RCN1 downregulation-driven endoplasmic reticulum stress impairs endothelial function and diabetic foot ulcer healing.

Diabetic foot ulcers (DFUs) are a leading cause of disability and mortality, with endothelial dysfunction playing a key role in the development of non-healing ulcers. A primary driver of endothelial cell impairment in this context is endoplasmic reticulum (ER) stress, triggered by glycolipotoxicity, though the underlying mechanisms are not fully understood. In this study, we observed that diabetic mice displayed poor ulcer healing associated with reduced angiogenesis and downregulated Reticulocalbin 1 (RCN1) expression.

TLR4 mediates lipotoxic β-cell dysfunction by inhibiting the TMEM24/PI3K/AKT pathway.

Immune imbalance is the core pathophysiological mechanism of the deterioration of β-cell function driven by lipid metabolism disorders. Toll-like receptor 4 (TLR4) inflammatory signaling is a key pathway that mediates lipotoxic injury in β-cells, but the underlying mechanism needs to be further elucidated. Transmembrane protein 24 (TMEM24) is a key transporter that regulates pulsatile insulin secretion, but its pathophysiology in lipotoxicity remains unclear.

Phenotypic and genetic stepwise changes in during adaptive laboratory evolution under the selective pressure of tigecycline.

Compared with tigecycline-resistant gram-negative bacteria, tigecycline adaptive laboratory evolution (ALE) has been preliminarily performed in . This study aims to develop higher-level tigecycline-resistant mutants (TRSAms) and explore the mechanisms behind decreasing susceptibility to tigecycline. In this study, strains were cultured in serial-increasing concentrations of tigecycline and successfully obtained high-level TRSAms.

Revitalizing zinc-ion batteries with advanced zinc anode design.

Rechargeable aqueous zinc-ion batteries (AZIBs) have attracted significant attention in large-scale energy storage systems due to their unique merits, such as intrinsic safety, low cost, and relatively high theoretical energy density. However, the dilemma of the uncontrollable Zn dendrites, severe hydrogen evolution reaction (HER), and side reactions that occur on the Zn anodes have hindered their commercialization. Herein, a state-of-the-art review of the rational design of highly reversible Zn anodes for high-performance AZIBs is provided.

Thermal-Stable Separators: Design Principles and Strategies Towards Safe Lithium-Ion Battery Operations.

Lithium-ion batteries (LIBs) are momentous energy storage devices, which have been rapidly developed due to their high energy density, long lifetime, and low self-discharge rate. However, the frequent occurrence of fire accidents in laptops, electric vehicles, and mobile phones caused by thermal runaway of the inside batteries constantly reminds us of the urgency in pursuing high-safety LIBs with high performance. To this end, this Review surveyed the state-of-the-art developments of high-temperature-resistant separators for highly safe LIBs with excellent electrochemical performance.