Clinical Study of Hydromorphone Combined with Dexmedetomidine via Patient Controlled Analgesia for the Treatment of Acute Herpes Zoster Neuralgia.

Objective: To investigate the efficacy of hydromorphone combined with dexmedetomidine with patient-controlled intravenous analgesia (PCIA) in treating patients with acute herpes zoster (HZ) neuralgia.

Study Design: Randomised controlled trial. Place and Duration of the Study: Department of Pain, Leshan Hospital of Traditional Chinese Medicine, Leshan, China, from May 2023 to April 2024.

Trigeminal neuralgia causes neurodegeneration in rats associated with upregulation of the CD95/CD95L pathway.

Objectives: To explore the effects of trigeminal neuralgia on neurodegeneration in rats and the underlining mechanism.

Methods: Sixty adult male Sprague Dawley rats were divided randomly into Chronic Constriction Injury of the Rat’s Infraorbital Nerve (ION-CCI) group and sham group ( = 30). Right suborbital nerve was ligated in ION-CCI group to establish a trigeminal neuralgia model.