Comparison of early clinical outcomes between CR and PS prostheses in total knee arthroplasty for rheumatoid arthritis patients - a retrospective cross-sectional study.

Objective: To compare the early clinical outcomes of posterior cruciate ligament-retaining (CR) and posterior stabilized (PS) knee prostheses in total knee arthroplasty for patients with rheumatoid arthritis.

Methods: A retrospective analysis was conducted on 74 patients with rheumatoid arthritis (RA) who underwent unilateral total knee arthroplasty (TKA) from January 2021 to December 2022. Among these, 39 patients received CR prostheses (CR group), while 35 received PS prostheses (PS group).

Biochar-based metal tolerating plant growth promoting bacterial inoculants enhanced the ability of ryegrass for phytostabilization.

Metal-tolerant microbes with plant growth-promoting traits represent a promising biological amendment for enhancing the phytostabilization of contaminated soils. However, the relationship between phytostabilization efficiency and microbial consortium composition and diversity remains unclear. This study selected three cadmium (Cd) resistant plant growth promoting bacteria (PGPB) from Bacillus, Pseudomonas, and Rhodopseudomonas were selected as candidates for biochar-based microbial inoculants.

Spatiotemporal mode-locking and dissipative solitons in multimode fiber lasers.

Multimode fiber (MMF) lasers are emerging as a remarkable testbed to study nonlinear spatiotemporal physics with potential applications spanning from high energy pulse generation, precision measurement to nonlinear microscopy. The underlying mechanism for the generation of ultrashort pulses, which can be understood as a spatiotempoal dissipative soliton (STDS), in the nonlinear multimode resonators is the spatiotemporal mode-locking (STML) with simultaneous synchronization of temporal and spatial modes. In this review, we first introduce the general principles of STML, with an emphasize on the STML dynamics with large intermode dispersion.

The effect of JuanBiQiangGu granules in combination with methotrexate on joint inflammation in rheumatoid arthritis: a randomized controlled trial.

Rheumatoid arthritis (RA) joint inflammation severely affects joint function and quality of life in patients and leads to joint deformities and limb disability. The non-steroidal anti-inflammatory drugs used in the treatment of RA do not fully control the progression of joint inflammation and bone destruction and have notable adverse reactions. Traditional Chinese medicine formula JuanBiQiangGu Granules (JBQG) are commonly used for the treatment of RA inflammation and delay of bone destruction, but has not been evaluated through high-quality clinical studies.

Electroacupuncture alleviates pain after total knee arthroplasty through regulating neuroplasticity: A resting-state functional magnetic resonance imaging study.

Introduction: We aimed to evaluate the efficacy of electroacupuncture in relieving acute pain after total knee arthroplasty (TKA) and related mechanism.

Methods: In this randomized, single-blind, and sham-acupuncture controlled study. Forty patients with postoperative acute pain were recruited and randomly divided electroacupuncture group (n = 20) and sham-acupuncture group (n = 20) from November 2020 to October 2021.

Self-starting spatiotemporal mode-locking using Mamyshev regenerators.

Bridging multi-mode fibers and Mamyshev regenerators holds promise for pulse energy scaling in fiber lasers. However, initialization of a multi-mode Mamyshev oscillator remains a practical challenge. Here we report self-starting spatiotemporal mode-locking (STML) in a multi-mode Mamyshev oscillator without active assistance.

Expanded CD1cCD163 DC3 Population in Synovial Tissues Is Associated with Disease Progression of Osteoarthritis.

The mechanisms underlying osteoarthritis (OA) have recently been hypothesized to involve a dysfunctional immune system. In this study, we collected synovium, synovial fluid (SF), and peripheral blood from 21 patients. Mononuclear cells were characterized using FCM.

Cerebral mechanism of opposing needling for managing acute pain after unilateral total knee arthroplasty: study protocol for a randomized, sham-controlled clinical trial.

Background: Opposing needling is a unique method used in acupuncture therapy to relieve pain, acting on the side contralateral to the pain. Although opposing needling has been used to treat pain in various diseases, it is not clear how opposing needling affects the activity of the central nervous system to relieve acute pain. We herein present the protocol for a randomized sham-controlled clinical trial aiming to explore the cerebral mechanism of opposing needling for managing acute pain after unilateral total knee arthroplasty (TKA).

Altered brain activity in end-stage knee osteoarthritis revealed by resting-state functional magnetic resonance imaging.

Introduction: Knee osteoarthritis (KOA) is characterized by a degenerative change of knee cartilage and secondary bone hyperplasia, resulting in pain, stiffness, and abnormal walking gait. Long-term chronic pain causes considerable cortical plasticity alternations in patients. However, the brain structural and functional alterations associated with the pathological changes in knee joints of end-stage KOA patients remain unclear.

Microbial inoculations improved rice yields by altering the presence of soil rare bacteria.

Microbial inoculation is a promising way to improve crop yields in an eco-friendly and economic manner. However, the effects of inoculation on soil resident rare species, representing most of the diversity, are still not well documented and need further assessment. Here, we conducted a pot experiment to test the effects of single-strain and co-inoculants of Rhodopseudomonas palustris and Bacillus subtilis on soil rare and abundant bacteria through sequencing 16S ribosomal RNA gene amplicons.

Risk factors of cervical cancer among ethnic minorities in Yunnan Province, China: a case-control study.

Background: Cervical cancer is a common malignant tumor of the female reproductive system in the world, which is a serious threat to women's life and health. According to the latest report, the incidence of cervical cancer is 11.42 per 100 000, and the mortality rate is 3.

Multiple intravenous tranexamic acid doses in total knee arthroplasty in patients with rheumatoid arthritis: a randomized controlled study.

Background: We aimed to determine the efficacy and safety of multiple doses of intravenous tranexamic acid (IV-TXA) on perioperative blood loss in patients with rheumatoid arthritis (RA) who had undergone primary unilateral total knee arthroplasty (TKA).

Methods: For this single-center, single-blind randomized controlled clinical trial, 10 male and 87 female participants with RA, aged 50-75 years, who underwent unilateral primary TKA were recruited. The patients received one dose of 1 g IV-TXA 10 min before skin incision, followed by articular injection of 1.

Vector quartic solitons in birefringent fibers.

We theoretically investigated the vector properties of quartic solitons in a pure fourth-order-dispersion birefringent fiber and a quartic-dispersion-dominant mode-locked fiber laser. We found that, compared with scalar pure quartic solitons, a vector quartic soliton (VQS) in the birefringent fiber still preserves the Gaussian shape, except for the distinctions of reduced peak power, central frequency offset, slight frequency chirp, and mitigated oscillatory tails. We also demonstrated that pulse shaping in the mode-locked laser cavity could explicitly facilitate the formation of Kelly sidebands and distortion of oscillatory tails.

Effect of Multiple Doses of Intravenous Tranexamic Acid on Perioperative Blood Loss in Total Knee Arthroplasty: A Randomized Controlled Study.

Objective: To identify the efficacy and safety of multiple doses of intravenous tranexamic acid (IV-TXA) following primary total knee arthroplasty (TKA) with a tourniquet.

Methods: This is a single-blind randomized controlled study that recruited osteoarthritis patients who had undergone primary unilateral TKA from May 2019 to May 2020 at our medical center. A total of 300 patients were randomly divided into three groups to receive: one dose (1 g) of IV-TXA before skin incision combined with one dose (1.

Multiple-dose tranexamic acid for perioperative blood loss in total knee arthroplasty in patients with rheumatoid arthritis：a single-blinded, randomised, parallel-controlled study protocol in China.

Introduction: This clinical trial is designed to evaluate the effect of multiple-dose tranexamic acid (TXA) on perioperative blood loss in patients with rheumatoid arthritis (RA).

Methods And Analysis: A randomised, single-blinded, parallel-controlled study will be designed. Patients with RA (age 50-75 years) undergoing unilateral primary end-stage total knee arthroplasty will be randomly divided into group A or group B.

Using electroacupuncture to recover muscle strength in patients with knee osteoarthritis after total knee arthroplasty: a study protocol for a double-blinded, randomized, and placebo-controlled trial.

Background: Total knee arthroplasty (TKA) is a gold standard for patients with terminal term gonarthrosis for reducing pain, correcting deformities, and regaining stability. However, post-TKA muscle strength recovery is often difficult. Although electroacupuncture (EA) enhances lower extremity muscle strength of the lower extremity, there is limited evidence regarding its effect on lower extremity muscle strength in post-TKA patients.

Buildup dynamics of asynchronous vector solitons in a polarization-multiplexed dual-comb fiber laser.

Polarization-multiplexed dual-comb fiber lasers enable significant applications in dual-comb spectroscopy and optical sensing. However, the complexity of the underlying formation dynamics of dual-comb solitons has not been unveiled so far. Here, we capture the real-time spectral evolutions of both vector solitons from the initial fluctuations, with the help of the time-stretch dispersive Fourier transform technique.

Downregulation of lncRNA ITSN1-2 correlates with decreased disease risk and activity of rheumatoid arthritis (RA), and reduces RA fibroblast-like synoviocytes proliferation and inflammation via inhibiting NOD2/RIP2 signaling pathway.

This study aimed to investigate the effect of lnc-ITSN1-2 knockdown on cell proliferation, apoptosis, inflammation and mRNA expression patterns in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS), and the correlation of its synovium tissue expression with disease risk, inflammatory cytokines and disease activity of RA. Control shRNA plasmids and lnc-ITSN1-2 shRNA plasmids were transfected into RA FLS, and then cell proliferation, apoptosis, inflammatory cytokines expressions were evaluated. Subsequently, mRNA sequencing and bioinformatics analyses were conducted, and rescue experiment of nucleotide-binding oligomerization domain 2 (NOD2) mRNA overexpression on alleviating the functions of lnc-ITSN1-2 was performed.

Circulating lnc-ITSN1-2 expression presents a high value in diagnosis of rheumatoid arthritis and correlates with disease activity.

This study was aimed to investigate the correlation of lnc-ITSN1-2, lnc-APOC3-2 and lnc-AL355149.1 expressions in plasma by qPCR with rheumatoid arthritis (RA) risk and disease activity. 30 RA patients and 30 health controls (HC) were enrolled in this study.

Cyr61 participates in the pathogenesis of rheumatoid arthritis via promoting MMP-3 expression by fibroblast-like synoviocytes.

Objectives: The aim of this study was to investigate the effect and potential mechanism of Cysteine-rich 61 (Cyr61) on stimulating MMP-3 expression by fibroblast-like synoviocytes (FLS) from rheumatoid arthritis (RA) patients.

Methods: Primarily cultured RA FLS were treated with exogenous Cyr61 protein or Cyr61-siRNA, then, MMP-3 expression was analyzed by real-time PCR, western blotting and ELISA. Signal transduction pathways in Cyr61-induced MMP-3 production were examined by real-time PCR, western blotting, confocal microscopy, luciferase reporter assay.