Correlation between stress hyperglycemic ratio and all-cause mortality in diabetic patients with heart failure.

Objective: The stress hyperglycemia ratio (SHR) quantifies the intensity of stress hyperglycemia by highlighting the rate of change in fasting blood glucose during stress. Several studies have validated the association of SHR with poor prognosis in cardiovascular disease. However, the value of SHR in diabetic patients with severe heart failure requiring ICU admission remains unclear.

Exploring Therapeutic Targets for Preventing Cardiac Arrest by Modulating Dyslipidemia and 25-Hydroxyvitamin D Metabolism: A Mendelian Randomization Study.

Cardiac arrest (CA) prevention continues to be a substantial hurdle for global public health. Although dyslipidemia and 25-hydroxyvitamin D (25(OH)D) insufficiency are recognized contributing factors for cardiovascular disease (CVD), their causal relationship with CA risk is still uncertain. Here, we explored these correlations and pinpointed possible therapeutic targets for CA prevention though Mendelian randomization (MR).

p-phenoxyphenol impaired male fertility by disrupting the testicular function and local microenvironment.

p-phenoxyphenol (PhOP) is an endocrine-disrupting chemical commonly used as an industrial raw material. It can be released either as a monomer or as a metabolite from products containing PhOP. PhOP has been reported to have estrogenic activity, but its reproductive toxicity effect on males remains unclear.

Integrative single-cell RNA sequencing and bulk RNA sequencing reveals the characteristics of glutathione metabolism and protective role of GSTA4 gene in pancreatic cancer.

Background: Recent studies have increasingly reported abnormal glutathione (GSH) metabolism within the tumor microenvironment across various solid tumors. However, the specific mechanisms underlying aberrant GSH metabolism in pancreatic cancer (PC) remain unclear. This study aims to investigate the prognostic significance of GSH metabolism-related genes in PC and to identify key molecular targets, thereby providing novel perspectives for targeted PC therapy.

TLR4 mediates lipotoxic β-cell dysfunction by inhibiting the TMEM24/PI3K/AKT pathway.

Immune imbalance is the core pathophysiological mechanism of the deterioration of β-cell function driven by lipid metabolism disorders. Toll-like receptor 4 (TLR4) inflammatory signaling is a key pathway that mediates lipotoxic injury in β-cells, but the underlying mechanism needs to be further elucidated. Transmembrane protein 24 (TMEM24) is a key transporter that regulates pulsatile insulin secretion, but its pathophysiology in lipotoxicity remains unclear.

Lipid metabolism-mediated fertility decline in male mice exposed to Fluorene-9-bisphenol: An integrated DNA methylation and transcriptomics analysis.

Fluorene-9-bisphenol (BHPF), a widely recognized alternative to bisphenol A (BPA), has been increasingly used in a wide range of industries. However, despite numerous studies, the direct mechanism underlying its male reproductive toxicity remains poorly understood. Here, a BHPF-exposed mouse model was established to evaluate the effect of BHPF on male fertility.

A new endoscopic treatment for gastric fundal subepithelial lesions using loop-assisted inversion and double suture technique.

The loop-assisted inversion and double suture technique has been used as an endoscopic treatment for gastric fundal subepithelial lesions. This study aimed to analyse the efficacy and safety of the loop-assisted inversion and double suture technique for the treatment of gastric fundal subepithelial lesions. Consecutive patients with gastric fundal tumours who underwent the loop-assisted inversion and double suture technique at our centre between January 2023 and January 2024 were retrospectively assessed.

TLR4 mediates glucolipotoxicity-induced mitochondrial dysfunction in osteoblasts by enhancing NLRP3-MAVS expression and interaction.

Mitochondrial dysfunction is a critical mechanism underlying diabetic bone loss, which is driven by the inhibition of osteoblast differentiation due to glucolipotoxicity. The molecular mechanisms through which glucolipotoxicity induces mitochondrial dysfunction remain poorly understood. In this study, we observed an upregulation of Toll-like receptor 4 (TLR4) expression in osteoblasts subjected to glycolipotoxic conditions, which was associated with mitochondrial dysfunction.

A versatile alginate aerogel with spatially separated sorption sites for simultaneously and collaboratively scavenging Pb(II) and tetracycline in wastewater: Insight into behavior and mechanisms in the mixture system.

Alleviating combined pollution caused by heavy metals and antibiotics is of great significance for ecological sustainability and human health. It is still quite challenging to simultaneously and efficiently scavenge both pollutants due to their completely different physicochemical properties and the fierce competition between multi-pollutants faced by traditional adsorbents. In present work, a novel alginate-based aerogel microbead (GO/Fe-Ca-Alg) with specific sorption sites toward these two sorts of pollutants was fabricated via a 'multi-site coupling' strategy.

Landscape analysis of m6A modification reveals the dysfunction of bone metabolism in osteoporosis mice.

Osteoporosis (OP) is a prevalent chronic bone metabolic disorder that affects the elderly population, leading to an increased susceptibility to bone fragility. Despite extensive research on the onset and progression of OP, the precise mechanisms underlying this condition remain elusive. The m6A modification, a prevalent form of chemical RNA modification, primarily regulates posttranscriptional processes, including RNA stability, splicing, and translation.

Unphysiological lung strain promotes ventilation-induced lung injury via activation of the PECAM-1/Src/STAT3 signaling pathway.

Introduction: In patients with acute respiratory distress syndrome, mechanical ventilation often leads to ventilation-induced lung injury (VILI), which is attributed to unphysiological lung strain (UPLS) in respiratory dynamics. Platelet endothelial cell adhesion molecule-1 (PECAM-1), a transmembrane receptor, senses mechanical signals. The Src/STAT3 pathway plays a crucial role in the mechanotransduction network, concurrently triggering pyroptosis related inflammatory responses.

JZL-184 Alleviate Neurological Impairment through Regulation of Mitochondrial Transfer and Lipid Droplet Accumulation after Cardiac Arrest.

Astrocytes are abundant glial cells in the central nervous system (CNS) that play important roles in brain injury following cardiac arrest (CA). Following brain ischemia, astrocytes trigger endogenous neuroprotective mechanisms, such as fatty acid transport. Lipid droplets (LDs) are cellular structures involved in neutral lipid storage and play essential roles in many biological processes.

Multifunctional cyclic biomimetic peptides: Self-assembling nanotubes for effective treatment of sepsis.

Antibiotic abuse has led to an increasingly serious risk of antimicrobial resistance, developing alternative antimicrobials to combat this alarming issue is urgently needed. Rhesus theta defensin-1 (RTD-1) is a theta-defensin contributing to broad-spectrum bactericidal activity via the mechanisms of membrane perturbation. Intriguingly, human defensin-6 (HD6), an enteric defensin secreted by Paneth cells without direct bactericidal effect, could self-assembled into fibrous networks to trap enteric pathogens for assistance of innate immunity.

Immune dysregulation of decidual NK cells mediated by GRIM19 downregulation contributes to the occurrence of recurrent pregnancy loss.

In patients with recurrent pregnancy loss (RPL), excessive activation of decidual natural killer (dNK) cells has been widely observed, yet the precise underlying mechanisms remain to be elucidated. We collected decidual specimens from RPL patients and controls to assess GRIM19 expression, activation phenotype, cytotoxic function, inflammatory cytokine secretion, and mitochondrial homeostasis in dNK cells. Furthermore, we established a GRIM19-knockout NK-92MI cell line and a GRIM19 ± C57BL/6J mouse model to investigate the relationship between GRIM19 downregulation and dNK immune dysregulation, ultimately contributing to pregnancy loss.

Gut microbiota combined with metabolome dissects Fluorene-9-bisphenol exposure-induced male reproductive toxicity.

A major alternative to bisphenol A (BPA), fluorene-9-bisphenol (BHPF) has been shown to cause multiorgan toxicity. However, its reproductive toxicity and the underlying biological mechanism remain largely unknown. Recently, changes in the gut microbiota and metablome caused by environmental contaminant exposure and their potential impact on male reproductive health have been of great concern.

EHDPP induces proliferation inhibition and apoptosis to spermatocyte: Insights from transcriptomic and metabolomic profiles.

Background: 2-ethylhexyldiphenyl phosphate (EHDPP) was used widespread in recent years and it was reported to impair reproductive behaviors and decrease fertility in male Japanese medaka. However, whether EHDPP causes spermatogenesis disturbance remains uncertain.

Objectives: We aimed to study the male reproductive toxicity of EHDPP and its related mechanism.

Fluorene-9-bisphenol impaired male fertility through disrupting the testicular function and local microenvironment.

Past studies have observed that BHPF induces multi-organ toxicity, however, whether it induces damage to male reproductive system and the specific mechanism remains unclear. In the present study, male mice were given 0, 2, 10 or 50 mg/kg/day of BHPF by gavage for 35 days to observe its effect on reproductive organ and sperm quality. The results indicated that BHPF decreased sperm count and sperm motility in a dose-dependent manner.

Discovery of mmu-lncRNA129814/hsa-lncRNA582795 as a Potential Biomarker and Intervention Target for Ischemia Reperfusion Injury-Induced AKI.

Background: Acute kidney injury (AKI) is associated with higher perioperative mortality and morbidity, as well as increased medical expenses. The molecular mechanisms underlying ischemia-reperfusion (I/R)-induced AKI remain unclear.

Methods And Results: We applied an RT-qPCR assay to measure the expression of mmu-lncRNA129814, hsa-lncRNA582795, and miRNA-494-5p, immunoblotting to detect IL-1α and cleaved caspase-3 expression, and TUNEL staining and flow cytometry (FCM) to evaluate apoptosis.

Compared with other methods, cyanoacrylate and lauromacrogol in treating esophagogastric varices did not increase the risk of postoperative infection.

Background: Patients with cirrhosis commonly undergo endoscopic cyanoacrylate injection for gastric and esophageal variceal bleeding. However, postoperative infections can increase the risk of rebleeding and mortality.

Aim: This study aimed to determine the risk of postoperative infections and its associated factors following cyanoacrylate injection treatment in these patients.