Ecological safety evaluation method for plateau characteristic agribusinesses based on knowledge granularity.

The ecological safety of plateau-characteristic agribusinesses (PCABs) encompasses not only environmental protection during production but also enhancing output without harming the ecosystem. Objectively evaluating PCABs' ecological safety levels is crucial for making management decisions and promoting local sustainable development. However, existing evaluation methods fail to incorporate expert knowledge structures, leading to limitations in both scientific validity and practical applicability.

The Prevalence of Olfactory Dysfunction and Its Recovery in Chinese Young and Middle-Aged Group COVID-19 Patients.

Objectives: Olfactory dysfunction (OD) is a common symptom of SARS-CoV-2 infection. This study aimed to determine the prevalence and clinical characteristics of OD, evaluate its recovery trajectory, and identify predictors of its onset and persistence.

Methods: We conducted a prospective cohort study of 3477 participants recruited through an online questionnaire between December 1 and 31, 2022.

Ultra-processed foods, biological ageing, and all-cause mortality risk: a prospective cohort study using 172,225 participants from UK Biobank.

Ultra-processed foods (UPF) are increasingly linked to negative health outcomes, including chronic diseases and mortality. Recent evidence suggests that UPF may accelerate biological ageing, potentially explaining their harmful effects. Therefore, this study was aimed to investigate associations between UPF intake categories and mortality risk, examining biological ageing's mediating and modifying effects.

Flexible, nonfused sulfone functionalized polymer with enhanced active site access for photocatalytic sacrificial hydrogen evolution.

The fused sulfone unit has been a key building block for hydrogen evolution photocatalysts for 9 years but still faces the challenge of a poor water/polymer interface due to its rigid structure. This work introduces nonfused, flexible sulfur segments (SSs) into the polymer's backbone to enhance hydrophilicity and active site access. Unlike rigid, fused sulfone moieties, our flexible SS improves interfacial water contact and charge transport.

The Flagellin-Specific Chaperone FliS of Borrelia burgdorferi Controls the Cytoplasmic Pool of Flagellins at the Level of Translation Initiation, Secretion, and Proteolysis.

The flagellin-specific chaperone FliS has been studied in externally flagellated bacteria; however, its role in spirochetes, a group of bacteria that possess unique internalized flagella (termed endo- or periplasmic flagella), remains unexplored. Here, we investigate the function of FliS in the Lyme disease spirochete Borrelia burgdorferi . Using loss-of-function studies, combined with biochemical assays and cryo-electron tomography, we demonstrate that FliS deletion selectively reduces FlaB expression, the major flagellin protein, resulting in non-motile mutants with defective flagellar filaments.

Development and validation of a machine learning-based model for predicting intraoperative blood loss during burn surgery.

Background: Intraoperative blood loss is a critical issue in the care of patients with burns. The timely identification of patients at elevated risk for substantial blood loss during surgical procedures is imperative.

Methods: Demographic data, laboratory test results, and surgical factors of patients were collected.

Lactate dehydrogenase is the Achilles' heel of Lyme disease bacterium .

Unlabelled: As a zoonotic pathogen, the Lyme disease bacterium has evolved unique metabolic pathways, some of which are specific and essential for its survival and thus present as ideal targets for developing new therapeutics. dispenses with the use of thiamin as a cofactor and relies on lactate dehydrogenase (BbLDH) to convert pyruvate to lactate for balancing NADH/NAD ratios. This report first demonstrates that BbLDH is a canonical LDH with some unique biochemical and structural features.

Perovskite-Coupled NIR Organic Hybrid Solar Cells Achieving an 84.2% Fill Factor and a 25.2% Efficiency: A Comprehensive Mechanistic Exploration.

The integration of organic dyes in perovskite solar cells (PSCs) to utilize near-infrared (NIR) photons remains a challenge. In this study, a selenium-incorporated ortho-benzodipyrrole-based NIR dye CB-2Se was developed. CB-2Se, featuring a lower bandgap of 1.

Borrelia burgdorferi serine protease HtrA is a pleiotropic regulator of stress response, motility, flagellar hemostasis, and infectivity.

High-temperature requirement protease A (HtrA) is a family of serine proteases that regulate bacterial stress response through controlling protein quality. This report shows that the Lyme disease bacterium Borrelia burgdorferi HtrA has a pleiotropic role in regulation of bacterial stress response, motility, flagellar hemostasis, and infectivity. Loss-of-function study first shows that a deletion mutant of htrA (∆htrA) fails to establish an infection in a murine model of Lyme disease.

Inhibitors of Lysinoalanine Cross-Linking in the Flagella Hook as Antimicrobials against Spirochetes.

Spirochetes are especially invasive bacteria that are responsible for several human diseases, including Lyme disease, periodontal disease, syphilis, and leptospirosis. Spirochetes rely on an unusual form of motility based on periplasmic flagella (PFs) to infect hosts and evade the immune system. The flexible hook of these PFs contains a post-translational modification in the form of a lysinoalanine (Lal) cross-link between adjacent subunits of FlgE, which primarily comprise the hook.

Lactate dehydrogenase is the Achilles' heel of Lyme disease bacterium .

As a zoonotic pathogen, the Lyme disease bacterium has evolved unique metabolic pathways, some of which are specific and essential for its survival and thus present as ideal targets for developing new therapeutics. dispenses with the use of thiamin as a cofactor and relies on lactate dehydrogenase (BbLDH) to convert pyruvate to lactate for balancing NADH/NAD ratios. This report first demonstrates that BbLDH is a canonical LDH with some unique biochemical and structural features.

Revealing ionically isolated Li loss in practical rechargeable Li metal pouch cells.

The degradation of rechargeable lithium (Li) metal batteries is primarily attributed to active Li loss, encompassing isolated Li, also known as "dead Li", and solid electrolyte interphase (SEI-Li). Comprehending the formation of dead Li is pivotal for devising strategies to mitigate Li loss. Herein, we reveal the existence of an alternative form of dead Li, termed ionically isolated Li (I-iLi), which diverges from the traditionally recognized electronically isolated Li (E-iLi).

MCP5, a methyl-accepting chemotaxis protein regulated by both the Hk1-Rrp1 and Rrp2-RpoN-RpoS pathways, is required for the immune evasion of Borrelia burgdorferi.

Borrelia (or Borreliella) burgdorferi, the causative agent of Lyme disease, is a motile and invasive zoonotic pathogen adept at navigating between its arthropod vector and mammalian host. While motility and chemotaxis are well known to be essential for its enzootic cycle, the role of each methyl-accepting chemotaxis proteins (MCPs) in the infectious cycle of B. burgdorferi remains unclear.

A bipartite bacterial virulence factor targets the complement system and neutrophil activation.

The complement system and neutrophils constitute the two main pillars of the host innate immune defense against infection by bacterial pathogens. Here, we identify T-Mac, a novel virulence factor of the periodontal pathogen Treponema denticola that allows bacteria to evade both defense systems. We show that T-Mac is expressed as a pre-protein that is cleaved into two functional units.

LRRC8A drives NADPH oxidase-mediated mitochondrial dysfunction and inflammation in allergic rhinitis.

Objectives: Allergic rhinitis (AR) is a complex disorder with variable pathogenesis. Increasing evidence suggests that the LRRC8A is involved in maintaining cellular stability, regulating immune cell activation and function, and playing significant roles in inflammation. However, the involvement of LRRC8A in AR inflammation and its underlying mechanisms remain unclear.

Neural repair function of osteopontin in stroke and stroke‑related diseases (Review).

Stroke, including hemorrhagic stroke and ischemic stroke, is a common disease of the central nervous system. It is characterized by a high mortality and disability rate and is closely associated with atherosclerosis, hypertension hyperglycemia, atrial fibrillation and unhealthy living habits. The continuous development of surgery and medications has decreased the mortality rate of patients with stroke and has greatly improved the disease prognosis.

Digital technology application on corporate internationalization: Co-moderating effect of centralizing decision power and internationalization experience.

Digital technologies are a significant additional powerhouse for corporate internationalization and competitiveness. The existing research has not effectively distinguished the breadth and depth of internationalization, and there are also inadequate context considerations of how much digital technology applications influence enterprise internationalization. To bridge this gap, this paper has selected 203 valid questionnaires from manufacturing enterprises in Zhejiang Province, China, then elaborates and constructs a theoretical model based on existing studies, and using multiple linear regression analysis, finally to empirically assess and further explain the mechanisms of digital technologies' influence on corporate internationalization.

Revealing the overlithiation effect on cycling and calendar aging of a silicon/graphite electrode for high-energy lithium-ion batteries.

Lithium (Li) plating, triggered by fast charging and low temperature, will cause performance degradation and safety concerns for lithium-ion batteries (LIBs). However, strategically limited and controlled Li deposition might be advantageous for enhancing energy density. The detailed mechanism and regulation for performance improvement are yet to be fully explored.

MCP5, a methyl-accepting chemotaxis protein regulated by both the Hk1-Rrp1 and Rrp2-RpoN-RpoS pathways, is required for the immune evasion of .

(or ) , the causative agent of Lyme disease, is a motile and invasive zoonotic pathogen, adept at navigating between its arthropod vector and mammalian host. While motility and chemotaxis are well established as essential for its enzootic cycle, the function of methyl-accepting chemotaxis proteins (MCPs) in the infectious cycle of remains unclear. In this study, we demonstrate that MCP5, one of the most abundant MCPs in , is differentially expressed in response to environmental signals as well as at different stages of the pathogen's enzootic cycle.

Association Between Ultra-Processed Food Consumption and Leucocyte Telomere Length: A cross-sectional study of UK Biobank.

Objective: This study aimed to investigate the association between consumption of ultra-processed foods (UPFs) and leucocyte telomere length (LTL).

Methods: This cross-sectional study utilized data from the UK Biobank, including a total of 64,690 participants. LTL was measured using Q-PCR with natural logarithmic conversion and Z-score normalization.

Mental health difficulties and related factors in Chinese children and adolescents during the COVID-19 pandemic: a cross-sectional study.

Objective: To examine the mental health status and related factors in children and adolescents, and to assess age groups and sexes differences in factors influencing mental health.

Methods: This cross-sectional study was performed on Chinese children aged 6-18 years from November 2021 to January 2022. Mental health difficulties were accessed by the Strengths and Difficulties Questionnaire.

A comprehensive exploration of twist1 to identify a biomarker for tumor immunity and prognosis in pan-cancer.

Twist1 has been identified as a critical gene in tumor, but current study of this gene remains limitative. This study aims to investigate its roles and potential mechanisms across pan-cancer. The study used various databases and computational techniques to analyze twist's RNA expression, clinical data, gene mutations, tumor stemness, tumor microenvironment, immune regulation.

The association of sleep duration and leukocyte telomere length in middle-aged and young-old adults: A cross-sectional study of UK Biobank.

Background: The relationships between sleep duration and aging-associated diseases are intricate. Leukocyte telomere length (LTL) is a biomarker of aging, while the association of sleep duration and LTL is unclear.

Methods: The 310,091 study participants from UK Biobank were enrolled in this cross-sectional study.