Predicting Lu-DOTATATE therapy response through immune microenvironment parameters in gastroenteropancreatic neuroendocrine tumors (GEP-NETs).

Background: The prognosis of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) following metastasis is often poor. The efficacy of Lu-DOTATATE therapy and the subgroups that benefit from it remain unclear. Our objective is to characterize the composition of the tumor immune microenvironment in GEP-NETs and to identify predictive biomarkers associated with response and PFS following Lu-DOTATATE.

A Rare Case of Retroperitoneal Angiolipoma Mimicking Paraganglioma on Multimodality Imaging.

We discuss a patient with a retroperitoneal mass demonstrating marked enhancement on contrast-enhanced CT and heterogeneous uptake of both 18F-FDG and 68Ga-DOTATOC on PET/CT. The postoperative pathologic diagnosis revealed an angiolipoma, a benign entity composed of mature adipocytes interspersed with capillaries and containing fibrin thrombi within the vessels. This case underscores the positive uptake of angiolipoma on 18F-FDG and 68Ga-DOTATOC PET/CT, which should be recognized as a crucial differential diagnosis.

A novel relative-equilibrium graphical plot for rapid reversible tracer studies in dynamic PET imaging.

This study aims to address the issue of long scan durations required by traditional graphical analysis methods, such as the Logan plot and its variant, the reversible equilibrium (RE) Logan plot, for dynamic PET imaging of tracer kinetics.We propose a relative RE Logan model that builds on the principles of the Logan plot and its variant to significantly reduce scan time without compromising the accuracy of tracer kinetics analysis. The model is supported by theoretical evidence and experimental validations, including two computer simulations and one clinical data analysis.

Somatostatin Receptor Imaging in Mice with Difference Positive Rate of SSTR2.

Introduction: Imaging with [68Ga]Ga-DOTA-TATE, [68Ga]Ga-DOTA-JR11, and [18F]AlF-NOTA-JR11 was performed to analyze differences among the three probes and to analyze the correlation between the image and pathology parameters.

Method: Tumor-bearing mice with different positive rates of somatostatin receptor II (SSTR2) were established with HEK293-SSTR2 and HEK293 cells, and imaging was performed on the same mouse with [68Ga]Ga-DOTA-TATE, [68Ga]Ga-DOTA-JR11, and [18F]AlF-NOTA-JR11 at 20, 60, and 120 min. The image parameters were obtained, including the maximum standard uptake value (SUVmax), mean standard uptake value (SUVmean), standard deviation of SUVmean, tumor volume, and coefficient of variation (CoV).

Detection of Bone Metastases by Ga-DOTA-SSAs and F-FDG PET/CT: A Two-Center Head-to-Head Study of Gastroenteropancreatic Neuroendocrine Neoplasms.

Purpose: This study aimed to assess the efficacy of dual-tracer [Ga-DOTA-somatostatin receptor analogs (SSAs) and F-fluorodeoxyglucose (FDG)] positron emission tomography/computed tomography (PET/CT) imaging for detecting bone metastases (BMs) in patients with gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs).

Methods: We retrospectively enrolled 74 GEP-NEN patients with BMs from two centers, who underwent dual-tracer PET/CT from January 2014 to March 2021. We compared and analyzed effectiveness of the dual PET/CT imaging techniques on the BMs, based on F-FDG and Ga-DOTA-SSAs.

A novel diagnostic model for differentiation of lung metastasis from primary lung cancer in patients with colorectal cancer.

Objective: This study aimed to evaluate the F-FDG PET/CT in differentiating lung metastasis(LM) from primary lung cancer(LC) in patients with colorectal cancer (CRC).

Methods: A total of 120 CRC patients (80 male, 40 female) who underwent F-FDG PET/CT were included. The diagnosis of primary lung cancer or lung metastasis was based on histopathology The patients were divided into a training cohort and a validation cohort randomized 1:1.

Ga-P15-041, A Novel Bone Imaging Agent for Diagnosis of Bone Metastases.

Objectives: Ga-P15-041 (Ga-HBED-CC-BP) is a novel bone-seeking PET radiotracer, which can be readily prepared by using a simple kit formulation and an in-house Ga/Ge generator. The aim of this study is to assess the potential human application of Ga-P15-041 for clinical PET/CT imaging and to compare its efficacy to detect bone metastases of different cancers with mTc-MDP whole-body bone scintigraphy (WBBS).

Methods: Initial kinetic study using Patlak analysis and parametric maps were performed in five histopathologically proven cancer patients (three males, two females) using Ga-P15-041 PET/CT scan only.

Correlation between NEN Bone Metastasis Performance and Tumor Proliferation: 112 Cases of [68Ga]Ga-DOTA-TATE Result Analysis.

Purpose: This study aimed to analyze neuroendocrine neoplasm (NEN) bone metastasis (BM) and gallium-68 (68Ga)-DOTA-TATE performance and to explore their correlation with the immunohistochemical proliferation index (Ki-67).

Procedures: A total of 112 patients with BMs were screened from 1082 NEN patients who underwent [68Ga]Ga-DOTA-TATE imaging. All patients had pathological results, and BMs were affirmed by clinical/imaging follow-up and/or histopathology.

Content-Noise Complementary Learning for Medical Image Denoising.

Medical imaging denoising faces great challenges, yet is in great demand. With its distinctive characteristics, medical imaging denoising in the image domain requires innovative deep learning strategies. In this study, we propose a simple yet effective strategy, the content-noise complementary learning (CNCL) strategy, in which two deep learning predictors are used to learn the respective content and noise of the image dataset complementarily.

Diagnostic Value of Delayed PET/MR in Liver Metastasis in Comparison With PET/CT.

Objectives: The aim of this study was to evaluate the value of a delayed positron emission tomography/magnetic resonance (PET/MR) scan relative to a single positron emission tomography/computed tomography (PET/CT) scan for liver metastasis detection.

Methods: In this study, 70 patients with solid malignancies and suspicious liver lesions undergoing 2-deoxy-2-[F]fluoro--glucose [(F)FDG] PET/CT and subsequent delayed liver PET/MR scans were analyzed. The histopathological analysis and/or imaging follow-up were performed as the standard of reference.

Machine Learning-Based Noninvasive Quantification of Single-Imaging Session Dual-Tracer F-FDG and Ga-DOTATATE Dynamic PET-CT in Oncology.

Ga-DOTATATE PET-CT is routinely used for imaging neuroendocrine tumor (NET) somatostatin receptor subtype 2 (SSTR2) density in patients, and is complementary to FDG PET-CT for improving the accuracy of NET detection, characterization, grading, staging, and predicting/monitoring NET responses to treatment. Performing sequential F-FDG and Ga-DOTATATE PET scans would require 2 or more days and can delay patient care. To align temporal and spatial measurements of F-FDG and Ga-DOTATATE PET, and to reduce scan time and CT radiation exposure to patients, we propose a single-imaging session dual-tracer dynamic PET acquisition protocol in the study.

Correlation and Comparison of Somatostatin Receptor Type 2 Immunohistochemical Scoring Systems with 68Ga-DOTATATE Positron Emission Tomography/Computed Tomography Imaging in Gastroenteropancreatic Neuroendocrine Neoplasms.

Introduction: The overexpression of somatostatin receptor type 2 (SSTR2) is a unique characteristic of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs), which establishes the basis for both diagnosis and therapy. The SSTR status can be evaluated by immunohistochemical staining (IHC) and 68Ga-DOTATATE positron emission tomography/computed tomography (PET/CT) imaging. This study attempted to determine the relationship between IHC and 68Ga-DOTATATE PET/CT imaging and to explore the optimal cutoff value for SSTR IHC reading.

Potential application value of PET/computed tomography in retroperitoneal leiomyosarcoma and a literature review.

Objective: To analyze the fluorine-18 fludeoxyglucose PET/computed tomography (18F-FDG PET/CT) findings of retroperitoneal leiomyosarcoma (RLMS) and the role of this method in differentiating between benign and malignant masses and classifying the malignant degree to improve the understanding of this rare disease.

Methods: Eight leiomyomas (A group), 13 RLMSs (B group), and 20 postoperative recurrence/metastasis RLMSs (C group) were enrolled. PET/CT features of B group were analyzed.

Synthesis, preclinical evaluation, and a pilot clinical imaging study of [F]AlF-NOTA-JR11 for neuroendocrine neoplasms compared with [Ga]Ga-DOTA-TATE.

Purpose: A [F]AlF-labeled somatostatin receptor (SSTR) antagonist was developed for imaging of neuroendocrine neoplasms (NENs), evaluated and compared with [Ga]Ga-DOTA-TATE.

Method: [F]AlF-NOTA-JR11 was synthesized manually and qualified with high-performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS). The cellular uptake, internalization, and saturation binding were performed with HEK293-SSTR2 cells.

A FDG PET/CT-based volume parameter is a predictor of overall survival in patients with local advanced gastric cancer.

Objective: The present study investigated the prognosis value of preoperative fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with local advanced gastric cancer (LAGC).

Methods: In total, 144 patients [median age 63 (range: 48-80) years old] with LAGC underwentF-FDG PET/CT prior to any treatment. The maximum standardized uptake values (SUV), mean standardized uptake values (SUV), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) of the primary lesion were measured on PET/CT and correlated with clinicopathological features and survival.

The Correlation Between [Ga]DOTATATE PET/CT and Cell Proliferation in Patients With GEP-NENs.

Purpose: Objectives of the study are to analyze the correlation between [Ga]DOTATATE positron emission tomography (PET)/X-ray computed tomography (CT) measurements and various biological characteristics of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs), and to determine optimal cutoff value of SUVmax (standard uptake value) to differentiate neuroendocrine tumors (NETs) and neuroendocrine cancers (NECs).

Procedures: Of the GEP-NEN cases (73 males, 53 females; age 18-77 years) with pathologically proven primary and/or metastatic lesions, 126 were studied. All of the short axes of lesions were larger than 0.

Clinical and Prognostic Value of PET/CT Imaging with Combination of Ga-DOTATATE and F-FDG in Gastroenteropancreatic Neuroendocrine Neoplasms.

Background: To evaluate the clinical and prognostic value of PET/CT with combination of Ga-DOTATATE and F-FDG in gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs).

Method: 83 patients of GEP-NENs who underwent Ga-DOTATATE and F-FDG PET/CT were enrolled between June 2013 and December 2016. Well-differentiated (WD) NETs are divided into group A (Ki-67 < 10%) and group B (Ki-67 ≥ 10%), and poorly differentiated (PD) NECs are defined as group C.

Retrospective analysis of interventional treatment of hepatic metastasis from gastroenteropancreatic neuroendocrine tumors.

Objective: To analyze the angiography appearance of liver metastases from gastroenteropancreatic neuroendocrine tumors (GEP-NETs), and evaluate the clinical efficacy and prognostic factors of interventional treatment for hepatic metastases.

Methods: Fifty GEP-NETs patients with hepatic metastases were treated from January 2012 to December 2016, and received transarterial embolization (TAE) in the hepatic tumor or hepatic arterial infusion chemotherapy (HAIC). All patients received 179 times of the intervention therapy in total.

Ga/Lu-labeled DOTA-TATE shows similar imaging and biodistribution in neuroendocrine tumor model.

Somatostatin receptors are overexpressed in neuroendocrine tumors, whose endogenous ligands are somatostatin. DOTA-TATE is an analogue of somatostatin, which shows high binding affinity to somatostatin receptors. We aim to evaluate the Ga/Lu-labeling DOTA-TATE kit in neuroendocrine tumor model for molecular imaging and to try human-positron emission tomography/computed tomography imaging of Ga-DOTA-TATE in neuroendocrine tumor patients.

[Research Progress of Implantable Biosensors for Continuous Glucose Monitoring].

Continuous glucose monitoring plays an important role in severe diabetic patients.However,there is no available commercial implanted glucose biosensor for long-term clinic application.This paper firstly introduces the classification of biosensors for continuous glucose monitoring,and then discusses the failure mechanism for implanted biosensors.

Chronic inflammatory pain upregulates expression of P2Y2 receptor in small-diameter sensory neurons.

Roles of ionotropic purinergic (P2X) receptors in chronic pain have been intensively investigated. However, the contribution of metabotropic purinergic (P2Y) receptors to pathological pain is controversial. In the present study, using single cell RT-PCR (reverse transcription-polymerase chain reaction) and single cell nested-PCR techniques, we examined the expression of P2X(2), P2X(3), P2Y(1) and P2Y(2) mRNA transcripts in retrogradely labeled cutaneous sensory neurons from mouse lumber dorsal root ganglia (DRGs) following peripheral inflammation.