Clinical Study of Hydromorphone Combined with Dexmedetomidine via Patient Controlled Analgesia for the Treatment of Acute Herpes Zoster Neuralgia.

Objective: To investigate the efficacy of hydromorphone combined with dexmedetomidine with patient-controlled intravenous analgesia (PCIA) in treating patients with acute herpes zoster (HZ) neuralgia.

Study Design: Randomised controlled trial. Place and Duration of the Study: Department of Pain, Leshan Hospital of Traditional Chinese Medicine, Leshan, China, from May 2023 to April 2024.

ATG8ylation-mediated tonoplast invagination mitigates vacuole damage.

While ATG8ylation, the lipidation of ATG8-family proteins, is canonically linked to double-membrane autophagosome formation, emerging studies demonstrate its non-canonical association with single-membrane organelles. The functional significance of ATG8ylation in these compartments, however, remains unclear. Here, we demonstrate that ionophores rapidly trigger ATG8 conjugation to the vacuolar membrane (tonoplast), a process reliant on the ATG conjugation system rather than the upstream autophagic regulators.

Innovative rapid pathological assessment technology for hepatocellular carcinoma following comprehensive treatment guided by indocyanine green fluorescence imaging.

Background: Traditional pathological techniques for diagnosing liver cancer are limited by the need for examination of multiple points. Preoperative treatment can complicate the evaluation by causing tumor necrosis. The evolving treatment landscape requires precise, integrated, and comprehensive management to address the limitations, specifically in localization, sampling, and speed.

Neoadjuvant versus adjuvant radiotherapy for centrally located hepatocellular carcinoma: a propensity score matching study based on two prospective phase II trials.

Background: The prognosis of centrally located hepatocellular carcinoma (cl-HCC) was unsatisfactory when treated with surgery alone. Adjuvant radiotherapy (RT) and neoadjuvant radiotherapy have been reported to correlate with better disease-free survival (DFS) and overall survival (OS) in cl-HCC.

Objectives: To compare the survival outcomes and safety of neoadjuvant intensity-modulated radiotherapy (Neo-IMRT) plus surgery with surgery plus adjuvant IMRT (Adj-IMRT) in patients with cl-HCC.

Comparative transcriptomic analysis and genome-wide identification provide insights into the potential role of fungal-responsive MAPK cascade genes in tanshinone accumulation in .

is a well-known traditional Chinese medicine (TCM) for its bioactive tanshinones that are used to treat various diseases and have high antimicrobial properties. Previous studies have shown that tanshinone accumulation in was shown to be significantly induced by fungal elicitors. Mitogen-activated protein kinases (MAPKs), which play critical roles in plant-microbe interactions and cellular processes, are known to regulate the accumulation of antimicrobial metabolites.

Integrated and confinable paper-based chip biosensor for all-in-one colorimetric detection of aflatoxin B.

This study presents the development of a rapid and highly sensitive colorimetric biosensor for the detection of aflatoxin B (AFB), utilizing a peroxidase-mimetic nanozyme in combination with a membrane-confined signal amplification strategy. The biosensor platform incorporates AFB-specific aptamer-labeled Fe-doped mesoporous carbon nanospheres, which hybridize with a complementary strand immobilized on paper nanofibers. Upon binding with AFB, the nanozyme detaches and is subsequently removed through a washing step.

Phase II study with sorafenib plus radiotherapy for advanced HCC with portal and/or hepatic vein tumor thrombosis.

Background & Aims: Portal and hepatic vein tumor thrombosis is associated with inferior outcomes in patients with hepatocellular carcinoma (HCC), and systemic treatment alone is often insufficient. This phase II trial evaluated the efficacy and safety of combining sorafenib with radiotherapy in advanced HCC with thrombosis.

Methods: Registered at ClinicalTrials.

Effect of Narrow-Margin Hepatectomy Combined with Intraoperative Radiotherapy on Long-Term Prognosis of Patients with Centrally Located Hepatocellular Carcinoma: A Propensity Score Matching Analysis.

Background: Radiotherapy offers potential benefits for patients with hepatocellular carcinoma (HCC); however, the distinct role of intraoperative radiotherapy (IORT) during narrow-margin hepatectomy remains inadequately defined. This study aims at assessing the safety and effectiveness of IORT for centrally located HCCs during narrow-margin hepatectomy.

Methods: This single-center, retrospective research incorporated 659 patients with centrally located HCCs.

Global antibiotic prescription practices in hospitals and associated factors: a systematic review and meta-analysis.

Background: The prevalence of antibiotic prescribing among total prescriptions, the percentage of combined antibiotic prescribing among prescriptions containing at least one antibiotic, and factors influencing hospital antibiotic prescribing are currently unknown. In this systematic review, we aimed to summarise antibiotic prescribing in hospitals worldwide and identify the associated factors.

Methods: We searched PubMed/MEDLINE, Ovid/Embase, and the Web of Science for articles published between 1 January 2000 and 28 February 2023 that reported antibiotic prescribing in hospitals or the associated factors.

[Spatio-temporal Distributions and Source Analysis of Nitrogen in the Surface Water of Dianbu River Basin].

Dianbu River, flowing into the western part of Chaohu Lake, has been heavily polluted, and nitrogen is one of the key factors. During three periods （wet, normal, and dry）, 30 surface water samples were collected from the Dianbu River Basin as the research objects. The water chemistry, multiple stable isotopes （N-NO, O-NO, and N-NH）, and a SIAR mixing model were analyzed not only to understand the spatio-temporal distribution characteristics of nitrogen and its influencing factors but also the sources of nitrogen.

Comparison of depressive symptoms among emergency physicians and the general population in China: a cross-sectional study based on national data.

Background: While physicians are considered to be more susceptible to developing depressive symptoms, empirical data are lacking. The study aims to compare the risk of depressive symptoms between emergency physicians and the general population in China based on national data.

Methods: This was a national cross-sectional study.

Long-term outcome of adjuvant radiotherapy upon postoperative relapse of centrally located hepatocellular carcinoma: a real-world study.

Despite that surgical resection is widely regarded as the most effective approach to the treatment of liver cancer, its safety and efficacy upon centrally located hepatocellular carcinoma (HCC) remain unsatisfactory. In consequence, seeking an integrated treatment, like combined with adjuvant radiotherapy, to enhance the prognosis of patients is of critical importance. By recruiting patients undergoing surgical resection for centrally located HCC ranging from June 2015 to 2020, they were divided into liver resection combined with adjuvant radiotherapy (LR + RT) and mere liver resection (LR) groups.

[Hydrochemical Characteristics and Its Origin of Surface Water and Groundwater in Dianbu River Basin].

Chaohu lake is a key water body for water pollution prevention and treatment in our country. However， it has been at a higher eutrophication level recently. Here， the surface water and groundwater in the Dianbu River Basin， a secondary tributary of Chaohu Lake， were taken as the research object.

Prevalence of self-medication with antibiotics and its related factors among the general public and health professionals during the COVID-19 pandemic: A cross-sectional study in China.

Background: Self-medication with antibiotics (SMA) is a common public health concern. This study aimed to assess the prevalence of SMA in the general public and health professionals during the COVID-19 pandemic and identify the associated factors.

Methods: A cross-sectional study was conducted from October 28, 2022, to November 6, 2022.

Postoperative radiotherapy following null-margin hepatectomy in patients with hepatocellular carcinoma adhering to the major vessels: A propensity score-matched survival analysis cohort study.

Background & Aims: This study aims to analyze the prognosis of null-margin (≤1.0 mm) hepatectomy (NH) in patients with hepatocellular carcinoma (HCC) adhering to the major vessels and explore the value of postoperative radiotherapy (RT) in these patients.

Methods: HCC patients who underwent null-margin or wide-margin (≥1.

Prevalence of occupational injury and its associated factors among emergency department physicians in China: A large sample, cross-sectional study.

Background: Medical personnel, particularly emergency department (ED) physicians, face a variety of occupational hazards. However, the current state of occupational injuries among ED physicians remains unknown. This study aimed to assess the occupational injury of Chinese ED physicians and to identify its associated factors.

Long-term outcome of centrally located hepatocellular carcinoma treated by neoadjuvant radiotherapy and radical resection: a propensity score matched study.

Objective: Centrally located hepatocellular carcinoma (HCC) typically presents challenges in surgical intervention and is associated with a bleak prognosis. In order to address this pressing issue, it is imperative to identify a comprehensive treatment approach, such as neoadjuvant radiotherapy (neoRT), that can enhance the prognosis of patients diagnosed with centrally located HCC.

Methods: Patients who had surgical resections for HCC between March 2015 and December 2020 were included in the study.

Noninvasive urinary protein signatures combined clinical information associated with microvascular invasion risk in HCC patients.

Background: Microvascular invasion (MVI) is the main factor affecting the prognosis of patients with hepatocellular carcinoma (HCC). The aim of this study was to identify accurate diagnostic biomarkers from urinary protein signatures for preoperative prediction.

Methods: We conducted label-free quantitative proteomic studies on urine samples of 91 HCC patients and 22 healthy controls.

Prevalence and associated factors for depressive symptoms among the general population from 31 provinces in China: The utility of social determinants of health theory.

Background: Depression is one of the most common types of mental disorders. Guided by the theory of social determinants of health (SDH), the study aimed to assess the prevalence of depressive symptoms and to identify factors related to depressive symptoms in the general population of China.

Methods: A cross-sectional, online survey was conducted among 101,392 residents from 31 provinces of mainland China from January to March 2019, and 97,126 survey responses were included in the final analysis.

Clinical benefits of intraoperative radiotherapy for the recurrence of centrally located hepatocellular carcinoma with microvascular invasion.

Background: Although the efficacy and safety of intraoperative radiotherapy (IORT) in the treatment of malignant tumours, such as breast cancer, have been documented, it remains unclear whether this treatment is effective for centrally located hepatocellular carcinoma (HCC) with microvascular invasion (MVI).

Aims: This study aimed to explore the efficacy and safety of IORT in the treatment of centrally located HCC with MVI.

Methods And Results: Patients with centrally located HCC, who underwent surgery between January 2016 and January 2020, were enrolled.