MoS) for lithium polysulfide conversion. E-MoS features expanded interlayer spacing (from 0.

Colonoscopy-Related Adverse Events in the 21st Century: An Updated Systematic Review and Meta-Analysis.

Introduction: Colonoscopy is one of the most commonly performed endoscopic procedures and is generally considered low-risk. However, when adverse events (AEs) occur, they can present significant challenges in clinical practice. The aim of this study was to estimate the global incidence of colonoscopy-related AEs.