Multi-Strain Probiotic Regulates the Intestinal Mucosal Immunity and Enhances the Protection of Piglets Against Porcine Epidemic Diarrhea Virus Challenge.

Porcine epidemic diarrhea virus (PEDV) infection induces severe, often fatal, watery diarrhea and vomiting in neonatal piglets, characterized by profound dehydration, villus atrophy, and catastrophic mortality rates approaching 100% in unprotected herds. This study developed a composite probiotic from Min-pig-derived LCM233, LSM231, and LPM239, which exhibited synergistic growth, potent acid/bile salt tolerance, and broad-spectrum antimicrobial activity against pathogens. In vitro, the probiotic combination disrupted pathogen ultrastructure and inhibited PEDV replication in IPI-2I cells.

Case Report: From Kaposi's sarcoma to primary effusive lymphoma.

Primary effusion lymphoma (PEL) is a rare B-cell lymphoma with an extremely poor prognosis that is associated with long-term persistent latent infection with Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV). However, studies on the correlation between KSHV genotype and PEL development in elderly patients are still lacking. We present the first global case of non-HIV, non-effusive, difficult-to-diagnose PEL with disseminated Kaposi's sarcoma (KS) in an elderly patient of Bouyei nationality, dynamically demonstrating that KSHV and EBV co-infection promote tumorigenesis.

High-Entropy Oxide Memristors for Neuromorphic Computing: From Material Engineering to Functional Integration.

High-entropy oxides (HEOs) have emerged as a promising class of memristive materials, characterized by entropy-stabilized crystal structures, multivalent cation coordination, and tunable defect landscapes. These intrinsic features enable forming-free resistive switching, multilevel conductance modulation, and synaptic plasticity, making HEOs attractive for neuromorphic computing. This review outlines recent progress in HEO-based memristors across materials engineering, switching mechanisms, and synaptic emulation.

Senecavirus a can replicate in apical-out porcine intestinal organoids and induce stress granules and innate immune response.

Senecavirus A (SVA) causes clinical blistering and ulcerative lesions resembling foot-and-mouth disease (FMD), often with mixed infections that exacerbate the disease and impact pig industry development. SVA has been demonstrated to induce diarrhea, dehydration and mortality in piglets. However, the underlying mechanisms of SVA-related intestinal infections remain underexplored.

Dynamic network entropy for pinpointing the pre-outbreak stage of infectious disease.

Infectious disease outbreaks have the potential to result in substantial human casualties and financial losses. Issuing timely warnings and taking appropriate measures before infectious disease outbreaks can effectively hinder or even prevent the spread of epidemics. However, the spread of infectious diseases is a complex and dynamic process that involves both biological and social systems.

An Optoelectronic Artificial Synapse Based on CuInGaSe/ Al-doped ZnO p-n Heterojunction for Bioinspired Neuromorphic Computing.

The traditional von Neumann architecture continues to limit the development of artificial intelligence. Memristors have become one of the most promising devices for breaking through the traditional von Neumann architecture. In this work, an optoelectronic synapse based on the CuInGaSe (CIGS)/ Al-doped ZnO (AZO) p-n heterojunction is prepared by radio-frequency (RF) magnetron sputtering.

Association between mental health and HPV in American women: an analysis based on the 2005-2016 NHANES database.

Background: Human papillomavirus (HPV) is one of the most prevalent sexually transmitted infections (STIs). Individuals with depression face higher risks of other STIs; however, the relationship between depression and HPV remains unclear.

Objective: To investigate the association between depression and HPV among American women.

Influence of Social Support Gap During Daily Stress on Daily Affect of Older Adults.

Objectives: We investigated the interactive effects of social support gap and daily event stress on daily affect among older adults. We hypothesized that social support gap would be associated with decreased daily positive affect and increased daily negative affect. We also hypothesized that there would be significant interactive effects of daily social support gap and daily event stress on daily affect.

Neighborhood disadvantage and elevated CD14 gene expression among middle-aged adults: Findings from the Midlife in the United States study.

Social and environmental factors are crucial in health, partly through immune system programming that begins decades before chronic disease onset. This study quantified the associations between neighborhood opportunity and CD14 gene expression, a key marker of monocyte abundance and inflammatory potential in the circulating leukocyte pool. Neighborhood opportunity was measured using the Childhood Opportunity Index 3.

Ferroelectric polarization modulated optoelectronic synapses based on BaTiO/TiO heterojunction for non-volatile visual memory.

The growing demand for neuromorphic computing architectures that mimic biological information processing has driven extensive research on optoelectronic synapses with multimodal neuromodulation capabilities. In this study, BaTiO/TiO optoelectronic synaptic devices with high non-volatile memory characteristics were constructed by interfacial energy band engineering. This heterojunction synaptic device achieves a 1350 % enhancement in relaxation time (τ = 84.

Intratumoral Bacterial-Targeted Cascade-Responsive Sonoafterglow Nanoprobes for Immune Reprogramming and Visualization in Glioblastoma.

Bacteria within glioblastoma (GBM) promote tumor progression and immunosuppression, while current treatments face challenges such as poor blood-brain barrier (BBB) penetration and immunosuppressive macrophages. To overcome these, we developed cascade-responsive sonoafterglow nanoprobes for bacteria-targeting, immune reprogramming, and imaging. These nanoprobes, incorporating a sonoafterglow pro-substrate, sonosensitizer, and maltodextrin, selectively targeted bacteria via the ATP-binding cassette sugar transporter pathway.

Establishment of an infectious clone of the porcine transmissible gastroenteritis virus and a study on the location and function of accessory protein 3.

Introduction: Transmissible gastroenteritis virus (TGEV), as the causative agent of TGE, causes huge economic losses in the pig industry worldwide.

Methods: In this study, we successfully constructed a reverse genetic system for the TGEV TH-98 strain and rescued the recombinant virus rTH-98-Δ3-COE-HA based on this system.

Results: The results showed that ORF3 is a non-structural protein and does not exist in mature virions.

2D van der Waals heterostructure memristors: from band structure regulation to neuromorphic computing applications.

Two-dimensional (2D) materials and their van der Waals heterostructures (vdWHs) have shown tremendous potential in the fields of memristors and neuromorphic computing due to their unique band structures and tunable physical properties. This paper reviews the band structures of 2D vdWHs, as well as the mechanisms for their regulation, and discusses the impact of preparation methods such as wet and dry transfer on the interfaces of heterojunctions. On this basis, it delves into the switching mechanisms of memristors based on vdWHs, including the conductive filament model, charge trapping and release, and interfacial barrier modulation.

Antifungal resistance of the Trichophyton mentagrophytes/Trichophyton interdigitale species complex: Insights from the China Antifungal Resistance Dermatophytes Surveillance network Study (CARDS).

Background: Dermatophytosis caused by the Trichophyton mentagrophytes/T. interdigitale species complex (TMTISC) has attracted global attention, with increasing reports of terbinafine-resistant T. indotineae in China.

Unraveling the cross-talk between a highly virulent PEDV strain and the host via single-cell transcriptomic analysis.

Porcine epidemic diarrhea virus (PEDV) causes severe intestinal damage and high mortality in neonatal piglets. The continuous emergence of new strains has brought new challenges to prevention and control. In this study, we isolated and characterized a prevalent PEDV virulent strain and analyzed 19,612 jejunal cells from PEDV-infected and control piglets using single-cell sequencing, revealing significant changes in cellular composition, gene expression, and intercellular communication.

Achieving Excellent Energy Storage and Discharge Performance in PbHfO-Based Antiferroelectric Ceramics via Optimization of Parameters.

Antiferroelectric (AFE) materials demonstrate potential application in pulse power systems and energy-storage devices due to outstanding power density () and rapid charge-discharge capability. Simultaneously achieving a high discharge energy density () and large energy-storage density in AFE ceramics remains a key research focus. In this work, a method for optimizing parameters is proposed for ameliorating the grain size of the ceramic and enhancing antiferroelectricity, ultimately enhancing the energy-storage density and breakdown strength ().

Development and evaluation of immunogenicity and protective efficacy of two recombinant attenuated newcastle disease viruses expressing the VP2 protein of infectious bursal disease virus.

Newcastle disease (ND) and Infectious bursal disease (IBD) are highly contagious and economically significant viral diseases affecting poultry worldwide. Despite widespread vaccination, current vaccines often require multiple doses and provide limited protection against emerging strains. This study developed and evaluated bivalent vaccines based on recombinant Newcastle disease virus (NDV) expressing the VP2 protein of a novel variant Infectious bursal disease virus (IBDV), SHG19 strain.

The preparation of an allyl isothiocyanate and avermectin B microcapsule suspension against plant root-knot nematodes (Meloidogyne incognita).

Background: Root-knot nematodes (Meloidogyne incognita) are one of the main pathogens affecting agricultural production. Conventional fumigants like methyl bromide have been phased out because of environmental risks, while alternatives face challenges of soil toxicity and resistance evolution. This study aims to develop a novel microencapsulated dual-agent system combining allyl isothiocyanate (AITC) and avermectin B (AVB) for sustainable nematode control.

Evaluating the MS-HLJ strain as a novel inactivated vaccine candidate: Long-term immune protection against Mycoplasma synoviae in poultry.

Mycoplasma synoviae (MS) is highly prevalent in chicken flocks and causes significant economic losses in the poultry industry. Vaccination is an effective measure for preventing and controlling MS infection in chickens, making it crucial to isolate, identify, and analyze the immunogenicity of MS to develop vaccines against mycoplasmosis in poultry. In this study, the MS-HLJ strain was isolated from the joint tissue fluid of a suspected case of MS infection in chickens, and its pathogenicity in specific-pathogen-free chickens was investigated.

Intergenerational Solidarity and Mental Health in Chinese American Families: A Dyadic Approach.

Objectives: Existing family and caregiving studies have primarily focused on the mental health of either older adults or adult children. Less is known about the effect of intergenerational relations on the mental health of both generations. This study examined the association between intergenerational solidarity and mental health among older Chinese Americans and their adult children using a dyadic analysis, considering the gendered nature of these relationships.

Inhibitory Effects of Bovine Lactoferricin-Lactoferrampin on Senecavirus A and Foot-and-Mouth Disease Virus with Recombinant Lactobacillus Oral Treatment in Mice.

Foot-and-mouth disease virus (FMDV) and Senecavirus A (SVA) have similar pathogenic characteristics, and both are important pathogens that harm the livestock industry. Studies have shown that lactoferrin peptides can inhibit the replication of various viruses and enhance the body's immune functions. Based on this, in the present study, we aimed to investigate the effects of bovine lactoferricin-lactoferrampin (LFCA) on replicating FMDV and SVA and to analyze its role in the cellular antioxidant response caused by viral infection; in addition, we fed mice with constructed recombinant expressing LFCA.

Child Maltreatment and Whole-person Health: Investigation of Psychosocial Buffers Using Structural Equation Modeling.

Objective: The purpose of this study was to investigate psychosocial factors that may modify associations between child maltreatment and whole-person health (ie, depressive symptoms, chronic health conditions, psychological well-being, and inflammation).

Methods: Data were drawn from a subsample ( N = 1255) of Midlife in the United States study, a national longitudinal study of health and well-being. Structural equation modeling was applied to test hypotheses.