The therapeutic effect of Qishen Huoxue Granule on myocardial injury in sepsis rats and its underlying mechanism via suppressing excessive autophagy.

To determine therapeutic effect of Qishen Huoxue Granule (QHG) on the myocardial injury in sepsis and whether it is through the inhibition of excessive autophagy by using network pharmacological analysis and in vitro.120 SPF male Wistar rats were divided into 6 groups. Firstly, the function of the heart were evaluated through echocardiography, and pathological changes of myocardial tissue was observed by Hematoxylin-eosin (H&E) and Transmission electron microscopy (TEM).

Automated Pediatric Delirium Recognition via Deep Learning-Powered Video Analysis.

Delirium is an acute, fluctuating state of consciousness disturbance characterized by cognitive alterations and perceptual disturbances. Pediatric delirium has a notably higher incidence rate than adult delirium, and it is time-consuming and labor-intensive for clinicians to analyze, requiring effective recognition approaches. Deep learning has shown potential for the extraction of robust representations and improvement of patient outcomes.

Global, regional, and national burden of endocrine, metabolic, blood, and immune disorders from 1990 to 2021, and projections to 2050: a systematic analysis of the global burden of disease study.

Background: Endocrine, metabolic, blood, and immune disorders (EMBID) are a leading cause of morbidity and mortality worldwide, with substantial regional disparities. Despite advancements in diagnosis and treatment, the burden of EMBID continues to rise. This study aimed to comprehensively assess the global, regional, and national burden of EMBID from 1990 to 2021, with projections to 2050.

Research on the oil retention effect of pneumatic oil barriers under current and wave action.

The pneumatic oil barrier is a novel device that intercepts oil spills by releasing high-pressure gas underwater to form a curtain of bubbles. However, its performance can be affected by both internal factors and external influences like water flow and waves, leading to varying degrees of oil interception failure and reduced effectiveness. This study combines physical experiments with numerical simulations to analyze the impact of nozzle parameters, arrangement, flow velocity, and wave effects on oil interception loss and effective containment distance under uniform flow and wave conditions.

Artifact-Tolerant Electrophysiological Sensor Interface with 3.6V/1.8V DM/CM Input Range and 52.3mV/μs Recovery Using Asynchronous Signal Folding.

In the practical implementations of wearable sensors, motion artifacts with large amplitudes often cause signal chain saturation, significantly degrading biopotential signal integrity. Similarly, rapid stimulation artifacts are inevitable during closed-loop brain stimulation therapy, posing additional challenges for real-time signal acquisition. To address motion and stimulation artifacts with amplitudes reaching hundreds of mV while minimizing information loss, a sensor interface with high input range and fast artifacts recovery capability is essential.

Qishen Huoxue Granule Ameliorates LPS-induced Cardiomyocyte Injury by Suppressing Excessive Autophagy via MasR/PI3K-AKT-mTOR Pathway.

Objective: Qishen Huoxue Granule (QHG), a classical Traditional Chinese Medicine prescription, can reduce septic cardiomyopathy in the clinic. However, the mechanism of QHG remains unclear. This study aims to investigate the mechanism and effect of QHG-contained serum (QHG-CS) on sepsis-induced cardiomyopathy (SICM).

Wnt-5a ameliorates sepsis-induced downregulation of renal AQP2 via the calcineurin signaling pathway.

Background: Aquaporin 2 (AQP2), a vasopressin-sensitive water channel in the renal collecting ducts, maintains body water homeostasis. Sepsis reduces AQP2 and vasopressin receptor 2 (V2R) levels, contributing to acute kidney injury. In a heritable nephrogenic diabetes insipidus mouse model with V2R mutation, Wnt-5a, a ligand for frizzled receptors (Fzds), enhances AQP2 expression and translocation through calcium/calmodulin/calcineurin signaling.

CTCNet: a fine-grained classification network for fluorescence images of circulating tumor cells.

The identification and categorization of circulating tumor cells (CTCs) in peripheral blood are imperative for advancing cancer diagnostics and prognostics. The intricacy of various CTCs subtypes, coupled with the difficulty in developing exhaustive datasets, has impeded progress in this specialized domain. To date, no methods have been dedicated exclusively to overcoming the classification challenges of CTCs.

Stable and Tunable Quantum Conductance in Spider-Silk-like Synaptic Device for Neurocomputing.

The quantum conductance (QC) behaviors in synaptic devices with stable and tunable conductance states are essential for high-density storage and brain-like neurocomputing (NC). In this work, inspired by the discontinuous transport of fluid in spider silk, a synaptic device composed of a silicon oxide nanowire network embedded with silicon quantum dots (Si-QDs@SiO) is designed. The tunable QC behaviors are achieved in both the SET and RESET processes, and the QC states exhibit stable retention time exceeding 10 s in the synaptic device and show stable reproducibility after an interval of two months.

An Energy-Efficient FD-fNIRS Readout Circuit Employing a Mixer-First Analog Frontend and a Σ-Δ Phase-to-Digital Converter.

This paper presents a low-power frequency-domain functional near-infrared spectroscopy (FD-fNIRS) readout circuit for the absolute value measurement of tissue optical characteristics. The paper proposes a mixer-first analog front-end (AFE) structure and a 1-bit Σ-Δ phase-to-digital converter (PDC) to reduce the required circuit bandwidth and the laser modulation frequency, thereby saving power while maintaining high resolution. The proposed chip achieves sub-0.

Meta-Analysis of Pulse Transition Features in Non-Invasive Blood Pressure Estimation Systems: Bridging Physiology and Engineering Perspectives.

The pulse transition features (PTFs), including pulse arrival time (PAT) and pulse transition time (PTT), hold significant importance in estimating non-invasive blood pressure (NIBP). However, the literature showcases considerable variations in terms of PTFs' correlation with blood pressure (BP), accuracy in NIBP estimation, and the comprehension of the relationship between PTFs and BP. This inconsistency is exemplified by the wide-ranging correlations reported across studies investigating the same feature.

Discovery of Novel Tryptanthrin Derivatives with Benzenesulfonamide Substituents as Multi-Target-Directed Ligands for the Treatment of Alzheimer's Disease.

Based on the multi-target-directed ligands (MTDLs) approach, two series of tryptanthrin derivatives with benzenesulfonamide substituents were evaluated as multifunctional agents for the treatment of Alzheimer's disease (AD). In vitro biological assays indicated most of the derivatives had good cholinesterase inhibitory activity and neuroprotective properties. Among them, the target compound was considered as a mixed reversible dual inhibitor of acetylcholinesterase (AChE, IC = 0.

COMPARISON AMONG PRESEPSIN, PROCALCITONIN, AND C-REACTIVE PROTEIN IN PREDICTING BLOOD CULTURE POSITIVITY AND PATHOGEN IN SEPSIS PATIENTS.

Background: Sepsis is caused by the invasion of the bloodstream by microorganisms from local sites of infection, leading to high mortality. This study aimed to compare the predictive ability of the biomarkers presepsin, procalcitonin (PCT), and C-reactive protein for bacteraemia. Methods: In this retrospective, multicentre study, a dataset of patients with sepsis who were prospectively enrolled between November 2017 and June 2021 was analyzed.

Construction and validation of a immune-related prognostic gene DHRS1 in hepatocellular carcinoma based on bioinformatic analysis.

A member of the short-chain dehydrogenase/reductase superfamily (DHRS1, SDR19C1) is a member of the short-chain dehydrogenase/reductase superfamily and a potential predictor of hepatocellular carcinoma (HCC). However, the role of DHRS1 in HCC immunity remains unclear. We systematically analyzed the association between DHRS1 and HCC immunity with transcriptional and clinical data from the Tumor Immune Estimation Resource, an integrated repository portal for tumor immune system interactions, and cBioPortal databases.

Controllability of the Conductive Filament in Porous SiO Memristors by Humidity-Mediated Silver Ion Migration.

Oxide-based memristors composed of Ag/porous SiO/Si stacks are fabricated using different etching time durations between 0 and 90 s, and the memristive properties are analyzed in the relative humidity (RH) range of 30-60%. The combination of humidity and porous structure provides binding sites to control silver filament formation with a confined nanoscale channel. The memristive properties of devices show high on/off ratios up to 10 and a dispersion coefficient of 0.

Self-Adaptive Perception of Object's Deformability with Multiple Deformation Attributes Utilizing Biomimetic Mechanoreceptors.

The perception of object's deformability in unstructured interactions relies on both kinesthetic and cutaneous cues to adapt the uncertainties of an object. However, the existing tactile sensors cannot provide adequate cutaneous cues to self-adaptively estimate the material softness, especially in non-standard contact scenarios where the interacting object deviates from the assumption of an elastic half-infinite body. This paper proposes an innovative design of a tactile sensor that integrates the capabilities of two slow-adapting mechanoreceptors within a soft medium, allowing self-decoupled sensing of local pressure and strain at specific locations within the contact interface.

Emulation of Brain Metabolic Activities Based on a Dynamically Controllable Optical Phantom.

This paper presents a dynamic optical phantom for the simulation of metabolic activities in the brain, and a linear equivalent model is built for control voltage versus substance concentration. A solid-solid dynamic optical phantom is realized by using liquid crystal film as a voltage-controlled light intensity regulator on the surface of basic phantom, which uses epoxy resin as matrix material and nanometer carbon powder and titanium dioxide powder as absorption and scattering dopants, respectively. The dynamic phantom could mimic near-infrared spectrum (NIRS) signals with sampling rate up to 10 Hz, and the maximum simulation errors for oxy-hemoglobin and deoxy-hemoglobin concentrations varying in the range of 1 μmol/l are 7.

High-normal free thyroxine level is related with decreased bone mineral density in nonobese male patients with type 2 diabetes over 50 years old.

Background: The prevalence of 'low bone mineral density (BMD)' in Type 2 diabetes (T2DM), especially stratified by body mass index, is seldom reported. The relation of the euthyroid range and low BMD in T2DM remains to be further elucidated.

Objectives: We aim to investigate the thyroid hormones' impact on BMD among euthyroid patients with T2DM.

A Re-Configurable Body Channel Transceiver Towards Wearable and Flexible Biomedical Sensor Networks.

Body channel communication (BCC) has become a promising candidate in wireless body area networks (WBAN) due to its advantages in energy efficiency and security. However, BCC transceivers face two challenges: diverse application requirements and varying channel conditions. To overcome these challenges, this article proposes a re-configurable architecture for BCC transceivers (TRXs), whose key parameters and communication protocols can be software-defined (SD) according to the requirements.

CLINICAL CHARACTERISTICS AND PREDICTORS OF MORTALITY DIFFER BETWEEN PULMONARY AND ABDOMINAL SEPSIS.

Background: Pulmonary sepsis and abdominal sepsis have pathophysiologically distinct phenotypes. This study aimed to compare their clinical characteristics and predictors of mortality. Methods: In this multicenter retrospective trial, 1,359 adult patients who fulfilled the Sepsis-3 criteria were enrolled and classified into the pulmonary sepsis or abdominal sepsis groups.

Optimal antiplatelet therapy for patients after antiplatelet therapy induced gastrointestinal bleeding: timing.

Adjusting antiplatelet strategies after antiplatelet-associated gastrointestinal bleeding (GIB) is a complex clinical challenge. To assess the risk of outcomes at different times of resumption of antiplatelet therapy in an attempt to find the optimal time to resume therapy. The study analyzed consecutive patients with antiplatelet-associated GIB from Beijing Friendship Hospital Information System between October 2019 and June 2022.