Publications by authors named "Mae Morton-Dutton"
Idiopathic generalized epilepsy (IGE) is a brain network disease, but the location of this network and its relevance for treatment remain unclear. We combine the locations of brain abnormalities in IGE (131 coordinates from 21 studies) with the human connectome to identify an IGE network. We validate this network by showing alignment with structural brain abnormalities previously identified in IGE and brain areas activated by generalized epileptiform discharges in simultaneous electroencephalogram-functional magnetic resonance imaging.
View Article and Find Full Text PDFImportance: Drug-resistant temporal lobe epilepsy (TLE) has been associated with hippocampal pathology. Most surgical treatment strategies, including resection and responsive neurostimulation (RNS), focus on this disease epicenter; however, imaging alterations distant from the hippocampus, as well as emerging data from responsive neurostimulation trials, suggest conceptualizing TLE as a network disorder.
Objective: To assess whether brain networks connected to areas of atrophy in the hippocampus align with the topography of distant neuroimaging alterations and RNS response.
Article Synopsis
- * The research compared brain lesions causing parkinsonism with those causing seizures using advanced brain network mapping techniques.
- * Findings indicate that lesions related to parkinsonism and seizures are associated with distinct, opposite brain networks, particularly highlighting the role of the substantia nigra in this relationship.
Article Synopsis
- Recent studies suggest a link between parkinsonism and seizures, but it's unclear which causes which.
- Researchers analyzed brain lesions in patients with parkinsonism and those with seizures to understand their connection to brain networks.
- They found that lesions associated with parkinsonism and seizures mapped to opposite brain networks, highlighting a distinct neuroanatomical relationship that clarifies previous conflicting findings.