Holographic modulation of a structured light array through a general 4D redefinable network.

Highly flexible phase holograms have significantly advanced the manipulation of various structured light beams and their arrays. Although numerous methods for phase modulation of structured light arrays have been provided, they frequently encounter challenges related to excessive specialization and limited degrees of freedom. Additionally, the generation of phase holograms typically necessitates iterative optimization, which constrains their real-time application potential.

Inter-session reliability of markerless lower extremity joint kinematics and kinetics for return-to-sport screening tasks.

Evaluating movement quality in dynamic tasks is vital in return-to-sport (RTS) decision-making, yet marker-based motion capture (MoCap) can be complex. This study assessed the inter-session reliability of lower extremity joint kinematics and kinetics obtained using Theia3D, a markerless MoCap solution, during dynamic RTS screening tasks. Eighteen healthy participants performed six tasks over two sessions.

Update on Erythrodermic Psoriasis: Proposal of a Management Algorithm by an Innovative Severity Evaluation Approach.

Erythrodermic psoriasis (EP) is an uncommon and severe form of psoriasis, which exhibits a Th1/Th17/TNF inflammatory pattern. Most patients with EP experience systemic symptoms that necessitate systemic treatments. These treatments include conventional systemic drugs (such as acitretin, cyclosporin A, and methotrexate), biologics (including IL-17, IL-12/23, and TNF-α inhibitors), and small molecule drugs (such as apremilast and JAK inhibitors).

Machine Learning-Assisted Molecular Orbital Insights into OER Activity Descriptors of Component Gradient Ni-Based LDH Electrocatalysts.

The conventional theories to predict the oxygen evolution reaction (OER) performance in electrochemical water-electrolysis, including the d-band center and the e orbital occupancy, encounter limitations under specific conditions. The d-band center serves as a partial descriptor of adsorption energy, leading to inconsistencies, and the e orbital occupancy theory underestimates the contributions of other orbitals. Here, a machine learning-assisted molecular orbital investigation is conducted to explore 3d orbitals characteristics.

Humans use underestimates of auditory spatial and temporal uncertainty for perceptual inference.

Making decisions based on noisy sensory information is a crucial function of the brain. Various decisions take each sensory signal's uncertainty into account. Here, we investigated whether perceptual inferences rely on accurate estimates of sensory uncertainty.

Unmet needs of patients with intravascular large B-cell lymphoma: three case reports and a literature review.

Intravascular large B-cell lymphoma (IVLBCL), a rare subtype of non-Hodgkin lymphoma, is classified as an independent subtype of extranodal diffuse large B-cell lymphoma (DLBCL) in the 2008 World Health Organization (WHO) Classification (Turner et al., 2010). The 5th edition of the World Health Organization (WHO 2022) classification of hematolymphoid tumors retains this subtype (Alaggio et al.

Protective Effects of a Novel Storage Solution on Membrane Integrity and Oxidative Stress in Erythrocytes From Patients With Type 2 Diabetes.

This study aimed to evaluate the protective efficacy of a novel red blood cell (RBC) preservation solution on erythrocytes during storage, with specific focus on RBCs from Type 2 diabetes mellitus (T2DM) patients. Whole blood samples were obtained from T2DM patients and healthy donors. RBCs were isolated and stored in either the novel solution or the conventional solution.

Comprehensive analysis of risk factors for intracranial aneurysm rupture: a retrospective cohort study.

Background: Intracranial aneurysms (IAs) can lead to subarachnoid hemorrhage, a life-threatening event associated with high morbidity and mortality. Identifying individuals at elevated risk is crucial for guiding timely interventions and improving patient outcomes.

Methods: In this retrospective cohort study, 850 patients who received interventional or surgical treatment for IAs between January 2018 and January 2024 were included.

Current status of generalized pustular psoriasis: Findings from a multicenter hospital-based survey of 127 Chinese patients.

Background: Generalized pustular psoriasis (GPP), a rare and recurrent autoinflammatory disease, imposes a substantial burden on patients and society. Awareness of GPP in China remains limited.

Methods: This cross-sectional survey, conducted between September 2021 and May 2023 across 14 hospitals in China, included GPP patients of all ages and disease phases.

Anti-nephrin antibody: a potential biomarker of minimal change disease.

Background: Minimal change disease (MCD) is a common pathological type of nephrotic syndrome in children and adults, and the mechanisms remain obscure. The diagnosis of MCD still relies on renal biopsy, lacking effective biological markers. This study explores the diagnostic value of circulating anti-nephrin antibody in MCD patients and evaluates the correlation with disease activity indicators such as proteinuria.

Expression and purification of recombinant glutaredoxin 1 and protection against oxidative stress injury during cerebral ischemia-reperfusion injury.

Glutaredoxin (Grx) is a small molecular protein widely found in both prokaryotes and eukaryotes, serving various biological functions, including participation in redox reactions and exerting anti-apoptotic effects[1]. To evaluate the protective effect of recombinant Grx1 against oxidative stress, we constructed the pET-30a (+)/Grx1 recombinant plasmid and performed soluble expression and purification of the recombinant Grx1. In vitro experiments, including ABTS and DPPH radical scavenging assays, showed that recombinant Grx1 has significant antioxidant activity.

Spirulina Supplementation Alleviates Intense Exercise-Induced Damage and Modulates Gut Microbiota in Mice.

Background: , which are filamentous cyanobacteria, have gained significant popularity in the food industry, medicine, and aquaculture.

Methods: In this study, our objective was to explore the influence of on the gut microbiota and exercise capacity of mice undergoing high-intensity exercise. Twenty-four male BALB/c mice were divided into four groups, with six mice in each group.

Effects of Lipid Headgroups on the Mechanical Properties and In Vitro Cellular Internalization of Liposomes.

We performed all-atom and coarse-grained simulations of lipid bilayer mixtures of the unsaturated lipid DOPC, with saturated lipids having the same 18-carbon acyl tails and different headgroups, to understand their mechanical properties. The secondary lipids were DSPG, DSPA, DSPS, DSPC, and DSPE. The DOPC:DSPG system with 65:35 molar ratio was the softest, with area compressibility modulus ∼ 22% smaller than the pure DOPC value.

Kill two birds with one stone: Biochar immobilised polydopamine coated compound bacterial agent for remediation of dibutyl phthalate contaminated soil.

The severe contamination of the plasticizer dibutyl phthalate (DBP) in agriculture soils is often accompanied by a decrease in nutrient utilization. Though the combined application of a variety of microorganisms can simultaneously address the problems of soil contamination and nutrient deprivation, the activity and function of microorganisms can be severely inhibited by DBP, and studies on their protection under DBP contamination are almost non-existent. In this study, a compound bacterial agent KPSB was prepared by optimising with FeO-modified biochar loaded with DBP-degrading bacterium Enterobacterium sp.

Efgartigimod treatment for therapy-refractory autoimmune encephalitis with coexistent NMDAR and LGI1 antibodies: a case report and literature review.

The Fc receptor (FcRn) inhibitors can ameliorate autoimmune conditions such as myasthenia gravis through a rapid and specific clearance of serum IgG levels, and they also have potential for future use in a wider variety of antibody-mediated autoimmune diseases. Some patients with therapy-refractory autoimmune encephalitis (AE) continue to be unresponsive to initial and secondary treatment regimens. A 32-year-old male presented with predominant psychiatric symptoms and seizures, along with imaging evidence indicating multifocal cerebral cortical involvement.

Study on the developmental, behavioral toxicity, and toxicological mechanism of the antidepressant drug venlafaxine and its active metabolites in zebrafish.

As a representative agent of bicyclic antidepressants, venlafaxine (VEN) has become widely used worldwide and is frequently detected in surface waters with concentrations ranging from ng/L to µg/L. To evaluate the toxicological effects of such medications on aquatic species, studies on environmentally relevant concentrations are essential. Zebrafish were used as a model organism to assess growth and development in larvae and examine tissue accumulation, oxidative stress, and DNA methylation in adults.

The compensatory enrichment of sphingosine-1-phosphate on HDL in FSGS enhances the protective function of glomerular endothelial cells compared to MCD.

Glomerular endothelial cells (GECs) are pivotal in developing glomerular sclerosis disorders. The advancement of focal segmental glomerulosclerosis (FSGS) is intimately tied to disruptions in lipid metabolism. Sphingosine-1-phosphate (S1P), a molecule transported by high-density lipoproteins (HDL), exhibits protective effects on vascular endothelial cells by upregulating phosphorylated endothelial nitric oxide synthase (p-eNOS) and enhancing nitric oxide (NO) production.

Crystallographic, kinetic, and calorimetric investigation of PKA interactions with L-type calcium channels and Rad GTPase.

β-Adrenergic signaling activates cAMP-dependent PKA, which regulates the activity of L-type voltage-gated calcium channels such as Ca1.2. Several PKA target sites in the C-terminal tail of Ca1.

Scalable Production of Functional Fibers with Nanoscale Features for Smart Textiles.

Functional fibers, retaining nanoscale characteristics or nanomaterial properties, represent a significant advance in nanotechnology. Notably, the combination of scalable manufacturing with cutting-edge nanotechnology further expands their utility across numerous disciplines. Manufacturing kilometer-scale functional fibers with nanoscale properties are critical to the evolution of smart textiles, wearable electronics, and beyond.

The value of tissue quantitative diffusion analysis of ultrasound elastography in the diagnosis of early-stage chronic kidney disease.

Purpose: To explore the value of tissue quantitative diffusion analysis of ultrasound elastography in the diagnosis of early-stage chronic kidney disease (CKD).

Methods: The observation group comprised 54 patients with early-stage CKD treated at Fuzhou No 7 Hospital, and the control group consisted of 40 healthy individuals who underwent physical examinations at the same hospital. The renal parenchyma of the participants were examined using ultrasonography, color Doppler ultrasonography, and tissue quantitative diffusion analysis of ultrasound elastography.

Enhanced Fenton catalytic degradation of methylene blue by the synergistic effect of Fe and Ce in chitosan-supported mixed-metal MOFs (Fe/Ce-BDC@CS).

Methylene blue (MB) is a refractory organic pollutant that poses a potential threat to the aquatic environment. Fenton reaction is considered a primrose strategy to treat MB. However, the traditional Fenton process is plagued by narrow pH application range, poor stability, and secondary pollution.

Association of EEG and cognitive impairment in overweight and non-overweight patients with schizophrenia.

Objective: Schizophrenia (SCZ) is a globally prevalent, severe chronic mental disorder, with cognitive dysfunction being one of its core symptoms. Notably, overweight is exceedingly common among individuals with SCZ, and overweight can also impact cognitive function. Therefore, the relationship between overweight and cognition in SCZ is a clinical issue that is in need of research attention.

Predictive role and molecular biological function of proline-rich small repeat protein SPRR3 in the diagnosis of lung adenocarcinoma.

The fascinating role of SPRR3 in various malignant tumors has prompted extensive research to unravel its expression patterns and prognostic significance. To comprehensively investigate SPRR3, we leveraged multiple datasets containing invaluable biomedical information, specifically focusing on the comparative analysis of SPRR3 gene expression levels across different cancer types. Meticulous examination of lung adenocarcinoma allowed us to delve deeper into the correlation between SPRR3 expression and its molecular biological functions.

Repair of Underwater Concrete Cracks on Dam Surface: Optimization Analysis of the Grouting Process with Surface Sealing.

The grouting repair process of the sealing baffle on the surface of dam cracks can improve the repair slurry diffusion distance in the cracks; however, the process must be optimized. To address the problem of crack repair technology of underwater dam concrete with one section open and the other closed, a grouting analysis model was established. By adjusting various parameters in the grouting process, the influences of the grouting pressure, position of the grouting hole, diameter of the grouting hole, and water pressure on the diffusion of the Bingham fluid repair slurry in these cracks were studied.

A Network of Circular RNA and MicroRNA Sequencing Provides Insights into Pigment Deposition of Changshun Blue Eggshell Chickens.

Eggshell color plays important biological roles and attracts the attention of both egg retailers and researchers. However, whether non-coding RNAs are involved in pigment deposition among different eggshell colors remains unknown. In this study, RNA sequencing was used to analyse the uterine gland transcriptome (CircRNA and miRNA) of Changshun chicken blue-shell hens producing four different eggshell color eggs including dark blue PK(DB) and light blue (LB), dark brown and greenish (between blue and pink, DP) and pink (p).