[Effects and mechanisms of Yuxuebi Tablets combined with ibuprofen in treating chronic musculoskeletal pain through "integrated regulation of inflammation and pain-related oxylipins"].

This study adopted a three-dimensional "effect-dose-mechanism" evaluation system to screen the optimal regimen of Yuxuebi Tablets(YXB) combined with ibuprofen(IBU) for chronic musculoskeletal pain(CMP) intervention and elucidate its pharmacological mechanism, so as to provide a scientific basis for the clinical application of the regimen. The experiments were conducted using 8-week-old ICR mice, which were randomly divided into sham operation(sham) group, model(CFA) group, IBU group, YXB group, stasis paralysis tablets combined with ibuprofen low-dose group(IBU-L-YXB), stasis paralysis combined with ibuprofen high-dose group(IBU-H-YXB), stasis paralysis tablets combined with ibuprofen high-dose with ibuprofen discontinuation on the 10th day of administration(IBU-10-YXB), and stasis paralysis tablets combined with ibuprofen high-dose with ibuprofen halving on the 10th day of administration(IBU-1/2-YXB) group. An animal model was established using the CFA plantar injection method.

Digital Profiling Subpopulations of Cancer Cell-Derived Exosomes via Aptamer-SERS Nanotags on a Wafer-Level Micropillar Array Chip.

The clinical translation of exosome-based diagnostics and therapies is hindered by significant molecular heterogeneity. Current exosome phenotyping methods suffer from insufficient sensitivity, limited multiplexing capability, and poor scalability. To address these challenges, we developed a digital wafer-level micropillar array (WLM-Exo) platform.

Identification of a Selective YTHDF1 Inhibitor Targeting the mA Recognition Domain for Breast Cancer.

As a key N-methyladenosine (mA) reader, YTH domain-containing family protein 1 (YTHDF1) promotes protein synthesis by recognizing mA-modified mRNA, and its abnormal expression is closely related to breast cancer (BC) progression. To date, the scarce reported YTHDF1 inhibitors suffer from poor selectivity and limited potency, primarily due to the high homology of the YTH domain within the YTHDF family, which poses significant challenges for the discovery of subtype-selective inhibitors. Here, we report SKLB-Y13, the first small-molecule inhibitor achieving exclusive targeting of the YTHDF1 mA-binding pocket (IC = 0.

Clinical characteristics of Chlamydia psittaci pneumonia: a single-center, retrospective study over 5 years.

Background: Psittacosis pneumonia is not uncommon, and it can progress to severe illness or even death. Identifying the clinical characteristics of Chlamydia psittaci (C. psittaci ) pneumonia and its risk factors were the aim of improving decision-making regarding diagnosis and treatment.

Evaluating the effectiveness of intelligent interaction technology in autism interventions: A meta-analysis based on trial assessment.

Purpose: This research aims to conduct a systematic review of the literature on the utilization of intelligent interaction technologies, including Extended Reality (XR) and robotic systems, within the context of autism interventions.

Method: This study commenced on June 16, 2022, and conducted a systematic search of publications from 2017 to 2024 using Boolean terms such as "Virtual Reality" AND "autism" AND "RCT" in PubMed, Web of Science, Cochrane Library, SpringerLink, and Embase. Two reviewers independently conducted research selection, data extraction, and quality assessment (using Cochrane Risk of Bias tool, RoB 2), and resolved differences through discussion.

Protein Corona-Detachable Microwave Ablation Amplifiers Actuate Pyroptosis to Repolarize Immortal Cancer into Senescent Ones.

Cancer immortality represents high plasticity and tolerance, and incomplete treatment methods such as microwave ablation (MWA) remodel the residual cancer microenvironment to further potentiate cancer resistance. Nanomedicine is a solution, but the serum protein corona and abnormal intratumoral blood vessels attenuate their delivery efficiency. Herein, protein corona-detachable MWA amplifiers consisting of O-binding mesoporous silica nanoparticles and doxorubicin (DOX) have been engineered.

Rare Primary Diffuse Large B-Cell Lymphoma Confined to Bone Marrow: Features and Prognosis.

Background: Primary bone marrow diffuse large B-cell lymphoma (PBM-DLBCL) represents an uncommon yet clinically aggressive hematologic malignancy. Despite its significant clinical impact, this entity lacks standardized diagnostic criteria in current WHO classifications.

Methods: We performed a retrospective analysis of 55 PBM-DLBCL cases from our institutional database and published literature (2001-2022) to characterize disease features and identify prognostic factors, with particular focus on assessing how different treatment regimens influence therapeutic efficacy and long-term outcomes.

Minocycline Regulates PARP-1 and HDAC3 Pathways to Inhibit Inflammation and Oxidative Stress in LPS-Induced Acute Lung Injury.

Background: Acute lung injury (ALI) is characterized by excessive lung inflammation and apoptosis of alveolar epithelial cells, resulting in acute hypoxemic respiratory failure. Minocycline, a tetracycline antibiotic, is known to have excellent anti-inflammatory activity.

Objectives: The present study aims to reveal the protective effect and potential mechanism of the anti-inflammatory effects of minocycline on lipopolysaccharide (LPS)-induced ALI in mice and A549 cells.

Breaking the diabetes-depression cycle: Exploring shared mechanisms, neuroinflammation, and emerging interventions for metabolic-mood comorbidities.

This article explores the bidirectional relationship between type 2 diabetes mellitus (T2DM) and depression, focusing on their shared pathophysiological mechanisms, including immune-inflammatory responses, gut-brain axis dysregulation, metabolic abnormalities, and neuroendocrine modulation. Research indicates that T2DM contributes to anxiety and depression through chronic low-grade inflammation, insulin resistance, gut microbiota imbalance, and hyperactivation of the hypothalamic-pituitary-adrenal axis. Conversely, depression may increase the risk of T2DM lifestyle disruption, immune activation, and neurotransmitter imbalance.

Multi-dimensional PK-PD insights into Lianhua Qingwen's formula compatibility.

Ethnopharmacological Relevance: Lianhua Qingwen (LHQW), a traditional Chinese medicine, combines three classical formulas-Maxing Shigan decoction (MXSGD), Yinqiao powder (YQP), and Rhei Radix et Rhizoma (Dahuang)-demonstrating adaptive optimization of classical prescriptions. Despite its well-documented pharmacological effects, the scientific rationale for its compatibility remains underexplored.

Aim Of The Study: To elucidate the functional roles and synergistic mechanisms of LHQW through a formula-disassembled strategy combined pharmacodynamic (PD) and pharmacokinetic (PK) analysis.

Association of systemic immune-inflammation index with severity in acute ischemic stroke patients: a cross-sectional study.

Objective: To investigate the association between the Systemic Immune-Inflammation Index (SII) and the severity of acute ischemic stroke (AIS), as measured by the National Institutes of Health Stroke Scale (NIHSS), and to explore its potential as a predictive marker for clinical outcomes.

Methods: We used the data of 1723 AIS patients in the Stroke Center of Quzhou People's Hospital from September 2016 to September 2022 for a cross-sectional study. SII was calculated as platelet count × neutrophil count divided by lymphocyte count.

Remnant cholesterol inflammatory index, calculated from residual cholesterol to C-reactive protein ratio, and stroke outcomes: a retrospective study using the National institutes of health stroke scale and modified Rankin scale.

Background: Globally, acute ischemic stroke (AIS) persists as a significant driver of both mortality and prolonged disability. Reliable biomarkers for predicting stroke outcomes must be identified to improve clinical decision-making. Residual cholesterol (RC) and RC inflammatory index (RCII) have been proposed as potential biomarkers, although their precise prognostic significance in stroke remains unclear.

Comparative effectiveness and safety of tofacitinib vs. adalimumab in patients with rheumatoid arthritis: A systematic review and meta-analysis.

Objectives: To provide the latest systematic review and meta-analysis comparing the effectiveness and safety of tofacitinib and adalimumab in rheumatoid arthritis (RA) patients.

Methods: A systematic search of PubMed, Embase, Web of Science, and Cochrane databases was conducted until April 2025. Randomized controlled trials and cohorts comparing tofacitinib and adalimumab in RA patients were included.

Serum levels of Galectin-1 and Galectin-3 for monitoring rheumatoid arthritis severity: a meta-analysis.

Background: Galectin-1 (Gal-1) and galectin-3 (Gal-3) have emerged as promising biomarkers for diagnosing and managing rheumatoid arthritis (RA). This study aims to synthesize current evidence through a systematic review and meta-analysis to evaluate the clinical effectiveness of serum Gal-1 and Gal-3 as biomarkers for monitoring disease severity and predicting clinical outcomes in RA patients.

Methods: We conducted a comprehensive literature search in PubMed, Web of Science, and the Cochrane Library, including studies published up to March 2024.

A study on the factors influencing mortality risk in sepsis-induced acute kidney injury based on analysis of the MIMIC database.

Sepsis-induced acute kidney injury (SA-AKI) significantly increases mortality and healthcare burdens. Identifying key mortality risk factors is crucial for improving patient outcomes. This study aims to identify the primary factors affecting mortality in SA-AKI patients using the MIMIC-III database.

Partner Smoking/Drinking Is Associated with Increased Risk of Gestational Diabetes Mellitus and Perinatal Outcomes.

Background: Gestational diabetes mellitus (GDM) is a common pregnancy complication associated with adverse fetal-maternal outcomes. This research investigated the association of partner smoking/drinking with GDM and adverse pregnancy outcomes.

Method: A prospective cohort study was conducted, involving 1005 pregnant women in Guangzhou from July 2015 to December 2016.

Disrupting calcium homeostasis and glycometabolism in engineered lipid-based pharmaceuticals propel cancer immunogenic death.

Homeostasis and energy and substance metabolism reprogramming shape various tumor microenvironment to sustain cancer stemness, self-plasticity and treatment resistance. Aiming at them, a lipid-based pharmaceutical loaded with CaO and glucose oxidase (GOx) (LipoCaO/GOx, LCG) has been obtained to disrupt calcium homeostasis and interfere with glycometabolism. The loaded GOx can decompose glucose into HO and gluconic acid, thus competing with anaerobic glycolysis to hamper lactic acid (LA) secretion.

Association of gut microbiota with overweight/obesity combined with gestational diabetes mellitus.

Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy and negatively affects the health of mothers and infants. The aim of this study was to explore the associations between gut microbiota and the risk of GDM amongst overweight/obese women, and the interaction between gut microbiota dysbiosis and overweight/obesity in pregnant women with GDM. Previous studies revealed that there may be a link between gut microbiota and GDM and obesity, but these studies have not reported the associations between gut microbiota and the risk of GDM amongst overweight/obese women, whilst the interaction between gut microbiota dysbiosis and overweight/obesity in pregnant women with GDM remains unknown.

Celastrol Mediated Regulation of the HnRNPA1-Thyroxine Axis in the Amygdala Alleviates High Fat Diet-Induced Demyelination and Cognitive Deficits in Mice.

High fat diet (HFD) is closely linked to demyelination and cognitive deficiency. Previously, we reported that the covalent binding and downregulation of heterogeneous nuclear ribonucleoprotein A1 (HnRNPA1) were responsible for the effectiveness of celastrol against high fat diet (HFD) induced obesity. However, little is known about cognitive functions.

Association between thyroid hormone levels and early neurological deterioration in acute ischemic stroke.

Background: Acute ischemic stroke (AIS) prognosis is significantly influenced by early neurological deterioration (END). Emerging evidence suggests that thyroid function, particularly free triiodothyronine (FT3) levels and the FT3/FT4 ratio, may play a crucial role in END occurrence. This study aimed to investigate the association between thyroid function parameters and END.

Constructing Robust Electrode/Electrolyte Interphases for Highly Stable Lithium-Sulfurized Polyacrylonitrile Batteries.

Lithium-sulfurized polyacrylonitrile (SPAN) batteries show great promise for energy storage, but are plagued by poor cycling stability, which can be attributed to unfavorable electrode/electrolyte interphases for both anode and cathode. Here we design and achieve the anion-moderate solvation structure based interconnected clusters in electrolyte by regulating the interactions of solvent with Li and diluent to construct robust anode/electrolyte and cathode/electrolyte interphases simultaneously for high-performance Li-SPAN batteries. The optimal electrolyte endows Li plating/stripping with a high Coulombic efficiency of 99.

Temporal characteristics of moral disgust in obsessive-compulsive disorder (OCD) from a lexical perspective: An ERPs and sLORETA study.

Background: Although many studies have hinted at the essential role of moral disgust in obsessive-compulsive disorder (OCD), few studies focused on moral disgust have been reported. Exploring the temporal characterization of moral disgust can enhance our understanding of emotional processing.

Methods: This study included 58 patients with OCD and 45 healthy controls (HCs) and used an adapted lexical decision task paradigm (explicit LDT) combined with event-related potentials (ERPs) analysis and standardized low-resolution brain electromagnetic tomography analysis (sLORETA) to explore the performance of patients with OCD in processing moral disgust words.

A generalized epilepsy network derived from brain abnormalities and deep brain stimulation.

Idiopathic generalized epilepsy (IGE) is a brain network disease, but the location of this network and its relevance for treatment remain unclear. We combine the locations of brain abnormalities in IGE (131 coordinates from 21 studies) with the human connectome to identify an IGE network. We validate this network by showing alignment with structural brain abnormalities previously identified in IGE and brain areas activated by generalized epileptiform discharges in simultaneous electroencephalogram-functional magnetic resonance imaging.