PRMT1 inhibition enhances the cardioprotective effect of adipose-derived mesenchymal stem cells against myocardial infarction through RUNX1.

Background: The poor viability and paracrine function of transplanted mesenchymal stem cells (MSCs) hamper their therapeutic efficacy in ischemic heart injury treatment. Protein arginine methyltransferases (PRMTs) mediate arginine methylation and have important functions in cellular responses. However, the role of PRMTs in MSC-based therapies for ischemic heart injury remains unclear.

Methods and instruments for the evaluation of food texture: Advances and perspectives.

Evaluation of food texture is crucial for product development and quality control in the food industry. To objectively evaluate the texture, the methods to characterize the texture attributes by instruments become increasingly important. This review mainly introduces the advances of instrumental methods by rheology and tribology in food texture studies, with a focus on the instrumental applications in four complex texture attributes, including thickness, astringency, creaminess, and graininess.

Characterizing Common Factors Affecting Replication Initiation During HO Exposure and Genetic Mutation-Induced Oxidative Stress in .

Oxidative stress is prevalent in organisms, and excessive oxidative damage can trigger cell death. Bacteria have evolved multiple pathways to cope with adverse stress, including the regulation of the cell cycle. Previous studies show that non-lethal exposure to HO and mutations in antioxidant enzymes suppress replication initiation in .

Application of biomimetic tongue substrate to investigate the role of friction and vibration in sensory texture perception.

This study proposed a novel biomimetic tongue substrate to better understand food texture perception, expanding the scope of this mechanism from merely friction to also include vibration in oral lubrication. With our bioinspired setup, friction and vibration signals were simultaneously acquired using the polyvinyl alcohol (PVA) hydrogel substrates fabricated with different parameters of surface roughness and thickness. Results showed that the feature parameters of friction coefficient and vibration amplitude were positively correlated to surface roughness, while substrate thickness had little effect on these features.

Uncovering the effects of non-lethal oxidative stress on replication initiation in Escherichia coli.

Cell cycle adaptability assists bacteria in response to adverse stress. The effect of oxidative stress on replication initiation in Escherichia coli remains unclear. This work examined the impact of exogenous oxidant and genetic mutation-mediated oxidative stress on replication initiation.

Effect of Amorphous -PHB on Growth, Body Composition, Immune-Related Gene Expression and Resistance of Hybrid Grouper ( ♀ × . ♂) Juveniles.

Poly-β-hydroxybutyrate (PHB) is a bacterial metabolite produced by bacteria such as sp. that serves as a carbon and energy storage compound for bacteria under nutrient-limited conditions. Two experiments were conducted to investigate the effects of dietary supplementation with -PHB on hybrid grouper ( ♀ × .

Investigating the association between gut microbiome and aortic aneurysm diseases: a bidirectional two-sample Mendelian randomization analysis.

Objective: This study aims to investigate the associations between specific bacterial taxa of the gut microbiome and the development of aortic aneurysm diseases, utilizing Mendelian Randomization (MR) to explore these associations and overcome the confounding factors commonly present in observational studies.

Methods: Employing the largest available gut microbiome and aortic aneurysm Genome-Wide Association Study databases, including MiBioGen, Dutch Microbiome Project, FinnGen, UK Biobank, and Michigan Genomics Initiative, this study performs two-sample bidirectional MR analyses. Instrumental variables, linked to microbiome taxa at significant levels, were selected for identifying relationships with abdominal aortic aneurysms (AAA), thoracic aortic aneurysms (TAA), and aortic dissection (AD).

Genetic predisposition to type 2 diabetes mellitus and aortic dissection: a Mendelian randomisation study.

Background: This Mendelian randomization (MR) study aimed to explore the causal relationship between the genetic predisposition to type 2 diabetes mellitus (T2DM) and aortic dissection (AD), and to assess associations with genetically predicted glycemic traits. The study sought to verify the inverse relationship between T2DM and AD using a more robust and unbiased method, building on the observational studies previously established.

Materials And Methods: The study employed a two-sample and multivariable MR approach to analyze genetic data from the DIAbetes Meta-ANalysis of Trans-Ethnic association studies (DIAMANTE) with 74,124 cases and 824,006 controls, and the Meta-Analyses of Glucose and Insulin-Related Traits Consortium (MAGIC) involving up to 196,991 individuals.

Biofilm Formation, Motility, and Virulence of Are Reduced by Deletion of the Gene , a Novel Listerial LPXTG Surface Protein.

Listeria monocytogenes () is a foodborne pathogen that causes listeriosis in humans and other animals. Surface proteins with the LPXTG motif have important roles in the virulence of . Lmo0159 is one such protein, but little is known about its role in virulence, motility, and biofilm formation.

Aerobic training attenuates cardiac remodeling in mice post-myocardial infarction by inhibiting the p300/CBP-associated factor.

Aerobic training (AT), an effective form of cardiac rehabilitation, has been shown to be beneficial for cardiac repair and remodeling after myocardial infarction (MI). The p300/CBP-associated factor (PCAF) is one of the most important lysine acetyltransferases and is involved in various biological processes. However, the role of PCAF in AT and AT-mediated cardiac remodeling post-MI has not been determined.

Retrospective Analysis of Aberrant Hepatic Artery in 1250 Patients with Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization.

Aim: Aberrant hepatic artery is particularly common, and its diversity and complexity play a critical role in surgery. The aim of this study was to describe the incidence and type of aberrant hepatic artery, and to compare differences in transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC) with vs without aberrant hepatic artery.

Methods: This was a retrospective study of patients with HCC who received TACE at the same intervention center between March 15, 2020 and December 31, 2022.

Dietary Bacillus velezensis T23 fermented products supplementation improves growth, hepatopancreas and intestine health of Litopenaeus vannamei.

This study aimed to elucidate the effects of dietary fermented products of Bacillus velezensis T23 on the growth, immune response and gut microbiota in Pacific white shrimp (Litopenaeus vannamei). Shrimp were fed with diets containing fermentation products of B. velezensis T23 at levels of (0, 0.

Establishment and comparison of detection models for foodborne pathogen contamination on mutton based on SWIR-HSI.

Introduction: Rapid and accurate detection of food-borne pathogens on mutton is of great significance to ensure the safety of mutton and its products and the health of consumers.

Objectives: The feasibility of short-wave infrared hyperspectral imaging (SWIR-HSI) in detecting the contamination status and species of (EC), (SA) and (ST) contaminated on mutton was explored.

Materials And Methods: The hyperspectral images of uncontaminated and contaminated mutton samples with different concentrations (10, 10, 10, 10, 10, 10 and 10 CFU/mL) of EC, SA and ST were acquired.

Fe(OH) modified ultra-small Ru nanoparticles for highly efficient hydrogen evolution reaction and its application in water splitting.

Developing highly active electrocatalysts for overall water splitting is of remarkable significance for industrial production of H. Herein, exceptionally active Fe(OH) modified ultra-small Ru nanoparticles on Ni(OH) nanosheets array (Fe(OH)-Ru/Ni(OH)) for both hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) are reported. The Fe(OH)-Ru/Ni(OH) nanosheets array prepared with Fe/Ru molar ratio of 5 only requires extremely low overpotentials of 61, 127 and 170 mV to reach current densities of 100, 500 and 800 mA cm in 1 M KOH, respectively, exceeding Pt/C catalyst (75, 160 and 177 mV).

Involvement of OxyR and Dps in the repression of replication initiation by DsrA small RNA in Escherichia coli.

Regulation of the cell cycle process is an effective measure to ensure the stability and fidelity of genetic material during the reproduction of bacteria under different stresses. The small RNA DsrA helps bacteria adapt to environments by binding to multiple targets, but its association with the cell cycle remains unclear. Detection by flow cytometry, we first found that the knockout of dsrA promoted replication initiation, and corresponding overexpression of DsrA inhibited replication initiation in Escherichia coli.

Alkaline stress reduces root waving by regulating PIN7 vacuolar transport.

Root development and plasticity are assessed diverse endogenous and environmental cues, including phytohormones, nutrition, and stress. In this study, we observed that roots in model plant exhibited waving and oscillating phenotypes under normal conditions but lost this pattern when subjected to alkaline stress. We later showed that alkaline treatment disturbed the auxin gradient in roots and increased auxin signal in columella cells.

Application progress of intelligent flavor sensing system in the production process of fermented foods based on the flavor properties.

Fermented foods are sensitive to the production conditions because of microbial and enzymatic activities, which requires intelligent flavor sensing system (IFSS) to monitor and optimize the production process based on the flavor properties. As the simulation system of human olfaction and gustation, IFSS has been widely used in the field of food with the characteristics of nondestructive, pollution-free, and real-time detection. This paper reviews the application of IFSS in the control of fermentation, ripening, and shelf life, and the potential in the identification of quality differences and flavor-producing microbes in fermented foods.

Histone demethylase KDM3C regulates the lncRNA GAS5-miR-495-3p-PHF8 axis in cardiac hypertrophy.

Cardiac hypertrophy (CH) is a pathological phenotype of cardiomyopathy. Epigenetic modification is a mechanism associated with CH. Our study here investigated the histone demethylase KDM3C in relation to epigenetic regulation in CH.

Surface-Displayed Amuc_1100 From on ZHY1 Improves Hepatic Steatosis and Intestinal Health in High-Fat-Fed Zebrafish.

Fatty liver and intestinal barrier damage were widespread in most farmed fish, which severely restrict the development of aquaculture. Therefore, there was an urgent need to develop green feed additives to maintain host liver and intestinal health. In this study, a probiotic pili-like protein, Amuc_1100 (AM protein), was anchored to the surface of ZHY1, and the effects of the recombinant bacteria AM-ZHY1 on liver fat accumulation and intestinal health were evaluated.

Predictive Value of let-7a for Cancer Cell Repopulation between Chemotherapy and Long-Term Survival: A Prospective Study.

Objective: Repopulation during radiation is a classic theory in radiobiology. The long intervals between cycles of chemotherapy provide better micro-circumstance than radiation for the repopulation of cancer cells.

Methods: Patients with inoperable stage III and stage IV lung cancer were enrolled prospectively.

YfiF, an unknown protein, affects initiation timing of chromosome replication in Escherichia coli.

The Escherichia coli YfiF protein is functionally unknown, being predicted as a transfer RNA/ribosomal RNA (tRNA/rRNA) methyltransferase. We find that absence of the yfiF gene delays initiation of chromosome replication and the delay is reversed by ectopic expression of YfiF, whereas excess YfiF causes an early initiation. A slight decrease in both cell size and number of origin per mass is observed in ΔyfiF cells.

Photo-induced oxidative cleavage of C-C double bonds for the synthesis of biaryl methanone via CeCl catalysis.

A Ce-catalyzed strategy is developed to produce biaryl methanones via photooxidative cleavage of C-C double bonds at room temperature. This reaction is performed under air and demonstrates high activity as well as functional group tolerance. A synergistic Ce/ROH catalytic mechanism is also proposed based on the experimental observations.

Visible-Light-Driven Selective Air-Oxygenation of C-H Bond via CeCl Catalysis in Water.

Visible-light-induced C-H aerobic oxidation is an important chemical transformation that can be applied for the synthesis of aromatic ketones. High-cost catalysts and toxic solvents were generally needed in the present methodologies. Here, an efficient aqueous C-H aerobic oxidation protocol was reported.

Deletion of the oligopeptide transporter Lmo2193 decreases the virulence of Listeria monocytogenes.

Background: is a gram-positive bacterium that causes listeriosis mainly in immunocompromised hosts. It can also cause foodborne outbreaks and has the ability to adapt to various environments. Peptide uptake in gram-positive bacteria is enabled by oligopeptide permeases (Opp) in a process that depends on ATP hydrolysis by OppD and F.