Urolithin A Attenuates Periodontitis in Mice via Dual Anti-Inflammatory and Osteoclastogenesis Inhibition: A Natural Metabolite-Based Therapeutic Strategy.

Periodontitis is an inflammatory disease that affects the periodontal supporting tissues. Its cardinal clinical manifestations encompass gingival inflammation, periodontal pocket formation, and alveolar bone resorption. Urolithin A (UA), a gut microbiota-derived metabolite of ellagitannins, is known for its anti-inflammatory and osseous-protective properties.

Surgical Treatment of Intracranial Rosai-Dorfman Disease.

Rosai-Dorfman disease (RDD) is a rare non-Langerhans histiocytosis characterized by systemic lymphadenopathy and extranodal involvement. Isolated central nervous system (CNS) involvement accounts for <5% of cases. Its clinical and radiological features often mimic meningioma, lymphoma, or metastatic disease, leading to frequent misdiagnosis.

RETREG1-mediated reticulophagy is activated by an ATF4-CEBPG/C/EBPγ heterodimer and confers protection against lipotoxicity.

Excessive fatty acid triggers endoplasmic reticulum (ER) stress, leading to lipotoxicity, which plays a vital role in the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD). Reticulophagy is recently identified as an integral process in maintaining ER homeostasis during ER stress. However, our knowledge of reticulophagy in lipotoxicity remains limited, and the underlying molecular mechanisms are unclear.

Delayed Multiple Cerebral Infarction Following Rupture of a Dermoid Cyst in the Right Lateral Wall of the Cavernous Sinus-Meckel Cave Area.

This case report details a 50-year-old male with a ruptured intracranial dermoid cyst in the right lateral wall of the cavernous sinus-Meckel cave area, leading to delayed cerebral ischemia postsurgery. The rupture released lipid components, potentially causing inflammatory vascular reactions and ischemic events. Initial symptoms included binocular diplopia and later progressed to limb weakness and facial twitching.

High-performance CT features supporting accurate pre-operative tumor staging in colon cancer.

Background And Aims: Accurate pre-treatment tumor staging is essential for treatment decision-making. Multi-slice spiral computed tomography (CT) is currently the standard method for pre-operative clinical tumor staging, but accurately applying the CT findings in tumor staging remains a challenge due to the poor pathological understanding of the CT signs. We aimed to pathologically interpret the key CT findings in order to identify reliable markers for pre-treatment staging of colon cancer.

Topological states in Penrose-square photonic crystals.

Topological edge states (TESs) and topological corner states (TCSs) in photonic crystals (PCs) provide an effective way to control the propagation and localization of light. The topological performance of integrated photonic devices can be improved by introducing the basic structural unit of photonic quasicrystals (PQCs) into PCs. However, the previous works arranged the basic structural unit of Stampfli-type and 12-fold Penrose-type photonic quasicrystals into triangular lattices, which have a complex structure and allow light to only propagate around 60° or 120° corners, limiting their applications.

Performance Improvement of TiO Ultraviolet Photodetectors by Using Atomic Layer Deposited AlO Passivation Layer.

This study employed atomic layer deposition (ALD) to fabricate an AlO passivation layer to optimize the performance of ultraviolet (UV) photodetectors with a TiO-nanorod-(NR)-containing active layer and a solid-liquid heterojunction (SLHJ). To reduce the processing time and enhance light absorption, a hydrothermal method was used to grow a relatively thick TiO-NR-containng working electrode. Subsequently, a 5-nm-thick AlO passivation layer was deposited on the TiO NRs through ALD, which has excellent step coverage, to reduce the surface defects in the TiO NRs and improve the carrier transport efficiency.

Optimization Design of Quenching and Tempering Parameters for Crankshaft Based on Response Surface Methodology.

Existing optimization research on the crankshaft heat treatment process is mostly based on one-sided considerations, and less consideration is given to the matching of multiple process parameters, leading to irrational designs of heat treatment. To address this problem, this work investigates the influence mechanisms of cooling speed, tempering temperature, and holding time on the performance evaluation indexes of the straightness, residual stress, and martensite content of a crankshaft based on the response surface method. The results showed that the order of influence of these three different process parameters on the performance evaluation index was cooling speed > holding time > tempering temperature, and the order of influence on the performance evaluation indexes under multifactorial process parameters was cooling speed-holding time > cooling speed-tempering temperature > holding time-tempering temperature.

Erosion Effects of OTC Paediatric Oral Liquids and Traditional Chinese Medicine on Primary Teeth.

Background: This study compared the in vitro erosive effects of 2 western and 2 Chinese medicinal over-the-counter paediatric medications on primary teeth in a continuous time scale.

Methods: Twenty enamel blocks obtained from 10 deciduous incisors were randomly assigned into 5 groups (n = 4 each): Group GA and Group GB-paracetamol liquid (Jean-Marie Pharmacal Co. Ltd and Universal Pharmaceutical Laboratories Ltd, respectively); Group GC and Group GD-reconstituted Chinese medicinal granules (Huarun 999 and Guizhou Bailing Group Pharmaceutical Co.

circZNF532 promotes endothelial-to-mesenchymal transition in diabetic retinopathy by recruiting TAF15 to stabilize PIK3CD.

Endothelial-to-mesenchymal transition (EndMT) is a pivotal event in diabetic retinopathy (DR). This study explored the role of circRNA zinc finger protein 532 (circZNF532) in regulating EndMT in DR progression. Human retinal microvascular endothelial cells (HRMECs) were exposed to high glucose (HG) to induce the DR cell model.

USP14 Regulates ATF2/PIK3CD Axis to Promote Microvascular Endothelial Cell Proliferation, Migration, and Angiogenesis in Diabetic Retinopathy.

Diabetic retinopathy (DR) is one of the leading causes of blindness in diabetic patients. However, the pathogenesis of DR is complex, and no firm conclusions have been drawn so far. It has become a hot spot in ophthalmology research to deeply study the mechanism of DR pathological changes and find effective treatment options.

Up-regulation of miR-192-5p inhibits the ELAVL1/PI3Kδ axis and attenuates microvascular endothelial cell proliferation, migration and angiogenesis in diabetic retinopathy.

Background: Diabetic retinopathy (DR) is a common complication of diabetes mellitus that poses a threat to adults. MicroRNAs (miRNAs) play a key role in DR progression. However, the role and mechanism of miR-192-5p in DR remain unclear.

LncRNA SNHG1 targets miR-340-5p/PIK3CA axis to regulate microvascular endothelial cell proliferation, migration, and angiogenesis in DR.

Diabetic retinopathy (DR) is a serious long-term complication of diabetes. However, the current treatment of DR is still challenging. We aimed to investigate the role of lncRNA SNHG1/miR-340-5p/PIK3CA in DR and the mechanisms involved.

[Application of Wechat public platform in teaching reform of prosthodontics].

Purpose: To explore the law of development and existing problems in prosthodontics teaching in the new era, through flipped classroom teaching based on WeChat public platform.

Methods: WeChat public number was applied and WeChat groups were set up among the students of grade 2013, and 93 students were divided into 20 WeChat groups, with 4 to 5 students in each group. The main platform on reform of prosthodontics teaching was WeChat app, supplemented by platforms of Lediaocha and Youkaoshi.

Toward Eliminating Discontinuous Yielding Behavior of the EA4T Steel.

Cold-rolled EA4T steel was heat-treated by inter-critical holding at 755 °C for 90, 120, 180, and 240 s, respectively, and then quenching in water. The tensile testing results of the EA4T specimens show an evident transition from the discontinuous yielding to the continuous yielding of the steel specimens by prolonging the holding time. A novel relationship between the discontinuous yielding behavior of tensile-deformed steel specimens and the carbide size was proposed based on experimental results and Cottrell's theory.

The integration of differentially expressed genes based on multiple microarray datasets for prediction of the prognosis in oral squamous cell carcinoma.

Oral squamous cell carcinoma (OSCC) is a common human malignancy. However, its pathogenesis and prognostic information are poorly elucidated. In the present study, we aimed to probe the most significant differentially expressed genes (DEGs) and their prognostic performance in OSCC.

A Traditional Clinic Chinese Medicine Prescription Qu-Zhuo-Tong-Bi () Alleviates Gouty Arthritis in Model Rats.

Qu-Zhuo-Tong-Bi () is an empirical traditional Chinese medicine prescription for treating acute gouty arthritis clinically without serious adverse effects in mainland China. However, the biochemical mechanism underlying the therapeutic action produced by treatment against acute gouty arthritis and the effect on recurrent attack remain unknown. In this study, we investigated the anti-inflammatory and analgesic effects of on acute gouty arthritis and the recurrent attack in rats, as well as the underlying mechanisms.

[Influence of electroacupuncture of "Zhongwan" (CV12) and "Zusanli" (ST36) in different combinations of stimulating strength and sequence on intragastric pressure in normal rats].

Objective: To observe the effect of electroacupuncture (EA) of "Zhongwan" (CV12) and "Zusanli" (ST36) in different combinations of stimulating parameters on intragastric pressure (IGP) in normal rats so as to explore their best combinations for promoting gastrointestinal mobility.

Methods: A total of 90 male SD rats were randomly divided into 6 EA groups：CV12-1 mA＋ST36-1 mA, CV12-1 mA＋ST36-2 mA, CV12-1 mA＋ST36-4 mA, ST36-1 mA＋CV12-1 mA, ST36-2 mA＋CV12-1 mA, and ST36-4 mA＋CV12-1 mA which the first acupoint was stimulated first, followed by the second in each group (＝15 rats/group). Before (1 min), and 0-30 s, 30-60 s, 60 -90 s, and 90-120 s during EA stimulation of the left ST36 or CV12 first or later, the IGP was measured via an inserted intragastric balloon, a connected pressure transducer and an amplifier.

[Last critical step for transanal total mesorectal excision: anastomosis].

Colorectal anastomosis remains a key aspect in mid- and lower-rectal surgery, particularly in patients who are male, obese, status post neoadjuvant chemoradiation, or possess narrow pelvic anatomy. Transanal total mesorectal excision (taTME) and transabdominal total mesorectal excision (TME) both primarily allow position of the tumor to dictate whether circular stapling or hand-sewing is utilized to achieve anastomosis. Given that taTME only requires a single circular stapler to achieve anastomosis, it consequently decreases the risk of jeopardizing blood supply to the anastomotic site.

Focal Anomalous Expression of Cytokeratin and p63 in Malignant Phyllodes Tumor: A Comparison With Spindle Cell Metaplastic Carcinoma.

Differentiating between malignant phyllodes tumors and metaplastic spindle cell carcinomas could be problematic, especially on core biopsies. Immunohistochemical staining for cytokeratin cocktail and p63 has been utilized to differentiate between these tumor types. Forty-three phyllodes tumors (27 benign, 6 borderline, and 10 malignant) and 22 metaplastic carcinomas, consisting at least 80% of spindle cells, were identified.

Notoginsenoside R1 significantly promotes in vitro osteoblastogenesis.

Notoginsenoside R1 (NGR1), one of the main effective components of Panax notoginseng, appears to be effective in promoting osteogenesis and treating osteoporosis. However, hitherto, whether NGR1 can directly promote osteoblastogenesis remains to be elucidated. In the present study, we hereby examined the effects of NGR1 on the osteoblastogenesis of a pre-osteoblast cell line (MC3T3-E1) in in vitro time-course and dose-dependent experiments.

Preparation and Characterization of Surface Photocatalytic Activity with NiO/TiO₂ Nanocomposite Structure.

This study achieved a nanocomposite structure of nickel oxide (NiO)/titanium dioxide (TiO₂) heterojunction on a TiO₂ film surface. The photocatalytic activity of this structure evaluated by decomposing methylene blue (MB) solution was strongly correlated to the conductive behavior of the NiO film. A -type NiO film of high concentration in contact with the native -type TiO₂ film, which resulted in a strong inner electrical field to effectively separate the photogenerated electron-hole pairs, exhibited a much better photocatalytic activity than the controlled TiO₂ film.

[Attachment and spreading of fibroblasts on titanium coatings by different micro-arc oxidation time].

Purpose: To investigate the attachment and spreading of fibroblasts on titanium coatings by different micro-arc oxidation(MAO) time.

Methods: Micro-arc oxidation film was formed on the titanium surface by using micro-arc oxidation. The film morphology and the cell shape on the samples were observed by scanning electron microscopy (SEM) and the surface roughness of film with different time was analyzed by surface coarseness profiling instrument.

[Effects of the micro-arc oxidized film on pure titanium surface on attachment and growth of BMSCs].

Purpose: To evaluate the biocompatibility of oxide film formed by micro-arc oxidation(MAO) on titanium surface by culturing bone marrow stromal cells(BMSCs) on its surface and observing the BMSCs's biological behavior of early adhesion, growth and alkaline phosphatase activity.

Methods: According to the surface treatments, the samples were classified into 4 groups: MAO group, abrator group, abrator and NaOH-treated group, and untreated titanium group. Attachment, growth and alkaline phosphatase (ALP) activity of BMSCs cultured on the titanium surface of each group were assessed at different time.