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Article Abstract
The association between leukocyte telomere length (LTL) alteration and major adverse cardiovascular events (MACE) or mortality in patients with hypertension is still unclear. 20,034 patients with essential hypertension were enrolled from UK biobank. Multivariable COX regression models were performed to assess the association. LTL was shorter in hypertensive patients with MACE compared to those without MACE. Hypertensive patients in the lowest LTL quartile were at higher risk to develop MACE (adjusted HR 1.15 [95% CI 1.02-1.29], vs top LTL quartile, p-trend = 0.03). Similarly, shorter LTL was related with increased mortality (adjusted HR 1.18[95% CI 1.06-1.3], lowest vs top LTL quartile, p-trend < 0.001). This investigation demonstrated that shorter LTL is associated with increased risk of MACE or mortality in patients with essential hypertension, which indicates that LTL may be a potential predictor of prognosis or underlying therapeutic target for hypertension.
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Article Synopsis
- A study involving 20,034 patients with essential hypertension from the UK Biobank aimed to examine the link between leukocyte telomere length (LTL) and the risk of major adverse cardiovascular events (MACE) and mortality.
- The results indicated that patients with shorter LTL had a higher risk of experiencing MACE (adjusted HR 1.15) and increased mortality (adjusted HR 1.18) compared to those with longer LTL.
- The findings suggest that shorter LTL could serve as a potential predictor of health outcomes or could be targeted for therapeutic interventions in hypertensive patients.