Metabolic and Renal Profile Differences in Pure vs Mixed Uric Acid Kidney Stones: A Retrospective Study.

Objective: Uric acid stones are commonly classified into pure uric acid stones (PUCS) and mixed uric acid stones with calcium oxalate (MUCS). This study aims to investigate the metabolic differences between PUCS and MUCS patients, in order to inform prevention strategies and guide management and follow-up care for uric acid urolithiasis.

Methods: We conducted a retrospective analysis of 88 patients diagnosed with uric acid stones (PUCS: 37, MUCS: 51).

The use of a novel complication reporting system: the comprehensive complication index in thulium laser enucleation of the prostate.

Objectives: To evaluate the application of the comprehensive complication index (CCI) in the assessment of postoperative complications after thulium laser prostate enucleation (ThuLEP) and compare it with the Clavien‒Dindo classification (CDC) grading system.

Methods: A retrospective analysis of the clinical data of 467 patients hospitalized for benign prostatic hyperplasia treated with ThuLEP surgery from August 2019 to October 2023 was conducted. The postoperative complications of patients were assessed via both the CDC and CCI complication evaluation systems, and the correlation between both systems and the postoperative length of stay (LOS) was analyzed.

Promoting selective dephosphorylation and aromatic nitroreduction by in-situ anchoring gold/silver bimetallic nanoparticles on ceria/polyethyleneimine nanosheets.

Addressing the dual challenges of phosphorus resource scarcity and organic pollutant treatment, this study develops a bifunctional ceria/polyethyleneimine/AuAg (CeO/PEI/AuAg) catalyst through self-assembly and in-situ reduction anchoring strategies for both efficient dephosphorylation and aromatic nitroreduction. Its components optimize the catalytic process through multilevel synergy: i) the oxygen vacancies in the CeO component interact with HO to generate lots of protonated hydroxyl groups, which not only enhance the adsorption for phosphates but also facilitate continuous electron enrichment through the Ce/Ce redox cycle, ii) the PEI component enhances the interfacial enrichment of phosphates, BH, and p-nitrophenol through amino group protonation and serves as a green reductant to drive the in-situ uniform anchoring of AuAg bimetallic nanoparticles onto the CeO support, iii) the AuAg bimetallic component directs the electrons enriched in CeO oxygen vacancies and the reducing electrons provided by BH to dual reaction sites via strong metal-support interactions and hierarchical electron transfer channels, thereby improving reaction kinetics. Experimental results show that this catalyst achieves a 3.

Reported prevalence and risk factors of malignant tumors in the elderly population in China: a nationwide cross-sectional study.

Background: Malignant tumors are one of the most challenging public health problems facing mankind. It is of great significance to systematically, comprehensively, and fully understand and analyze the prevalence and distribution of malignant tumors in the elderly population.

Aims: To evaluate the prevalence and associated factors of malignant tumors in the elderly population in China, and quantify the differences in prevalence and associated factors by urban and rural area, sex, and age.

CHEK1 variant is a risk factor for premature ovarian insufficiency by mis- regulating metabolism and inflammation-related genes.

Background: Premature ovarian insufficiency (POI) is affecting approximately 1% of females and increasingly contributing to female infertility. The etiology of POI is heterogeneous. CHEK1, a critical component of the DNA damage and replication stress response, has recently been linked to female reproductive biology.

Antifungal resistance of the Trichophyton mentagrophytes/Trichophyton interdigitale species complex: Insights from the China Antifungal Resistance Dermatophytes Surveillance network Study (CARDS).

Background: Dermatophytosis caused by the Trichophyton mentagrophytes/T. interdigitale species complex (TMTISC) has attracted global attention, with increasing reports of terbinafine-resistant T. indotineae in China.

Approximately Invertible Neural Network for Learned Image Compression.

Learned image compression has attracted considerable interests in recent years. An analysis transform and a synthesis transform, which can be regarded as coupled transforms, are used to encode an image to latent feature and decode the feature after quantization to reconstruct the image. Inspired by the success of invertible neural networks in generative modeling, invertible modules can be used to construct the coupled analysis and synthesis transforms.

Study on Non-Destructive Testing Method of Existing Asphalt Pavement Based on the Principle of Geostatistics.

In the context of the rapid advancement of reconstruction and expansion projects, there has been a significant increase in the demand for the inspection and evaluation of existing asphalt pavements. In order to enhance the efficiency and effectiveness of joint detection using 3D ground-penetrating radar and falling weight deflectometers, this study investigates non-destructive testing methods for existing asphalt pavements based on geostatistical correlation principles. The relationship between crack rate and deflection is analyzed using group average values.

Chronic cutaneous and mucosal mucormycosis: as a major pathogenic fungus.

Chronic cutaneous mucormycosis is a rare condition distinct from the acute form, characterized by a prolonged, indolent course and varied clinical presentations. This study presents a 5-year experience from a tertiary dermato-mycology clinic, identifying six cases, the majority of whom were immunocompetent, with trauma history reported in four patients. The median duration from symptom onset to diagnosis was 60 months.

Targeting the Galectin-7/TRPM2/Zn/DRP-1 Signaling Pathway: A Potential Therapeutic Intervention in the Pathogenesis of SJS/TEN.

Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) represent a spectrum of severe drug-induced cutaneous reactions. These conditions are characterized by widespread and confluent keratinocyte apoptosis, which differentiates them from erythema multiforme (EM). Mounting evidence has implicated the mitochondrial-dependent apoptosis pathway in the pathogenesis of SJS/TEN, but the potential roles and specific mechanisms of these pathways in SJS/TEN remain largely unexplored.

Exosomal mediated lipid metabolism, ferritinophagy and CoQ-dependent pathway contributes to the ferroptosis of keratinocyte in SJS/TEN.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) manifest life-threatening cutaneous adverse drug reactions characterized by keratinocyte death. Previous studies have indicated that apoptosis and necroptosis are implicated in SJS/TEN pathogeneses. However, other forms of cell death involved in this process remain unidentified.

Repeated transcranial magnetic stimulation on the bilateral cerebellum to improve symptoms of ataxia with multiple system atrophy: a prospective, randomized, sham-controlled pilot study.

Objectives: Ataxia is a common symptom in patients with Cerebellar subtype of Multiple system atrophy (MSA-C), but effective treatments remain elusive. The present study aims to investigate whether repetitive transcranial magnetic stimulation (rTMS) over the bilateral cerebellum could relieve ataxia in patients with MSA-C.

Patients And Methods: This is a single-center, randomized and double-blind trial.

Early activity after strong sutures helps to tendon healing in a rat tendon rupture model.

The purpose of this study was to investigate the effect of different times return to activity on tendon healing after Double Kessler method suture in rats with Achilles tendon rupture. The left Achilles tendon of 80 10-week-old rats was repaired. The rats were randomly divided into 4 groups: non-fixed group, fixed one week group, fixed two weeks group and fixed three weeks group.

Causal effects of circulating lipids and lipid-lowering drugs on the risk of atopic dermatitis: a mendelian randomization study.

Lipid metabolism disorders are frequently noted in atopic dermatitis (AD) patients, prompting the long-term use of lipid-lowering drugs. However, the causal effects of circulating lipids and different lipid-lowering drugs on the risk of AD are not thoroughly understood. Using publicly available genome-wide association studies (GWAS) summary data from two different cohorts, a series of Mendelian randomization (MR) analyses were conducted to explore the causal effects of genetically proxied circulating lipids and lipid-lowering drugs on the risk of AD.

[Effect of Dendrobii Officinalis Caulis water extract on hyperviscosity rats based on TLR4/NF-κB/ICAM-1 signaling pathway].

This study aims to reveal the effect and mechanism of Dendrobii Officinalis Caulis water extract on the rat model of hyperviscosity induced by a high-sugar, high-salt, and high-fat diet. Thirty-six male SD rats were randomized into normal, model, Compound Danshen Tablets(0.5 g·kg~(-1)), and low-, medium-, and high-dose(0.

[Effects of different fractions of Polygonati Rhizoma on reproductive dysfunction in male mice with kidney essence deficiency].

This study aims to reveal the effects and mechanisms of different fractions of Polygonati Rhizoma on the reproductive dysfunction in male mice with kidney essence deficiency due to excess of sexual intercourse. Fifty male ICR mice with good sexual function were selected and randomized into normal(NC), model(MC), n-butanol fraction of Polygonati Rhizoma(0.4 g·kg~(-1), HJCT), remaining fraction of Polygonati Rhizoma(0.

Development and validation of a simple clinical nomogram for predicting infectious diseases in pediatric kidney transplantation recipients: a retrospective study.

To construct and verify an easy-to-use nomogram for predicting the risk of infectious diseases in pediatric kidney transplant recipients. Clinical data of hospitalized pediatric kidney transplant recipients were retrospectively analyzed. Meaningful variables identified from the multivariate stepwise logistic regression analysis were used to construct the nomogram.

A carbamazepine metabolite activates NLRP3 and controls skin homing of CD8 T-cells in SJS/TEN.

Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe adverse drug reactions with extensive keratinocyte death. Carbamazepine (CBZ), the most commonly implicated drug in SJS/TEN, is metabolized by the cytochrome P450 enzyme 3A4 (CYP3A4) into carbamazepine-10,11-epoxide (CBZE) in the liver. While CD8 cytotoxic T cells play an important role in SJS/TEN, the underlying mechanism of exuberant immune response by CD8 T cells in these conditions remains incompletely understood.

Risk factors for occurrence and death of sepsis-associated acute kidney injury in children with sepsis.

Introduction: The 28th Acute Disease Quality Initiative (ADQI) Workgroup proposed the first international consensus on definition of SA-AKI in June 2023. The incidence and mortality of ADQI-defined SA-AKI in septic children is unknown, and the risk factors for the occurrence and death of SA-AKI is unexplored.

Methods: We conducted a retrospective study of septic children between January 1, 2018 and December 31, 2022.

Analysis of risk factors for carotid artery plaque in asymptomatic adults.

Objective: This study aimed to investigate the risk factors affecting the presence of carotid plaque in asymptomatic adults.

Methods: Asymptomatic adults (age > 40 years, no symptoms of cardiovascular and cerebrovascular diseases) undergoing routine health examinations from physical examination department were included in this study. Carotid plaque was measured by Resona 7OB and Resona 8EXP color Doppler ultrasound and L9-3U and L4-5WU probes.

Association of critical hypoperfusion biomarkers on CT with futile recanalization and poor outcome after mechanical thrombectomy in acute ischemic stroke.

Background And Purpose: We aimed to investigate the association between critical perfusion delay and poor outcome among recanalized stroke patients with anterior large-vessel occlusion, and to use pretreatment hypoperfusion biomarkers on CT to predict futile recanalization even after successful thrombectomy.

Methods: An ischemic region with time-to-maximum (Tmax) > 12s-10s was defined as critical hypoperfusion, Tmax > 8s as moderate hypoperfusion, and hypoperfusion intensity ratio (HIR, volumetric ratio of Tmax > 10s / Tmax > 6s) represented for severity of critical hypoperfusion and rCBF < 30% for ischemic core. The associations between these CT perfusion characteristics and favorable or unfavorable outcome (mRS 0-2 versus 3-6) were analyzed in univariable regression, and a multivariable model was then used to predict futile recanalization.

Closure of a secondary tracheoesophageal fistula in severe pneumonia using an Amplatzer Duct Occluder II during invasive mechanical ventilation: A case report.

Key Clinical Message: Early and timely closure of secondary tracheoesophageal fistula (TEF) is crucial for critically ill patients. For those requiring invasive mechanical ventilation, the Amplatzer Duct Occluder II (ADO II) can be used as an emergency therapeutic option to rapidly close secondary TEF, providing opportunities for subsequent treatments.

Abstract: Secondary tracheoesophageal fistula (TEF) is a life-threatening condition characterized by high mortality, high recurrence rates, and multiple complications.

The value of adjusted PSAD in prostate cancer detection in the Chinese population.

Objective: To investigate the value of adjusted prostate-specific antigen density (PSAD) in the diagnosis of prostate cancer (PCa).

Methods: Data from 410 patients who underwent transrectal ultrasound-guided prostate biopsy were retrospectively analyzed in Beijing Tsinghua Changgung Hospital between November 2014 and March 2024. All patients were divided into PCa and benign prostatic hyperplasia (BPH) groups according to pathological results.