End-to-end contact enables long-distance electron transport between filaments in cable bacteria.

Filamentous cable bacteria are capable of centimeter-scale long-distance electron transport and play crucial roles in the biogeochemistry of aquatic sediments. However, the mechanisms underlying long-distance electron transport remain incompletely understood. This study reports dynamic contacts between separate filaments of cable bacteria, enabling them to relay electrons between sulfidic and oxic zones.

RB1 and p53 are diagnostic markers for treatment-related neuroendocrine prostate cancer: a clinical and pathological analysis of 23 cases.

The synergistic interplay between RB1 deletions and TP53 mutations drives androgen deprivation therapy (ADT) resistance and neuroendocrine transdifferentiation in advanced prostate cancer, culminating in treatment-related neuroendocrine prostate cancer (t-NEPC). This investigation systematically examines the clinicopathological characteristics and immunohistochemical phenotypes of t-NEPC to enhance diagnostic accuracy and prognostic understanding. We conducted a retrospective analysis of 23 t-NEPC cases diagnosed at the First Affiliated Hospital of Zhejiang University School of Medicine (2013-2024).

Family Resilience and Quality of Life Among Chinese Patients With Acute Leukaemia: A Moderated Mediation Model of Cognitive Appraisal and Coping Style.

Aims And Objectives: To identify whether cognitive appraisal and coping style have moderating and mediating effects on the relationship between family resilience and quality of life (QoL) in patients with acute leukaemia (AL).

Background: AL is a clonal and aggressive haematological malignancy that requires long-term and continuous therapy, which may negatively influence QoL. Family resilience can be used as a psychosocial resource that may enhance patients' coping processes and QoL.

The Awakening Brain is Characterized by a Widespread and Spatiotemporally Heterogeneous Increase in High Frequencies.

Morning awakening is part of everyday life. Surprisingly, information remains scarce on its underlying neurophysiological correlates. Here simultaneous polysomnography and stereo-electroencephalography recordings from 18 patients are used to assess the spectral and connectivity content of the process of awakening at a local level 15 min before and after the awakening.

Methanogenesis in the presence of oxygenic photosynthetic bacteria may contribute to global methane cycle.

Accumulating evidences are challenging the paradigm that methane in surface water primarily stems from the anaerobic transformation of organic matters. Yet, the contribution of oxygenic photosynthetic bacteria, a dominant species in surface water, to methane production remains unclear. Here we show methanogenesis triggered by the interaction between oxygenic photosynthetic bacteria and anaerobic methanogenic archaea.

Growth of electroautotrophic microorganisms using hydrovoltaic energy through natural water evaporation.

It has been previously shown that devices based on microbial biofilms can generate hydrovoltaic energy from water evaporation. However, the potential of hydrovoltaic energy as an energy source for microbial growth has remained unexplored. Here, we show that the electroautotrophic bacterium Rhodopseudomonas palustris can directly utilize evaporation-induced hydrovoltaic electrons for growth within biofilms through extracellular electron uptake, with a strong reliance on carbon fixation coupled with nitrate reduction.

Cribiform and intraductal carcinoma in hereditary prostate cancer: clinical and pathological analysis of 20 cases.

Cribiform and intraductal carcinoma are patterns of aggressive prostate carcinoma. This study investigated the clinical and pathological features of hereditary prostate cancer. Twenty cases of hereditary prostate cancer from 11 family lines treated at the First Affiliated Hospital of Zhejiang University School of Medicine between 2016-2022 were included to summarize the clinical and pathological features by analyzing clinical information including follow up the survival of the patients and pathological features.

Abiotic Methane Production Driven by Ubiquitous Non-Fenton-Type Reactive Oxygen Species.

Abiotic CH production driven by Fenton-type reactive oxygen species (ROS) has been confirmed to be an indispensable component of the atmospheric CH budget. While the chemical reactions independent of Fenton chemistry to ROS are ubiquitous in nature, it remains unknown whether the produced ROS can drive abiotic CH production. Here, we first demonstrated the abiotic CH production at the soil-water interface under illumination.

Microbial biofilms for self-powered noncontact sensing.

Noncontact sensing technology plays a vital role in the intelligent human-machine interface, as the essential medium for exchanging information between human and electronic devices. To date, several inorganic materials-based noncontact sensing techniques have been used to accurately detect touch, electrical property, and physical motion. However, limited available materials, dependence on additional power supplies, and poor power production performance, have seriously obstructed the practical applications of noncontact sensing technology.

Cerebral glucose hypometabolism and hypoperfusion of cingulate gyrus: an imaging biomarker of autoimmune encephalitis with psychiatric symptoms.

Background: About 60% of autoimmune encephalitis (AE) patients present psychiatric symptoms, but the underlying mechanism remains unknown. This study examined the role of the cingulate cortex in such patients to identify predictive poor psychiatric factors.

Methods: In this study, 49 AE patients and 39 healthy controls were enrolled.

Mechanism and Influence of Dispersants on the Action of Polymer Flocculants Used in Slurry Separation.

The application of polymer flocculants plays a pivotal role in the slurry separation process of shields, and the dispersant used for treating cutter mud cakes can significantly impact the effectiveness of polymer flocculants, potentially leading to reduced efficiency in slurry separation. Experiments were conducted to select appropriate flocculants and investigate the influence of dispersants on flocculant effectiveness, aiming to assess the effect of flocculants and explore the relationships and mechanisms governing their influence. Changes in the patterns of slurry flocculation were revealed in terms of flocculation-driven precipitation and vacuum-filtration effects.

CCDC50, an essential driver involved in tumorigenesis, is a potential severity marker of diffuse large B cell lymphoma.

Diffuse Large B Cell Lymphoma (DLBCL) is the most common form of blood cancer. Among the subtypes, the activated B-cell (ABC) subtype is typically more aggressive and associated with worse outcomes. However, the underlying mechanisms are not fully understood.

Clinical features and brain MRI volumetric changes in anti-mGluR5 encephalitis.

Background: Anti-metabotropic glutamate receptor 5 (mGluR5) encephalitis is a rare and under-recognized autoimmune encephalitis. This study is conducted to characterize its clinical and neuroimaging features.

Methods: Twenty-nine patients with anti-mGluR5 encephalitis (15 new cases identified in this study and 14 previously reported cases) were included in this study and their clinical features were characterized.

Microbial biofilm-based hydrovoltaic technology.

Hydrovoltaic electricity generation (HEG) utilizes the latent environmental heat stored in water, and subsequently harvests the electrical energy. However, sustainable HEG has remained extremely challenging due either to complex fabrication and high cost, or to restricted environmental compatibility and renewability. Electroactive microorganisms are environmentally abundant and viable in performing directional electron transport to produce currents.

Solar-driven methanogenesis with ultrahigh selectivity by turning down H production at biotic-abiotic interface.

Integration of methanogens with semiconductors is an effective approach to sustainable solar-driven methanogenesis. However, the H production rate by semiconductors largely exceeds that of methanogen metabolism, resulting in abundant H as side product. Here, we report that binary metallic active sites (namely, NiCu alloys) are incorporated into the interface between CdS semiconductors and Methanosarcina barkeri.

All-Biobased Hydrovoltaic-Photovoltaic Electricity Generators for All-Weather Energy Harvesting.

Hygroelectricity generators (HEGs) utilize the latent heat stored in environmental moisture for electricity generation, but nevertheless are showing relatively low power densities due to their weak energy harvesting capacities. Inspired by epiphytes that absorb ambient moisture and concurrently capture sunlight for dynamic photosynthesis, we propose herein a scenario of all-biobased hydrovoltaic-photovoltaic electricity generators (HPEGs) that integrate photosystem II (PSII) with () for simultaneous energy harvesting from both moisture and sunlight. This proof of concept illustrates that the all-biobased HPEG generates steady hygroelectricity induced by moisture absorption and meanwhile creates a photovoltaic electric field which further strengthens electricity generation under sunlight.

Sustained Biotic-Abiotic Hybrids Methanogenesis Enabled Using Metal-Free Black Phosphorus/Carbon Nitride.

Biotic-abiotic hybrid systems (BAHs) constructed by integrating biological methanogens with photocatalysts offer novel approaches for the effective solar-driven conversion of CO to CH, providing significant inspiration for achieving carbon neutrality and alleviating the energy crisis. As metal photocatalysts would cause photocorrosion that damages microbial cells and lead to system imbalance. Therefore, exploring suitable metal-free photocatalysts is of particular importance in the search for more efficient and sustainable BAHs to improve the actual operability and applicability.

Dual block HER2 assessment increased HER2 immunohistochemistry positive rate in resected specimens of gastric cancer: a prospective multicenter clinical trial from China.

Background: Former single center studies indicated that HER2 assessment with two primary tumor blocks (dual block HER2 assessment) could be an efficient and practical approach to overcome the adverse impact of heterogeneity and acquire a HER2 positive rate in gastric cancer (GC). This multicenter prospective clinical trial (NCT02843412) was launched to verify its value and generality.

Methods: A total of 3806 participants with primary GCs have been enrolled from 8 hospitals in China.

Metal-Free Semiconductor-Based Bio-Nano Hybrids for Sustainable CO -to-CH Conversion with High Quantum Yield.

Bio-nano hybrids with methanogens and nano-semiconductors provide an innovative strategy for solar-driven CO -to-CH conversion; however, the efficiency mismatch between electron production and utilisation results in low quantum yield and CH selectivity. Herein, we report the integration of metal-free polymeric carbon nitrides (CN ) decorated with cyanamide (NCN) groups and Methanosarcina barkeri (M. b).

KIF23 is a potential biomarker of diffuse large B cell lymphoma: Analysis based on bioinformatics and immunohistochemistry.

Diffuse Large B Cell Lymphoma (DLBCL), the most common form of blood cancer. The genetic and clinical heterogeneity of DLBCL poses a major barrier to diagnosis and treatment. Hence, we aim to identify potential biomarkers for DLBCL.

Identification of novel biomarkers differentially expressed between African-American and Caucasian-American prostate cancer patients.

Prostate cancer (PCa) incidence and mortality rate vary among racial and ethnic groups with the highest occurrence in African American (AA) men who have mortality rates twice that of Caucasians (CA). In this study, we focused on differential expression of proteins in AA prostate cancer compared to CA using Protein Pathway Array Analysis (PPAA), in order to identify protein biomarkers associated with PCa racial disparity. Fresh frozen prostate samples (n=90) obtained from radical prostatectomy specimens with PCa, including 25 AA tumor, 21 AA benign, 23 CA tumor, 21 CA benign samples were analyzed.